Aim:Secondary malignancy estimation after radiotherapy of post mastectomy patients is becoming an important subject for comparative treatment planning.The data from modern treatment planning systems provide accurate t...Aim:Secondary malignancy estimation after radiotherapy of post mastectomy patients is becoming an important subject for comparative treatment planning.The data from modern treatment planning systems provide accurate three-dimensional dose distributions for each individual patients,thereby opening up new possibilities for more precise estimates of secondary cancer incidence rates in the irradiated organs.Methods:This study estimates the probability of secondary malignancy using radiobiological model for post mastectomy patients in a low-resource center,Nigeria.The secondary cancer complication probability(SCCP)was computed for linear,linear-exponent and linear-plateau models.Results:The result shows that comparing the three models the mean SCCP for the contralateral breast ranged between 0.41%-0.93%;for the lung(0.34%-5.93%);while for the chest wall is between 0.65%-31.95%.Also,the result showed that based on the differential dose volume histogram,the SCCP in the chest wall is highest compared to the lung and contralateral breast;while the linear model overestimate the risk of secondary malignancy,the linear-exponent and the linear plateaus gave values not outrageously high.Conclusion:The models in this study have shown that the risk of secondary malignancy in these post mastectomy patients is low.展开更多
文摘Aim:Secondary malignancy estimation after radiotherapy of post mastectomy patients is becoming an important subject for comparative treatment planning.The data from modern treatment planning systems provide accurate three-dimensional dose distributions for each individual patients,thereby opening up new possibilities for more precise estimates of secondary cancer incidence rates in the irradiated organs.Methods:This study estimates the probability of secondary malignancy using radiobiological model for post mastectomy patients in a low-resource center,Nigeria.The secondary cancer complication probability(SCCP)was computed for linear,linear-exponent and linear-plateau models.Results:The result shows that comparing the three models the mean SCCP for the contralateral breast ranged between 0.41%-0.93%;for the lung(0.34%-5.93%);while for the chest wall is between 0.65%-31.95%.Also,the result showed that based on the differential dose volume histogram,the SCCP in the chest wall is highest compared to the lung and contralateral breast;while the linear model overestimate the risk of secondary malignancy,the linear-exponent and the linear plateaus gave values not outrageously high.Conclusion:The models in this study have shown that the risk of secondary malignancy in these post mastectomy patients is low.
