Radiodermatitis is a constant complication after radiotherapy with no efficient drug for prevention and treatment. Its physiopathology is complex, possibly related to injury of epidermis and endothelial cells from the...Radiodermatitis is a constant complication after radiotherapy with no efficient drug for prevention and treatment. Its physiopathology is complex, possibly related to injury of epidermis and endothelial cells from the basal layer by radiolysis, overproduction of free radicals, pro-inflammatory cytokines, and inflammation. PTCTS gel is an after sun cosmetic gel composed by anti-oxidative plant extract rich in natural nanoparticles and thermal water (Complex A) and recombinant protein of Trypanosoma cruzi transialidase (Complex B), with high anti-oxidative and anti-apoptotic effects, presenting anti-aging and healing cutaneous properties. Objective: To study the safety and efficacy of PTCTS gel for topic use in volunteer subjects with healthy skin, and in patients with radiodermatitis, in different concentrations of Complexes A and B. Material and Methods: The project was approved by the Ethical Committee of Arnaldo Vieira de Carvalho Institute, Sao Paulo, Brazil. The individuals were submitted to laboratorial toxicity study through tests for liver and kidney function, levels of blood glucose and blood count before and after 7 days of PTCTS application. We studied two groups: GI-22 volunteers with healthy skin, presenting articular or skeletal muscle pain and GII-38 patients in radiotherapy for breast or head and neck cancer, with radiodermatitis grade 2 or 3. The patients were evaluated before and after 1.0 ml/cm2 PTCTS gel application, twice a day. We tested Complex B in four different concentrations, and Complex A concentrations varied inversely. Results: No irritation signs were observed in GI nor GII group, 64% of GI had important decrease in the intensity of the muscular or articular pain, and 99% of GII showed regression of radiodermatitis, all exhibiting relief of pain. No patient presented hematologic, renal or hepatic toxicity. Conclusion: PTCTS cosmetic gel is a safe option for radiodermatitis treatment, with no side effects or laboratorial toxicity in different concentrations. This product presented excellent clinical results even if used diluted 4 times more than the original product and may be a good option for treatment of radiodermatitis. Further studies may show if it is also indicated in the prevention of the lesion, and if it is better than products containing corticoids.展开更多
目的系统评价康复新液治疗头颈部肿瘤放射性皮炎的效果。方法计算机检索PubMed、Co⁃chrane Library、Embase、Web of Science、中国生物医学文献服务系统、中国知网、维普、万方数据库自建库以来至2023年9月公开发表的与康复新液治疗头...目的系统评价康复新液治疗头颈部肿瘤放射性皮炎的效果。方法计算机检索PubMed、Co⁃chrane Library、Embase、Web of Science、中国生物医学文献服务系统、中国知网、维普、万方数据库自建库以来至2023年9月公开发表的与康复新液治疗头颈部肿瘤放射治疗所造成放射性皮炎相关的随机对照研究。由2人独立进行文献筛选、质量评价和资料提取,采用Revman 5.4软件进行数据分析。结果共纳入10篇中文文献,包括688例患者。Meta分析结果显示:康复新液组治疗头颈部肿瘤放射性皮炎的总体有效性优于对照组,差异有统计学意义[OR=4.04,95%CI(2.29,7.15),P<0.05];康复新液组Ⅱ级及以上放射性皮炎的发生率低于对照组,差异有统计学意义[OR=0.34,95%CI(0.19,0.63),P<0.05]。结论当前证据显示,康复新液治疗头颈部肿瘤放射性皮炎的效果显著,有助于降低Ⅱ级及以上头颈部肿瘤放射性皮炎的发生率。展开更多
目的应用网状meta分析对5种常用中成药外治放射性皮炎的疗效进行评价。方法计算机检索中国知网(CNKI)、万方(Wanfang)、中国生物医学文献服务系统(SinoMed)、维普(VIP)、PubMed、Cochrane Library、Embase、Web of Science等数据库,搜...目的应用网状meta分析对5种常用中成药外治放射性皮炎的疗效进行评价。方法计算机检索中国知网(CNKI)、万方(Wanfang)、中国生物医学文献服务系统(SinoMed)、维普(VIP)、PubMed、Cochrane Library、Embase、Web of Science等数据库,搜索有关中成药治疗放射性皮炎的随机对照试验(RCTs)。采用Stata 15.1软件进行网状meta分析。结果最终纳入30项研究,共包含2793例患者,网状meta分析显示,临床总有效率累计概率排序为三黄膏(81.8%)>金黄散(80.6%)>康复新液(71%)>复方紫草油(64.9%)>射线防护剂(56.9%)>湿润烧伤膏(46.1%)>生长因子(27.6%)>抗菌药物(16.5%)>常规护理(4.6%);皮肤损伤愈合时间累计概率排序为康复新液(98%)>抗菌药物(66.1%)>湿润烧伤膏(35.9%)>常规护理(0%);重度皮炎发生率累计概率排序为三黄膏(78.6%)>湿润烧伤膏(57%)>康复新液(56.2%)>医用射线防护剂(51.4%)>常规护理(6.9%);结果提示,与常规护理、抗菌药物和生长因子相比,5种中成药均能改善临床总有效率;与常规护理比较,康复新液和湿润烧伤膏可缩短皮肤损伤愈合时间;在控制重度皮炎发生率方面,三黄膏、湿润烧伤膏和康复新液均优于医用射线防护剂和常规护理。结论5种中成药外治放射性皮炎的临床疗效较常见西医治疗更佳,其中三黄膏的疗效可能更为突出。但鉴于不同治疗措施间纳入的质量、研究数量存在较大差异,本研究中成药的SUCRA累计概率排序需谨慎参考。展开更多
Objective:To explore the concept of radiation dermatitis wet healing through a literature review and provide references for future treatment of patients with radiation skin injury.Methods:Related ar ticles selected fr...Objective:To explore the concept of radiation dermatitis wet healing through a literature review and provide references for future treatment of patients with radiation skin injury.Methods:Related ar ticles selected from China National Knowledge Infrastructure(CNKI),Wanfang Database,Pub Med,Web of Science,Medline,and EBSCO were analyzed with Rodger’s concept analysis.Results:We identified the application status of wet healing in domestic and foreign literature,defined explicit attributes of the procedure,and clarified concepts related to wet healing of radiation skin injury to provide a reference for the management of radiation dermatitis with wet healing.Conclusions:Treatment of radiation dermatitis with wet healing is a unique procedure.Analyzing this concept can contribute to its development in the future and can offer a theoretical basis for treatment of patients with radiation skin injury.展开更多
文摘Radiodermatitis is a constant complication after radiotherapy with no efficient drug for prevention and treatment. Its physiopathology is complex, possibly related to injury of epidermis and endothelial cells from the basal layer by radiolysis, overproduction of free radicals, pro-inflammatory cytokines, and inflammation. PTCTS gel is an after sun cosmetic gel composed by anti-oxidative plant extract rich in natural nanoparticles and thermal water (Complex A) and recombinant protein of Trypanosoma cruzi transialidase (Complex B), with high anti-oxidative and anti-apoptotic effects, presenting anti-aging and healing cutaneous properties. Objective: To study the safety and efficacy of PTCTS gel for topic use in volunteer subjects with healthy skin, and in patients with radiodermatitis, in different concentrations of Complexes A and B. Material and Methods: The project was approved by the Ethical Committee of Arnaldo Vieira de Carvalho Institute, Sao Paulo, Brazil. The individuals were submitted to laboratorial toxicity study through tests for liver and kidney function, levels of blood glucose and blood count before and after 7 days of PTCTS application. We studied two groups: GI-22 volunteers with healthy skin, presenting articular or skeletal muscle pain and GII-38 patients in radiotherapy for breast or head and neck cancer, with radiodermatitis grade 2 or 3. The patients were evaluated before and after 1.0 ml/cm2 PTCTS gel application, twice a day. We tested Complex B in four different concentrations, and Complex A concentrations varied inversely. Results: No irritation signs were observed in GI nor GII group, 64% of GI had important decrease in the intensity of the muscular or articular pain, and 99% of GII showed regression of radiodermatitis, all exhibiting relief of pain. No patient presented hematologic, renal or hepatic toxicity. Conclusion: PTCTS cosmetic gel is a safe option for radiodermatitis treatment, with no side effects or laboratorial toxicity in different concentrations. This product presented excellent clinical results even if used diluted 4 times more than the original product and may be a good option for treatment of radiodermatitis. Further studies may show if it is also indicated in the prevention of the lesion, and if it is better than products containing corticoids.
文摘目的系统评价康复新液治疗头颈部肿瘤放射性皮炎的效果。方法计算机检索PubMed、Co⁃chrane Library、Embase、Web of Science、中国生物医学文献服务系统、中国知网、维普、万方数据库自建库以来至2023年9月公开发表的与康复新液治疗头颈部肿瘤放射治疗所造成放射性皮炎相关的随机对照研究。由2人独立进行文献筛选、质量评价和资料提取,采用Revman 5.4软件进行数据分析。结果共纳入10篇中文文献,包括688例患者。Meta分析结果显示:康复新液组治疗头颈部肿瘤放射性皮炎的总体有效性优于对照组,差异有统计学意义[OR=4.04,95%CI(2.29,7.15),P<0.05];康复新液组Ⅱ级及以上放射性皮炎的发生率低于对照组,差异有统计学意义[OR=0.34,95%CI(0.19,0.63),P<0.05]。结论当前证据显示,康复新液治疗头颈部肿瘤放射性皮炎的效果显著,有助于降低Ⅱ级及以上头颈部肿瘤放射性皮炎的发生率。
文摘目的应用网状meta分析对5种常用中成药外治放射性皮炎的疗效进行评价。方法计算机检索中国知网(CNKI)、万方(Wanfang)、中国生物医学文献服务系统(SinoMed)、维普(VIP)、PubMed、Cochrane Library、Embase、Web of Science等数据库,搜索有关中成药治疗放射性皮炎的随机对照试验(RCTs)。采用Stata 15.1软件进行网状meta分析。结果最终纳入30项研究,共包含2793例患者,网状meta分析显示,临床总有效率累计概率排序为三黄膏(81.8%)>金黄散(80.6%)>康复新液(71%)>复方紫草油(64.9%)>射线防护剂(56.9%)>湿润烧伤膏(46.1%)>生长因子(27.6%)>抗菌药物(16.5%)>常规护理(4.6%);皮肤损伤愈合时间累计概率排序为康复新液(98%)>抗菌药物(66.1%)>湿润烧伤膏(35.9%)>常规护理(0%);重度皮炎发生率累计概率排序为三黄膏(78.6%)>湿润烧伤膏(57%)>康复新液(56.2%)>医用射线防护剂(51.4%)>常规护理(6.9%);结果提示,与常规护理、抗菌药物和生长因子相比,5种中成药均能改善临床总有效率;与常规护理比较,康复新液和湿润烧伤膏可缩短皮肤损伤愈合时间;在控制重度皮炎发生率方面,三黄膏、湿润烧伤膏和康复新液均优于医用射线防护剂和常规护理。结论5种中成药外治放射性皮炎的临床疗效较常见西医治疗更佳,其中三黄膏的疗效可能更为突出。但鉴于不同治疗措施间纳入的质量、研究数量存在较大差异,本研究中成药的SUCRA累计概率排序需谨慎参考。
文摘Objective:To explore the concept of radiation dermatitis wet healing through a literature review and provide references for future treatment of patients with radiation skin injury.Methods:Related ar ticles selected from China National Knowledge Infrastructure(CNKI),Wanfang Database,Pub Med,Web of Science,Medline,and EBSCO were analyzed with Rodger’s concept analysis.Results:We identified the application status of wet healing in domestic and foreign literature,defined explicit attributes of the procedure,and clarified concepts related to wet healing of radiation skin injury to provide a reference for the management of radiation dermatitis with wet healing.Conclusions:Treatment of radiation dermatitis with wet healing is a unique procedure.Analyzing this concept can contribute to its development in the future and can offer a theoretical basis for treatment of patients with radiation skin injury.
