The mechanism of radiotherapy or chemotherapy-induced oral mucositis is not yet clear.And model establishment is needed in further study.In order to summarize the methods of model establishment and make a comparison,l...The mechanism of radiotherapy or chemotherapy-induced oral mucositis is not yet clear.And model establishment is needed in further study.In order to summarize the methods of model establishment and make a comparison,literature databases including Web of Science、Pubmed and CNKI were searched for related researches from January 2015 to January 2021.Hamsters,mice,rats,guinea pigs and miniature pigs were chosen to be modeling animals and modeling methods could be classified into:chemotherapy,chemotherapy combined with superficial mucosal irritation,radiotherapy,radiotherapy combined with superficial mucosal irritation and chemoradiotherapy.Advantages and disadvantages had been analyzed in this study to provide reference for following studies.展开更多
Oral mucositis is a common adverse reaction of radiotherapy and chemotherapy in cancer patients,which reduces the quality of life of patients and affects the progress of cancer treatment.Most of the patients with mali...Oral mucositis is a common adverse reaction of radiotherapy and chemotherapy in cancer patients,which reduces the quality of life of patients and affects the progress of cancer treatment.Most of the patients with malignant tumor belong to the syndrome of deficiency in root case and excess in manifestation.When undergoing radiotherapy or chemotherapy,the patients’ministerial fire becomes hyperactive,which may cause oral mucositis.With the method of“conducting fire back to its origin”,ministerial fire can be led to vital gate,as well as recovering its physiological functions.In the treatment of oral mucositis,instead of attacking ministerial fire with too much heat-clearing herbs,we should,under the guidance of the theory of“conducting fire back to its origin”,differentiate the syndrome,and then we can use the methods of treatment of clearing and lowering heart fire,warmly invigorating spleen and stomach,nourishing liver and kidney,or warmly invigorating vital gate,to conduct ministerial fire back to vital gate.This article aims to provide theoretical reference for Traditional Chinese Medicine treatment of radiotherapy or chemotherapy induced oral mucositis.展开更多
目的探究重组人粒细胞集落刺激因子(recombinant human granulocyte-colony stimulating factor,rhG-CSF)在治疗儿童化疗性口腔黏膜炎中的应用效果。方法选取2020年1月至2022年6月于笔者医院肿瘤外科化疗的60例化疗性口腔黏膜炎患儿,按...目的探究重组人粒细胞集落刺激因子(recombinant human granulocyte-colony stimulating factor,rhG-CSF)在治疗儿童化疗性口腔黏膜炎中的应用效果。方法选取2020年1月至2022年6月于笔者医院肿瘤外科化疗的60例化疗性口腔黏膜炎患儿,按随机数字表法分为两组,每组30例。对照组采取生理盐水口腔护理,实验组采取rhG-CSF口腔护理。比较两组患儿干预效果、口腔黏膜炎分度、生存质量[健康状况调查简表(36-item short—form,SF-36)]、患儿家长护理满意度。结果实验组总有效率较对照组高,差异有统计学意义(P<0.05)。干预5d,实验组患儿口腔黏膜炎分度结果优于对照组,差异有统计学意义(P<0.05)。干预5d,两组患儿SF-36评分较干预前高,实验组较对照组高,差异有统计学意义(P<0.05)。实验组患儿家长满意度较对照组高,差异有统计学意义(P<0.05)。结论rhG-CSF口腔护理可有效提高儿童化疗性口腔黏膜炎的干预效果,减轻口腔黏膜炎分度,改善患儿生存质量,提高患儿家长护理满意度。展开更多
目的:探讨重组人表皮生长因子(rh-EGF)外用溶液治疗放射性口腔黏膜炎(RIOM)的效果。方法:选取2020年1月—2022年3月89例接受放疗并出现RIOM的头颈部肿瘤患者作为研究对象,根据随机数表法分为对照组(n=44)和研究组(n=45)。对照组接受地...目的:探讨重组人表皮生长因子(rh-EGF)外用溶液治疗放射性口腔黏膜炎(RIOM)的效果。方法:选取2020年1月—2022年3月89例接受放疗并出现RIOM的头颈部肿瘤患者作为研究对象,根据随机数表法分为对照组(n=44)和研究组(n=45)。对照组接受地塞米松+庆大霉素+利多卡因稀释液漱口,研究组在对照组治疗基础上加用rh-EGF治疗。采用数字评价量表(numerical rating scale,NRS)和成人癌症生存者生命质量量表(quality of life in adult cancer survivors,QLACS)评估两组口腔疼痛程度与生活质量。比较两组疗效、口腔疼痛及生活质量的差异。结果:研究组近期总有效率为95.56%(43/45),而对照组仅77.27%(34/44),两组比较差异有统计学意义(χ^(2)=7.299,P=0.026)。两组治疗前NRS、QLACS评分比较,差异均无统计学意义(P>0.05);研究组治疗后NRS、QLACS评分均低于对照组,且差异均有统计学意义(P<0.05)。结论:RIOM患者采用重组人表皮生长因子治疗,可以有效缓解疼痛,提高治疗效果,提高生活质量,值得推广应用。展开更多
基金National Natural Science Foundation of China(No.81973693)。
文摘The mechanism of radiotherapy or chemotherapy-induced oral mucositis is not yet clear.And model establishment is needed in further study.In order to summarize the methods of model establishment and make a comparison,literature databases including Web of Science、Pubmed and CNKI were searched for related researches from January 2015 to January 2021.Hamsters,mice,rats,guinea pigs and miniature pigs were chosen to be modeling animals and modeling methods could be classified into:chemotherapy,chemotherapy combined with superficial mucosal irritation,radiotherapy,radiotherapy combined with superficial mucosal irritation and chemoradiotherapy.Advantages and disadvantages had been analyzed in this study to provide reference for following studies.
基金General project of national science foundation of China(No.81973693)。
文摘Oral mucositis is a common adverse reaction of radiotherapy and chemotherapy in cancer patients,which reduces the quality of life of patients and affects the progress of cancer treatment.Most of the patients with malignant tumor belong to the syndrome of deficiency in root case and excess in manifestation.When undergoing radiotherapy or chemotherapy,the patients’ministerial fire becomes hyperactive,which may cause oral mucositis.With the method of“conducting fire back to its origin”,ministerial fire can be led to vital gate,as well as recovering its physiological functions.In the treatment of oral mucositis,instead of attacking ministerial fire with too much heat-clearing herbs,we should,under the guidance of the theory of“conducting fire back to its origin”,differentiate the syndrome,and then we can use the methods of treatment of clearing and lowering heart fire,warmly invigorating spleen and stomach,nourishing liver and kidney,or warmly invigorating vital gate,to conduct ministerial fire back to vital gate.This article aims to provide theoretical reference for Traditional Chinese Medicine treatment of radiotherapy or chemotherapy induced oral mucositis.
文摘目的:探讨重组人表皮生长因子(rh-EGF)外用溶液治疗放射性口腔黏膜炎(RIOM)的效果。方法:选取2020年1月—2022年3月89例接受放疗并出现RIOM的头颈部肿瘤患者作为研究对象,根据随机数表法分为对照组(n=44)和研究组(n=45)。对照组接受地塞米松+庆大霉素+利多卡因稀释液漱口,研究组在对照组治疗基础上加用rh-EGF治疗。采用数字评价量表(numerical rating scale,NRS)和成人癌症生存者生命质量量表(quality of life in adult cancer survivors,QLACS)评估两组口腔疼痛程度与生活质量。比较两组疗效、口腔疼痛及生活质量的差异。结果:研究组近期总有效率为95.56%(43/45),而对照组仅77.27%(34/44),两组比较差异有统计学意义(χ^(2)=7.299,P=0.026)。两组治疗前NRS、QLACS评分比较,差异均无统计学意义(P>0.05);研究组治疗后NRS、QLACS评分均低于对照组,且差异均有统计学意义(P<0.05)。结论:RIOM患者采用重组人表皮生长因子治疗,可以有效缓解疼痛,提高治疗效果,提高生活质量,值得推广应用。
