This paper extends a prediction model for multi-directional random wave transformation based on an energy balance equation by Mase with the consideration of wave shoaling, refraction, diffraction, reflection and break...This paper extends a prediction model for multi-directional random wave transformation based on an energy balance equation by Mase with the consideration of wave shoaling, refraction, diffraction, reflection and breaking. This numerical model is improved by 1) introducing Wen's frequency spectrum and Mitsuyasu's directional function, which are more suitable to the coastal area of China; 2) considering energy dissipation caused by bottom friction, which ensures more accurate results for large-scale and shallow water areas; 3) taking into account a non-linear dispersion relation. Predictions using the extended wave model are carried out to study the feasibility of constructing the Ai Hua yacht port in Qingdao, China, with a comparison between two port layouts in design. Wave fields inside the port for different incident wave directions, water levels and return periods are simulated, and then two kinds of parameters are calculated to evaluate the wave conditions for the two layouts. Analyses show that Layout I is better than Layout II. Calculation results also show that the harbor will be calm for different wave directions under the design water level. On the contrary, the wave conditions do not wholly meet the requirements of a yacht port for ship berthing under the extreme water level. For safety consideration, the elevation of the breakwater might need to be properly increased to prevent wave overtopping under such water level. The extended numerical simulation model may provide an effective approach to computing wave heights in a harbor.展开更多
An optimized device structure for reducing the RESET current of phase-change random access memory (PCRAM) with blade-type like (BTL) phase change layer is proposed. The electrical thermal analysis of the BTL cell ...An optimized device structure for reducing the RESET current of phase-change random access memory (PCRAM) with blade-type like (BTL) phase change layer is proposed. The electrical thermal analysis of the BTL cell and the blade heater contactor structure by three-dimensional finite element modeling are compared with each other during RESET operation. The simulation results show that the programming region of the phase change layer in the BTL cell is much smaller, and thermal electrical distributions of the BTL cell are more concentrated on the TiN/GST interface. The results indicate that the BTL cell has the superiorities of increasing the heating efficiency, decreasing the power consumption and reducing the RESET current from 0.67mA to 0.32mA. Therefore, the BTL cell will be appropriate for high performance PCRAM device with lower power consumption and lower RESET current.展开更多
Based on random theory, fluid dynamics , porous media and soil mechanics, the porosity and random characteristic of the two-layer soft soil in Wuhan region were studied in this paper. The random seepage coefficient on...Based on random theory, fluid dynamics , porous media and soil mechanics, the porosity and random characteristic of the two-layer soft soil in Wuhan region were studied in this paper. The random seepage coefficient on the two-layer soft soil was analyzed, and the seepage model and its random distribution Junction mere given. The groundwater flow differential equations related to the two layer soft soil structure were also established. The evaluation procedure of effect boundary on the pumping water in deep foundation pit was put forward. Moreover , with an engineering example, the probability distribution on random boundary prediction for pumping water of foundation pit was computed.展开更多
The theory of Monte-Carlo simulation method is that the event happened probability was estimated by happened frequency in the experiments. So it is very im-portant to ascertain the times of simulation. The probability...The theory of Monte-Carlo simulation method is that the event happened probability was estimated by happened frequency in the experiments. So it is very im-portant to ascertain the times of simulation. The probability and statistic theory are used to determine the optimal simulation times through strict mathematic reasoning. The study of two cases is made to show the availability of the presented method, and some relative problems were discussed.展开更多
The mesoscopic failure mechanism and the macro-mechanical characteristics of soil-rock mixture(S-RM) under external load are largely controlled by S-RM's meso-structural features. The objective of this work is to ...The mesoscopic failure mechanism and the macro-mechanical characteristics of soil-rock mixture(S-RM) under external load are largely controlled by S-RM's meso-structural features. The objective of this work is to improve the three-dimensional technology for the generation of the random meso-structural models of S-RM, for randomly generating irregular rock blocks in S-RM with different shapes, sizes, and distributions according to the characteristics of the rock blocks' size distribution. Based on the new improved technology, a software system named as R-SRM3 D for generation and visualization of S-RM is developed. Using R-SRM3 D, a three-dimensional meso-structural model of S-RM is generated and used to study the meso-mechanical behavior through a series of true-triaxial numerical tests. From the numerical tests, the following conclusions are obtained. The meso-stress field of S-RM is influenced by the distribution of the internal rock blocks, and the macro-mechanical characteristics of S-RM are anisotropic in 3D; the intermediate principal stress and the soil-rock interface properties have significant influence on the macro strength of S-RM.展开更多
An efficient importance sampling algorithm is presented to analyze reliability of complex structural system with multiple failure modes and fuzzy-random uncertainties in basic variables and failure modes. In order to ...An efficient importance sampling algorithm is presented to analyze reliability of complex structural system with multiple failure modes and fuzzy-random uncertainties in basic variables and failure modes. In order to improve the sampling efficiency, the simulated annealing algorithm is adopted to optimize the density center of the importance sampling for each failure mode, and results that the more significant contribution the points make to fuzzy failure probability, the higher occurrence possibility the points are sampled. For the system with multiple fuzzy failure modes, a weighted and mixed importance sampling function is constructed. The contribution of each fuzzy failure mode to the system failure probability is represented by the appropriate factors, and the efficiency of sampling is improved furthermore. The variances and the coefficients of variation are derived for the failure probability estimations. Two examples are introduced to illustrate the rationality of the present method. Comparing with the direct Monte-Carlo method, the improved efficiency and the precision of the method are verified by the examples.展开更多
Slope reliability analysis considering inherent spatial variability(ISV)of soil properties is timeconsuming when response surface method(RSM)is used,because of the"curse of dimensionality".This paper propose...Slope reliability analysis considering inherent spatial variability(ISV)of soil properties is timeconsuming when response surface method(RSM)is used,because of the"curse of dimensionality".This paper proposes an effective method for identification of representative slip surfaces(RSSs)of slopes with spatially varied soils within the framework of limit equilibrium method(LEM),which utilizes an adaptive K-means clustering approach.Then,an improved slope reliability analysis based on the RSSs and RSM considering soil spatial variability,in perspective of computation efficiency,is established.The detailed implementation procedure of the proposed method is well documented,and the ability of the method in identifying RSSs and estimating reliability is investigated via three slope examples.Results show that the proposed method can automatically identify the RSSs of slope with only one evaluation of the conventional deterministic slope stability model.The RSSs are invariant with the statistics of soil properties,which allows parametric studies that are often required in slope reliability analysis to be efficiently achieved with ease.It is also found that the proposed method provides comparable values of factor of safety(FS)and probability of failure(Pf)of slopes with those obtained from direct analysis and lite rature.展开更多
Fishery-independent surveys are often used for collecting high quality biological and ecological data to support fisheries management. A careful optimization of fishery-independent survey design is necessary to improv...Fishery-independent surveys are often used for collecting high quality biological and ecological data to support fisheries management. A careful optimization of fishery-independent survey design is necessary to improve the precision of survey estimates with cost-effective sampling efforts. We developed a simulation approach to evaluate and optimize the stratification scheme for a fishery-independent survey with multiple goals including estimation of abundance indices of individual species and species diversity indices. We compared the performances of the sampling designs with different stratification schemes for different goals over different months. Gains in precision of survey estimates from the stratification schemes were acquired compared to simple random sampling design for most indices. The stratification scheme with five strata performed the best. This study showed that the loss of precision of survey estimates due to the reduction of sampling efforts could be compensated by improved stratification schemes, which would reduce the cost and negative impacts of survey trawling on those species with low abundance in the fishery-independent survey. This study also suggests that optimization of a survey design differed with different survey objectives. A post-survey analysis can improve the stratification scheme of fishery-independent survey designs.展开更多
Reliability optimal design is an integrated approach widely adopted in engineering. The fuze components are designed by a BP neural network combined with an optimal design approach based on their multi-failure modes. ...Reliability optimal design is an integrated approach widely adopted in engineering. The fuze components are designed by a BP neural network combined with an optimal design approach based on their multi-failure modes. Their reliability probabilities in multi-failure modes are transformed into deterministic design parameters. The designed results by an example of optimizing the fuze spring under a certain reliability show that the integrated approach is practical and efficient.展开更多
Aiming at the dynamic response of reticulated shell structures under wind load,systematic parameter analyses on wind-induced responses of Kiewitt6-6 type single-layer spherical reticulated shell structures and three-w...Aiming at the dynamic response of reticulated shell structures under wind load,systematic parameter analyses on wind-induced responses of Kiewitt6-6 type single-layer spherical reticulated shell structures and three-way grid single-layer cylindrical reticulated shell structures were performed with the random simulation method in time domain,including geometric parameters,structural parameters and aerodynamic parameters.Moreover,a wind-induced vibration coefficient was obtained,which can be a reference to the wind-resistance design of reticulated shell structures.The results indicate that the geometric parameters are the most important factor influencing wind-induced responses of the reticulated shell structures;the wind-induced vibration coeffi-cient is 3.0-3.2 for the spherical reticulated shell structures and that is 2.8-3.0 for the cylindrical reticula-ted shell structures,which shows that the wind-induced vibration coefficients of these two kinds of space frames are well-proportioned.展开更多
Based on the theory of random process and the characteristic of the functioning of a system component subject to a certain specific probability distribution, emulated the whole process of system production on Iongwall...Based on the theory of random process and the characteristic of the functioning of a system component subject to a certain specific probability distribution, emulated the whole process of system production on Iongwall face was emulated, in which the methods of time pace and computer random emulation were adopted. The paper provides an objective basis for the analysis of a mining Iongwall face and the varied lines of effectiveness, machine stoppage rate and coal flow of components and system, and output etc.lt also offers some theories to improve productivity by discussing the application of the transformation plan and optimization of reasonable coal stock capacity, as well as selection of system equipment and matching optimization.展开更多
The vortex-in-cell method in the discrete vortex simulation for the separated flow around a bluff body is discussed,Some improvements are made.The separated flow around a circular cylinder in oscillatory flow is inves...The vortex-in-cell method in the discrete vortex simulation for the separated flow around a bluff body is discussed,Some improvements are made.The separated flow around a circular cylinder in oscillatory flow is investigated.展开更多
According to Lorenz, chaotic dynamic systems have sensitive dependence on initial conditions(SDIC), i.e., the butterfly-effect: a tiny difference on initial conditions might lead to huge difference of computer-gene...According to Lorenz, chaotic dynamic systems have sensitive dependence on initial conditions(SDIC), i.e., the butterfly-effect: a tiny difference on initial conditions might lead to huge difference of computer-generated simulations after a long time. Thus, computer-generated chaotic results given by traditional algorithms in double precision are a kind of mixture of "true"(convergent) solution and numerical noises at the same level. Today, this defect can be overcome by means of the "clean numerical simulation"(CNS) with negligible numerical noises in a long enough interval of time. The CNS is based on the Taylor series method at high enough order and data in the multiple precision with large enough number of digits, plus a convergence check using an additional simulation with even smaller numerical noises. In theory, convergent(reliable) chaotic solutions can be obtained in an arbitrary long(but finite) interval of time by means of the CNS. The CNS can reduce numerical noises to such a level even much smaller than micro-level uncertainty of physical quantities that propagation of these physical micro-level uncertainties can be precisely investigated. In this paper, we briefly introduce the basic ideas of the CNS, and its applications in long-term reliable simulations of Lorenz equation, three-body problem and Rayleigh-Bénard turbulent flows. Using the CNS, it is found that a chaotic three-body system with symmetry might disrupt without any external disturbance, say, its symmetry-breaking and system-disruption are "self-excited", i.e., out-of-nothing. In addition, by means of the CNS, we can provide a rigorous theoretical evidence that the micro-level thermal fluctuation is the origin of macroscopic randomness of turbulent flows. Naturally, much more precise than traditional algorithms in double precision, the CNS can provide us a new way to more accurately investigate chaotic dynamic systems.展开更多
In order to illustrate the ion transport mechanism of chloride channel(Cl C) protein,a type of Cl C protein,Cl C-ec1,from Escherichia coli is embedded into an explicit membranewater system by using software VMD. The...In order to illustrate the ion transport mechanism of chloride channel(Cl C) protein,a type of Cl C protein,Cl C-ec1,from Escherichia coli is embedded into an explicit membranewater system by using software VMD. Then a parallel molecular dynamics(MD) simulation is employed to equilibrate the Cl C-ec1 structure for 27.5 ns at temperature 298.15 K. Based on this equilibrated structure,we compute the channel geometric size variation and electrostatic potential distribution along the channel. Meanwhile,Cl^- transport process is simulated using oriented random walk method under variable external potential. The simulation result shows that Cl^- transport velocity depends on the width of the narrowest channel region. Mutation of negative glutamate E148 can produce positive potential,which is beneficial for Cl^- transport,around external Cl^- binding region in the channel. The simulated current-voltage curves about Cl^- transporting in Cl C-ec1 protein agree with Jayaram's experimental results.展开更多
基金supported by the National Natural Science Foundation of China (50879085)the Program for New Century Excellent Talents in University(NCET-07-0778)Fundamental Research Funds for the Central Universities (2012QNA4020)
文摘This paper extends a prediction model for multi-directional random wave transformation based on an energy balance equation by Mase with the consideration of wave shoaling, refraction, diffraction, reflection and breaking. This numerical model is improved by 1) introducing Wen's frequency spectrum and Mitsuyasu's directional function, which are more suitable to the coastal area of China; 2) considering energy dissipation caused by bottom friction, which ensures more accurate results for large-scale and shallow water areas; 3) taking into account a non-linear dispersion relation. Predictions using the extended wave model are carried out to study the feasibility of constructing the Ai Hua yacht port in Qingdao, China, with a comparison between two port layouts in design. Wave fields inside the port for different incident wave directions, water levels and return periods are simulated, and then two kinds of parameters are calculated to evaluate the wave conditions for the two layouts. Analyses show that Layout I is better than Layout II. Calculation results also show that the harbor will be calm for different wave directions under the design water level. On the contrary, the wave conditions do not wholly meet the requirements of a yacht port for ship berthing under the extreme water level. For safety consideration, the elevation of the breakwater might need to be properly increased to prevent wave overtopping under such water level. The extended numerical simulation model may provide an effective approach to computing wave heights in a harbor.
基金Supported by the Strategic Priority Research Program of the Chinese Academy of Sciences under Grant No XDA09020402the National Integrate Circuit Research Program of China under Grant No 2009ZX02023-003+1 种基金the National Natural Science Foundation of China under Grant Nos 61261160500,61376006,61401444 and 61504157the Science and Technology Council of Shanghai under Grant Nos 14DZ2294900,15DZ2270900 and 14ZR1447500
文摘An optimized device structure for reducing the RESET current of phase-change random access memory (PCRAM) with blade-type like (BTL) phase change layer is proposed. The electrical thermal analysis of the BTL cell and the blade heater contactor structure by three-dimensional finite element modeling are compared with each other during RESET operation. The simulation results show that the programming region of the phase change layer in the BTL cell is much smaller, and thermal electrical distributions of the BTL cell are more concentrated on the TiN/GST interface. The results indicate that the BTL cell has the superiorities of increasing the heating efficiency, decreasing the power consumption and reducing the RESET current from 0.67mA to 0.32mA. Therefore, the BTL cell will be appropriate for high performance PCRAM device with lower power consumption and lower RESET current.
基金Supported by Financial Aid Project for Key Teachers of U-niversities
文摘Based on random theory, fluid dynamics , porous media and soil mechanics, the porosity and random characteristic of the two-layer soft soil in Wuhan region were studied in this paper. The random seepage coefficient on the two-layer soft soil was analyzed, and the seepage model and its random distribution Junction mere given. The groundwater flow differential equations related to the two layer soft soil structure were also established. The evaluation procedure of effect boundary on the pumping water in deep foundation pit was put forward. Moreover , with an engineering example, the probability distribution on random boundary prediction for pumping water of foundation pit was computed.
基金Supported by the National Natural Science Foundation of China(50274043)and Education Department of Hunan Province(04C544)
文摘The theory of Monte-Carlo simulation method is that the event happened probability was estimated by happened frequency in the experiments. So it is very im-portant to ascertain the times of simulation. The probability and statistic theory are used to determine the optimal simulation times through strict mathematic reasoning. The study of two cases is made to show the availability of the presented method, and some relative problems were discussed.
基金Project(51109117)supported by the National Natural Science Foundation of ChinaProject(20111081125)supported by the Independent Research Plan of Tsinghua University,ChinaProject(2013-KY-4)supported by the State Key Laboratory of Hydroscience and Engineering Project,China
文摘The mesoscopic failure mechanism and the macro-mechanical characteristics of soil-rock mixture(S-RM) under external load are largely controlled by S-RM's meso-structural features. The objective of this work is to improve the three-dimensional technology for the generation of the random meso-structural models of S-RM, for randomly generating irregular rock blocks in S-RM with different shapes, sizes, and distributions according to the characteristics of the rock blocks' size distribution. Based on the new improved technology, a software system named as R-SRM3 D for generation and visualization of S-RM is developed. Using R-SRM3 D, a three-dimensional meso-structural model of S-RM is generated and used to study the meso-mechanical behavior through a series of true-triaxial numerical tests. From the numerical tests, the following conclusions are obtained. The meso-stress field of S-RM is influenced by the distribution of the internal rock blocks, and the macro-mechanical characteristics of S-RM are anisotropic in 3D; the intermediate principal stress and the soil-rock interface properties have significant influence on the macro strength of S-RM.
基金This project is supported by National Natural Science Foundation of China (No.10572117)Aerospace Science Foundation of China(No.N3CH0502,No.N5CH0001)Provincial Natural Science Foundation of Shanxi, China(No.N3CS0501).
文摘An efficient importance sampling algorithm is presented to analyze reliability of complex structural system with multiple failure modes and fuzzy-random uncertainties in basic variables and failure modes. In order to improve the sampling efficiency, the simulated annealing algorithm is adopted to optimize the density center of the importance sampling for each failure mode, and results that the more significant contribution the points make to fuzzy failure probability, the higher occurrence possibility the points are sampled. For the system with multiple fuzzy failure modes, a weighted and mixed importance sampling function is constructed. The contribution of each fuzzy failure mode to the system failure probability is represented by the appropriate factors, and the efficiency of sampling is improved furthermore. The variances and the coefficients of variation are derived for the failure probability estimations. Two examples are introduced to illustrate the rationality of the present method. Comparing with the direct Monte-Carlo method, the improved efficiency and the precision of the method are verified by the examples.
基金The work described in this paper was nancially supported by the Natural Science Foundation of China(Grant Nos.51709258,51979270 and 41902291),the CAS Pioneer Hundred Talents Pro-gram and the Research Foundation of Key Laboratory of Deep Geodrilling Technology,Ministry of Land and Resources,China(Grant No.F201801).
文摘Slope reliability analysis considering inherent spatial variability(ISV)of soil properties is timeconsuming when response surface method(RSM)is used,because of the"curse of dimensionality".This paper proposes an effective method for identification of representative slip surfaces(RSSs)of slopes with spatially varied soils within the framework of limit equilibrium method(LEM),which utilizes an adaptive K-means clustering approach.Then,an improved slope reliability analysis based on the RSSs and RSM considering soil spatial variability,in perspective of computation efficiency,is established.The detailed implementation procedure of the proposed method is well documented,and the ability of the method in identifying RSSs and estimating reliability is investigated via three slope examples.Results show that the proposed method can automatically identify the RSSs of slope with only one evaluation of the conventional deterministic slope stability model.The RSSs are invariant with the statistics of soil properties,which allows parametric studies that are often required in slope reliability analysis to be efficiently achieved with ease.It is also found that the proposed method provides comparable values of factor of safety(FS)and probability of failure(Pf)of slopes with those obtained from direct analysis and lite rature.
基金The Public Science and Technology Research Funds Projects of Ocean under contract No.201305030the Specialized Research Fund for the Doctoral Program of Higher Education under contract No.20120132130001
文摘Fishery-independent surveys are often used for collecting high quality biological and ecological data to support fisheries management. A careful optimization of fishery-independent survey design is necessary to improve the precision of survey estimates with cost-effective sampling efforts. We developed a simulation approach to evaluate and optimize the stratification scheme for a fishery-independent survey with multiple goals including estimation of abundance indices of individual species and species diversity indices. We compared the performances of the sampling designs with different stratification schemes for different goals over different months. Gains in precision of survey estimates from the stratification schemes were acquired compared to simple random sampling design for most indices. The stratification scheme with five strata performed the best. This study showed that the loss of precision of survey estimates due to the reduction of sampling efforts could be compensated by improved stratification schemes, which would reduce the cost and negative impacts of survey trawling on those species with low abundance in the fishery-independent survey. This study also suggests that optimization of a survey design differed with different survey objectives. A post-survey analysis can improve the stratification scheme of fishery-independent survey designs.
文摘Reliability optimal design is an integrated approach widely adopted in engineering. The fuze components are designed by a BP neural network combined with an optimal design approach based on their multi-failure modes. Their reliability probabilities in multi-failure modes are transformed into deterministic design parameters. The designed results by an example of optimizing the fuze spring under a certain reliability show that the integrated approach is practical and efficient.
基金the National Natural Science Foundation of China (Grant No. 50608022)the Foundation of National Science and Technology(GrantNo.2006BAJ03B04)
文摘Aiming at the dynamic response of reticulated shell structures under wind load,systematic parameter analyses on wind-induced responses of Kiewitt6-6 type single-layer spherical reticulated shell structures and three-way grid single-layer cylindrical reticulated shell structures were performed with the random simulation method in time domain,including geometric parameters,structural parameters and aerodynamic parameters.Moreover,a wind-induced vibration coefficient was obtained,which can be a reference to the wind-resistance design of reticulated shell structures.The results indicate that the geometric parameters are the most important factor influencing wind-induced responses of the reticulated shell structures;the wind-induced vibration coeffi-cient is 3.0-3.2 for the spherical reticulated shell structures and that is 2.8-3.0 for the cylindrical reticula-ted shell structures,which shows that the wind-induced vibration coefficients of these two kinds of space frames are well-proportioned.
基金Supported by the Special Topics of Major Scientific and Technological Research Projects Shanxi Province (2006031099-01)Youth Science Funds of Shanxi Province (2006021024)Science and Technology Project of Taiyuan City (07010728)
文摘Based on the theory of random process and the characteristic of the functioning of a system component subject to a certain specific probability distribution, emulated the whole process of system production on Iongwall face was emulated, in which the methods of time pace and computer random emulation were adopted. The paper provides an objective basis for the analysis of a mining Iongwall face and the varied lines of effectiveness, machine stoppage rate and coal flow of components and system, and output etc.lt also offers some theories to improve productivity by discussing the application of the transformation plan and optimization of reasonable coal stock capacity, as well as selection of system equipment and matching optimization.
文摘The vortex-in-cell method in the discrete vortex simulation for the separated flow around a bluff body is discussed,Some improvements are made.The separated flow around a circular cylinder in oscillatory flow is investigated.
基金Project supported by the National Natural Science Foundation of China(Grant No.1432009)
文摘According to Lorenz, chaotic dynamic systems have sensitive dependence on initial conditions(SDIC), i.e., the butterfly-effect: a tiny difference on initial conditions might lead to huge difference of computer-generated simulations after a long time. Thus, computer-generated chaotic results given by traditional algorithms in double precision are a kind of mixture of "true"(convergent) solution and numerical noises at the same level. Today, this defect can be overcome by means of the "clean numerical simulation"(CNS) with negligible numerical noises in a long enough interval of time. The CNS is based on the Taylor series method at high enough order and data in the multiple precision with large enough number of digits, plus a convergence check using an additional simulation with even smaller numerical noises. In theory, convergent(reliable) chaotic solutions can be obtained in an arbitrary long(but finite) interval of time by means of the CNS. The CNS can reduce numerical noises to such a level even much smaller than micro-level uncertainty of physical quantities that propagation of these physical micro-level uncertainties can be precisely investigated. In this paper, we briefly introduce the basic ideas of the CNS, and its applications in long-term reliable simulations of Lorenz equation, three-body problem and Rayleigh-Bénard turbulent flows. Using the CNS, it is found that a chaotic three-body system with symmetry might disrupt without any external disturbance, say, its symmetry-breaking and system-disruption are "self-excited", i.e., out-of-nothing. In addition, by means of the CNS, we can provide a rigorous theoretical evidence that the micro-level thermal fluctuation is the origin of macroscopic randomness of turbulent flows. Naturally, much more precise than traditional algorithms in double precision, the CNS can provide us a new way to more accurately investigate chaotic dynamic systems.
基金Supported by the National Natural Science Foundation of China(11304123)the Scientific Research Foundation of Jianghan University(2013016)
文摘In order to illustrate the ion transport mechanism of chloride channel(Cl C) protein,a type of Cl C protein,Cl C-ec1,from Escherichia coli is embedded into an explicit membranewater system by using software VMD. Then a parallel molecular dynamics(MD) simulation is employed to equilibrate the Cl C-ec1 structure for 27.5 ns at temperature 298.15 K. Based on this equilibrated structure,we compute the channel geometric size variation and electrostatic potential distribution along the channel. Meanwhile,Cl^- transport process is simulated using oriented random walk method under variable external potential. The simulation result shows that Cl^- transport velocity depends on the width of the narrowest channel region. Mutation of negative glutamate E148 can produce positive potential,which is beneficial for Cl^- transport,around external Cl^- binding region in the channel. The simulated current-voltage curves about Cl^- transporting in Cl C-ec1 protein agree with Jayaram's experimental results.