Two novel rare earth substituted phosphotungstates containing 5-fluorouracil,K 9（C 4 H 4 FN 2 O 2） 2 Nd（PW 11 O 39） 2 ·25H 2 O（FNdPW） and K 9（C 4 H 4 FN 2 O 2） 2 Ce（PW 11 O 39） 2 ·23H 2 O（FCePW）,...Two novel rare earth substituted phosphotungstates containing 5-fluorouracil,K 9（C 4 H 4 FN 2 O 2） 2 Nd（PW 11 O 39） 2 ·25H 2 O（FNdPW） and K 9（C 4 H 4 FN 2 O 2） 2 Ce（PW 11 O 39） 2 ·23H 2 O（FCePW）,were synthesized and characterized by elementary analysis,FT-IR spectra,X-ray powder diffraction and 1 H NMR.The thermal analysis showed that FNdPW decomposed at 210 and 493 oC,and FCePW decomposed at 223 and 471 oC,both of which had good thermal stabilities.MTT tests were performed to study the antitumor activities against HeLa cells and HepG-2 cells of FNdPW,FCePW,5-fluorouracil,C 4 H 4 FN 2 O 2 H 2 PW 12 O 40 ·8H 2 O and K 11 Ln（PW 11 O 39） 2 ·xH 2 O（Ln=Nd,Ce）,and their cytotoxicities against HEK 293 cells.The results showed that FNdPW and FCePW possessed higher antitumor activities and lower cytotoxicities than those of 5-fluorouracil and C 4 H 4 FN 2 O 2 H 2 PW 12 O 40 ·8H 2 O,of which FNdPW exhibited the highest antitumor activates against HeLa cells（EC 50 =3.41×10-6 mol/L） and HepG-2 cells（EC 50 =6.24×10-6 mol/L）.Thus the introduction of rare earth elements and 5-fluorouracil could significantly enhance antitumor effect of polyoxometalates.展开更多
基金supported by Doctoral Innovation Research Assistance Program of the Science and Technology Review (kjdb200902-11)
文摘Two novel rare earth substituted phosphotungstates containing 5-fluorouracil,K 9（C 4 H 4 FN 2 O 2） 2 Nd（PW 11 O 39） 2 ·25H 2 O（FNdPW） and K 9（C 4 H 4 FN 2 O 2） 2 Ce（PW 11 O 39） 2 ·23H 2 O（FCePW）,were synthesized and characterized by elementary analysis,FT-IR spectra,X-ray powder diffraction and 1 H NMR.The thermal analysis showed that FNdPW decomposed at 210 and 493 oC,and FCePW decomposed at 223 and 471 oC,both of which had good thermal stabilities.MTT tests were performed to study the antitumor activities against HeLa cells and HepG-2 cells of FNdPW,FCePW,5-fluorouracil,C 4 H 4 FN 2 O 2 H 2 PW 12 O 40 ·8H 2 O and K 11 Ln（PW 11 O 39） 2 ·xH 2 O（Ln=Nd,Ce）,and their cytotoxicities against HEK 293 cells.The results showed that FNdPW and FCePW possessed higher antitumor activities and lower cytotoxicities than those of 5-fluorouracil and C 4 H 4 FN 2 O 2 H 2 PW 12 O 40 ·8H 2 O,of which FNdPW exhibited the highest antitumor activates against HeLa cells（EC 50 =3.41×10-6 mol/L） and HepG-2 cells（EC 50 =6.24×10-6 mol/L）.Thus the introduction of rare earth elements and 5-fluorouracil could significantly enhance antitumor effect of polyoxometalates.
