Objective Allograft vasculopathy ( AV) ,feature of chronic rejection,is a major serious long - term post - operation complication in organ transplantation. The accurate mechanisms for AV have not been definitively est...Objective Allograft vasculopathy ( AV) ,feature of chronic rejection,is a major serious long - term post - operation complication in organ transplantation. The accurate mechanisms for AV have not been definitively established,but extensive basic and clinical studies dem-展开更多
To investigate the effects of RDP1258 on survival of rat cardiac allograft.Methods RDP1258 was synthesized and the model of rat heart abdominal transplantation was established.Animals were divided into four groups.Gro...To investigate the effects of RDP1258 on survival of rat cardiac allograft.Methods RDP1258 was synthesized and the model of rat heart abdominal transplantation was established.Animals were divided into four groups.Group 1 received no immunosuppression.Group 2 received CsA alone.Group 3 received RDP1258 alone.Group 4 received RDP1258 and subtherapeutic CsA.In all cases RDP1258 was administrated intraperitoneally and CsA was gavaged.Light and electron microscopic examinations were taken.Transplanted hearts were monitored daily by direct palpation.Results The purity of synthesized RDP1258 was over 95% and the molecular weight was in accord with theoretical value.The histology and the ultrastructure changed little in grafts in group 3 and group 4.Survival of rat cardiac allograft was significantly prolonged in group 4.Conclusion RDP1258 can suppress acute rejection.Perioperative administration of RDP1258 in combination with CsA can significantly prolong survival of rat cardiac allograft.15 refs.展开更多
Objective To investigate the effect of sirolimus ( SRL) on the expression of integrin αυβ3 mRNA in vascular smooth muscle cells of cardiac allografts in rats, and the possible mechanism of SRL in the prevention of ...Objective To investigate the effect of sirolimus ( SRL) on the expression of integrin αυβ3 mRNA in vascular smooth muscle cells of cardiac allografts in rats, and the possible mechanism of SRL in the prevention of cardiac allograft vasculopathy. Methods Heterotopic heart transplantation models were established Hearts展开更多
文摘Objective Allograft vasculopathy ( AV) ,feature of chronic rejection,is a major serious long - term post - operation complication in organ transplantation. The accurate mechanisms for AV have not been definitively established,but extensive basic and clinical studies dem-
文摘To investigate the effects of RDP1258 on survival of rat cardiac allograft.Methods RDP1258 was synthesized and the model of rat heart abdominal transplantation was established.Animals were divided into four groups.Group 1 received no immunosuppression.Group 2 received CsA alone.Group 3 received RDP1258 alone.Group 4 received RDP1258 and subtherapeutic CsA.In all cases RDP1258 was administrated intraperitoneally and CsA was gavaged.Light and electron microscopic examinations were taken.Transplanted hearts were monitored daily by direct palpation.Results The purity of synthesized RDP1258 was over 95% and the molecular weight was in accord with theoretical value.The histology and the ultrastructure changed little in grafts in group 3 and group 4.Survival of rat cardiac allograft was significantly prolonged in group 4.Conclusion RDP1258 can suppress acute rejection.Perioperative administration of RDP1258 in combination with CsA can significantly prolong survival of rat cardiac allograft.15 refs.
文摘Objective To investigate the effect of sirolimus ( SRL) on the expression of integrin αυβ3 mRNA in vascular smooth muscle cells of cardiac allografts in rats, and the possible mechanism of SRL in the prevention of cardiac allograft vasculopathy. Methods Heterotopic heart transplantation models were established Hearts
