[ Object] The research is aimed to provide scientific basis for irradiated pet food＇s standardized production, supervision and commercial- ized application. E Method] Take broiler breast meat with high-dose irradiati...[ Object] The research is aimed to provide scientific basis for irradiated pet food＇s standardized production, supervision and commercial- ized application. E Method] Take broiler breast meat with high-dose irradiation as testing material, then evaluate its safety after 30 days feeding test of rats [ Result] Compared with control group （Pet food＇s irradiation dose is 0 kGy）, the general situation, weight, food-intake, food utilization rate, hematological examinations, bio-chemical analysis of blood, viscera weight, ratio of viscera and body weight, histopathological examinations, physi- ological feature, life＇s basic characteristics （including height, tail length, body temperature, heart rate and blood pressure ） and other indexes of rats, which were fed respectively with 10, 15, 25 kGy irradiation dose pet food for 30 days, were not found abnormal. [ Conclusion] Pet food with 10, 15, 25kGy irradiation dose is safe.展开更多
To corroborate the hypothesis that mastication affects the motivation to get food, we examined the effects of dietary consistency on the development of meal anticipation in locomotor activity of rats subjected to rest...To corroborate the hypothesis that mastication affects the motivation to get food, we examined the effects of dietary consistency on the development of meal anticipation in locomotor activity of rats subjected to restricted daily feeding (RF), in which food supply was restricted to a fixed time each day. RF of both liquid and solid meals produced anticipatory locomotor activity. However, the strength of the activity in rats subjected to RF of liquid meal was lower than that in rats subjected to RF of solid meal. These results suggest that the feeding-associated circadian oscillation that developed by feeding with liquid meal is less potent than that in the case of feeding with solid meal. Furthermore, mastication for digesting solid meal might be one of the factors that determine the strength of the feeding-associated circadian oscillation.展开更多
D-Psicose is a rare sugar present in small quantities in natural products. In a previous study, we showed that D-psicose suppresses increase in plasma glucose and reduces body fat accumulation in rats. Based on acute ...D-Psicose is a rare sugar present in small quantities in natural products. In a previous study, we showed that D-psicose suppresses increase in plasma glucose and reduces body fat accumulation in rats. Based on acute and chronic toxicity testing in rats, D-psicose is classified as an ordinary and safe substance. Recently, we developed a high D-psicose syrup (PS) made from high fructose corn syrup (HFCS) by the alkaline isomerization method. However, the safety of PS as a food additive has not been demonstrated. In this study, we investigated the effects of 90-day feeding of PS in male Wistar rats. The rats were fed diets containing 3% D-psicose (control) or 4.3% PS for 90 days. The body weight gain and intra-abdominal adipose tissue weight did not differ between the control and PS group. The weights of the tissues did not differ between the two dietary groups. In clinical chemistry and hematological analyses, no differences were found between the control and PS groups. No gross pathological findings were evident at dietary doses of 4.3% PS. Therefore, the present study found no adverse effects of PS in rats fed a diet containing 4.3% PS for 90 days.展开更多
Genetic modification (GM) represents new opportunities for enhanced crop features such as improved insect resistance and herbicide tolerance. The technology allows for cross-species alterations, therefore potentially ...Genetic modification (GM) represents new opportunities for enhanced crop features such as improved insect resistance and herbicide tolerance. The technology allows for cross-species alterations, therefore potentially allowing a vast array of novel traits. Many GM crops have been developed and approved for human and animal consumption. The present study investigated a triple-stacked GM corn variety containing modifications for insect resistance (via cry1Ab and cry3Bb1 genes) and herbicide tolerance (via an EPSPS gene), which was fed to rats for six months. The study investigated the mucosa of the stomach. Alterations to tight junction apposition, gland dilatations with epithelial elongation and dysplasia in the GM-fed rats were observed. These results indicate that GM-corn may have an effect on rat stomach mucosa, which may have health implications.展开更多
Wistar rats were exposed to a 916 MHz, 10 W/m2 mobile phone electromagnetic field for 6 hours a day 5 days a week. Average completion times in an eight-arm radial maze were longer in the exposed rats than control rats...Wistar rats were exposed to a 916 MHz, 10 W/m2 mobile phone electromagnetic field for 6 hours a day 5 days a week. Average completion times in an eight-arm radial maze were longer in the exposed rats than control rats after 4-5 weeks of exposure. Error rates in the exposed rats were greater than the control rats at 6 weeks. Hippocampal neurons from the exposed rats showed irregular firing patterns during the experiment, and they exhibited decreased spiking activity 6-9 weeks compared with that after 2 5 weeks of exposure. These results indicate that 916 MHz electromagnetic fields influence leaming and memory in rats during exposure, but long-term effects are not obvious.展开更多
基金supported by" Special Fund for Agro-scientific Research in the Public Interest (201103007) "Jiangsu Agricultural Science Independent Innovation Capital[Serial Number:cx(10)449]
文摘[ Object] The research is aimed to provide scientific basis for irradiated pet food＇s standardized production, supervision and commercial- ized application. E Method] Take broiler breast meat with high-dose irradiation as testing material, then evaluate its safety after 30 days feeding test of rats [ Result] Compared with control group （Pet food＇s irradiation dose is 0 kGy）, the general situation, weight, food-intake, food utilization rate, hematological examinations, bio-chemical analysis of blood, viscera weight, ratio of viscera and body weight, histopathological examinations, physi- ological feature, life＇s basic characteristics （including height, tail length, body temperature, heart rate and blood pressure ） and other indexes of rats, which were fed respectively with 10, 15, 25 kGy irradiation dose pet food for 30 days, were not found abnormal. [ Conclusion] Pet food with 10, 15, 25kGy irradiation dose is safe.
文摘To corroborate the hypothesis that mastication affects the motivation to get food, we examined the effects of dietary consistency on the development of meal anticipation in locomotor activity of rats subjected to restricted daily feeding (RF), in which food supply was restricted to a fixed time each day. RF of both liquid and solid meals produced anticipatory locomotor activity. However, the strength of the activity in rats subjected to RF of liquid meal was lower than that in rats subjected to RF of solid meal. These results suggest that the feeding-associated circadian oscillation that developed by feeding with liquid meal is less potent than that in the case of feeding with solid meal. Furthermore, mastication for digesting solid meal might be one of the factors that determine the strength of the feeding-associated circadian oscillation.
文摘D-Psicose is a rare sugar present in small quantities in natural products. In a previous study, we showed that D-psicose suppresses increase in plasma glucose and reduces body fat accumulation in rats. Based on acute and chronic toxicity testing in rats, D-psicose is classified as an ordinary and safe substance. Recently, we developed a high D-psicose syrup (PS) made from high fructose corn syrup (HFCS) by the alkaline isomerization method. However, the safety of PS as a food additive has not been demonstrated. In this study, we investigated the effects of 90-day feeding of PS in male Wistar rats. The rats were fed diets containing 3% D-psicose (control) or 4.3% PS for 90 days. The body weight gain and intra-abdominal adipose tissue weight did not differ between the control and PS group. The weights of the tissues did not differ between the two dietary groups. In clinical chemistry and hematological analyses, no differences were found between the control and PS groups. No gross pathological findings were evident at dietary doses of 4.3% PS. Therefore, the present study found no adverse effects of PS in rats fed a diet containing 4.3% PS for 90 days.
文摘Genetic modification (GM) represents new opportunities for enhanced crop features such as improved insect resistance and herbicide tolerance. The technology allows for cross-species alterations, therefore potentially allowing a vast array of novel traits. Many GM crops have been developed and approved for human and animal consumption. The present study investigated a triple-stacked GM corn variety containing modifications for insect resistance (via cry1Ab and cry3Bb1 genes) and herbicide tolerance (via an EPSPS gene), which was fed to rats for six months. The study investigated the mucosa of the stomach. Alterations to tight junction apposition, gland dilatations with epithelial elongation and dysplasia in the GM-fed rats were observed. These results indicate that GM-corn may have an effect on rat stomach mucosa, which may have health implications.
基金funded by the National Basic Research Program of China(973 Program),No. 2011CB503700,2011CB503702the National Natural Science Foundation of China,No.81071231,30670543the Research Program of Beijing Municipal Education Commission,No. KM200910005016,and No.JX015999201001
文摘Wistar rats were exposed to a 916 MHz, 10 W/m2 mobile phone electromagnetic field for 6 hours a day 5 days a week. Average completion times in an eight-arm radial maze were longer in the exposed rats than control rats after 4-5 weeks of exposure. Error rates in the exposed rats were greater than the control rats at 6 weeks. Hippocampal neurons from the exposed rats showed irregular firing patterns during the experiment, and they exhibited decreased spiking activity 6-9 weeks compared with that after 2 5 weeks of exposure. These results indicate that 916 MHz electromagnetic fields influence leaming and memory in rats during exposure, but long-term effects are not obvious.
