BACKGROUND： The prognostic factors related to lymph node involvement [lymph node status, the number of positive lymph nodes, lymph node ratio （LNR）] and the number of nodes evaluated in patients with pancreatic ade...BACKGROUND： The prognostic factors related to lymph node involvement [lymph node status, the number of positive lymph nodes, lymph node ratio （LNR）] and the number of nodes evaluated in patients with pancreatic adenocarcinoma after pancreatectomy are poorly defined. METHODS： A total of 167 patients who had undergone resection of pancreatic adenocarcinoma from February 2010 to August 2011 were included in this study. Histological examination was performed to evaluate the tumor differentiation and lymph node involvement. Univariate and multivariate analyses were made to determine the relationship between the variables related to nodal involvement and the number of nodes and survival. RESULTS： The median number of total nodes examined was 10 （range 0-44） for the entire cohort. The median number of total nodes examined in node-negative （pN0） patients was similar to that in node-positive （pN1） patients. Patients with pN1 diseases had significantly worse survival than those with pN0 ones （P=0.000）. Patients with three or more positive nodes had a poorer prognosis compared with those with the negative nodes （P=0.000）. The prognosis of the patients with negative nodes was similar to that of those with one to two positive nodes （P=0.114）. The median survival of patients with an LNR ≥0.4 was shorter than that of patients with an LNR 〈0.4 in the pN1 cohort （P=0.014）. No significance was found between the number of total nodes examined and the prognosis, regardless of the cutoff of 10 or 12 and in the entire cohort or the pN0 and pN1 groups. Based on the multivariate analysis of the entire cohort and the pN1 group, the nodal status, the number of positive nodes and the LNR were all associated with survival. CONCLUSIONS： In addition to the nodal status, the number of positive nodes and the LNR can serve as comprehensive factors for the evaluation of nodal involvement. This approach may be more effective for predicting the survival of patients with pancreatic adenocarcinoma after pancreatectomy.展开更多
The organic Rankine cycle is widely used in industrial waste heat, engine waste heat and other waste heat recovery applications, and as a key component of the system, it affects the efficiency and output power of the ...The organic Rankine cycle is widely used in industrial waste heat, engine waste heat and other waste heat recovery applications, and as a key component of the system, it affects the efficiency and output power of the system. In this paper, a centripetal turbine is designed for the organic Rankine cycle, using vehicle exhaust gas as the heat source. Numerical simulations are performed to analyze the effect of the ratio of the number of guide vane blades to the number of impeller blades (vane number ratio) on the turbine performance and flow field. The results show that the effect of the number of impeller blades on the turbine entropy efficiency, the average exit velocity and the temperature of the guiding grate becomes less and less as the ratio of the number of blades increases. The optimum turbine performance is obtained when the number of impeller blades and the ratio of the number of blades are 17 and 1.5882, respectively, and the expansion performance of the guide impeller is improved and the isentropic efficiency of the turbine is improved by 3.84% compared with the preliminary number of blades.展开更多
逐次逼近寄存器模数转换器(SAR ADC)在逐次逼近的过程中,电容的切换会使参考电压上出现参考纹波噪声,该噪声会影响比较器的判定,进而输出错误的比较结果。针对该问题,基于CMOS 0.5μm工艺,设计了一种具有纹波消除技术的10 bit SAR ADC...逐次逼近寄存器模数转换器(SAR ADC)在逐次逼近的过程中,电容的切换会使参考电压上出现参考纹波噪声,该噪声会影响比较器的判定,进而输出错误的比较结果。针对该问题,基于CMOS 0.5μm工艺,设计了一种具有纹波消除技术的10 bit SAR ADC。通过增加纹波至比较器输入端的额外路径,将参考纹波满摆幅输入至比较器中;同时设计了消除数模转换器(DAC)模块,对参考纹波进行采样和输入,通过反转纹波噪声的极性,消除参考纹波对ADC输出的影响。该设计将信噪比(SNR)提高到56.75 dB,将有效位数(ENOB)提升到9.14 bit,将积分非线性(INL)从-1~5 LSB降低到-0.2~0.3 LSB,将微分非线性(DNL)从-3~4 LSB降低到-0.5~0.5 LSB。展开更多
采用模型试验方法,对多层互剪搅拌桩工法(contra-rotational shear deep soil mixing,简称CS-DSM工法)的工艺因素进行了试验研究,探索了水泥掺量、单位桩长搅拌次数T、单位体积搅拌能量E以及内外钻杆转速比RN等工艺因素对搅拌桩均匀性...采用模型试验方法,对多层互剪搅拌桩工法(contra-rotational shear deep soil mixing,简称CS-DSM工法)的工艺因素进行了试验研究,探索了水泥掺量、单位桩长搅拌次数T、单位体积搅拌能量E以及内外钻杆转速比RN等工艺因素对搅拌桩均匀性与强度UCS的影响。模型试验研究发现,通过多层互剪搅拌能够根除地表冒浆、防止糊钻抱钻、提高固化材料利用率。18组模型试验结果阐明搅拌桩在T-E-UCS之间存在固有关联,并揭示出机械参数、输出能量与桩身强度之间的本质关系。提供的计算方法可以定性指导选取合理的工艺参数,实现桩身设计强度目标。作为重要工艺因素,内外钻杆转速比RN与桩身强度试验曲线存在极值点,建议在工程中将1.80~2.20作为获取桩身峰值强度的最优RN值域。CS-DSM工法应用的系列研究结果为高质量搅拌桩工艺控制原则和质量保障体系提供了试验依据。展开更多
The activated TIG(ATIG) welding process mainly focuses on increasing the depth of penetration and the reduction in the width of weld bead has not been paid much attention.The shape of a weld in terms of its width-to-d...The activated TIG(ATIG) welding process mainly focuses on increasing the depth of penetration and the reduction in the width of weld bead has not been paid much attention.The shape of a weld in terms of its width-to-depth ratio known as aspect ratio has a marked influence on its solidification cracking tendency.The major influencing ATIG welding parameters,such as electrode gap,travel speed,current and voltage,that aid in controlling the aspect ratio of DSS joints,must be optimized to obtain desirable aspect ratio for DSS joints.Hence in this study,the above parameters of ATIG welding for aspect ratio of ASTM/UNS S32205 DSS welds are optimized by using Taguchi orthogonal array(OA)experimental design and other statistical tools such as Analysis of Variance(ANOVA) and Pooled ANOVA techniques.The optimum process parameters are found to be 1 mm electrode gap,130 mm/min travel speed,140 A current and 12 V voltage.The aspect ratio and the ferrite content for the DSS joints fabricated using the optimized ATIG parameters are found to be well within the acceptable range and there is no macroscopically evident solidification cracking.展开更多
基金supported in part by grants from the Sino-German Center (GZ857)Science Foundation of Shanghai (13ZR1407500)+2 种基金Shanghai Rising Star Program (12QH1400600 and 14QA1400900)Fudan University Young Investigator Promoting Program (20520133403)the National Science Foundation of China (81101807, 81001058, 81372649, 81372653 and 81172276)
文摘BACKGROUND： The prognostic factors related to lymph node involvement [lymph node status, the number of positive lymph nodes, lymph node ratio （LNR）] and the number of nodes evaluated in patients with pancreatic adenocarcinoma after pancreatectomy are poorly defined. METHODS： A total of 167 patients who had undergone resection of pancreatic adenocarcinoma from February 2010 to August 2011 were included in this study. Histological examination was performed to evaluate the tumor differentiation and lymph node involvement. Univariate and multivariate analyses were made to determine the relationship between the variables related to nodal involvement and the number of nodes and survival. RESULTS： The median number of total nodes examined was 10 （range 0-44） for the entire cohort. The median number of total nodes examined in node-negative （pN0） patients was similar to that in node-positive （pN1） patients. Patients with pN1 diseases had significantly worse survival than those with pN0 ones （P=0.000）. Patients with three or more positive nodes had a poorer prognosis compared with those with the negative nodes （P=0.000）. The prognosis of the patients with negative nodes was similar to that of those with one to two positive nodes （P=0.114）. The median survival of patients with an LNR ≥0.4 was shorter than that of patients with an LNR 〈0.4 in the pN1 cohort （P=0.014）. No significance was found between the number of total nodes examined and the prognosis, regardless of the cutoff of 10 or 12 and in the entire cohort or the pN0 and pN1 groups. Based on the multivariate analysis of the entire cohort and the pN1 group, the nodal status, the number of positive nodes and the LNR were all associated with survival. CONCLUSIONS： In addition to the nodal status, the number of positive nodes and the LNR can serve as comprehensive factors for the evaluation of nodal involvement. This approach may be more effective for predicting the survival of patients with pancreatic adenocarcinoma after pancreatectomy.
文摘The organic Rankine cycle is widely used in industrial waste heat, engine waste heat and other waste heat recovery applications, and as a key component of the system, it affects the efficiency and output power of the system. In this paper, a centripetal turbine is designed for the organic Rankine cycle, using vehicle exhaust gas as the heat source. Numerical simulations are performed to analyze the effect of the ratio of the number of guide vane blades to the number of impeller blades (vane number ratio) on the turbine performance and flow field. The results show that the effect of the number of impeller blades on the turbine entropy efficiency, the average exit velocity and the temperature of the guiding grate becomes less and less as the ratio of the number of blades increases. The optimum turbine performance is obtained when the number of impeller blades and the ratio of the number of blades are 17 and 1.5882, respectively, and the expansion performance of the guide impeller is improved and the isentropic efficiency of the turbine is improved by 3.84% compared with the preliminary number of blades.
文摘采用模型试验方法,对多层互剪搅拌桩工法(contra-rotational shear deep soil mixing,简称CS-DSM工法)的工艺因素进行了试验研究,探索了水泥掺量、单位桩长搅拌次数T、单位体积搅拌能量E以及内外钻杆转速比RN等工艺因素对搅拌桩均匀性与强度UCS的影响。模型试验研究发现,通过多层互剪搅拌能够根除地表冒浆、防止糊钻抱钻、提高固化材料利用率。18组模型试验结果阐明搅拌桩在T-E-UCS之间存在固有关联,并揭示出机械参数、输出能量与桩身强度之间的本质关系。提供的计算方法可以定性指导选取合理的工艺参数,实现桩身设计强度目标。作为重要工艺因素,内外钻杆转速比RN与桩身强度试验曲线存在极值点,建议在工程中将1.80~2.20作为获取桩身峰值强度的最优RN值域。CS-DSM工法应用的系列研究结果为高质量搅拌桩工艺控制原则和质量保障体系提供了试验依据。
文摘The activated TIG(ATIG) welding process mainly focuses on increasing the depth of penetration and the reduction in the width of weld bead has not been paid much attention.The shape of a weld in terms of its width-to-depth ratio known as aspect ratio has a marked influence on its solidification cracking tendency.The major influencing ATIG welding parameters,such as electrode gap,travel speed,current and voltage,that aid in controlling the aspect ratio of DSS joints,must be optimized to obtain desirable aspect ratio for DSS joints.Hence in this study,the above parameters of ATIG welding for aspect ratio of ASTM/UNS S32205 DSS welds are optimized by using Taguchi orthogonal array(OA)experimental design and other statistical tools such as Analysis of Variance(ANOVA) and Pooled ANOVA techniques.The optimum process parameters are found to be 1 mm electrode gap,130 mm/min travel speed,140 A current and 12 V voltage.The aspect ratio and the ferrite content for the DSS joints fabricated using the optimized ATIG parameters are found to be well within the acceptable range and there is no macroscopically evident solidification cracking.
