The research consistently highlights the gender disparity in cybersecurity leadership roles, necessitating targeted interventions. Biased recruitment practices, limited STEM education opportunities for girls, and work...The research consistently highlights the gender disparity in cybersecurity leadership roles, necessitating targeted interventions. Biased recruitment practices, limited STEM education opportunities for girls, and workplace culture contribute to this gap. Proposed solutions include addressing biased recruitment through gender-neutral language and blind processes, promoting STEM education for girls to increase qualified female candidates, and fostering inclusive workplace cultures with mentorship and sponsorship programs. Gender parity is crucial for the industry’s success, as embracing diversity enables the cybersecurity sector to leverage various perspectives, drive innovation, and effectively combat cyber threats. Achieving this balance is not just about fairness but also a strategic imperative. By embracing concerted efforts towards gender parity, we can create a more resilient and impactful cybersecurity landscape, benefiting industry and society.展开更多
Background: Epidemic of anemia is considered to be a significant threat to pregnant women or women in child bearing age. Anemia is one of the major nutritional health disorders affecting significant proportion of popu...Background: Epidemic of anemia is considered to be a significant threat to pregnant women or women in child bearing age. Anemia is one of the major nutritional health disorders affecting significant proportion of population not only in developing countries but also in developed countries. This threat is more alarming in developing countries where poverty, illiteracy may contribute to high risk for causes of anemia. Objective: The purpose of the current study was to investigate the main causes of anemia in pregnant women in the State of Azad Kashmir, Muzaffarabad and to investigate the relationship between education and anemia. Methods: A descriptive cross sectional study was conducted over a sample of 433 pregnant women. The Chi- square test has been used to assess the statistical significance of different risk factors with Hb% (Heamoglobin) of the respondent. The multiple logistic regression model was used to get the most significant risk factors of anemia. Results: The study shows that the most dominant risk factors of the anemia were age at the time of marriage at different age categories that are 16 - 20 (OR = 3.945) (OR Odds ratios) with 95% C-I (confidence interval) (0.294 to 52.985), 21 - 25 (OR = 2.316) with 95% C-I (0.192 to 27.932) and 26 - 30 (OR = 4.179) with 95% C-I (0.347 to 50.320). Education at different education levels that is illiterate (OR = 1.191) with 95% C-I (0.005 to 87.279) and primary (OR = 1.179) with 95% C-I (0.009 to 156.200). Hb% at different levels 3 - 4 g/dl (OR = 1.220) with 95% C-I (0.299 to 4.984), 5 - 6 g/dl (OR = 2.221) with 95% C-I (0.679 to7.263) and 7 - 10 g/dl (OR = 1.384) with 95% C-I (0.408 to 4.689). Monthly展开更多
AIM: To evaluate if static stretching influences peak and end-range functional hamstring-to-quadriceps(H/Q) strength ratios in elite women athletes. METHODS: Eleven healthy female athletes in an elite competitive leve...AIM: To evaluate if static stretching influences peak and end-range functional hamstring-to-quadriceps(H/Q) strength ratios in elite women athletes. METHODS: Eleven healthy female athletes in an elite competitive level participated to the study. All the participants fulfilled the static stretching or non-stretching(control) intervention protocol in a randomized design on different days. Two static unassisted stretching exercises, one in standing and one in sitting position, were used to stretch both the hamstring and quadriceps muscles during these protocols. The total time for the static stretching was 6 ± 1 min. The isokinetic peak torque measurements for the hamstring and quadriceps muscles in eccentric and concentric modes and the calculations for the functional H/Q strength ratios at angular velocities of 60°/s and 180°/s were made before(pre) and after(post) the control or stretching intervention. The strength measurements and functional strength ratio calculations were based during the entire- and end-range of knee extension.RESULTS: The pre-test scores for quadriceps and hamstring peak torque and end range values were not significantly different between the groups(P > 0.05). Subsequently, although the control group did notexhibit significant changes in quadriceps and hamstring muscle strength(P > 0.05), static stretching decreased eccentric and concentric quadriceps muscle strength at both the 60°/s and 180°/s test speeds(P < 0.01). Similarly, static stretching also decreased eccentric and concentric hamstring muscle strength at both the 60°/s and 180°/s test speeds(P < 0.01). On the other hand, when the functional H/Q strength ratios were taken into consideration, the pre-intervention values were not significant different between the groups both during the entire and end range of knee extension(P > 0.05). Furthermore, the functional H/Q strength ratios exhibited no significant alterations during the entire and end ranges of knee extension both in the static stretching or the control intervention(P > 0.05). CONCLUSION: According to our results, static stretching routine does not influence functional H/Q ratio. Athletes can confidently perform static stretching during their warm-up routines.展开更多
Liver marker {e.g., alanine aminotransferase (ALT) and aspartate aminotransferase (AST)} levels independently predict insulin resistance. The aim of the present study is to examine how changes in liver markers are ass...Liver marker {e.g., alanine aminotransferase (ALT) and aspartate aminotransferase (AST)} levels independently predict insulin resistance. The aim of the present study is to examine how changes in liver markers are associated with changes in insulin resistance after exercise in Japanese community-dwelling adults. The participants were 76 women aged 67 ± 6 years from a rural village. Nordic walk (NW) exercise of 120 min per week was performed for 12 weeks. Before and at the end of the 12-week intervention, various confounding factors and insulin resistance {e.g., Homeostatic Model Assessment of Insulin Resistance (HOMA-IR)} were measured. The baseline, follow-up, and changes in ALT/AST ratio (β = 0.390, P β = 0.393, P β = 0.321, P = 0.004, respectively) were each significantly and independently associated with HOMA-IR. When the data were further stratified by baseline and change in ASL/AST ratio, changes in HOMA-IR decreased more significantly in participants with baseline ASL/AST ratio ≥ 0.762 and change in ALT/AST ratio of < 0 than those with change in ALT/AST ratio of ≥ 0 (baseline ASL/AST ratio P = 0.002 and ASL/AST ratio ≥ 0.762, P = 0.047). This study is of interest because liver transaminase markers, which are inexpensive and routinely collected in clinical settings, may provide a simple and accurate enhancement to models currently used to identify subjects with changes in insulin resistance. These results suggest that a higher baseline and decreased change in ALT/AST ratio may be a predictor for decreased insulin resistance after a 12-week walking exercise in community-dwelling middle-aged and elderly women.展开更多
Background: Depression is one of the growing public health concerns among women worldwide. This is one of the most under-recognized and under-treated mental illnesses worldwide. Women of developing countries are inexp...Background: Depression is one of the growing public health concerns among women worldwide. This is one of the most under-recognized and under-treated mental illnesses worldwide. Women of developing countries are inexplicably affecting with depression. Purpose: The purpose of study is to assess the prevalence and associative factors of depression among women of aged 20 to 40 years living in urban squatter settlements of Karachi, Pakistan. The identification of all the potential determinants will potentially help in formulating preventive strategies in order to decline the prevalence of depression among women and improve the wellbeing of women. Methods: An analytical cross-sectional survey was employed among women living in Reta Plot and Kala Board communities of Karachi, Pakistan. Beck Depression Inventory II (BDI-II) was used to measure depression. Systematic sampling was used to recruit 636 married women. Cox proportional hazard was run to compute prevalence ratios and their 95% confidence interval. Results: Our study estimated 33.3% of depression among study participants. The current study showed that age, possession of own vehicle, years of schooling and recent deaths in family were significantly associated with depression. Conclusion: This research was a bold step to address the issue of increasing rate of depression among Pakistani population. Our study results can convince policy makers to extend mental health support to women by improving accessibility of services. Recommendation: Our study recommends that the women of our society should be encouraged for attaining education. This study also recommends that at primary health care setting, every health professional should be trained to screen the depression. Moreover, the results of our study can also encourage policy makers to expand mental health support services for women.展开更多
Initial prodiabetic risk profiles were invented here with three female study groups consisting of primarily healthy women (A1: 1990-1999, n = 160;A2: 2009, n = 88;A: n = 248, 36 ± 14 years;B: 2014: n = 65, aged 3...Initial prodiabetic risk profiles were invented here with three female study groups consisting of primarily healthy women (A1: 1990-1999, n = 160;A2: 2009, n = 88;A: n = 248, 36 ± 14 years;B: 2014: n = 65, aged 37± 11 years). Significantly higher blood pressure was found comparing intolerance versus tolerance to glucose (p p p = 0.02), of fasting blood glucose (p = 0.07) and of urine pathology (p = 0.07). High LDL-C of women who reported smoking at baseline was correlated with diastolic hypertension whereby alcohol problems overlapped (p = 0.036, A). Unhealthy combinations were found consisting of LDL-related intolerance to glucose, LDL-related smoking, of alcohol-related hypertriglyceridemia or of combined drinking and smoking testing urine pathology over the course of time. Obese women were at direct risk for hypertension in the presence of high LDL-C and submaximal ratio of serum albumin to triglycerides (Alb/Trig). Obese women reacted highly sensitive to critical alcohol consumption showing then macroalbuminuria. Current participants who disowned daily alcohol consumption showed healthy morning urines and normal fasting blood glucose. Mild decrease of HDL-C was observed during heavy smoking of relatively young women who had normal biomarkers. Women with intolerance to glucose were at direct risk for hypertension whereby high LDL-C and/or smoking triggered prodiabetic risk profiles. Obese women had elevated LDL-C during hypertension and reacted highly sensitive to alcohol-related proteinuria and/or hematuria.展开更多
Background:Women comprise more than half of people living with human immunodeficiency virus/acquired immune deficiency syndrome(HIV/AIDS)worldwide and incomplete immune recovery and metabolic abnormalities affect them...Background:Women comprise more than half of people living with human immunodeficiency virus/acquired immune deficiency syndrome(HIV/AIDS)worldwide and incomplete immune recovery and metabolic abnormalities affect them deeply.Studies of HIV antiretroviral therapy(ART)have a low female representation in China.We aimed to investigate immune reconstitution and metabolic changes of female HIV-positive cohort in China longitudinally.Methods:HIV-positive women who initiated ART from January 2005 to June 2021 and were followed up regularly at least once a year were included in this study.Immunological indicators(cluster of differentiation 4[CD4]counts and CD8 counts),viral load(VL),and metabolic indicators were collected at follow-up.All data were collected from the China Disease Prevention and Control Information System(CDPCIS).VL was tested half a year,1 year after receiving ART,and every other year subsequently according to local policy.CD4/CD8 ratio normalization was considered as the primary outcome and defined as a value≥1.Incidence rate and probability of CD4/CD8 ratio normalization were estimated through per 100 person-years follow-up(PYFU)and Kaplan-Meier curve,respectively.Multivariate Cox regression was used to identify independent risk factors associated with CD4/CD8 ratio normalization.We further studied the rate of dyslipidemia,hyperuricemia,diabetes,liver injury,and renal injury after ART initiation with the chi-squared tests or Fisher’s exact probability tests,and a generalized estimating equation model was used to analyze factors of dyslipidemia and hyperuricemia.Results:A total of 494 female patients with HIV/AIDS started ART within 16 years from January 2005 to June 2021,out of which 301 women were enrolled with a median duration of ART for 4.1 years(interquartile range,2.3-7.0 years).The overall incidence rate of CD4/CD8 ratio normalization was 8.9(95%confidence interval[CI],7.4-10.6)per 100 PYFU,and probabilities of CD4/CD8 normalization after initiating ART at 1 year,2 years,5 years,and 10 years follow-up were 11.7%,23.2%,44.0%,and 59.0%,respectively.Independent risk factors associated with CD4/CD8 normalization were baseline CD4 cell counts<200 cells/μL,CD8 counts>1000 cells/μL,and more than 6 months from the start of combined ART(cART)to first virological suppression.Longitudinally,the rate of hypercholesterolemia(total cholesterol[TC])and high triglyceride(TG)showed an increasing trend,while the rate of low high-density lipoprotein cholesterol(HDL)showed a decreasing trend.The rate of hyperuricemia presented a downtrend at follow-up.Although liver and renal injury and diabetes persisted during ART,the rate was not statistically significant.Older age and protease inhibitors were independent risk factors for increase of TC and TG,and ART duration was an independent factor for elevation of TC and recovery of HDL-C.Conclusions:This study showed that women were more likely to normalize CD4/CD8 ratio in comparison with findings reported in the literature even though immune reconstruction was incomplete.展开更多
目的分析子痫前期孕妇D-二聚体水平与中性粒细胞与淋巴细胞比值(NLR)的相关性。方法回顾性分析临床资料,选择2021年1月至12月于我院收治的子痫前期孕妇80例为观察对象,纳为子痫前期组,根据病情严重程度分为轻度组(42例)、重度组(38例),...目的分析子痫前期孕妇D-二聚体水平与中性粒细胞与淋巴细胞比值(NLR)的相关性。方法回顾性分析临床资料,选择2021年1月至12月于我院收治的子痫前期孕妇80例为观察对象,纳为子痫前期组,根据病情严重程度分为轻度组(42例)、重度组(38例),同期选择于我院产检的健康孕妇80名为健康对象组,采集各组孕妇空腹静脉血,比较各组孕妇血浆D-二聚体水平、NLR水平,查阅2组孕妇产后新生儿临床资料,比较各组新生儿体质量、1 min Apgar评分、5 min Apgar评分。采用Pearson相关性分析D-二聚体水平与NLR及其他指标相关性;采用受试者工作特征(ROC)曲线评估D-二聚体、NLR预测子痫前期发生的价值。结果子痫前期组孕妇血浆D-二聚体水平及NLR水平高于健康对照组(P<0.05)。重度组孕妇血浆D-二聚体水平及NLR水平高于轻度组(P<0.05)。重度组新生儿体质量低于轻度组,1min Apgar评分、5min Apgar评分低于轻度组(P<0.05)。子痫前期Pearson相关性分析显示,子痫前期孕妇血浆D-二聚体水平与NLR呈明显正相关(r=0.52,P<0.05),与新生儿体质量、1min Apgar评分、5min Apgar评分呈明显负相关(r=-0.47、-0.51、-0.45,P均<0.05)。ROC曲线显示,D-二聚体、NLR预测子痫前期发生的曲线下面积(AUC)分别为0.733、0.803,联合预测的AUC为0.906,联合预测价值较高。结论子痫前期孕妇普遍存在凝血功能异常情况,D-二聚体水平明显异常表达,且D-二聚体水平与子痫前期病情严重程度及NLR水平存在一定相关性,定期监测D-二聚体水平变化有助于评估病情,为临床治疗及预后预测提供合理参考。展开更多
目的探讨子痫前期孕妇血清内分泌腺源性血管内皮生长因子(EG-VEGF)、中性粒细胞淋巴细胞比值(NLR)、血小板淋巴细胞比值(PLR)表达与病情严重程度的相关性。方法回顾性分析2021年10月~2023年3月在承德市中心医院妇儿院区产检的90例孕妇...目的探讨子痫前期孕妇血清内分泌腺源性血管内皮生长因子(EG-VEGF)、中性粒细胞淋巴细胞比值(NLR)、血小板淋巴细胞比值(PLR)表达与病情严重程度的相关性。方法回顾性分析2021年10月~2023年3月在承德市中心医院妇儿院区产检的90例孕妇临床资料,根据是否患有子痫前期进行分组,将健康正常的30例孕妇纳入健康对照组,将确诊为子痫前期的60例孕妇纳入观察组,且观察组根据子痫前期严重程度分为轻度组(n=30)和重度组(n=30),比较健康对照组和观察组、轻度组和重度组的血清EG-VEGF、NLR、PLR表达水平,并应用ROC曲线分析血清EG-VEGF、NLR、PLR诊断子痫前期和评价病情严重程度的效能。结果观察组的血清EG-VEGF、NLR高于健康对照组[(53.65±17.46)pg ml vs.(28.93±9.37)pg ml、(3.15±1.02)vs.(2.12±0.67)],PLR低于健康对照组[(98.53±21.86)vs.(115.31±18.36)],差异有统计学意义(t=7.237、5.010、3.613,P<0.05)。经ROC曲线分析发现,血清EG-VEGF、NLR、PLR诊断子痫前期效能良好(P<0.05)。重度组的血清EG-VEGF、NLR高于轻度组[(57.93±13.19)pg ml vs.(49.63±15.63)pg ml、(3.40±0.95)vs.(2.93±0.71)],PLR低于轻度组[(163.72±35.41)vs.(146.70±28.63)],差异有统计学意义(t=2.223、2.171、2.047,P<0.05)。经ROC曲线分析,发现血清EG-VEGF、NLR、PLR评价子痫前期病情严重程度的效能良好(P<0.05)。结论子痫前期孕妇血清EG-VEGF、NLR呈高表达水平,PLR呈低水平表达,且病情越严重的孕妇血清EG-VEGF、NLR越高,PLR越低,且经ROC分析血清EG-VEGF、NLR、PLR在子痫前期和病情严重程度诊断评价方面效能良好。展开更多
Women’s emancipation is an important part of the people’s liberation movement led by the Communist Party of China.Improving women’s political status is the basic condition for improving their social welfare rights ...Women’s emancipation is an important part of the people’s liberation movement led by the Communist Party of China.Improving women’s political status is the basic condition for improving their social welfare rights and interests.Based on the data from county gazetteers covering more than 1,700 counties,the censuses of 1990 and 2000,and other representative surveys,we conducted an empirical study on the long-term effect of women’s political status on the sex ratio at birth.Our research found that the higher the ratio of female Communist Party members in each county in 1950,the more normal was the sex ratio at birth in the following 50 years.The improved political status of women aged 16-20 significantly raised the proportion of girls among surviving children,especially in the era of family planning.This demographic study provides empirical historical evidence for the first time on one aspect of the long-term social impact of the mission of the Chinese people’s liberation.展开更多
Monocyte to high-density lipoprotein cholesterol ratio(MHR)becomes a novel cardiovascular prognostic predictor.The retrospective study was performed to investigate the relationship between MHR and acute heart failure(...Monocyte to high-density lipoprotein cholesterol ratio(MHR)becomes a novel cardiovascular prognostic predictor.The retrospective study was performed to investigate the relationship between MHR and acute heart failure(AHF)in postmenopausal women with acute coronary syndromes(ACS).Methods A cohort of 127 postmenopausal women diagnosed with ACS were enrolled.They underwent coronary angiography in Shantou Central Hospital(Shantou,China)from December 2014 and July 2016.The patients were assigned to two groups based on the admission MHR:low MHR group(MHR≤0.3677,n=51)and high MHR group(MHR>0.3677,n=76).The relationship between MHR and AHF was assessed by logistic regression analysis.Results Left ventricular ejection fraction of the low MHR group(64.2%±8.8%)was higher than that of the high MHR group(57.6%±12.9%)(P=0.002).Fractional shortening of the low MHR group(35.4%±6.4%)was higher than that of the high MHR group(30.6%±8.9%)(P=0.001).Hospitalization days of high MHR group(11.4±6.6 days)was longer than that of low MHR group(8.4±3.5 days)(P=0.006).Incidence of AHF(21%)in the high MHR group was higher than that in the low MHR group(4%)(P=0.008).MHR(OR:25.701,95%CI:3.099-213.143,P=0.003)could be an independent predictor for AHF in postmenopausal women with acute coronary syndromes.Conclusions The incidence of AHF in high baseline MHR group was higher than that in low baseline MHR group.This study demonstrated that high MHR level was a risk factor for AHF in postmenopausal women with ACS.展开更多
文摘The research consistently highlights the gender disparity in cybersecurity leadership roles, necessitating targeted interventions. Biased recruitment practices, limited STEM education opportunities for girls, and workplace culture contribute to this gap. Proposed solutions include addressing biased recruitment through gender-neutral language and blind processes, promoting STEM education for girls to increase qualified female candidates, and fostering inclusive workplace cultures with mentorship and sponsorship programs. Gender parity is crucial for the industry’s success, as embracing diversity enables the cybersecurity sector to leverage various perspectives, drive innovation, and effectively combat cyber threats. Achieving this balance is not just about fairness but also a strategic imperative. By embracing concerted efforts towards gender parity, we can create a more resilient and impactful cybersecurity landscape, benefiting industry and society.
文摘Background: Epidemic of anemia is considered to be a significant threat to pregnant women or women in child bearing age. Anemia is one of the major nutritional health disorders affecting significant proportion of population not only in developing countries but also in developed countries. This threat is more alarming in developing countries where poverty, illiteracy may contribute to high risk for causes of anemia. Objective: The purpose of the current study was to investigate the main causes of anemia in pregnant women in the State of Azad Kashmir, Muzaffarabad and to investigate the relationship between education and anemia. Methods: A descriptive cross sectional study was conducted over a sample of 433 pregnant women. The Chi- square test has been used to assess the statistical significance of different risk factors with Hb% (Heamoglobin) of the respondent. The multiple logistic regression model was used to get the most significant risk factors of anemia. Results: The study shows that the most dominant risk factors of the anemia were age at the time of marriage at different age categories that are 16 - 20 (OR = 3.945) (OR Odds ratios) with 95% C-I (confidence interval) (0.294 to 52.985), 21 - 25 (OR = 2.316) with 95% C-I (0.192 to 27.932) and 26 - 30 (OR = 4.179) with 95% C-I (0.347 to 50.320). Education at different education levels that is illiterate (OR = 1.191) with 95% C-I (0.005 to 87.279) and primary (OR = 1.179) with 95% C-I (0.009 to 156.200). Hb% at different levels 3 - 4 g/dl (OR = 1.220) with 95% C-I (0.299 to 4.984), 5 - 6 g/dl (OR = 2.221) with 95% C-I (0.679 to7.263) and 7 - 10 g/dl (OR = 1.384) with 95% C-I (0.408 to 4.689). Monthly
文摘AIM: To evaluate if static stretching influences peak and end-range functional hamstring-to-quadriceps(H/Q) strength ratios in elite women athletes. METHODS: Eleven healthy female athletes in an elite competitive level participated to the study. All the participants fulfilled the static stretching or non-stretching(control) intervention protocol in a randomized design on different days. Two static unassisted stretching exercises, one in standing and one in sitting position, were used to stretch both the hamstring and quadriceps muscles during these protocols. The total time for the static stretching was 6 ± 1 min. The isokinetic peak torque measurements for the hamstring and quadriceps muscles in eccentric and concentric modes and the calculations for the functional H/Q strength ratios at angular velocities of 60°/s and 180°/s were made before(pre) and after(post) the control or stretching intervention. The strength measurements and functional strength ratio calculations were based during the entire- and end-range of knee extension.RESULTS: The pre-test scores for quadriceps and hamstring peak torque and end range values were not significantly different between the groups(P > 0.05). Subsequently, although the control group did notexhibit significant changes in quadriceps and hamstring muscle strength(P > 0.05), static stretching decreased eccentric and concentric quadriceps muscle strength at both the 60°/s and 180°/s test speeds(P < 0.01). Similarly, static stretching also decreased eccentric and concentric hamstring muscle strength at both the 60°/s and 180°/s test speeds(P < 0.01). On the other hand, when the functional H/Q strength ratios were taken into consideration, the pre-intervention values were not significant different between the groups both during the entire and end range of knee extension(P > 0.05). Furthermore, the functional H/Q strength ratios exhibited no significant alterations during the entire and end ranges of knee extension both in the static stretching or the control intervention(P > 0.05). CONCLUSION: According to our results, static stretching routine does not influence functional H/Q ratio. Athletes can confidently perform static stretching during their warm-up routines.
文摘Liver marker {e.g., alanine aminotransferase (ALT) and aspartate aminotransferase (AST)} levels independently predict insulin resistance. The aim of the present study is to examine how changes in liver markers are associated with changes in insulin resistance after exercise in Japanese community-dwelling adults. The participants were 76 women aged 67 ± 6 years from a rural village. Nordic walk (NW) exercise of 120 min per week was performed for 12 weeks. Before and at the end of the 12-week intervention, various confounding factors and insulin resistance {e.g., Homeostatic Model Assessment of Insulin Resistance (HOMA-IR)} were measured. The baseline, follow-up, and changes in ALT/AST ratio (β = 0.390, P β = 0.393, P β = 0.321, P = 0.004, respectively) were each significantly and independently associated with HOMA-IR. When the data were further stratified by baseline and change in ASL/AST ratio, changes in HOMA-IR decreased more significantly in participants with baseline ASL/AST ratio ≥ 0.762 and change in ALT/AST ratio of < 0 than those with change in ALT/AST ratio of ≥ 0 (baseline ASL/AST ratio P = 0.002 and ASL/AST ratio ≥ 0.762, P = 0.047). This study is of interest because liver transaminase markers, which are inexpensive and routinely collected in clinical settings, may provide a simple and accurate enhancement to models currently used to identify subjects with changes in insulin resistance. These results suggest that a higher baseline and decreased change in ALT/AST ratio may be a predictor for decreased insulin resistance after a 12-week walking exercise in community-dwelling middle-aged and elderly women.
文摘Background: Depression is one of the growing public health concerns among women worldwide. This is one of the most under-recognized and under-treated mental illnesses worldwide. Women of developing countries are inexplicably affecting with depression. Purpose: The purpose of study is to assess the prevalence and associative factors of depression among women of aged 20 to 40 years living in urban squatter settlements of Karachi, Pakistan. The identification of all the potential determinants will potentially help in formulating preventive strategies in order to decline the prevalence of depression among women and improve the wellbeing of women. Methods: An analytical cross-sectional survey was employed among women living in Reta Plot and Kala Board communities of Karachi, Pakistan. Beck Depression Inventory II (BDI-II) was used to measure depression. Systematic sampling was used to recruit 636 married women. Cox proportional hazard was run to compute prevalence ratios and their 95% confidence interval. Results: Our study estimated 33.3% of depression among study participants. The current study showed that age, possession of own vehicle, years of schooling and recent deaths in family were significantly associated with depression. Conclusion: This research was a bold step to address the issue of increasing rate of depression among Pakistani population. Our study results can convince policy makers to extend mental health support to women by improving accessibility of services. Recommendation: Our study recommends that the women of our society should be encouraged for attaining education. This study also recommends that at primary health care setting, every health professional should be trained to screen the depression. Moreover, the results of our study can also encourage policy makers to expand mental health support services for women.
文摘Initial prodiabetic risk profiles were invented here with three female study groups consisting of primarily healthy women (A1: 1990-1999, n = 160;A2: 2009, n = 88;A: n = 248, 36 ± 14 years;B: 2014: n = 65, aged 37± 11 years). Significantly higher blood pressure was found comparing intolerance versus tolerance to glucose (p p p = 0.02), of fasting blood glucose (p = 0.07) and of urine pathology (p = 0.07). High LDL-C of women who reported smoking at baseline was correlated with diastolic hypertension whereby alcohol problems overlapped (p = 0.036, A). Unhealthy combinations were found consisting of LDL-related intolerance to glucose, LDL-related smoking, of alcohol-related hypertriglyceridemia or of combined drinking and smoking testing urine pathology over the course of time. Obese women were at direct risk for hypertension in the presence of high LDL-C and submaximal ratio of serum albumin to triglycerides (Alb/Trig). Obese women reacted highly sensitive to critical alcohol consumption showing then macroalbuminuria. Current participants who disowned daily alcohol consumption showed healthy morning urines and normal fasting blood glucose. Mild decrease of HDL-C was observed during heavy smoking of relatively young women who had normal biomarkers. Women with intolerance to glucose were at direct risk for hypertension whereby high LDL-C and/or smoking triggered prodiabetic risk profiles. Obese women had elevated LDL-C during hypertension and reacted highly sensitive to alcohol-related proteinuria and/or hematuria.
基金Beijing Municipal Administration of Hospitals’Ascent Plan(No.DFL20191802)Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support(No.ZYLX202126)
文摘Background:Women comprise more than half of people living with human immunodeficiency virus/acquired immune deficiency syndrome(HIV/AIDS)worldwide and incomplete immune recovery and metabolic abnormalities affect them deeply.Studies of HIV antiretroviral therapy(ART)have a low female representation in China.We aimed to investigate immune reconstitution and metabolic changes of female HIV-positive cohort in China longitudinally.Methods:HIV-positive women who initiated ART from January 2005 to June 2021 and were followed up regularly at least once a year were included in this study.Immunological indicators(cluster of differentiation 4[CD4]counts and CD8 counts),viral load(VL),and metabolic indicators were collected at follow-up.All data were collected from the China Disease Prevention and Control Information System(CDPCIS).VL was tested half a year,1 year after receiving ART,and every other year subsequently according to local policy.CD4/CD8 ratio normalization was considered as the primary outcome and defined as a value≥1.Incidence rate and probability of CD4/CD8 ratio normalization were estimated through per 100 person-years follow-up(PYFU)and Kaplan-Meier curve,respectively.Multivariate Cox regression was used to identify independent risk factors associated with CD4/CD8 ratio normalization.We further studied the rate of dyslipidemia,hyperuricemia,diabetes,liver injury,and renal injury after ART initiation with the chi-squared tests or Fisher’s exact probability tests,and a generalized estimating equation model was used to analyze factors of dyslipidemia and hyperuricemia.Results:A total of 494 female patients with HIV/AIDS started ART within 16 years from January 2005 to June 2021,out of which 301 women were enrolled with a median duration of ART for 4.1 years(interquartile range,2.3-7.0 years).The overall incidence rate of CD4/CD8 ratio normalization was 8.9(95%confidence interval[CI],7.4-10.6)per 100 PYFU,and probabilities of CD4/CD8 normalization after initiating ART at 1 year,2 years,5 years,and 10 years follow-up were 11.7%,23.2%,44.0%,and 59.0%,respectively.Independent risk factors associated with CD4/CD8 normalization were baseline CD4 cell counts<200 cells/μL,CD8 counts>1000 cells/μL,and more than 6 months from the start of combined ART(cART)to first virological suppression.Longitudinally,the rate of hypercholesterolemia(total cholesterol[TC])and high triglyceride(TG)showed an increasing trend,while the rate of low high-density lipoprotein cholesterol(HDL)showed a decreasing trend.The rate of hyperuricemia presented a downtrend at follow-up.Although liver and renal injury and diabetes persisted during ART,the rate was not statistically significant.Older age and protease inhibitors were independent risk factors for increase of TC and TG,and ART duration was an independent factor for elevation of TC and recovery of HDL-C.Conclusions:This study showed that women were more likely to normalize CD4/CD8 ratio in comparison with findings reported in the literature even though immune reconstruction was incomplete.
文摘目的分析子痫前期孕妇D-二聚体水平与中性粒细胞与淋巴细胞比值(NLR)的相关性。方法回顾性分析临床资料,选择2021年1月至12月于我院收治的子痫前期孕妇80例为观察对象,纳为子痫前期组,根据病情严重程度分为轻度组(42例)、重度组(38例),同期选择于我院产检的健康孕妇80名为健康对象组,采集各组孕妇空腹静脉血,比较各组孕妇血浆D-二聚体水平、NLR水平,查阅2组孕妇产后新生儿临床资料,比较各组新生儿体质量、1 min Apgar评分、5 min Apgar评分。采用Pearson相关性分析D-二聚体水平与NLR及其他指标相关性;采用受试者工作特征(ROC)曲线评估D-二聚体、NLR预测子痫前期发生的价值。结果子痫前期组孕妇血浆D-二聚体水平及NLR水平高于健康对照组(P<0.05)。重度组孕妇血浆D-二聚体水平及NLR水平高于轻度组(P<0.05)。重度组新生儿体质量低于轻度组,1min Apgar评分、5min Apgar评分低于轻度组(P<0.05)。子痫前期Pearson相关性分析显示,子痫前期孕妇血浆D-二聚体水平与NLR呈明显正相关(r=0.52,P<0.05),与新生儿体质量、1min Apgar评分、5min Apgar评分呈明显负相关(r=-0.47、-0.51、-0.45,P均<0.05)。ROC曲线显示,D-二聚体、NLR预测子痫前期发生的曲线下面积(AUC)分别为0.733、0.803,联合预测的AUC为0.906,联合预测价值较高。结论子痫前期孕妇普遍存在凝血功能异常情况,D-二聚体水平明显异常表达,且D-二聚体水平与子痫前期病情严重程度及NLR水平存在一定相关性,定期监测D-二聚体水平变化有助于评估病情,为临床治疗及预后预测提供合理参考。
文摘目的探讨子痫前期孕妇血清内分泌腺源性血管内皮生长因子(EG-VEGF)、中性粒细胞淋巴细胞比值(NLR)、血小板淋巴细胞比值(PLR)表达与病情严重程度的相关性。方法回顾性分析2021年10月~2023年3月在承德市中心医院妇儿院区产检的90例孕妇临床资料,根据是否患有子痫前期进行分组,将健康正常的30例孕妇纳入健康对照组,将确诊为子痫前期的60例孕妇纳入观察组,且观察组根据子痫前期严重程度分为轻度组(n=30)和重度组(n=30),比较健康对照组和观察组、轻度组和重度组的血清EG-VEGF、NLR、PLR表达水平,并应用ROC曲线分析血清EG-VEGF、NLR、PLR诊断子痫前期和评价病情严重程度的效能。结果观察组的血清EG-VEGF、NLR高于健康对照组[(53.65±17.46)pg ml vs.(28.93±9.37)pg ml、(3.15±1.02)vs.(2.12±0.67)],PLR低于健康对照组[(98.53±21.86)vs.(115.31±18.36)],差异有统计学意义(t=7.237、5.010、3.613,P<0.05)。经ROC曲线分析发现,血清EG-VEGF、NLR、PLR诊断子痫前期效能良好(P<0.05)。重度组的血清EG-VEGF、NLR高于轻度组[(57.93±13.19)pg ml vs.(49.63±15.63)pg ml、(3.40±0.95)vs.(2.93±0.71)],PLR低于轻度组[(163.72±35.41)vs.(146.70±28.63)],差异有统计学意义(t=2.223、2.171、2.047,P<0.05)。经ROC曲线分析,发现血清EG-VEGF、NLR、PLR评价子痫前期病情严重程度的效能良好(P<0.05)。结论子痫前期孕妇血清EG-VEGF、NLR呈高表达水平,PLR呈低水平表达,且病情越严重的孕妇血清EG-VEGF、NLR越高,PLR越低,且经ROC分析血清EG-VEGF、NLR、PLR在子痫前期和病情严重程度诊断评价方面效能良好。
文摘Women’s emancipation is an important part of the people’s liberation movement led by the Communist Party of China.Improving women’s political status is the basic condition for improving their social welfare rights and interests.Based on the data from county gazetteers covering more than 1,700 counties,the censuses of 1990 and 2000,and other representative surveys,we conducted an empirical study on the long-term effect of women’s political status on the sex ratio at birth.Our research found that the higher the ratio of female Communist Party members in each county in 1950,the more normal was the sex ratio at birth in the following 50 years.The improved political status of women aged 16-20 significantly raised the proportion of girls among surviving children,especially in the era of family planning.This demographic study provides empirical historical evidence for the first time on one aspect of the long-term social impact of the mission of the Chinese people’s liberation.
基金supported by the fifth batch of Shantou Medical and Health Science and Technology Plan Project in 2019(financial fund support)(No.Shantou Government Technology[2019]106-20)。
文摘Monocyte to high-density lipoprotein cholesterol ratio(MHR)becomes a novel cardiovascular prognostic predictor.The retrospective study was performed to investigate the relationship between MHR and acute heart failure(AHF)in postmenopausal women with acute coronary syndromes(ACS).Methods A cohort of 127 postmenopausal women diagnosed with ACS were enrolled.They underwent coronary angiography in Shantou Central Hospital(Shantou,China)from December 2014 and July 2016.The patients were assigned to two groups based on the admission MHR:low MHR group(MHR≤0.3677,n=51)and high MHR group(MHR>0.3677,n=76).The relationship between MHR and AHF was assessed by logistic regression analysis.Results Left ventricular ejection fraction of the low MHR group(64.2%±8.8%)was higher than that of the high MHR group(57.6%±12.9%)(P=0.002).Fractional shortening of the low MHR group(35.4%±6.4%)was higher than that of the high MHR group(30.6%±8.9%)(P=0.001).Hospitalization days of high MHR group(11.4±6.6 days)was longer than that of low MHR group(8.4±3.5 days)(P=0.006).Incidence of AHF(21%)in the high MHR group was higher than that in the low MHR group(4%)(P=0.008).MHR(OR:25.701,95%CI:3.099-213.143,P=0.003)could be an independent predictor for AHF in postmenopausal women with acute coronary syndromes.Conclusions The incidence of AHF in high baseline MHR group was higher than that in low baseline MHR group.This study demonstrated that high MHR level was a risk factor for AHF in postmenopausal women with ACS.