Two new L-tryptophan derivatives,（S）-2-（4-acetoxybenzamido）-3-（1 H-indol-3-yl）propanoic acid（I） and（S）-2-（3-acetoxybenzamido）-3-（1H-indol-3-yl）propanoic acid（II）, were synthesized and characterized by ...Two new L-tryptophan derivatives,（S）-2-（4-acetoxybenzamido）-3-（1 H-indol-3-yl）propanoic acid（I） and（S）-2-（3-acetoxybenzamido）-3-（1H-indol-3-yl）propanoic acid（II）, were synthesized and characterized by FT-IR, NMR and MS. The single crystals were cultivated and determined with X-ray diffraction. It was determined that the two compounds crystallized in monoclinic space group P21. Compound I（C（21）H（20）N2O5, Mr = 380.39） with a = 8.5227（6）, b = 7.8310（6）, c = 15.2527（11） A°, Z = 2, V = 1017.81（13） A°^3, μ = 0.090 mm^-1, Dc = 1.241 g/cm^3, F（000） = 400, the final R = 0.0412 and w R = 0.1170 for all data. Compound II（C（21）H（20）N2O5, Mr = 380.39） with a = 9.5112（5）, b = 9.2197（4）, c = 10.9115（5） A°, Z = 2, V = 952.13（8） A°^3, μ = 0.096 mm^-1, Dc = 1.327 g/cm^3, F（000） = 400, the final R = 0.0377 and w R = 0.1009 for all data. The anticoagulant activities of L-tryptophan derivatives were evaluated by plasma re-calcification time（PRT） and blood concretion four items（APTT, PT, TT and FIB）. The results exhibited that L-tryptophan derivatives showed anticoagulant activity in normal coagulation pathway.展开更多
基金supported by the National Natural Science Foundation of China(No.21362001)High Level Innovation Team and Outstanding Scholar Project of Guangxi High School(2014.No.49)
文摘Two new L-tryptophan derivatives,（S）-2-（4-acetoxybenzamido）-3-（1 H-indol-3-yl）propanoic acid（I） and（S）-2-（3-acetoxybenzamido）-3-（1H-indol-3-yl）propanoic acid（II）, were synthesized and characterized by FT-IR, NMR and MS. The single crystals were cultivated and determined with X-ray diffraction. It was determined that the two compounds crystallized in monoclinic space group P21. Compound I（C（21）H（20）N2O5, Mr = 380.39） with a = 8.5227（6）, b = 7.8310（6）, c = 15.2527（11） A°, Z = 2, V = 1017.81（13） A°^3, μ = 0.090 mm^-1, Dc = 1.241 g/cm^3, F（000） = 400, the final R = 0.0412 and w R = 0.1170 for all data. Compound II（C（21）H（20）N2O5, Mr = 380.39） with a = 9.5112（5）, b = 9.2197（4）, c = 10.9115（5） A°, Z = 2, V = 952.13（8） A°^3, μ = 0.096 mm^-1, Dc = 1.327 g/cm^3, F（000） = 400, the final R = 0.0377 and w R = 0.1009 for all data. The anticoagulant activities of L-tryptophan derivatives were evaluated by plasma re-calcification time（PRT） and blood concretion four items（APTT, PT, TT and FIB）. The results exhibited that L-tryptophan derivatives showed anticoagulant activity in normal coagulation pathway.
