The Relevant Analysis on the Stop Time in Winter and Times of Plateau and the Index in Early Days for Garrisonned Plateau Constructors

Objective: Study the influence of the stop time in winter, times of plateau on the index in early days for plateau constructors meet;Method:Is it participate in plateau construction of 2002-2004 to choose,enter into the plateau again of 2003-2005 practise clothes finish to mate 326 materials “physical examination in front of the worker",which is passed in Nanshankou Hospital in early days, divided into 3 groups according to the difference of year for the physical examination, examine by leaning towards relevant analytical methods;Result: （1） In the situation of day controlling about the stop time in winter, times of garrison in plateau and blood and oxygen saturation lever （SaO2）, the systolic pressure （sBP） is presented and shouldered relevantly winter to control. Present positive correlation with the value of hemoglobin （Hb）;（2） It is stopped that in case of controlling and is garrisoned in the number of times of plateau in winter day and blood and oxygen saturation lever （SaO2） to present positive correlation. Present and shoulder with the hemoglobin （Hb） relevantly.Conclusion: In order to ensure the health of plateau constructors to the maximum extent, should try one’s best to reduce the number of times of returning to the plateau in possible cases. At the same time each one constructs for year and returns to the time that the hinterland concentrates rest should be on above 90 days.

Cardiac regeneration: Pre-existing cardiomyocyte as the hub of novel signaling pathway

In the mammalian heart,cardiomyocytes are forced to withdraw from the cell cycle shortly after birth,limiting the ability of the heart to regenerate and repair.The development of multimodal regulation of cardiac proliferation has verified that pre-existing cardiomyocyte proliferation is an essential driver of cardiac renewal.With the continuous development of genetic lineage tracking technology,it has been revealed that cell cycle activity produces polyploid cardiomyocytes during the embryonic,juvenile,and adult stages of cardiogenesis,but newly formed mononucleated diploid cardiomyocytes also elevated sporadically during myocardial infarction.It implied that adult cardiomyocytes have a weak regenerative capacity under the condition of ischemia injury,which offers hope for the clinical treatment of myocardial infarction.However,the regeneration frequency and source of cardiomyocytes are still low,and the mechanism of regulating cardiomyocyte proliferation remains further explained.It is noteworthy to explore what force triggers endogenous cardiomyocyte proliferation and heart regeneration.Here,we focused on summarizing the recent research progress of emerging endogenous key modulators and crosstalk with other signaling pathways and furnished valuable insights into the internal mechanism of heart regeneration.In addition,myocardial transcription factors,non-coding RNAs,cyclins,and cell cycle-dependent kinases are involved in the multimodal regulation of pre-existing cardiomyocyte proliferation.Ultimately,awakening the myocardial proliferation endogenous modulator and regeneration pathways may be the final battlefield for the regenerative therapy of cardiovascular diseases.