目的观察针刺配合通络益气汤治疗脑小血管病致认知功能障碍的临床疗效及其对患者脑微循环、步态平衡和血清神经元PAS结构域蛋白4(neuronal PAS domain protein 4,NPAS4)、P-选择素(CD62P)表达的影响。方法将98例脑小血管病致认知功能障...目的观察针刺配合通络益气汤治疗脑小血管病致认知功能障碍的临床疗效及其对患者脑微循环、步态平衡和血清神经元PAS结构域蛋白4(neuronal PAS domain protein 4,NPAS4)、P-选择素(CD62P)表达的影响。方法将98例脑小血管病致认知功能障碍患者随机分为治疗组和对照组,每组49例。治疗组采用针刺配合通络益气汤治疗,对照组采用单纯通络益气汤治疗。观察两组治疗前后各项实验室指标[谷胱甘肽过氧化物酶(glutathione peroxidase,GSH-Px)、晚期糖基化终末产物(advanced glycation end products,AGEs)、NPAS4、CD62P、一氧化氮(NO)、亲环素A(cyclophilin A,CyPA)、脂蛋白相关磷脂酶A2(lipoprotein-associated phospholipase A2,Lp-PLA2)、血管性血友病因子(von Willebrand factor,vFW)水平]、脑微循环指标[血脑屏障通透性、血管差压、临界压力(critical pressure,CP)、脑血管动态阻力(dynamic resistance,DR)]及各量表[Berg平衡量表(Berg balance scale,BBS)、Tinetti平衡与步态量表、蒙特利尔认知评估量表(Montreal cognitive assessment,MoCA]评分的变化情况,并比较两组临床疗效。结果两组治疗后GSH-Px、NO水平及CP、各量表评分均较同组治疗前显著上升,AGEs、NPAS4、CD62P、CyPA、Lp-PLA2、vFW水平及血脑屏障通透性、血管差压、DR显著下降,差异均具有统计学意义(P<0.05)。治疗组治疗后GSH-Px、NO水平及CP、各量表评分均明显高于对照组,AGEs、NPAS4、CD62P、CyPA、Lp-PLA2、vFW水平及血脑屏障通透性、血管差压、DR均明显低于对照组,两组比较差异均具有统计学意义(P<0.05)。治疗组总有效率为98.0%,明显高于对照组的87.8%,两组比较差异具有统计学意义(P<0.05)。结论针刺配合通络益气汤治疗脑小血管病致认知功能障碍疗效确切,可减少氧化应激反应及炎症反应,降低NPAS4、CD62P水平,减少血管内皮功能及认知功能损伤,改善血脑屏障通透性、脑微循环及步态平衡。展开更多
针对目前船厂实习路途遥远、实习内容有限、成本高且安全风险大等问题,基于互联网的开放共享特性、VR技术和可穿戴设备的沉浸式仿真效果,应用Unity3D和Visual Studio C#设计了虚拟船厂、船舶交互仿真实验教学系统。组建了学习、漫游、...针对目前船厂实习路途遥远、实习内容有限、成本高且安全风险大等问题,基于互联网的开放共享特性、VR技术和可穿戴设备的沉浸式仿真效果,应用Unity3D和Visual Studio C#设计了虚拟船厂、船舶交互仿真实验教学系统。组建了学习、漫游、考评一体化的实验平台,将“互联网+”概念应用到特色实验教学中去,结合传统实验教学,探索了一种新型实验教学和考核模式,克服了教学手段缺乏改革创新、学生学习兴趣不高、优质教学资源匮乏等问题。展开更多
It was focused on the applications and developments of microwave hydrothermal synthesis piezoelectric ceramic powder. The microwave hydrothermal vessel was designed and manufactured. The microwave hydrothermal synthes...It was focused on the applications and developments of microwave hydrothermal synthesis piezoelectric ceramic powder. The microwave hydrothermal vessel was designed and manufactured. The microwave hydrothermal synthesis system was established and the PZT piezoelectric ceramic powder was synthesized. XRD and TEM have been used to characterize the products in detail. The diameter of the PZT powder particle is from 40 to 60 nm.展开更多
A novel route to prepare nanocomposites was illustrated through preparing overbased calcium petroleum sulfonate lubricating oil detergent, where the rotating packed bed （RPB） was used as reactor in place of conventi...A novel route to prepare nanocomposites was illustrated through preparing overbased calcium petroleum sulfonate lubricating oil detergent, where the rotating packed bed （RPB） was used as reactor in place of conventional reaction vessel. The results showed that the carbonation efficiency is improved, the raw materials consumption is reduced, and the dispersibilities, sizes and morphologies of nano-sized CaCO3 particles in overbased detergent are enhanced. It is deduced reasonably that this route can be extensively applied to nanocomposites preparation in appropriate conditions and would be a platform technology in this field.展开更多
文摘针对目前船厂实习路途遥远、实习内容有限、成本高且安全风险大等问题,基于互联网的开放共享特性、VR技术和可穿戴设备的沉浸式仿真效果,应用Unity3D和Visual Studio C#设计了虚拟船厂、船舶交互仿真实验教学系统。组建了学习、漫游、考评一体化的实验平台,将“互联网+”概念应用到特色实验教学中去,结合传统实验教学,探索了一种新型实验教学和考核模式,克服了教学手段缺乏改革创新、学生学习兴趣不高、优质教学资源匮乏等问题。
文摘It was focused on the applications and developments of microwave hydrothermal synthesis piezoelectric ceramic powder. The microwave hydrothermal vessel was designed and manufactured. The microwave hydrothermal synthesis system was established and the PZT piezoelectric ceramic powder was synthesized. XRD and TEM have been used to characterize the products in detail. The diameter of the PZT powder particle is from 40 to 60 nm.
文摘A novel route to prepare nanocomposites was illustrated through preparing overbased calcium petroleum sulfonate lubricating oil detergent, where the rotating packed bed （RPB） was used as reactor in place of conventional reaction vessel. The results showed that the carbonation efficiency is improved, the raw materials consumption is reduced, and the dispersibilities, sizes and morphologies of nano-sized CaCO3 particles in overbased detergent are enhanced. It is deduced reasonably that this route can be extensively applied to nanocomposites preparation in appropriate conditions and would be a platform technology in this field.
