ISOMORPHISMS AND DERIVATIONS IN C*-ALGEBRAS

In this article, we prove the Hyers-Ulam-Rassias stability of the following Cauchy-Jensen functional inequality：‖f （x） ＋ f （y） ＋ 2f （z） ＋ 2f （w）‖ ≤‖ 2f x ＋ y2 ＋ z ＋ w ‖（0.1）This is applied to investigate isomorphisms between C＊-algebras, Lie C＊-algebras and JC＊-algebras, and derivations on C＊-algebras, Lie C＊-algebras and JC＊-algebras, associated with the Cauchy-Jensen functional equation 2f （x ＋ y/2 ＋ z ＋ w） = f（x） ＋ f（y） ＋ 2f（z） ＋ 2f（w）.

CHAIN CONDITIONS FOR C＊-ALGEBRAS COMING FROM HILBERT C＊-MODULES

In this paper we define and study chain conditions for Hilbert C＊-modules through their C＊-algebras of compact operators and discuss their perseverance under Morita equivalence and tensor products. We show that these chain conditions are passed from the C＊-algebra to its Hilbert module under certain conditions. We also study chain conditions for Hilbert modules coming from inclusion of C＊-algebra with a faithful conditional expectation.

鸽微RNA病毒实时荧光定量RT-PCR检测方法的建立

旨在建立鸽微RNA病毒(pigeon megrivirus,PiMeV)实时荧光定量RT-PCR检测方法。本研究根据GenBank中PiMeVs序列特征设计特异性检测引物,从信鸽粪便中检测到PiMeV阳性(命名为PiMeV-CHN001株),并对其3 C基因进行核苷酸同源性比较和遗传进化分析,明确其基因特征后,设计特异性实时荧光定量RT-PCR检测(RT-qPCR)引物组,建立检测PiMeV的RT-qPCR方法。结果显示:PiMeV-CHN001株3 C基因全长为591 bp,编码197个氨基酸,和其他2株野鸽源PiMeV(MeV-B1株和MeV-B2株)核苷酸相似性分别为89.5%和92.0%。建立的检测PiMeV的RT-qPCR方法的标准曲线Y轴截距为37.93,斜率为-3.335,相关系数为1.00,扩增效率为99.4%。特异性强,仅PiMeV出现特异性扩增信号和特异性峰值[Tm值为(81.69±0.22)℃],对鸽源禽流感病毒(avian influenza virus,AIV)、鸽源禽I型副黏病毒(pigeon paramyxovirus type I,PPMV-1)、鸽输血传播病毒(pigeon torque teno virus,PTTV)、鸽腺病毒(pigeon adenovirus,PiAd)及鸽圆环病毒(pigeon circovirus,PiCV)检测均未见特异性扩增信号;敏感性优,最低检测限为54.0拷贝·μL^(-1);重复性好,批内和批间变异系数均低于1.5%。用建立的检测方法对42份信鸽粪便样品进行检测,发现2份阳性样品(阳性率为4.76%)。本研究首次证实我国大陆地区信鸽中存在PiMeV,丰富了PiMeV宿主谱信息;建立的RT-qPCR方法为后续开展PiMeV流行病学研究提供支撑。

C-X3-C基序趋化因子配体1/C-X3-C基序趋化因子受体1通路参与失血性休克/复苏大鼠记忆功能恢复

目的探讨C-X3-C基序趋化因子配体1(CX3CL1)/C-X3-C基序趋化因子受体1(CX3CR1)通路调控的小胶质细胞活化对失血性休克/复苏大鼠记忆功能的影响。方法实验分为2部分。第1部分,将大鼠随机分为假手术组,模型-0.5 h组,模型-1.5 h组,模型-3 h组,每组10只,模型组之间失血性休克时间存在差异。第2部分,大鼠随机分为对照组与CX3CL1组,每组10只。CX3CL1组大鼠脑室注射CX3CL1蛋白,对照组大鼠注射生理盐水。所有大鼠在模型制作前开展Morris水迷宫训练,模型制作后4 d,开展水迷宫测试。完成后,取全脑组织进行HE染色与免疫组织化学染色,取脑脊液检测炎性细胞因子含量,取脑组织进行Real-time PCR检测与Western blotting检测。结果与假手术组相比,模型组大鼠逃避潜伏期增加,穿越平台次数与第Ⅲ象限停留时间减少,且HE染色中显示神经元状态受损。此外,与假手术组相比,模型组大鼠脑组织中离子钙结合衔接分子1(Iba1)表达升高,脑脊液中肿瘤细胞坏死因子α(TNF-α)与白细胞介素(IL)-6含量升高,M1型小胶质细胞标记CD16、TNF-α、IL-1β与诱导性一氧化氮合酶(iNOS)mRNA含量升高。与此同时,与假手术组相比,模型组大鼠脑组织中CX3CL1、CX3CR1蛋白表达降低,磷酸化核因子κB(p-NF-κB)与核苷酸结合寡聚结构域(NOD)样受体蛋白3(NLRP3)蛋白表达升高。然而,与模型组相比,CX3CL1组大鼠逃避潜伏期减少,穿越平台次数与第Ⅲ象限停留时间增加,且神经元状态恢复。此外,与对照组相比,CX3CL1组大鼠脑组织中Iba1表达降低,脑脊液中TNF-α与IL-6含量降低,M1型小胶质细胞标记CD16、TNF-α、IL-1β与iNOS mRNA含量降低,M2型小胶质细胞标记CD206、转化生长因子β(TGF-β)、精氨酸酶1(Arg1)、几丁质酶3样蛋白1(Ym1)mRNA含量升高。结论CX3CL1有助于抑制小胶质细胞过度激活,诱导小胶质细胞向M2型极化,抑制M1型极化,降低炎性细胞因子释放,减轻失血性休克/复苏诱发的记忆功能损伤。

AGGREGATE SPECIAL FUNCTIONS TO APPROXIMATE PERMUTING TRI-HOMOMORPHISMS AND PERMUTING TRI-DERIVATIONS ASSOCIATED WITH A TRI-ADDITIVEψ-FUNCTIONAL INEQUALITY IN BANACH ALGEBRAS

In this paper,we define a new class of control functions through aggregate special functions.These class of control functions help us to stabilize and approximate a tri-additiveψ-functional inequality to get a better estimation for permuting tri-homomorphisms and permuting tri-derivations in unital C*-algebras and Banach algebras by the vector-valued alternative fixed point theorem.

A Note on the Perturbation of MF Algebras and Quasidiagonal C^*-Algebras

Perturbation problem of operator algebras was first introduced by Kadison and Kastler. In this short note, we consider the uniform perturbation of two classes of operator algebras, i.e., MF algebras and quasidiagonal C*-algebras. We show that the sets of MF algebras and quasidiagonal C*-algebras of a given C*-algebra are closed under the perturbation of uniform norm.

基于C#语言的不动产附图二维码批量生成研究

为深入贯彻广东省“十四五”规划中“建设幸福广东”新目标,进一步促进广州智联汽车小镇“多测合一”服务项目落地,针对广州市不动产权附图中重要信息人工输入慢、耗时长等关键问题,利用C#编程语言设计实现了不动产附图二维码以及不动产单元号的批量生成程序,生产实践证明了程序能快速生成附图二维码和不动产单元号,提高了生产效率,具有较高的实用价值。

Radiation dose detection using a high-power portable optically stimulated luminescence real-time reading system

Optically stimulated luminescence(OSL) reading systems are becoming smaller and capable of real-time detection. To improve real-time and multipurpose radiation dosimetry readings, we built a real-time continuous-wave(RCW) OSL reading system. This system is both small and lightweight, and it employs powerful laser excitation(478 mW/cm^2) at the dosimetry probe location. We investigate the possibility of using the RCW mode to read the radiation luminescence(RL) or OSL by using a singlecrystal Al_2O_3:C dosimeter in a low-dose-rate137 Cs y field.Our results indicate that the RL/OSL follows a stable and uniform distribution. The minimum detected doses associated with the RL, OSL, and RL + OSL signals are2.1 9 10^(-2), 3.17 9 10^(-1), and 5.7 9 10^(-2) l Gy, respectively. This device provides a framework for the future development of applications for practical radiation dose measurements.

Real life efficacy and safety of direct-acting antiviral therapy for treatment of patients infected with hepatitis C virus genotypes 1, 2and 3 in northwest China

BACKGROUND Regimens involving direct-acting antiviral agents(DAAs)are recommended for the treatment of infection with hepatitis C virus(HCV)genotypes 1,2 and 3.But real-world data is still not enough,especially in Asia.AIM To investigate the efficacy and safety of DAA-based regimens in a real-life setting in China.METHODS This study included 366 patients infected with HCV genotypes 1,2 and 3,with or without cirrhosis,who were observed between May 2015 and December 2018.They were treated with ledipasvir and sofosbuvir(SOF)(genotype 1)with or without ribavirin(RBV),SOF and RBV(genotype 2),or SOF and daclatasvir(genotype 3),with or without RBV,for 12 or more wk.The participants’sustained virological responses(SVR)at post-treatment week 12(SVR12)was the primary endpoint.The occurrence of adverse events and drug-drug interactions were recorded.RESULTS In the 366 patients,genotype 1(59.0%)was the most common genotype,followed by genotypes 2(34.4%)and 3(6.6%).Liver cirrhosis was diagnosed in 154(42.1%)patients.Fifty(13.7%)patients were treatment-experienced.Intention-to-treat analysis revealed that SVR12 was 86.3%(316/366).For modified intention-totreat analysis,SVR12 was achieved in 96.6%of overall patients(316/327),96.3%in patients with genotype 1,97.5%in those with genotype 2,and 95.0%in those with genotype 3.Most of the treatment failures were due to lack of follow-up(3cases had non-responses,1 had virological breakthrough,11 relapsed and 36 did not participate in the follow-up).There was no significant difference in SVR between different genotypes and liver statuses(P<0.05).Patients with lower alanine aminotransferase levels at baseline who achieved an end of treatment response were more likely to achieve SVR12(P<0.05).High SVR was observed regardless of age,gender,liver status,alpha-fetoprotein,HCV RNA levels or history of antiviral therapy(P>0.05 for all).The cumulative hepatocellular carcinoma occurrence and recurrence rate after using the DAAs was 0.9%.Most of the adverse events were mild.We found two cases of special adverse events.One case involved facial and bilateral lower extremity edema,and the other case showed an interesting change in lipid levels while on medication.No severe adverse events were noted.CONCLUSION The DAA-based regimens tested in this study have excellent effectiveness and safety in all patients infected with HCV genotypes 1,2 and 3,including those with cirrhosis.

Application of Real-time Fluorescent Quantitative PCR in Studies on Plants

Real-Lime fluorescent quantitative PCR is a method for quantitative analysis of gene expression developed in recent years, which has been widely used in various fields such as basic scientific research, clinical diagnosis, disease study, drug research and development since its appearance. It starts relatively late in study on plants, but has already been used for analysis of gene expression in plants and gene identification of exogenous genes. The principles or advantages and dis- advantages of real-time fluorescent quantitative PCR, or its potential problems and condition optimizations in tests were introduced in this study, and then the appli- cation and prospect of real-time fluorescent quantitative PCR in study on plants were also been discussed.

Determining hepatitis C virus genotype distribution among high-risk groups in Iran using real-time PCR

AIM:To assess hepatitis C virus(HCV)genotype patterns among high-risk Iranian groups,using real-time RT-PCR.METHODS:In this study,we evaluated the distribution of different HCV genotypes among injection drug users and other high-risk groups over a 4-year period(from 2009 to 2012)using real-time polymerase chain reaction(PCR).Sera from 888 HCV-infected patients residing in southern and southwest Iran were genotyped using real-time PCR with common primers and specific probes.These patients were grouped into distinct exposure categories.Illicit drug users constituted the primary group and were further evaluated for HCV genotype distribution and parameters such as age range.RESULTS:Of the examined HCV-infected patients,62%were substance abusers,although the route of transmission could not be determined in approximately 30%of these patients.HCV genotyping revealed that Gt1 was the most prevalent genotype among the drug users as well as among patients with thalassemia,hemophilia,solid organ recipients and those on hemodialysis.Mixed infections were only seen in addict groups,where Gt2 genotype was also found.The highest frequencies in HCV-positive addict patients were observed in the 31-40 age group.Our research also showed that the addiction age has increased,whereas the addiction rate has dropped in this region.Most illicit drug users had more than one risk factor such as tattoo and/or a history of imprisonment.CONCLUSION:This study revealed that the most common HCV-infection route and HCV-genotype in southern and southwest Iran was illicit drug abuse and Gt1,respectively.

Exploring the hepatitis C virus genome using single molecule realtime sequencing

Single molecular real-time(SMRT)sequencing,also called third-generation sequencing,is a novel sequencing technique capable of generating extremely long contiguous sequence reads.While conventional short-read sequencing cannot evaluate the linkage of nucleotide substitutions distant from one another,SMRT sequencing can directly demonstrate linkage of nucleotide changes over a span of more than 20 kbp,and thus can be applied to directly examine the haplotypes of viruses or bacteria whose genome structures are changing in real time.In addition,an error correction method(circular consensus sequencing)has been established and repeated sequencing of a single-molecule DNA template can result in extremely high accuracy.The advantages of long read sequencing enable accurate determination of the haplotypes of individual viral clones.SMRT sequencing has been applied in various studies of viral genomes including determination of the full-length contiguous genome sequence of hepatitis C virus(HCV),targeted deep sequencing of the HCV NS5A gene,and assessment of heterogeneity among viral populations.Recently,the emergence of multi-drug resistant HCV viruses has become a significant clinical issue and has been also demonstrated using SMRT sequencing.In this review,we introduce the novel third-generation PacBio RSII/Sequel systems,compare them with conventional next-generation sequencers,and summarize previous studies in which SMRT sequencing technology has been applied for HCV genome analysis.We also refer to another long-read sequencing platform,nanopore sequencing technology,and discuss the advantages,limitations and future perspectives in using these thirdgeneration sequencers for HCV genome analysis.

Interferon-free treatments in patients with hepatitis C genotype 1-4 infections in a real-world setting

AIM To investigated the real-world effectiveness and safety of various regimens of interferon-free treatments in patients infected with hepatitis C virus(HCV).METHODS We performed an observational study to analyze different antiviral treatments administered to 462 HCV-infected patients, of which 56.7% had liver cirrhosis. HCV RNA after 4 wk of treatment and at 12 wk after treatment sustained virologic response(SVR) as well as serious adverse events(SAEs) was analyzed first for the whole cohort and then separately in patients who met or did not meet the inclusion criteria of a clinical trial(CT-met and CT-unmet, respectively).RESULTS The most frequently prescribed treatment was simeprevir/sofosbuvir(36.4%), followed by sofosbuvir/ledipasvir(24.9%) and ombitasvir/paritaprevir/ritonavir(r)/dasabuvir(19.9%). Ribavirin(RBV) was administered in 198 patients(42.9%). SVRs occurred in 437/462 patients(94.6%). The SVRs ranged between 93.3% and 100% for genotypes 1-4. SVRs were achieved in 96.2% patients in the CTmet group vs 91.9% patients in the CT-unmet group(P = 0.049). Undetectable HCV RNA at week 4 occurred in 72.9% of the patients. In the univariate analysis, the factors associated with SVRs were lower liver stiffness, absence of cirrhosis, higher platelet count, higher albumin levels, no RBV dose reduction, undetectable HCV RNA at week 4 and CT-met group. In the multivariate analysis, only albumin was an independent predictor of treatment failure(P = 0.04). Eleven patients(2.4%) developed SAEs; 5.2% and 0.7% of the patients in the CT-unmet and CT-met groups, respectively(P = 0.003).CONCLUSION A high proportion of patients with HCV infection achieved SVRs. For patients who did not meet the CT criteria, treatment regimens must be optimized.

A geometric characterisation of real C^(*)-algebras

We characterise the positive cone of a real C^(*)-algebra geometrically.Given an open coneΩin a real Banach space V,with the closureΩ,we show thatΩis the interior of the positive cone of a unital real C^(*)-algebra if and only if it is a Finsler symmetric cone with an orientable extension,which is equivalent to the condition that V is,in an equivalent norm,the Hermitian part of a unital real C^(*)-algebra with the positive coneΩ.

Predictors of functional benefit of hepatitis C therapy in a‘real-life’cohort

AIM To define predictors of functional benefit of direct-acting antivirals(DAAs) in patients with chronic hepatitis C virus(HCV) infection and liver cirrhosis.METHODS We analysed a cohort of 199 patients with chronic HCV genotype 1, 2, 3 and 4 infection involving previously treated and untreated patients with compensated(76%) and decompensated(24%) liver cirrhosis at two tertiary centres in Germany. Patients were included withtreatment initiation between February 2014 and August 2016. All patients received a combination regimen of one or more DAAs for either 12 or 24 wk. Predictors of functional benefit were assessed in a univariable as well as multivariable model by binary logistic regression analysis.RESULTS Viral clearance was achieved in 88%(175/199) of patients. Sustained virological response(SVR) 12 rates were as follows: among 156 patients with genotype 1 infection the SVR 12 rate was 90%(n = 141); among 7 patients with genotype 2 infection the SVR 12 rate was 57%(n = 4); among 30 patients with genotype 3 infection the SVR 12 rate was 87%(n = 26); and among 6 patients with genotype 4 infection the SVR 12 rate was 67%(n = 4). Follow-up MELD scores were available for 179 patients. A MELD score improvement was observed in 37%(65/179) of patients, no change of MELD score in 41%(74/179) of patients, and an aggravation was observed in 22%(40/179) of patients. We analysed predictors of functional benefit from antiviral therapy in our patients beyond viral eradication. We identified the Child-Pugh score, the MELD score, the number of platelets and the levels of albumin and bilirubin as significant factors for functional benefit.CONCLUSION Our data may contribute to the discussion of potential risks and benefits of antiviral therapy with individual patients infected with HCV and with advanced liver disease.

C-RAD Catalyst HD系统在乳腺癌保乳术后调强放疗中实时监测运动位移的剂量学研究

目的:分析光学体表监测系统C-RAD Catalyst HD在放疗中实时监测乳腺癌患者的体表运动位移,给出使用C-RAD Catalyst HD系统应当设定的建议运动阈值。方法:以C-RAD Catalyst HD系统实时监测乳腺癌患者体表运动位移数据为参考,分析其平移方向上的运动位移区间占比,模拟患者运动规律将不同位移等中心代入患者的QA计划中读取剂量学参数。结果:在Y(头脚)与Z(前后)的正方向上位移的计划,计划靶区的D_(2%)、HI呈线性递增趋势,计划靶区的D_(98%)、V_(95%)、CI及危及器官的剂量学参数呈线性递减趋势,且危及器官的剂量学参数均在临床可接受范围之内;在负方向上位移的计划,计划靶区剂量变化趋势和危及器官的剂量学参数均呈线性递增趋势。计划靶区不符合临床处方剂量要求的参数:正方向上位移超过3 mm时计划靶区的V_(95%);正方向上位移超过5 mm时计划靶区的D_(2%);负方向上位移超过4 mm时计划靶区的D_(2%)、V_(95%)。超出剂量参考限值的危及器官剂量学参数:负方向上位移超过3 mm时患侧肺的D_(mean)、V_(5 Gy)和左侧乳腺癌患者心脏的V 40 Gy;超过4 mm时健侧乳腺的D_(mean)、左侧乳腺癌患者心脏(D_(mean)、V_(5 Gy)、V_(30 Gy)),右侧乳腺癌患者(心脏的D_(mean)、肝脏的V_(5 Gy));超过5 mm时患侧肺的V_(20 Gy)。结论:使用C-RAD Catalyst HD系统监控乳腺癌保乳术后放疗患者在治疗过程中的运动位移时,建议设定3 mm的运动阈值控制加速器束流。

Digital arc welding power supply based on real-time operating system

A digital arc welding power supply was designed with the advanced reduced instruction set computer machine （ARM） and embedded real-time multi-task operating system micro C/OS- Ⅱ. The ARM, with its powerful calculating speed and complete peripheral equipments, is very suitable to work as the controller of the digital power supply. The micro C/OS- Ⅱ transplanted in ARM, helps to improve the respondent speed against various welding signals, as well as the reliability of the controlling software. The welding process consists of nine tasks. The tasks of great significance on reliability of the welder, for example, the A/D conversion of current and voltage, enjoy top priority. To avoid simultaneous-sharing on A/D converter and LCD module, two semaphores are introduced in to ensure the smooth performance of the welding power supply. Proven by experiments ,the ARM and the micro C/OS- Ⅱ can greatly improve both the respondent speed and the reliability of the digital welder.

基于模糊C均值聚类的振冲碎石桩加固地层识别

精准掌握软弱地基的地质信息资料是确定振冲碎石桩施工工艺和控制成桩质量的重要依据。现有地质勘探技术确定地层地质信息的方法存在较大的随机性和离散性,不能获取所有加固区域的地质条件。为了克服传统方法存在的缺陷,依托拉哇水电站振冲碎石桩施工过程实时监控系统采集到的大量桩成孔过程中与地层分类属性相关的数据,通过对大数据进行清洗,选取与地层分类属性相关的进尺深度、速度和电流为特征属性,采用模糊C均值聚类算法对软弱地基进行地层识别研究。结果表明,与传统的K-means算法相比,本文方法对地层分类识别具有更高的准确性和优越性,可实现对地层地质条件的实时研判。研究成果对后续进行振冲碎石桩施工质量合理评价以及振冲碎石桩桩成过程智能化施工等都有重要的指导意义。

基于AutoCAD、GDAL和Android农村房地权籍调查软件设计与实现

为提高农村不动产权籍调查工作效率,保障成果中图、数、库一致性质量,运用Visual C#编程语言、Android编程语言、AutoCAD二次开发技术、GDAL开发库等技术设计了一套满足贵州省农村不动产权籍调查工作内外业一体化的软件,并在农村房地一体项目中得到使用。

同步硝化反硝化SBBR处理低C/N比生活污水的启动与稳定运行

以低C/N比实际生活污水为处理对象,聚氨酯海绵填料为生物载体(填料填充率25%),采用逐步提高氮负荷的方式,在较短的时间内(98 d)成功启动了同步硝化反硝化(simultaneous nitrification and denitrification,SND)的序批式生物膜反应器(sequencing batch biofilm reactor,SBBR)。实时定量PCR(real-time qualitative polymerase chain reaction,real-time q PCR)结果表明系统内硝化菌得到富集。在稳定运行期间,系统对有机物及氮的去除效果良好,平均出水COD、4NH-N+、TN分别为38.28 mg·L-1、1.23 mg·L-1、8.23 mg·L-1。微生物将大部分碳源以聚羟基脂肪酸酯(poly-β-hydroxyalkanoate,PHA)的形式储存至体内,系统内3NO-N-的去除主要通过内源反硝化作用,且反硝化过程基本无2NO-N-积累,平均SND率为70.57%,TN去除率高达82.95%。由于硝化反应和反硝化反应在同一反应器内同时进行,反硝化过程产生的碱度可补充硝化过程消耗的碱度,维持系统内p H的相对稳定。此外,可以通过DO和p H的变化判断SND的进行状态,有效地控制反应时间,节省动力消耗。