B and T lymphocyte attenuator (BTLA), identified as an immune inhibitory receptor recently, plays widespread roles on T and B cells. Emerging evidence has generated plentiful information on the mechanisms which BTLA...B and T lymphocyte attenuator (BTLA), identified as an immune inhibitory receptor recently, plays widespread roles on T and B cells. Emerging evidence has generated plentiful information on the mechanisms which BTLA mediates negative regulation in immune responses and involves in a variety of physiological and pathological processes. The exploration of the biological mechanisms and regulation of BTLA will open possibilities on novel therapeutic strategies in immune-related diseases. Cellular & Molecular Immunology. 2005;2(6):427-432.展开更多
基金grants from National Natural Science Foundation for Distinguished Young Scholar (C030205O4,YZ.)the National Basic Research Program(973 Program,2003CB515501,Y.Z.)+1 种基金100 Quality Vocational Colleges of Chinese Academy of Sciences(2003-85,Y.Z.) the Scientific Research Foundation for the Returned Overseas Chinese Scholars of State Education M inistry (2005—546,Y.Z.).
文摘B and T lymphocyte attenuator (BTLA), identified as an immune inhibitory receptor recently, plays widespread roles on T and B cells. Emerging evidence has generated plentiful information on the mechanisms which BTLA mediates negative regulation in immune responses and involves in a variety of physiological and pathological processes. The exploration of the biological mechanisms and regulation of BTLA will open possibilities on novel therapeutic strategies in immune-related diseases. Cellular & Molecular Immunology. 2005;2(6):427-432.