基于NRS2002 TEN和SJS患者的营养风险筛查

目的基于欧洲营养风险筛查工具(NRS2002)对中毒性表皮坏死松解症(TEN)和Stevens-Johnson综合征(SJS)患者进行营养风险筛查,研究TEN和SJS患者营养风险的发生率,探讨此类患者发生营养风险的危险因素。方法回顾性调查2011年1月至2021年3月在本院住院的临床资料完整的TEN和SJS患者215例,按受累皮肤的体表面积(BSA)予以区分TEN、SJS、SJS/TEN重叠综合征。同时基于NRS2002进行营养风险筛查评分,探讨TEN和SJS患者存在营养风险的危险因素。结果TEN和SJS患者入院时营养风险的发生率为64.19%(138/215)。其中,年龄(χ^(2)=7.198,P<0.01)、SCORTEN(χ^(2)=18.843,P<0.01)、致敏药物(χ^(2)=13.169,P<0.01)、皮损面积(χ^(2)=119.245,P<0.01)、黏膜受累部位(χ^(2)=8.241,P<0.01)对于TEN和SJS患者发生营养风险有统计学意义。多因素Logistic回归分析提示,年龄(OR=0.604,95%CI:0.472~0.973)、10%≤BSA≤30%(OR=4.638,95%CI:1.062-13.903)、BSA>30%(OR=6.128,95%CI:1.674~12.068)、黏膜受累部位为口腔黏膜(OR=5.978,95%CI:1.728~16.368)、血液净化治疗(OR=6.008,95%CI:1.316~22.175)是造成TEN和SJS患者营养风险的独立危险因素。结论大约2/3的TEN和SJS患者入院时即存在营养风险。而年龄、10%≤BSA≤30%、BSA>30%、黏膜受累部位为口腔黏膜、血液净化治疗则是造成TEN和SJS患者营养风险的独立危险因素。

基于NRS2002量表评估的营养支持疗法对围手术期胃肠癌患者营养状况的影响

目的 探讨基于NRS2002量表评估的营养支持疗法对围手术期胃肠癌患者营养状况改善的影响。方法 选取2022年1—12月某三甲医院接收的40例需要进行手术的胃肠癌患者,并采用随机数字法分成观察组和对照组,对照组接受常规护理,观察组在对照组基础上接受营养支持疗法。结果 观察组白蛋白、转铁血红蛋白、血红蛋白、前白蛋白高于对照组,差异有统计学意义(P<0.05)。观察组不良反应发生率低于对照组(P<0.05)。结论 营养支持疗法能有效改善围手术期胃肠癌患者的营养状况,减少营养相关并发症的发生。

mNUTRIC与NRS⁃2002评分对重症病人预后的评估价值比较

目的:采用改良危重症营养风险(mNUTRIC)评分和营养风险筛查(NRS⁃2002)评分评估急诊重症监护病房(EICU)病人的营养风险,并比较两种工具对EICU病人28 d死亡率的评估价值。方法:选取2023年2月-5月EICU由急诊入院的病人,从电子医疗记录文件中收集资料,并于病人入住EICU 24 h内采用NRS⁃2002和mNUTRIC评分进行营养评估。采用Cox回归分析探讨营养风险对病人28 d死亡率的影响;绘制受试者工作特征(ROC)曲线评价NRS⁃2002评分、mNUTRIC评分、急性生理与慢性健康状态评分系统Ⅱ(APACHE)Ⅱ评分和序贯器官衰竭(SOFA)评分对28 d死亡率的预测价值。结果:纳入152例病人,mNUTRIC评分筛查出高营养风险(>5分)病人102例,占67.1%;NRS⁃2002评分筛查出高营养风险(≥5分)病人67例,占44.1%;两种评分筛查结果存在不一致性(κ=-0.230)。Cox回归分析显示,mNUTRIC评分(HR=1.782)和SOFA评分(HR=1.186)是EICU危重症病人28 d死亡的危险因素。mNUTRIC评分预测病人28 d死亡率的受试者工作特征(ROC)曲线下面积为0.82[95%CI(0.73,0.90)],最佳临界值为6分,预测价值优于NRS⁃2002评分、APACHEⅡ评分和SOFA评分。结论:mNUTRIC评分可作为EICU重症病人营养风险评估的有效工具,且与病人28 d死亡率相关,但应考虑病人急性阶段和恢复阶段的特征,动态评估营养风险。

基于NRS 2002评分的营养管理模式对脑梗死吞咽障碍患者营养状况的影响

目的:探讨基于NRS 2002评分的营养管理模式对脑梗死吞咽障碍患者营养状况的影响。方法:选取2022年6月—2023年6月苏州高新区人民医院神经内科收治的92例脑梗死吞咽障碍患者为研究对象。按照随机数字表,将92例患者平均分为对照组和观察组各46例。对照组患者接受常规营养管理,给予观察组患者基于NRS 2002评分的综合性营养管理。观察两组患者干预1月后血清营养指标白蛋白(ALB)、前白蛋白(PA)、血红蛋白(HGB),吞咽功能(采用洼田饮水试验评估)及肺部感染、电解质紊乱、恶心/呕吐、便秘/腹泻等并发症的变化情况。结果:经营养管理后,2组患者血清营养指标均较前改善,而基于NRS 2002指导下的营养管理模式较常规营养管理模式对患者血清ALB[(35.48±1.80)vs(33.27±1.98)g/L)、PA[(215.83±22.35)vs(194.72±21.57)mg/L]及HGB[(110.56±7.21)vs(104.61±6.68)g/L]增高水平更高,均有P<0.05。观察组吞咽功能改善有效率为60.87%,显著高于对照组(34.78%,χ^(2)=6.273,P<0.05);而并发症发生率显著低于对照组(13.04%vs 34.78%,χ^(2)=5.974,P<0.05)。结论:基于NRS 2002评分的营养管理模式可显著改善脑梗死吞咽障碍患者营养状况、吞咽功能,降低患者并发症发生率。

基于NRS2002评分结合肠内免疫微生态营养对重症肺炎患者肠道微生态的影响

目的:分析基于营养风险筛查2002(NRS2002)评分支持结合肠内免疫微生态营养对重症肺炎(SP)患者的肠道微生态及炎症因子的影响。方法:选择本院重症医学科2022年4月—2023年12月收治的98例SP患者,随机数字表法分为两组各49例。对照组给予常规营养支持,观察组基于NRS2002评分支持结合肠内免疫微生态营养。对比两组治疗前后的NRS2002评分、肠道菌群含量、炎症因子、不良风险事件。结果:治疗后两组NRS2002评分、HMGB1、MCP-1、IL-6水平、肠球菌菌落数对数值较治疗前降低,乳杆菌、双歧杆菌、大肠埃希菌菌落数对数值较治疗前升高,且观察组NRS2002营养风险评分、上述炎症因子表达、肠球菌菌落数对数值均低于对照组,乳杆菌、双歧杆菌、大肠埃希菌菌落数对数值均高于对照组(P<0.05)。观察组营养支持相关不良风险事件率低于对照组(P<0.05)。结论:基于NRS2002评分支持结合肠内免疫微生态营养应用于SP患者营养管理中效果显著,可有效改善炎症因子及营养状态,降低不良事件及肠道微生态失衡风险。

Melanocortin 3,5 receptors immunohistochemical expression in colonic mucosa of inflammatory bowel disease patients:A matter of disease activity?

BACKGROUND Melanocortin 3 and 5 receptors(i.e.,MC3R and MC5R)belong to the melanocortin family.However,data regarding their role in inflammatory bowel diseases(IBD)are currently unavailable.AIM This study aims to ascertain their expression profiles in the colonic mucosa of Crohn’s disease(CD)and ulcerative colitis(UC),aligning them with IBD disease endoscopic and histologic activity.METHODS Colonic mucosal biopsies from CD/UC patients were sampled,and immunohisto-chemical analyses were conducted to evaluate the expression of MC3R and MC5R.Colonic sampling was performed on both traits with endoscopic scores(Mayo endoscopic score and CD endoscopic index of severity)consistent with inflamed mucosa and not consistent with disease activity(i.e.,normal appearing mucosa).RESULTS In both CD and UC inflamed mucosa,MC3R(CD:+7.7 fold vs normal mucosa,P<0.01;UC:+12 fold vs normal mucosa,P<0.01)and MC5R(CD:+5.5 fold vs normal mucosa,P<0.01;UC:+8.1 fold vs normal mucosa,P<0.01)were significantly more expressed compared to normal mucosa.CONCLUSION MC3R and MC5R are expressed in the colon of IBD patients.Furthermore,expression may differ according to disease endoscopic activity,with a higher degree of expression in the traits affected by disease activity in both CD and UC,suggesting a potential use of these receptors in IBD pharmacology.

改进NRS与ELM相结合在住宅需求预测中的应用

针对住宅需求预测受到不同方面因素的影响且具有非线性特征等问题,本文在原始邻域粗糙集(NRS)的基础上进行改进,并与极限学习机(ELM)相结合来进行预测.首先改进算法(MNRS)解决了原始NRS无法在不同条件属性之间设定最佳邻域值的问题,根据不同条件属性的邻域半径和标准差构建邻域关系矩阵;然后在输出属性重要度排序时引入Pearson相关系数,克服了条件属性之间的影响,获得最小冗余属性的约简集构成住宅需求预测指标体系;最后将构建的住宅需求指标体系输入极限学习机模型,得到准确的预测值.实验结果表明:MNRS-ELM预测模型不仅有效降低了运算复杂度,而且能够获得更高的预测精度.

Immunomodulation of Proton-activated G Protein-coupled Receptors in Inflammation

Proton-activated G protein-coupled receptors(GPCRs),initially discovered by Ludwig in 2003,are widely distributed in various tissues.These receptors have been found to modulate the immune system in several inflammatory diseases,including inflammatory bowel disease,atopic dermatitis,and asthma.Proton-activated GPCRs belong to the G protein-coupled receptor family and can detect alternations in extracellular pH.This detection triggers downstream signaling pathways within the cells,ultimately influencing the function of immune cells.In this review,we specifically focused on investigating the immune response of proton-activated GPCRs under inflammatory conditions.

Role of bitter contributors and bitter taste receptors:a comprehensive review of their sources,functions and future development

Bitterness,one of the 5“basic tastes”,is usually undesired by humans.However,abundant literature reported that bitter fruits and vegetables have beneficial health effects due to their bitter contributors.This review provided an updated overview of the main bitter contributors of typical bitter fruits and vegetables and their health benefits.The main bitter contributors,including phenolics,terpenoids,alkaloids,amino acids,nucleosides and purines,were summarized.The bioactivities and wide range of beneficial effects of them on anti-cancers,anti-inflammations,anti-microbes,neuroprotection,inhibiting chronic and acute injury in organs,as well as regulating behavior performance and metabolism were reported.Furthermore,not only did the bitter taste receptors(taste receptor type 2 family,T2Rs)show taste effects,but extra-oral T2Rs could also be activated by binding with bitter components,regulating physiological activities via modulating hormone secretion,immunity,metabolism,and cell proliferation.This review provided a new perspective on exploring and explaining the nutrition of bitter foods,revealing the relationship between the functions of bitter contributors from food and T2Rs.Future trends may focus on revealing the possibility of T2Rs being targets for the treatment of diseases,exploring the mechanism of T2Rs mediating the bioactivities,and making bitter foods more acceptable without getting rid of bitter contributors.

Exploring the vital role of microglial membrane receptors in Alzheimer’s disease pathogenesis: a comprehensive review

Neurodegenerative diseases constitute a broad category of diseases caused by the degeneration of the neurons.They are mainly manifested by the gradual loss of neuron structure and function and eventually can cause death or loss of neurons.As the global population ages rapidly,increased people are being diagnosed with neurodegenerative diseases.It has been established that the onset of Alzheimer’s disease(AD)is closely linked with increasing age and its major pathological features include amyloid-beta plaques(Aβ),Tau hyperphosphorylation,Neurofibrillary tangles(NFTs),neuronal death as well as synaptic loss.The involvement of microglia is crucial in the pathogenesis and progression of AD and exhibits a dual role.For instance,in the early stage of AD,microglia surface membrane proteins or receptors can participate in immunophagocytosis,and anti-inflammatory functions and act as a physical barrier after recognizing various ligands such as Aβand NFTs.However,in the later stage of the disease,membrane receptors on the surface of microglia can cause its activation to release a substantial quantity of pro-inflammatory factors.Which can amplify the neuroinflammatory response.The rapid decline of normal immune phagocytosis can result in the continuous accumulation of abnormal proteins,leading to neuronal dysfunction and destruction of the formed physical barrier as well as the neurovascular microenvironment.It can also increase the transformation of microglia from anti-inflammatory phenotype M2 to pro-inflammatory phenotype M1,induce severe neuronal injury or apoptosis,and aggravate the progression of AD.Due to few articles have focused on the AD-related membrane protein receptors on microglia,thus in this paper,we have reviewed several representative microglial membrane proteins or receptors about their specific roles and functions implicated in AD,and expect that there will be more in-depth research and scientific research results in the treatment of AD by targeted regulation of microglia membrane protein receptors in the future.

Metabotropic glutamate receptors(mGluRs)in epileptogenesis:an update on abnormal mGluRs signaling and its therapeutic implications

Epilepsy is a neurological disorder characterized by high morbidity,high recurrence,and drug resistance.Enhanced signaling through the excitatory neurotransmitter glutamate is intricately associated with epilepsy.Metabotropic glutamate receptors(mGluRs)are G protein-coupled receptors activated by glutamate and are key regulators of neuronal and synaptic plasticity.Dysregulated mGluR signaling has been associated with various neurological disorders,and numerous studies have shown a close relationship between mGluRs expression/activity and the development of epilepsy.In this review,we first introduce the three groups of mGluRs and their associated signaling pathways.Then,we detail how these receptors influence epilepsy by describing the signaling cascades triggered by their activation and their neuroprotective or detrimental roles in epileptogenesis.In addition,strategies for pharmacological manipulation of these receptors during the treatment of epilepsy in experimental studies is also summarized.We hope that this review will provide a foundation for future studies on the development of mGluR-targeted antiepileptic drugs.

Characterization of Domeless receptors and the role of Bd Domeless3 in anti-symbiont-like virus defense in Bactrocera dorsalis

The Janus kinase/signal transducers and activators of transcription(JAK/STAT)signaling pathway play a pivotal role in innate immunity.Among invertebrates,Domeless receptors serve as the key upstream regulators of this pathway.In our study on Bactrocera dorsalis,we identified three cytokine receptors:BdDomeless1,BdDomeless2,and BdDomeless3.Each receptor encompasses five fibronectin-type-III-like(FN III)extracellular domains and a transmembrane domain.Furthermore,these receptors exhibit the increased responsiveness to diverse pathogenic challenges.Notably,only BdDomeless3 is upregulated during symbiont-like viral infections.Moreover,silencing BdDomeless3 enhanced the infectivity of Bactrocera dorsalis cripavirus(BdCV)and B.dorsalis picorna-like virus(BdPLV),underscoring BdDomeless3’s crucial role in antiviral defense of B.dorsalis.Following the suppression of Domeless3 expression,six antimicrobial peptide genes displayed decreased expression,potentially correlating with the rise in viral infectivity.To our knowledge,this is the first study identifying cytokine receptors associated with the JAK/STAT pathway in tephritid flies,shedding light on the immune mechanisms of B.dorsalis.

Controllable Synthesis of Au NRs and Its Flexible SERS Optical Fiber Probe with High Sensitivity

The surface-enhanced Raman scattering(SERS) optical fiber probes were successfully prepared by self-assembling on polyelectrolyte multilayers. Gold nanorods(Au NRs) were used as SERS enhancement material to give excellent biological affinity and stability to the SERS optical fiber probes. Au NRs were synthesized by seed growth method. The synergistic effect between AgNO_(3) and surfactant was investigated, and the highest yield was found when AgNO_(3) was 500 uL. Meanwhile, different SERS optical fiber probes were obtained by selecting silane coupling agent, polyelectrolyte multilayer and graphene oxide(GO) to treat quartz fiber. It was found that the SERS optical fiber probes obtained by the self-assembled on polyelectrolyte multilayers method performed better than those by other methods. In addition, Mapping was combined with finite element simulation to analyze the electromagnetic field distribution at the fiber end face.The electromagnetic field distribution of Au NRs was investigated, the difference of electromagnetic field intensity around the Au NRs with different arrangements was compared, the strongest signal was obtained when the Au NRs were head-to-head. Finally, sensitivity of the optimized SERS optical fiber probes could reach 10^(-9)mol/L, with excellent stability and repeatability.

缩宫素加间苯三酚对足月分娩产妇产程与NRS评分的影响

目的:探究缩宫素加间苯三酚对足月分娩产妇产程与NRS评分的影响。方法:选择我院产科2019年4月—2022年4月期间接诊的120例足月分娩产妇开展研究,随机抽签法分为对照组(采用缩宫素)、观察组(联合使用缩宫素、间苯三酚),每组60例,对比两组临床指标差异。结果:用药后,观察组第一产程时间、第二产程时间、总产程时间较对照组减短(P<0.05);观察组不良母婴结局总发生率较对照组低(P<0.05);观察组宫口扩张3cm时、宫口扩张6cm时、宫口全开时NRS评分较对照组低(P<0.05);两组不良反应总发生率比较差异无统计学意义(P>0.05)。结论:缩宫素联合间苯三酚的作用效果较明显,可减短足月分娩产妇产程时间,降低不良母婴结局发生率,减轻疼痛症状,以及保证产妇用药安全性,值得优选。

人文关怀护理对子宫肌瘤术后患者NRS评分及心理状况的影响

目的:探究人文关怀护理对子宫肌瘤术后患者NRS评分及心理状况的影响。方法:选取于2021年1月至2022年12月在本院接受手术治疗的91例子宫肌瘤患者,采用双盲法将其分为对照组(45例)和观察组(46例),其中对照组采取常规护理,观察组采取人文关怀护理,对比两组NRS、SAS、SDS、生活质量评分及护理满意度。结果:护理前,两组NRS评分差异不明显(P>0.05);护理后,两组NRS评分均有所降低,且观察组NRS评分显著低于对照组(P<0.05);护理前,两组SAS、SDS评分差异不明显(P>0.05);护理后,两组SAS、SDS评分均有所下降,且观察组显著低于对照组(P<0.05);护理前,两组生活质量评分差异不明显(P>0.05);护理后,两组生活质量评分均有所上升,且观察组生活质量评分显著高于对照组(P<0.05);护理后,观察组护理满意度显著高于对照组(P<0.05)。结论:人文关怀护理模式用于子宫肌瘤术后患者可显著减少NRS、SAS、SDS评分,有效降低患者疼痛程度,改善患者焦虑、抑郁心理状况,提高患者的生活质量及护理满意度,值得在临床护理中被广泛借鉴。

腹腔镜联合胆道镜保胆取石术对胆囊结石患者胃肠激素水平、炎性应激和NRS评分的影响

目的 探讨腹腔镜联合胆道镜保胆取石术对胆囊结石患者围术期指标、胃肠激素水平、炎性应激、疼痛程度(NRS)评分的影响。方法 选取2017年1月至2022年12月都昌县中医院和九江学院附属医院收治的胆囊结石患者86例为研究对象,采用随机数字表法分为对照组和观察组各43例。对照组采用腹腔镜胆囊切除术治疗,观察组采用腹腔镜联合胆道镜保胆取石术治疗。观察两组患者围术期指标、胃肠激素水平、炎性应激、NRS评分的影响。结果观察组手术时间长于对照组,术中出血量少于对照组,住院时间和肛门排气时间均短于对照组,差异有统计学意义(P<0.05);术后,两组SS、GAS、CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平高于术前,VIP、IL-6、IL-8、CRP、TNF-α、CD8^(+)、NRS评分低于术前,且观察组优于对照组,差异有统计学意义(P<0.05)。观察组不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论 腹腔镜联合胆道镜保胆取石术治疗胆囊结石临床疗效显著,能提高胃肠激素水平,围手术期应激反应较轻、术后恢复较快、降低血清炎症反应,缓解患者疼痛程度,不良反应少,值得临床推广。

Cortico-striatal gamma oscillations are modulated by dopamine D3 receptors in dyskinetic rats

Long-term levodopa administration can lead to the development of levodopa-induced dyskinesia.Gamma oscillations are a widely recognized hallmark of abnormal neural electrical activity in levodopa-induced dyskinesia.Currently,studies have reported increased oscillation power in cases of levodopa-induced dyskinesia.However,little is known about how the other electrophysiological parameters of gamma oscillations are altered in levodopa-induced dyskinesia.Furthermore,the role of the dopamine D3 receptor,which is implicated in levodopa-induced dyskinesia,in movement disorder-related changes in neural oscillations is unclear.We found that the cortico-striatal functional connectivity of beta oscillations was enhanced in a model of Parkinson’s disease.Furthermore,levodopa application enhanced cortical gamma oscillations in cortico-striatal projections and cortical gamma aperiodic components,as well as bidirectional primary motor cortex(M1)↔dorsolateral striatum gamma flow.Administration of PD128907(a selective dopamine D3 receptor agonist)induced dyskinesia and excessive gamma oscillations with a bidirectional M1↔dorsolateral striatum flow.However,administration of PG01037(a selective dopamine D3 receptor antagonist)attenuated dyskinesia,suppressed gamma oscillations and cortical gamma aperiodic components,and decreased gamma causality in the M1→dorsolateral striatum direction.These findings suggest that the dopamine D3 receptor plays a role in dyskinesia-related oscillatory activity,and that it has potential as a therapeutic target for levodopa-induced dyskinesia.

个体化饮食干预联合NRS2002在II型糖尿病患者中的应用

探讨运用量表化营养风险筛查工具NRS 2002对II型糖尿病患者进行营养风险评估,并给予个体化饮食干预治疗的临床意义研究。方法 选取100例II型糖尿病患者自愿作为研究对象,按随机分配的方式分为对照组和试验组,各50例。对两组患者均进行NRS 2002营养风险筛查,对照组采用常规的治疗方法,试验组在对照组的基础上进行个体化饮食干预治疗。观察比较两组患者治疗前后血糖、尿糖、随机血糖控制达标率等指标的变化水平。结果 干预治疗后,试验组随机血糖9.69±2.77mmol/L、尿糖0.68±1.11mmol/L、随机血糖控制达标率30%,均优于对照组的随机血糖11.17±3.73mmol/L、尿糖1.28±1.63mmol/L、随机血糖控制达标率14%,差异具有统计学意义(P<0.05)。另不同营养风险等级的II型糖尿病患者治疗效果方面,NRS 2002评分<3时RR=0.82、AR=0.15、PR=0.21、NNT=6.67;评分≥3时RR=0.79、AR=0.19、PR=0.27、NNT=5.26。结论 采用个体化饮食干预可以更好地降低患者随机血糖和尿糖水平,相较于传统基础治疗能够使更多的II型糖尿病患者恢复至随机血糖控制理想状态。另量表化营养风险筛查(NRS 2002)的评分结果≥3时,个体化饮食干预的治疗方式对II型糖尿病疗效更好且收益更大。综上,个体化饮食干预治疗联合NRS 2002评分可以达到更好的疗效,值得在临床推广。

Novel Role of Calcium-Sensitive Receptors in Chronic Hypoxia-Induced Proliferation of Pulmonary Vein Smooth Muscle Cells

Objective:Vascular remodeling due to chronic hypoxia(CH)occurs not only in the pulmonary arteries but also in the pulmonary veins.Pulmonary vascular remodeling arises from the proliferation of pulmonary vascular myocytes.However,the mechanism by which CH induces the proliferation of pulmonary vein smooth muscle cells(PVSMCs)is unknown.This study aimed to investigate the mechanism by which CH affects the proliferation of PVSMCs.Methods:PVSMCs were isolated from rat distal pulmonary veins and exposed to CH(4%O2,60h),and the expression of the calcium-sensitive receptor(CaSR)was detected by Western blotting and immunofluorescence.MTT assay was used to detect the proliferation viability of the cells,and the changes in the intracellular calcium concentration were detected by laser confocal scanning technique.Results:CaSR expression was present in rat distal PVSMCs,and CaSR protein expression was upregulated under hypoxia.The positive regulator spermine not only enhanced CH-induced CaSR upregulation but also enhanced CH-induced increase in cell viability and calcium ion concentration.The negative CaSR regulator NPS2143 not only attenuated CH-induced CaSR upregulation but also inhibited CH-induced cell viability and calcium ion concentration.Conclusion:CaSR-mediated hyperproliferation is a novel pathogenic mechanism for the development of proliferation in distal PVSMCs under CH conditions.

营养干预对维持性血液透析患者NRS-2002评估结果的影响研究

分析予以维持性血液透析(maintenance hemodialysis,MHD)患者营养干预的作用。选取2022年7月—2023年8月遵义市第一人民医院收治的82例MHD患者为研究对象,采用随机数字表法将其分为对照组(n=41,常规护理)和观察组(n=41,营养干预)。比较两组患者营养指标、钙磷代谢指标、炎症因子指标、NRS-2002评分、生活质量(KDQOL-SF评分)及并发症发生情况。结果显示,干预后,观察组营养指标、钙磷代谢指标、炎症因子指标均优于对照组(P<0.05);NRS-2002评分低于对照组,KDQOL-SF评分高于对照组(P<0.05),并发症发生率低于对照组(P<0.05)。研究发现,予以MHD患者营养干预可改善其营养指标,纠正其钙磷代谢紊乱状况,减轻患者炎症反应,降低并发症发生概率,提升患者生活质量。