Concentration-time profiles of <sup>125</sup>I-labeled recombinant human interleukin-3 （125IrhIL-3） were de-termined by reverse phase high performance liquid chromatography （RHPLC） after intravenous an...Concentration-time profiles of <sup>125</sup>I-labeled recombinant human interleukin-3 （125IrhIL-3） were de-termined by reverse phase high performance liquid chromatography （RHPLC） after intravenous and subcutaneous ad-ministration of the drug in 16 rhesus monkeys. The initial and terminal T1/2 in plasma after intravenous of 30 μg/kg were （0. 15 ±0.13） and （2. 21 ± 0. 59） h, respectively. Terminal half-lives after 30, 90 and 180μg/kg subcutaneous （s.c.） injections were 2. 0-3.8 h. Area under concentration-time curves （AUC） following s. c. were roughly in-creased with dose, while CL5 were similar among different dosages. The absorption rates were dependent on concentra-tion at injected site. Bioavailability was about 0.7 after s.c. Rapid biodegradation was found in plasma. Distribution profiles of total radioactivity were as follows: the highest level was found in urinary system; levels in bile-enteric sys-tem, lymph nodes, bone marrow and spleen were near to that in plasma, and level in brain was the展开更多
文摘Concentration-time profiles of <sup>125</sup>I-labeled recombinant human interleukin-3 （125IrhIL-3） were de-termined by reverse phase high performance liquid chromatography （RHPLC） after intravenous and subcutaneous ad-ministration of the drug in 16 rhesus monkeys. The initial and terminal T1/2 in plasma after intravenous of 30 μg/kg were （0. 15 ±0.13） and （2. 21 ± 0. 59） h, respectively. Terminal half-lives after 30, 90 and 180μg/kg subcutaneous （s.c.） injections were 2. 0-3.8 h. Area under concentration-time curves （AUC） following s. c. were roughly in-creased with dose, while CL5 were similar among different dosages. The absorption rates were dependent on concentra-tion at injected site. Bioavailability was about 0.7 after s.c. Rapid biodegradation was found in plasma. Distribution profiles of total radioactivity were as follows: the highest level was found in urinary system; levels in bile-enteric sys-tem, lymph nodes, bone marrow and spleen were near to that in plasma, and level in brain was the
