Microstructure evolution of AA5052 joint failure process and mechanical performance after reconditioning with tubular rivet

To extend the service life of the clinched joint,a reconditioning process conducted with an additional tubular rivet was proposed in this work.Different reconditioning forces were employed to produce dissimilar reconditioned joints by experimental method.The experimental results indicated that the neck fracture was the common failure mode of both original clinched and reconditioned joints.Compared with the original clinched joint,the shearing strength of the reconditioned joint produced by a reconditioning force of 40 kN increased from 1810.5 to 1986.47 N,and the energy absorption increased from 2.34 to 3.46 J.The range of effective reconditioning force was from 35 to 40 kN and 40 kN was the best choice for reconditioning the AA5052 failed joints.The mechanical properties of the reconditioned joints are obviously better than those of the original clinched joints,which fully demonstrates that the reconditioning method proposed in this work has a broad prospect of industrial application.

Machine perfusion of the liver: Which is the best technique to mitigate ischaemia-reperfusion injury?

Longstanding research describes the mechanisms whereby the restoration of blood flow and reoxygenation(reperfusion) aggravates the ischaemic injury caused by a period of anoxia to a donor liver. This phenomenon, called ischaemia-reperfusion injury(IRI), leads to parenchymal cell death,microcirculatory failure, and inflammatory immune response. Clinically, IRI is the main factor responsible for the occurrence of posttransplant graft dysfunction and ischaemic-type biliary lesions. While extended criteria donor livers are more vulnerable to IRI, their utilisation is required to address the shortfall in donor organs. Thus, the mitigation of IRI should drive the setting of a new benchmark for marginal organ preservation. Herein, strategies incorporating different modalities of machine perfusion of the liver to alleviate IRI are discussed in conjunction with advantages and disadvantages of individual protocols.Techniques leading to reperfusion of the liver during machine perfusion(in situ normothermic regional perfusion and ex situ normothermic machine perfusion)may mitigate IRI by shortening the ischaemic period of the organs. This benefit potentially escalates from the minimum level, obtained following just partial alleviation of the ischaemic period, to the maximum level, which can be potentially achieved with ischaemia-free organ transplantation. Techniques that do not lead to reperfusion of the liver during machine perfusion(hypothermic,subnormothermic, and controlled-oxygenated rewarming) optimise mitochondrial oxidative function and replenish cellular energy stores, thereby lowering reactive oxygen species production as well as the activation ofdownstream inflammatory pathways during reperfusion. Further mechanistic insights into IRI may guide the development of donor-specific protocols of machine perfusion on the basis of the limitations of individual categories of extended criteria donor organs.

Reconditional PCR方法在微生物分子生态学研究中的一种应用

虽然PCR扩增过程中所引入的杂和双链分子在TGGE或DGGE图谱分析微生物群落多样性结果时,对分析结果准确性的影响日益受到广泛关注,但迄今为止,尚未提出任何系统的关于去除PCR扩增过程中所引入杂和双链分子的可行性方法.本文将给出一种在克隆前较为有效减少样本中杂和双链的改良方法——“Reconditional PCR”.通过对原初PCR扩增进行上述改进,随后进行的TGGE分析可以更加准确反映种群遗传多样性,所构建的克隆文库也可以更准确地反映原初样本的生物多样性.

Therapeutic Acupunctural Resonance II: New Discoveries That Justify the Outcomes of This New Therapeutic Modality

Therapeutic Acupunctural Resonance was first introduced in the academic field in 2015 and was positively welcomed by colleagues all around the world. However, I have decided to do further research going deeply into new and more precise explanations which no longer refer to the effects of this particular treatment, but to how this technique works in the practice of Chinese Medicine. Being able to understand Therapeutic Acupunctural Resonance implies analyzing a series of phenomena related to historic landmarks of Classical Physics, as well as avant-garde theories within Quantum Physics and its theory of fields.

Therapeutic Acupunctural Resonance: The Original Research

The Chinese managed to interpret not only the natural rhythms of cosmic and seasonal cycles but the chrono-biological rhythms present in human body. What since long ago was merely taken to be a pre-scientific tradition has currently become a tangible reality. Nowadays, the specific frequencies pulsating along each meridian can be measured in hertz—according to its own resonance—as Acupuncture determined thousands of years ago. Their effort to establish a taxonomic classification of all environmental and human phenomena is closely related to Mathematics propositions of Euclid Five Regular Polyhedra, in order to consolidate the axiomatic-deductive model which we can now relate to the Chinese Theory of the Five Elements and their constant changes. As presented in OMICS Group Traditional Medicine-2015 Conference in Birmingham, it could be also proved that there also exists an inescapable relationship between Pythagoras and the Mathematical foundation of the Pentatonic Chinese Musical Scale. A simple way to incorporate the ideal frequency rhythm for each channel to correct its unbalanced situation is to insert said frequencies through the needles, by way of “antennae”, restructuring the meridian’s resonance affected and through it, of the Element it belongs to. Therapeutic Acupunctural Resonance therefore finds effective application when pins are used as “resonators”, putting the frequency of said Element of the channel in line, so that they transmit by means of punctures pure vibratory patterns which shall recondition the Qi flow frequency which has been altered by the Chinese syndrome diagnosed to be treated.

Maintenance Strategies and Spare Parts Inventory Management for Use of Reconditioned Items

The maintenance management of construction equipment occupies a prominent place in the overall strategy for managing the equipment fleet. It is also linked to the management of the stock of spare parts and particularly reconditioned spare parts. Because of the relatively low purchase cost of these, most companies are tempted by this option. The purpose of this article is precisely to study the impact of this category of parts in the stock and also in the optimization of maintenance costs, knowing that to do this;their use must obey certain constraints. It is therefore important to be able to characterize these reconditioned parts by estimating their optimal age, and studying their advantages and also their limits. The determination of the optimal age of reconditioned parts will be such that the total cost of replacement with used parts is at most equal to the total cost of replacement with new parts at the end of the operating period.