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Increased retinal venule diameter as a prognostic indicator for recurrent cerebrovascular events:a prospective observational study 被引量:1
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作者 Ying Zhao Dawei Dong +5 位作者 Ding Yan Bing Yang Weirong Gui Man Ke Anding Xu Zefeng Tan 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第5期1156-1160,共5页
Microvasculature of the retina is considered an alternative marker of cerebral vascular risk in healthy populations.However,the ability of retinal vasculature changes,specifically focusing on retinal vessel diameter,t... Microvasculature of the retina is considered an alternative marker of cerebral vascular risk in healthy populations.However,the ability of retinal vasculature changes,specifically focusing on retinal vessel diameter,to predict the recurrence of cerebrovascular events in patients with ischemic stroke has not been determined comprehensively.While previous studies have shown a link between retinal vessel diameter and recurrent cerebrovascular events,they have not incorporated this information into a predictive model.Therefore,this study aimed to investigate the relationship between retinal vessel diameter and subsequent cerebrovascular events in patients with acute ischemic stroke.Additionally,we sought to establish a predictive model by combining retinal veessel diameter with traditional risk factors.We performed a prospective observational study of 141 patients with acute ischemic stroke who were admitted to the First Affiliated Hospital of Jinan University.All of these patients underwent digital retinal imaging within 72 hours of admission and were followed up for 3 years.We found that,after adjusting for related risk factors,patients with acute ischemic stroke with mean arteriolar diameter within 0.5-1.0 disc diameters of the disc margin(MAD_(0.5-1.0DD))of≥74.14μm and mean venular diameter within 0.5-1.0 disc diameters of the disc margin(MVD_(0.5-1.0DD))of≥83.91μm tended to experience recurrent cerebrovascular events.We established three multivariate Cox proportional hazard regression models:model 1 included traditional risk factors,model 2 added MAD_(0.5-1.0DD)to model 1,and model 3 added MVD0.5-1.0DD to model 1.Model 3 had the greatest potential to predict subsequent cerebrovascular events,followed by model 2,and finally model 1.These findings indicate that combining retinal venular or arteriolar diameter with traditional risk factors could improve the prediction of recurrent cerebrovascular events in patients with acute ischemic stroke,and that retinal imaging could be a useful and non-invasive method for identifying high-risk patients who require closer monitoring and more aggressive management. 展开更多
关键词 acute ischemic stroke arteriolar cerebrovascular events DIAMETER digital retinal imaging MICROVASCULATURE prediction recurrent RETINA venular
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Mapping Network-Coordinated Stacked Gated Recurrent Units for Turbulence Prediction 被引量:1
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作者 Zhiming Zhang Shangce Gao +2 位作者 MengChu Zhou Mengtao Yan Shuyang Cao 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2024年第6期1331-1341,共11页
Accurately predicting fluid forces acting on the sur-face of a structure is crucial in engineering design.However,this task becomes particularly challenging in turbulent flow,due to the complex and irregular changes i... Accurately predicting fluid forces acting on the sur-face of a structure is crucial in engineering design.However,this task becomes particularly challenging in turbulent flow,due to the complex and irregular changes in the flow field.In this study,we propose a novel deep learning method,named mapping net-work-coordinated stacked gated recurrent units(MSU),for pre-dicting pressure on a circular cylinder from velocity data.Specifi-cally,our coordinated learning strategy is designed to extract the most critical velocity point for prediction,a process that has not been explored before.In our experiments,MSU extracts one point from a velocity field containing 121 points and utilizes this point to accurately predict 100 pressure points on the cylinder.This method significantly reduces the workload of data measure-ment in practical engineering applications.Our experimental results demonstrate that MSU predictions are highly similar to the real turbulent data in both spatio-temporal and individual aspects.Furthermore,the comparison results show that MSU predicts more precise results,even outperforming models that use all velocity field points.Compared with state-of-the-art methods,MSU has an average improvement of more than 45%in various indicators such as root mean square error(RMSE).Through comprehensive and authoritative physical verification,we estab-lished that MSU’s prediction results closely align with pressure field data obtained in real turbulence fields.This confirmation underscores the considerable potential of MSU for practical applications in real engineering scenarios.The code is available at https://github.com/zhangzm0128/MSU. 展开更多
关键词 Convolutional neural network deep learning recurrent neural network turbulence prediction wind load predic-tion.
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A gated recurrent unit model to predict Poisson’s ratio using deep learning 被引量:1
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作者 Fahd Saeed Alakbari Mysara Eissa Mohyaldinn +4 位作者 Mohammed Abdalla Ayoub Ibnelwaleed A.Hussein Ali Samer Muhsan Syahrir Ridha Abdullah Abduljabbar Salih 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2024年第1期123-135,共13页
Static Poisson’s ratio(vs)is crucial for determining geomechanical properties in petroleum applications,namely sand production.Some models have been used to predict vs;however,the published models were limited to spe... Static Poisson’s ratio(vs)is crucial for determining geomechanical properties in petroleum applications,namely sand production.Some models have been used to predict vs;however,the published models were limited to specific data ranges with an average absolute percentage relative error(AAPRE)of more than 10%.The published gated recurrent unit(GRU)models do not consider trend analysis to show physical behaviors.In this study,we aim to develop a GRU model using trend analysis and three inputs for predicting n s based on a broad range of data,n s(value of 0.1627-0.4492),bulk formation density(RHOB)(0.315-2.994 g/mL),compressional time(DTc)(44.43-186.9 μs/ft),and shear time(DTs)(72.9-341.2μ s/ft).The GRU model was evaluated using different approaches,including statistical error an-alyses.The GRU model showed the proper trends,and the model data ranges were wider than previous ones.The GRU model has the largest correlation coefficient(R)of 0.967 and the lowest AAPRE,average percent relative error(APRE),root mean square error(RMSE),and standard deviation(SD)of 3.228%,1.054%,4.389,and 0.013,respectively,compared to other models.The GRU model has a high accuracy for the different datasets:training,validation,testing,and the whole datasets with R and AAPRE values were 0.981 and 2.601%,0.966 and 3.274%,0.967 and 3.228%,and 0.977 and 2.861%,respectively.The group error analyses of all inputs show that the GRU model has less than 5% AAPRE for all input ranges,which is superior to other models that have different AAPRE values of more than 10% at various ranges of inputs. 展开更多
关键词 Static Poisson’s ratio Deep learning Gated recurrent unit(GRU) Sand control Trend analysis Geomechanical properties
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An Interpretable Light Attention-Convolution-Gate Recurrent Unit Architecture for the Highly Accurate Modeling of Actual Chemical Dynamic Processes
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作者 Yue Li Ning Li +1 位作者 Jingzheng Ren Weifeng Shen 《Engineering》 SCIE EI CAS CSCD 2024年第8期104-116,共13页
To equip data-driven dynamic chemical process models with strong interpretability,we develop a light attention–convolution–gate recurrent unit(LACG)architecture with three sub-modules—a basic module,a brand-new lig... To equip data-driven dynamic chemical process models with strong interpretability,we develop a light attention–convolution–gate recurrent unit(LACG)architecture with three sub-modules—a basic module,a brand-new light attention module,and a residue module—that are specially designed to learn the general dynamic behavior,transient disturbances,and other input factors of chemical processes,respectively.Combined with a hyperparameter optimization framework,Optuna,the effectiveness of the proposed LACG is tested by distributed control system data-driven modeling experiments on the discharge flowrate of an actual deethanization process.The LACG model provides significant advantages in prediction accuracy and model generalization compared with other models,including the feedforward neural network,convolution neural network,long short-term memory(LSTM),and attention-LSTM.Moreover,compared with the simulation results of a deethanization model built using Aspen Plus Dynamics V12.1,the LACG parameters are demonstrated to be interpretable,and more details on the variable interactions can be observed from the model parameters in comparison with the traditional interpretable model attention-LSTM.This contribution enriches interpretable machine learning knowledge and provides a reliable method with high accuracy for actual chemical process modeling,paving a route to intelligent manufacturing. 展开更多
关键词 Interpretable machine learning Light attention-convolution-gate recurrent unit architecture Process knowledge discovery Data-driven process model Intelligent manufacturing
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Recorded recurrent deep reinforcement learning guidance laws for intercepting endoatmospheric maneuvering missiles
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作者 Xiaoqi Qiu Peng Lai +1 位作者 Changsheng Gao Wuxing Jing 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2024年第1期457-470,共14页
This work proposes a recorded recurrent twin delayed deep deterministic(RRTD3)policy gradient algorithm to solve the challenge of constructing guidance laws for intercepting endoatmospheric maneuvering missiles with u... This work proposes a recorded recurrent twin delayed deep deterministic(RRTD3)policy gradient algorithm to solve the challenge of constructing guidance laws for intercepting endoatmospheric maneuvering missiles with uncertainties and observation noise.The attack-defense engagement scenario is modeled as a partially observable Markov decision process(POMDP).Given the benefits of recurrent neural networks(RNNs)in processing sequence information,an RNN layer is incorporated into the agent’s policy network to alleviate the bottleneck of traditional deep reinforcement learning methods while dealing with POMDPs.The measurements from the interceptor’s seeker during each guidance cycle are combined into one sequence as the input to the policy network since the detection frequency of an interceptor is usually higher than its guidance frequency.During training,the hidden states of the RNN layer in the policy network are recorded to overcome the partially observable problem that this RNN layer causes inside the agent.The training curves show that the proposed RRTD3 successfully enhances data efficiency,training speed,and training stability.The test results confirm the advantages of the RRTD3-based guidance laws over some conventional guidance laws. 展开更多
关键词 Endoatmospheric interception Missile guidance Reinforcement learning Markov decision process recurrent neural networks
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Recurrent neural network decoding of rotated surface codes based on distributed strategy
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作者 李帆 李熬庆 +1 位作者 甘启迪 马鸿洋 《Chinese Physics B》 SCIE EI CAS CSCD 2024年第4期322-330,共9页
Quantum error correction is a crucial technology for realizing quantum computers.These computers achieve faulttolerant quantum computing by detecting and correcting errors using decoding algorithms.Quantum error corre... Quantum error correction is a crucial technology for realizing quantum computers.These computers achieve faulttolerant quantum computing by detecting and correcting errors using decoding algorithms.Quantum error correction using neural network-based machine learning methods is a promising approach that is adapted to physical systems without the need to build noise models.In this paper,we use a distributed decoding strategy,which effectively alleviates the problem of exponential growth of the training set required for neural networks as the code distance of quantum error-correcting codes increases.Our decoding algorithm is based on renormalization group decoding and recurrent neural network decoder.The recurrent neural network is trained through the ResNet architecture to improve its decoding accuracy.Then we test the decoding performance of our distributed strategy decoder,recurrent neural network decoder,and the classic minimum weight perfect matching(MWPM)decoder for rotated surface codes with different code distances under the circuit noise model,the thresholds of these three decoders are about 0.0052,0.0051,and 0.0049,respectively.Our results demonstrate that the distributed strategy decoder outperforms the other two decoders,achieving approximately a 5%improvement in decoding efficiency compared to the MWPM decoder and approximately a 2%improvement compared to the recurrent neural network decoder. 展开更多
关键词 quantum error correction rotated surface code recurrent neural network distributed strategy
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Secrecy Outage Probability Minimization in Wireless-Powered Communications Using an Improved Biogeography-Based Optimization-Inspired Recurrent Neural Network
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作者 Mohammad Mehdi Sharifi Nevisi Elnaz Bashir +3 位作者 Diego Martín Seyedkian Rezvanjou Farzaneh Shoushtari Ehsan Ghafourian 《Computers, Materials & Continua》 SCIE EI 2024年第3期3971-3991,共21页
This paper focuses on wireless-powered communication systems,which are increasingly relevant in the Internet of Things(IoT)due to their ability to extend the operational lifetime of devices with limited energy.The mai... This paper focuses on wireless-powered communication systems,which are increasingly relevant in the Internet of Things(IoT)due to their ability to extend the operational lifetime of devices with limited energy.The main contribution of the paper is a novel approach to minimize the secrecy outage probability(SOP)in these systems.Minimizing SOP is crucial for maintaining the confidentiality and integrity of data,especially in situations where the transmission of sensitive data is critical.Our proposed method harnesses the power of an improved biogeography-based optimization(IBBO)to effectively train a recurrent neural network(RNN).The proposed IBBO introduces an innovative migration model.The core advantage of IBBO lies in its adeptness at maintaining equilibrium between exploration and exploitation.This is accomplished by integrating tactics such as advancing towards a random habitat,adopting the crossover operator from genetic algorithms(GA),and utilizing the global best(Gbest)operator from particle swarm optimization(PSO)into the IBBO framework.The IBBO demonstrates its efficacy by enabling the RNN to optimize the system parameters,resulting in significant outage probability reduction.Through comprehensive simulations,we showcase the superiority of the IBBO-RNN over existing approaches,highlighting its capability to achieve remarkable gains in SOP minimization.This paper compares nine methods for predicting outage probability in wireless-powered communications.The IBBO-RNN achieved the highest accuracy rate of 98.92%,showing a significant performance improvement.In contrast,the standard RNN recorded lower accuracy rates of 91.27%.The IBBO-RNN maintains lower SOP values across the entire signal-to-noise ratio(SNR)spectrum tested,suggesting that the method is highly effective at optimizing system parameters for improved secrecy even at lower SNRs. 展开更多
关键词 Wireless-powered communications secrecy outage probability improved biogeography-based optimization recurrent neural network
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Optimized Phishing Detection with Recurrent Neural Network and Whale Optimizer Algorithm
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作者 Brij Bhooshan Gupta Akshat Gaurav +3 位作者 Razaz Waheeb Attar Varsha Arya Ahmed Alhomoud Kwok Tai Chui 《Computers, Materials & Continua》 SCIE EI 2024年第9期4895-4916,共22页
Phishing attacks present a persistent and evolving threat in the cybersecurity land-scape,necessitating the development of more sophisticated detection methods.Traditional machine learning approaches to phishing detec... Phishing attacks present a persistent and evolving threat in the cybersecurity land-scape,necessitating the development of more sophisticated detection methods.Traditional machine learning approaches to phishing detection have relied heavily on feature engineering and have often fallen short in adapting to the dynamically changing patterns of phishingUniformResource Locator(URLs).Addressing these challenge,we introduce a framework that integrates the sequential data processing strengths of a Recurrent Neural Network(RNN)with the hyperparameter optimization prowess of theWhale Optimization Algorithm(WOA).Ourmodel capitalizes on an extensive Kaggle dataset,featuring over 11,000 URLs,each delineated by 30 attributes.The WOA’s hyperparameter optimization enhances the RNN’s performance,evidenced by a meticulous validation process.The results,encapsulated in precision,recall,and F1-score metrics,surpass baseline models,achieving an overall accuracy of 92%.This study not only demonstrates the RNN’s proficiency in learning complex patterns but also underscores the WOA’s effectiveness in refining machine learning models for the critical task of phishing detection. 展开更多
关键词 Phishing detection recurrent Neural Network(RNN) Whale Optimization Algorithm(WOA) CYBERSECURITY machine learning optimization
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Embryo Transfer Strategies for Women with Recurrent Implantation Failure During the Frozen-thawed Embryo Transfer Cycles:Sequential Embryo Transfer or Double-blastocyst Transfer?
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作者 Qiao-hang ZHAO Yu-wei SONG +8 位作者 Jian CHEN Xiang ZHOU Ji-lai XIE Qiu-ping YAO Qi-yin DONG Chun FENG Li-ming ZHOU Wei-ping FU Min JIN 《Current Medical Science》 SCIE CAS 2024年第1期212-222,共11页
Objective Both sequential embryo transfer(SeET)and double-blastocyst transfer(DBT)can serve as embryo transfer strategies for women with recurrent implantation failure(RIF).This study aims to compare the effects of Se... Objective Both sequential embryo transfer(SeET)and double-blastocyst transfer(DBT)can serve as embryo transfer strategies for women with recurrent implantation failure(RIF).This study aims to compare the effects of SeET and DBT on pregnancy outcomes.Methods Totally,261 frozen-thawed embryo transfer cycles of 243 RIF women were included in this multicenter retrospective analysis.According to different embryo quality and transfer strategies,they were divided into four groups:group A,good-quality SeET(GQ-SeET,n=38 cycles);group B,poor-quality or mixed-quality SeET(PQ/MQ-SeET,n=31 cycles);group C,good-quality DBT(GQ-DBT,n=121 cycles);and group D,poor-quality or mixed-quality DBT(PQ/MQ-DBT,n=71 cycles).The main outcome,clinical pregnancy rate,was compared,and the generalized estimating equation(GEE)model was used to correct potential confounders that might impact pregnancy outcomes.Results GQ-DBT achieved a significantly higher clinical pregnancy rate(aOR 2.588,95%CI 1.267–5.284,P=0.009)and live birth rate(aOR 3.082,95%CI 1.482–6.412,P=0.003)than PQ/MQ-DBT.Similarly,the clinical pregnancy rate was significantly higher in GQ-SeET than in PQ/MQ-SeET(aOR 4.047,95%CI 1.218–13.450,P=0.023).The pregnancy outcomes of GQ-SeET were not significantly different from those of GQ-DBT,and the same results were found between PQ/MQ-SeET and PQ/MQ-DBT.Conclusion SeET relative to DBT did not seem to improve pregnancy outcomes for RIF patients if the embryo quality was comparable between the two groups.Better clinical pregnancy outcomes could be obtained by transferring good-quality embryos,no matter whether in SeET or DBT.Embryo quality plays a more important role in pregnancy outcomes for RIF patients. 展开更多
关键词 recurrent implantation failure sequential embryo transfer frozen-thawed embryo transfer embryo transfer strategies
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Effects of data smoothing and recurrent neural network(RNN)algorithms for real-time forecasting of tunnel boring machine(TBM)performance
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作者 Feng Shan Xuzhen He +1 位作者 Danial Jahed Armaghani Daichao Sheng 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2024年第5期1538-1551,共14页
Tunnel boring machines(TBMs)have been widely utilised in tunnel construction due to their high efficiency and reliability.Accurately predicting TBM performance can improve project time management,cost control,and risk... Tunnel boring machines(TBMs)have been widely utilised in tunnel construction due to their high efficiency and reliability.Accurately predicting TBM performance can improve project time management,cost control,and risk management.This study aims to use deep learning to develop real-time models for predicting the penetration rate(PR).The models are built using data from the Changsha metro project,and their performances are evaluated using unseen data from the Zhengzhou Metro project.In one-step forecast,the predicted penetration rate follows the trend of the measured penetration rate in both training and testing.The autoregressive integrated moving average(ARIMA)model is compared with the recurrent neural network(RNN)model.The results show that univariate models,which only consider historical penetration rate itself,perform better than multivariate models that take into account multiple geological and operational parameters(GEO and OP).Next,an RNN variant combining time series of penetration rate with the last-step geological and operational parameters is developed,and it performs better than other models.A sensitivity analysis shows that the penetration rate is the most important parameter,while other parameters have a smaller impact on time series forecasting.It is also found that smoothed data are easier to predict with high accuracy.Nevertheless,over-simplified data can lose real characteristics in time series.In conclusion,the RNN variant can accurately predict the next-step penetration rate,and data smoothing is crucial in time series forecasting.This study provides practical guidance for TBM performance forecasting in practical engineering. 展开更多
关键词 Tunnel boring machine(TBM) Penetration rate(PR) Time series forecasting recurrent neural network(RNN)
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Aerial target threat assessment based on gated recurrent unit and self-attention mechanism
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作者 CHEN Chen QUAN Wei SHAO Zhuang 《Journal of Systems Engineering and Electronics》 SCIE CSCD 2024年第2期361-373,共13页
Aerial threat assessment is a crucial link in modern air combat, whose result counts a great deal for commanders to make decisions. With the consideration that the existing threat assessment methods have difficulties ... Aerial threat assessment is a crucial link in modern air combat, whose result counts a great deal for commanders to make decisions. With the consideration that the existing threat assessment methods have difficulties in dealing with high dimensional time series target data, a threat assessment method based on self-attention mechanism and gated recurrent unit(SAGRU) is proposed. Firstly, a threat feature system including air combat situations and capability features is established. Moreover, a data augmentation process based on fractional Fourier transform(FRFT) is applied to extract more valuable information from time series situation features. Furthermore, aiming to capture key characteristics of battlefield evolution, a bidirectional GRU and SA mechanisms are designed for enhanced features.Subsequently, after the concatenation of the processed air combat situation and capability features, the target threat level will be predicted by fully connected neural layers and the softmax classifier. Finally, in order to validate this model, an air combat dataset generated by a combat simulation system is introduced for model training and testing. The comparison experiments show the proposed model has structural rationality and can perform threat assessment faster and more accurately than the other existing models based on deep learning. 展开更多
关键词 target threat assessment gated recurrent unit(GRU) self-attention(SA) fractional Fourier transform(FRFT)
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Ocular rosacea without facial erythema involvement manifesting as bilateral multiple recurrent chalazions:A case report
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作者 Xue-Mei Han Yi-Mai Zhou Lu-Sha Cen 《World Journal of Clinical Cases》 SCIE 2024年第17期3253-3258,共6页
BACKGROUND In addition to the non-specific symptomatology of ocular rosacea,currently,there are no reliable diagnostic tests for the disease,which may lead to its misdiagnosis.Here,we report a case of ocular rosacea p... BACKGROUND In addition to the non-specific symptomatology of ocular rosacea,currently,there are no reliable diagnostic tests for the disease,which may lead to its misdiagnosis.Here,we report a case of ocular rosacea presenting with multiple recurrent chalazion on both eyelids.CASE SUMMARY A 63-year-old female patient presented with multiple chalazion and dry eyes in both eyes,with no facial erythema.Initial management done were application of steroid eye ointment on both eyelids,hot compresses,and eyelid margin cleaning;noting that there was no relief of symptoms.Surgical excision of the chalazion was done on both eyes,however,bilateral recurrence occurred post-operatively.The pathological studies showed infiltration of a small amount of fibrous tissue with many chronic inflammatory cells.Immunohistochemistry studies were positive for LL-37.Resolution of the chalazion occurred after oral administration of doxycycline and azithromycin.CONCLUSION Our findings show that ophthalmologists should recognize the ocular manifestations of skin diseases. 展开更多
关键词 Ocular rosacea ROSACEA recurrent chalazion Bilateral chalazion Multiple chalazion Case report
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Recurrent herpes infection showing a new facial phenotype:A case report
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作者 Eun Bit Bae 《World Journal of Clinical Cases》 SCIE 2024年第22期5271-5275,共5页
BACKGROUND Facial herpes is a common form of the herpes simplex virus-1 infection and usually presents as vesicles near the mouth,nose,and periocular sites.In contrast,we observed a new facial symptom of herpes on the... BACKGROUND Facial herpes is a common form of the herpes simplex virus-1 infection and usually presents as vesicles near the mouth,nose,and periocular sites.In contrast,we observed a new facial symptom of herpes on the entire face without vesicles.CASE SUMMARY A 33-year-old woman with a history of varicella infection and shingles since an early age presented with sarcoidosis of the entire face and neuralgia without oral lesions.The patient was prescribed antiviral treatment with valacyclovir and acyclovir cream.One day after drug administration,facial skin lesions and neurological pain improved.Herpes simplex without oral blisters can easily be misdiagnosed as pimples upon visual examination in an outpatient clinic.CONCLUSION As acute herpes simplex is accompanied by neuralgia,prompt diagnosis and prescription are necessary,considering the pathological history and health conditions. 展开更多
关键词 Facial herpes recurrent herpes infection Cutaneous sarcoidosis Herpes simplex virus Herpes zoster VARICELLA-ZOSTER Chicken pox Immune system Case report
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Lymphovenous anastomosis and complex decongestive therapy for severe deformed lymphedema with recurrent infection:A case report
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作者 He-Jun Wang Qing-Qing He +2 位作者 Chang-Rui Liu Ying-Ying Wang Xun-Wei Liu 《World Journal of Clinical Cases》 SCIE 2024年第22期5159-5167,共9页
BACKGROUND Lower extremity lymphedema is a common complication following treatment for gynecological malignancies.Its incidence rate can reach up to 70%,affecting~20 million people worldwide.However,specialized treatm... BACKGROUND Lower extremity lymphedema is a common complication following treatment for gynecological malignancies.Its incidence rate can reach up to 70%,affecting~20 million people worldwide.However,specialized treatment centers are scarce,and there is a lack of consensus on treatment approaches.Furthermore,there are even fewer reports on the systematic and effective treatment of severe lymphedema with malformations.Effective management of this condition remains a significant challenge for clinicians.CASE SUMMARY A 40-year-old woman developed bilateral leg swelling 6 years after receiving treatment for endometrial cancer.Since August 2018,she experienced>30 episodes of lymphangitis.Upon presentation,she exhibited bilateral leg swelling and deformation,with four large swellings in the posterior thigh that impeded movement,and pain in the limbs.Skin manifestations included lichenoid lesions and features of deep sclerosis.Radionuclide lymphoscintigraphy confirmed the diagnosis of lower limb lymphedema.After 6 mo of complex decongestive therapy(CDT)and three lymphaticovenous anastomosis(LVA)treatments,the patient lost 49 kg in weight.She also experienced a maximum circumference reduction of 35.2 cm in the left lower limb and 37.5 cm in the right lower limb.The leg pain disappeared,her swelling significantly decreased,and she regained the ability to walk,cycle,and run normally.CONCLUSION The combined application of CDT and LVA therapy demonstrates significant positive effects in the treatment of severe,deformed stage III lymphedema. 展开更多
关键词 Lower extremity lymphedema Endometrial cancer Lymphaticovenous anastomosis Complex decongestive therapy Gynecological malignancies recurrent infection Case report
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Diagnosis and management of benign recurrent intrahepatic cholestasis and psychosocial stressors in an adolescent:A case report
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作者 Ya-Xin Xu Xiao-Xuan Niu +2 位作者 Bei-Li Xu Yuan Ji Qun-Yan Yao 《World Journal of Clinical Cases》 SCIE 2024年第20期4427-4433,共7页
BACKGROUND Benign recurrent intrahepatic cholestasis(BRIC)is a rare autosomal recessive disorder,characterized by episodes of intense pruritus,elevated serum levels of alkaline phosphatase and bilirubin,and near-norma... BACKGROUND Benign recurrent intrahepatic cholestasis(BRIC)is a rare autosomal recessive disorder,characterized by episodes of intense pruritus,elevated serum levels of alkaline phosphatase and bilirubin,and near-normal-glutamyl transferase.These episodes may persist for weeks to months before spontaneously resolving,with patients typically remaining asymptomatic between occurrences.Diagnosis entails the evaluation of clinical symptoms and targeted genetic testing.Although BRIC is recognized as a benign genetic disorder,the triggers,particularly psychosocial factors,remain poorly understood.CASE SUMMARY An 18-year-old Chinese man presented with recurrent jaundice and pruritus after a cold,which was exacerbated by self-medication involving vitamin B and paracetamol.Clinical and laboratory evaluations revealed elevated levels of bilirubin and liver enzymes,in the absence of viral or autoimmune liver disease.Imaging excluded biliary and pancreatic abnormalities,and liver biopsy demonstrated centrilobular cholestasis,culminating in a BRIC diagnosis confirmed by the identification of a novel ATP8B1 gene mutation.Psychological assessment of the patient unveiled stress attributable to academic and familial pressures,regarded as potential triggers for BRIC.Initial relief was observed with ursodeoxycholic acid and cetirizine,followed by an adjustment of the treatment regimen in response to elevated liver enzymes.The patient's condition significantly improved following a stress-related episode,thanks to a comprehensive management approach that included psychosocial support and medical treatment.CONCLUSION Our research highlights genetic and psychosocial influences on BRIC,emphasizing integrated diagnostic and management strategies. 展开更多
关键词 Benign recurrent intrahepatic cholestasis Genetic testing Psychosocial factors ATP8B1 gene mutation CHOLESTASIS JAUNDICE PRURITUS Case report
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Recurrent acute pancreatitis as an initial presentation of primary hyperparathyroidism:A case report
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作者 Masood M Karim Hira Raza Om Parkash 《World Journal of Clinical Cases》 SCIE 2024年第29期6302-6306,共5页
BACKGROUND With 4.9 to 35 instances per 100000 cases,hyperparathyroidism is one of the rarest causes of acute pancreatitis.The major cause of primary hyperparathyroidism is a parathyroid adenoma,which can manifest cli... BACKGROUND With 4.9 to 35 instances per 100000 cases,hyperparathyroidism is one of the rarest causes of acute pancreatitis.The major cause of primary hyperparathyroidism is a parathyroid adenoma,which can manifest clinically in various ways.CASE SUMMARY We discuss the unusual case of a 13-year-old boy with recurrent pancreatitis as the initial presentation of primary hyperparathyroidism.The cause of his recurrent pancreatitis remained unknown,and the patient had multiple admissions with acute pancreatitis over 3 years.His diagnosis was delayed due to the initial normal levels of parathyroid hormone,which were later reported elevated in a subsequent episode where ultrasound neck and thyroid scintigraphy revealed a parathyroid adenoma as the underlying cause.After the diagnosis was made,he underwent surgical resection of the adenoma.CONCLUSION This case study stresses the importance of considering uncommon causes for recurrent pancreatitis. 展开更多
关键词 recurrent pancreatitis Primary hyperparathyroidism Normal serum parathyroid hormone Parathyroid adenoma Case report
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Populational change of CD4^(+)CD25^(+)Treg cells is responsible for the synergistic effect of the combination of RAMP2 with baicalin in treating recurrent spontaneous abortion mouse models
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作者 Cong Chen Zhuo-Lan Li +2 位作者 Jing-Tian Guo Wen-Yao Xue Wei Guo 《Traditional Medicine Research》 2024年第8期59-66,共8页
Background: The absence of a safe and effective therapy for recurrent spontaneous abortion due to a maternofetal failure in immunological tolerance remains an intractable clinical obstacle for surgeons. Recently, trad... Background: The absence of a safe and effective therapy for recurrent spontaneous abortion due to a maternofetal failure in immunological tolerance remains an intractable clinical obstacle for surgeons. Recently, traditional Chinese medicine has become a feasible alternative for certain diseases, including recurrent spontaneous abortion. However, because of the complex composition of the traditional Chinese medicine formula, its action mechanism remains unclear. Methods: We selected two isolated active ingredients (RAMP and baicalin) from the traditional Chinese medicine formula and used an abortion-prone CBA/J × DBA/2 model to simulate human RSA and compared the changes in fetal resorption rate, Treg cell percentage, and relevant cytokines before and after combination therapy. In addition, The mechanisms were preliminarily discussed using in vitro differentiation models. Results: In CBA/J × DBA/2 abortion-prone mice, the combination therapy resulted in a lower embryo resorption rate compared to that obtained with individual delivery of either RAMP or baicalin, thereby playing an embryo-protective role through the increase in Treg cells for the maintenance of maternal-fetal immune tolerance. In in vitro primary cell differentiation experiments, the concentration of Treg cells significantly increased from 11% to 17.9% after the combination therapy compared to that of the single administration group. Conclusion: the synergistic effects of RAMP and baicalin were responsible for Treg differentiation. The present study provides a solid basis for improving the applicability of traditional Chinese herbs in the treatment of recurrent spontaneous abortion. 展开更多
关键词 recurrent spontaneous abortion Atractylodes macrocephala Koidz. Scutellaria baicalensis Georgi CBA/J×DBA/2 regulatory T cells
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Radiofrequency ablation combined with transcatheter arterial chemoembolization for recurrent liver cancer
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作者 Jin-You Guo Li-Li Zhao +2 位作者 Hui-Jun Cai Hui Zeng Wei-Dong Mei 《World Journal of Gastrointestinal Surgery》 SCIE 2024年第6期1756-1764,共9页
BACKGROUND The recurrence rate of liver cancer after surgery is high.Radiofrequency ablation(RFA)combined with transcatheter arterial chemoembolization(TACE)is an effective treatment for liver cancer;however,its effic... BACKGROUND The recurrence rate of liver cancer after surgery is high.Radiofrequency ablation(RFA)combined with transcatheter arterial chemoembolization(TACE)is an effective treatment for liver cancer;however,its efficacy in recurrent liver cancer remains unclear.AIM To investigate the clinical effect of TACE combined with RFA in the treatment of recurrent liver cancer.METHODS Ninety patients with recurrent liver cancer were divided into 2 groups according to treatment plan:Control(RFA alone);and experimental[TACE combined with RFA(TACE+RFA)].The incidence of increased alanine aminotransferase levels,complications,and other indices were compared between the two groups before and after the procedures.RESULTS One month after the procedures,the short-term efficacy rate and Karnofsky Performance Status scores of the experimental group were significantly higher than those of the control group(P<0.05).Alpha-fetoprotein(AFP)and total bilirubin levels were lower than those in the control group(P<0.05);The overall response rate was 82.22%and 66.67%in the experimental and control groups,respectively;The disease control rate was 93.33%and 82.22%in the experimental and control groups,respectively,the differences are statistically significant(P<0.05).And there were no statistical differences in complications between the two groups(P>0.05).CONCLUSION TACE+RFA was effective for the treatment of recurrent liver cancer and significantly reduced AFP levels and improved various indices of liver function. 展开更多
关键词 Transcatheter arterial chemoembolization Radiofrequency ablation recurrent liver cancer Clinical efficacy Overall response rate Disease control rate
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A Double-Interactively Recurrent Fuzzy Cerebellar Model Articulation Controller Model Combined with an Improved Particle Swarm Optimization Method for Fall Detection
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作者 Jyun-Guo Wang 《Computer Systems Science & Engineering》 2024年第5期1149-1170,共22页
In many Eastern and Western countries,falling birth rates have led to the gradual aging of society.Older adults are often left alone at home or live in a long-term care center,which results in them being susceptible t... In many Eastern and Western countries,falling birth rates have led to the gradual aging of society.Older adults are often left alone at home or live in a long-term care center,which results in them being susceptible to unsafe events(such as falls)that can have disastrous consequences.However,automatically detecting falls fromvideo data is challenging,and automatic fall detection methods usually require large volumes of training data,which can be difficult to acquire.To address this problem,video kinematic data can be used as training data,thereby avoiding the requirement of creating a large fall data set.This study integrated an improved particle swarm optimization method into a double interactively recurrent fuzzy cerebellar model articulation controller model to develop a costeffective and accurate fall detection system.First,it obtained an optical flow(OF)trajectory diagram from image sequences by using the OF method,and it solved problems related to focal length and object offset by employing the discrete Fourier transform(DFT)algorithm.Second,this study developed the D-IRFCMAC model,which combines spatial and temporal(recurrent)information.Third,it designed an IPSO(Improved Particle Swarm Optimization)algorithm that effectively strengthens the exploratory capabilities of the proposed D-IRFCMAC(Double-Interactively Recurrent Fuzzy Cerebellar Model Articulation Controller)model in the global search space.The proposed approach outperforms existing state-of-the-art methods in terms of action recognition accuracy on the UR-Fall,UP-Fall,and PRECIS HAR data sets.The UCF11 dataset had an average accuracy of 93.13%,whereas the UCF101 dataset had an average accuracy of 92.19%.The UR-Fall dataset had an accuracy of 100%,the UP-Fall dataset had an accuracy of 99.25%,and the PRECIS HAR dataset had an accuracy of 99.07%. 展开更多
关键词 Double interactively recurrent fuzzy cerebellar model articulation controller(D-IRFCMAC) improved particle swarm optimization(IPSO) fall detection
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Recurrent Transient Ischemic Attacks Revealing Cerebral Amyloid Angiopathy: A Comprehensive Case
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作者 Kenza Khelfaoui Tredano Houyam Tibar +3 位作者 Kaoutar El Alaoui Taoussi Wafae Regragui Abdeljalil El Quessar Ali Benomar 《World Journal of Neuroscience》 CAS 2024年第1期33-36,共4页
This case report investigates the manifestation of cerebral amyloid angiopathy (CAA) through recurrent Transient Ischemic Attacks (TIAs) in an 82-year-old patient. Despite initial diagnostic complexities, cerebral ang... This case report investigates the manifestation of cerebral amyloid angiopathy (CAA) through recurrent Transient Ischemic Attacks (TIAs) in an 82-year-old patient. Despite initial diagnostic complexities, cerebral angiography-MRI revealed features indicative of CAA. Symptomatic treatment resulted in improvement, but the patient later developed a fatal hematoma. The discussion navigates the intricate therapeutic landscape of repetitive TIAs in the elderly with cardiovascular risk factors, emphasizing the pivotal role of cerebral MRI and meticulous bleeding risk management. The conclusion stresses the importance of incorporating SWI sequences, specifically when suspecting a cardioembolic TIA, as a diagnostic measure to explore and exclude CAA in the differential diagnosis. This case report provides valuable insights into these challenges, highlighting the need to consider CAA in relevant cases. 展开更多
关键词 Cerebral Amyloid Angiopathy Transient Ischemic Attacks recurrent Hemiparesis Susceptibility-Weighted Imaging Cardioembolic Origin Bleeding Risk Management Differential Diagnosis
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