Background The redirected jumping(RDJ)technique is a new locomotion method that saves physical tracking area and enhances the body movement experience of users in virtual reality.In a previous study,the range of imper...Background The redirected jumping(RDJ)technique is a new locomotion method that saves physical tracking area and enhances the body movement experience of users in virtual reality.In a previous study,the range of imperceptible manipulation gains in RDJ was discussed in an empty virtual environment(VE).Methods In this study,we conducted three tasks to investigate the influence of alley width on the detection threshold of jump redirection in a VE.Results The results demonstrated that the imperceptible distance gain range in RDJ was not associated with the width of the alleys.The imperceptible height and rotation gain ranges in RDJ are related to the width of the alleys.Conclusions We preliminarily summarized the relationship between the occlusion distance and manipulation range of the three gains in a complex environment.Simultaneously,the guiding principle for choosing three gains in RDJ according to the occlusion distance in a complex environment is provided.展开更多
Background Redirected jumping(RDJ)allows users to explore virtual environments(VEs)naturally by scaling a small real-world jump to a larger virtual jump with virtual camera motion manipulation,thereby addressing the p...Background Redirected jumping(RDJ)allows users to explore virtual environments(VEs)naturally by scaling a small real-world jump to a larger virtual jump with virtual camera motion manipulation,thereby addressing the problem of limited physical space in VR applications.Previous RDJ studies have mainly focused on detection threshold estimation.However,the effect VE or self representation(SR)has on the perception or performance of RDJs remains unclear.Methods In this paper,we report experiments to measure the perception(detection thresholds for gains,presence,embodiment,intrinsic motivation,and cybersickness)and physical performance(heart rate intensity,preparation time,and actual jumping distance)of redirected forward jumping under six different combinations of VE(low and high visual richness)and SRs(invisible,shoes,and human-like).Results Our results indicated that the detection threshold ranges for horizontal translation gains were significantly smaller in the VE with high rather than low visual richness.When different SRs were applied,our results did not suggest significant differences in detection thresholds,but it did report longer actual jumping distances in the invisible body case compared with the other two SRs.In the high visual richness VE,the preparation time for jumping with a human-like avatar was significantly longer than that with other SRs.Finally,some correlations were found between perception and physical performance measures.Conclusions All these findings suggest that both VE and SRs influence users'perception and performance in RDJ and must be considered when designing locomotion techniques.展开更多
Background: Mesh expansion and fixation at retro-rectus plane through multiples stabs produces good results. But these stabs cause cosmetic disorders for the patients and doctors. So, we find some modification to do t...Background: Mesh expansion and fixation at retro-rectus plane through multiples stabs produces good results. But these stabs cause cosmetic disorders for the patients and doctors. So, we find some modification to do this procedure without these stabbing wounds in midline hernial repair. Patients and methods: This technique was used to fix the mesh at retro-rectus plane in 50 patients suffering from midline hernias, from January 2008 through January 2010 at Zagazig university Hospital, Egypt. Laparotomy incision was done over the hernial sac or at old incision;the contents were then released and reduced into peritoneal cavity without much subcutaneous dissection. The suitable sheet of polypropylene mesh to cover the hernial defect and any weak area was prepared and fixed at retro-rectus plane percutaneously without stabbing wounds by using redirecting suture hook. The mean period of follow up was 26 months. Results: There was no recurrence during the period of follow up. Five patients developed subcutaneous bluish discoloration at the site of some stitches, which disappear within two weeks with conservative treatment. Conclusion: Percutaneous mesh expansion and fixation at retro-rectus plane by using redirecting suture hook procedure has good results in recurrence rate and cosmetic appearance.展开更多
Locomotion is a fundamental interaction technique that allows free navigation in virtual scenes.A large body of literature has demonstrated that natural locomotion experience can significantly improve the sense of pre...Locomotion is a fundamental interaction technique that allows free navigation in virtual scenes.A large body of literature has demonstrated that natural locomotion experience can significantly improve the sense of presence and help users achieve better performance in tasks such as searching and training.In the upcoming metaverse era,locomotion will play a critical role in the success of large-scale interactive applications.Perception and redirection are two tightly connected problems in virtual locomotion.Given a limited physical condition and a target virtual scene,how to make the perceived locomotion as natural as possible,and further unknowingly redirect the user in the physical world is an open question.In this special issue,we have selected five papers that provide their latest updates for research problems of view control,virtual jumping,climbing,and searching.展开更多
T cell-redirecting bispecific antibodies are specifically designed to bind to tumor-associated antigens,thereby engaging with CD3 on the T cell receptor.This linkage between tumor cells and T cells actively triggers T...T cell-redirecting bispecific antibodies are specifically designed to bind to tumor-associated antigens,thereby engaging with CD3 on the T cell receptor.This linkage between tumor cells and T cells actively triggers T cell activation and initiates targeted killing of the identified tumor cells.These antibodies have emerged as one of the most promising avenues within tumor immunotherapy.However,despite success in treating hematological malignancies,significant advancements in solid tumors have yet to be explored.In this review,we aim to address the critical challenges associated with T cellredirecting bispecific antibodies and explore novel strategies to overcome these obstacles,with the ultimate goal of expanding the application of this therapy to include solid tumors.展开更多
As the virtual reality(VR)technology strives to provide immersive and natural user experiences,the challenge of aligning vast virtual environments with limited physical spaces remains significant.This survey comprehen...As the virtual reality(VR)technology strives to provide immersive and natural user experiences,the challenge of aligning vast virtual environments with limited physical spaces remains significant.This survey comprehensively explores the advancements in redirected walking(RDW)techniques aimed at overcoming spatial constraints in VR.RDW addresses this by subtly manipulating users’physical movements to allow for seamless navigation within constrained areas.The survey delves into gain perception mechanisms,detailing how slight discrepancies between virtual and real-world movements can be utilized without user awareness,thus extending the effective navigable space.Various RDW control algorithms for gain-based RDW are analyzed,highlighting their implementation and effectiveness in maintaining immersion and minimizing perceptual disturbances.Furthermore,novel methods extending beyond traditional gain-based techniques are discussed,showcasing innovative approaches that further refine VR interactions.The practical implications of RDW in enhancing safety and reducing physical collisions in VR environments are underscored,alongside its potential to improve user experience by aligning virtual exploration more closely with natural human behavior patterns.Through a thorough review of existing literature and recent advancements,this survey provides a systematic understanding for researchers,developers,and industry professionals.It underscores the importance of RDW in the future of VR,emphasizing RDW's role in making VR more accessible and practical across various applications,from education and training to therapy and entertainment.The paper concludes with a forward-looking perspective on the continued evolution and potential of RDW in revolutionizing virtual reality experiences.展开更多
目的对运用反应中断再定向干预孤独症谱系障碍(ASD)儿童刻板语言的研究进行Scoping综述分析。方法检索EBSCO、PubMed、Web of Science、中国知网、万方数据库中使用反应中断再定向的方法对ASD儿童的刻板语言进行干预的相关文献,提取文...目的对运用反应中断再定向干预孤独症谱系障碍(ASD)儿童刻板语言的研究进行Scoping综述分析。方法检索EBSCO、PubMed、Web of Science、中国知网、万方数据库中使用反应中断再定向的方法对ASD儿童的刻板语言进行干预的相关文献,提取文献中的数据信息对其进行Scoping综述。结果最终纳入16篇英文文献,均采用单一受试时间序列研究设计。共涉及41例ASD儿童,出现刻板语言行为的ASD儿童基本语言功能有显著差异。刻板语言表现为语言和非语言声音两种形式。多数研究使用实验功能评价来确认刻板语言的功能,绝大多数ASD儿童刻板语言的功能为自动强化。实验功能评价以Iwata等的范式为主,其他评价范式在此范式基础上进行一定的改变,使操作更简洁。反应中断再定向常在个别化的情境中进行,少数研究尝试在特殊教育班级中进行。因刻板语言和其他行为的障碍程度不同,干预时长和频率差异较大。通过比较传统反应中断再定向与其变形程序对刻板语言的改善效果发现,改变再定向任务内容,减少再定向任务数量及不同执行时长对其效果没有显著影响。反应中断再定向与匹配刺激的非后效强化、反应代价、语言操作训练、药物治疗等方法进行比较的结果认为,反应中断再定向及其他方法(除药物治疗)都可以在一定程度上减少ASD儿童的刻板语言,并促进适当行为的出现,但反应中断再定向与匹配刺激、反应代价等其他方法共同使用会更有效。结论伴有刻板语言的ASD儿童具有不同功能性语言表现,其刻板语言表现形式包括语言和非语言的声音。刻板语言绝大多数功能为自动强化。反应中断再定向作为一种行为干预,均在个别化的情境下进行,干预时长和频率根据ASD儿童的刻板语言及其他行为障碍的严重程度等进行调整。改变再定向指令内容、数量等的变形反应中断再定向不会对行为改善结果有显著影响,匹配刺激和反应代价等其他干预方法也能够有效地减少刻板语言,但反应中断再定向与这些方法一同使用可能效果更好。反应中断再定向干预不仅可以有效改善ASD儿童语言功能,减少刻板语言,还能增加适当语言、任务参与、指令服从。展开更多
Honeypot is a recent developed computer security concept which uses active offense to against attacks from hackers . It lures hackers to attack a seemly vulnerable fake network where they could be well observed in ord...Honeypot is a recent developed computer security concept which uses active offense to against attacks from hackers . It lures hackers to attack a seemly vulnerable fake network where they could be well observed in order to learn about the tactics and tools used by the attackers, so that we may improve the system security accordingly later. In this paper, we propose a novel approach for redirecting technique in honeypot system. First, we introduce briefly concepts of the honeypot system. Then we describe a redirection technique and an implementation algorithm. Finally, using the IDS Snort and the firewall IPTable, we set up a testing environment and give some simulations results. We also discuss some future research topics.展开更多
Novel biologics that redirect cytotoxic T lymphocytes (CTLs) to kill tumor cells bearing a tumor associated antigen hold great promise in the clinic. However, the ability to safely and potently target CD3 on CTL tow...Novel biologics that redirect cytotoxic T lymphocytes (CTLs) to kill tumor cells bearing a tumor associated antigen hold great promise in the clinic. However, the ability to safely and potently target CD3 on CTL toward tumor associated antigens (TAA) expressed on tumor cells remains a challenge of both technology and biol- ogy. Herein we describe the use of a Half DVD-Ig format that can redirect CTL to kill tumor cells. Notably, Half DVD-Ig molecules that are monovalent for each speci- ficity demonstrated reduced non-specific CTL activation and conditional CTL activation upon binding to TAA compared to intact tetravalent DVD-Ig molecules that are bivalent for each specificity, while maintaining good drug like properties and appropriate PK properties.展开更多
Virtual reality(VR)allows users to explore and experience a computer-simulated virtual environment so that VR users can be immersed in a totally artificial virtual world and interact with arbitrary virtual objects.How...Virtual reality(VR)allows users to explore and experience a computer-simulated virtual environment so that VR users can be immersed in a totally artificial virtual world and interact with arbitrary virtual objects.However,the limited physical tracking space usually restricts the exploration of large virtual spaces,and VR users have to use special locomotion techniques to move from one location to another.Among these techniques,redirected walking(RDW)is one of the most natural locomotion techniques to solve the problem based on near-natural walking experiences.The core idea of the RDW technique is to imperceptibly guide users on virtual paths,which might vary from the paths they physically walk in the real world.In a similar way,some RDW algorithms imperceptibly change the structure and layout of the virtual environment such that the virtual environment fits into the tracking space.In this survey,we first present a taxonomy of existing RDW work.Based on this taxonomy,we compare and analyze both contributions and shortcomings of the existing methods in detail,and find view manipulation methods offer satisfactory visual effect but the experience can be interrupted when users reach the physical boundaries,while virtual environment manipulation methods can provide users with consistent movement but have limited application scenarios.Finally,we discuss possible future research directions,indicating combining artificial intelligence with this area will be effective and intriguing.展开更多
With the support by the National Natural Science Foundation of China,the research team led by Dr.Liu Yuchen(刘宇辰)at the State Engineering Laboratory of Medical Key Technologies Application of Synthetic Biology,Shenz...With the support by the National Natural Science Foundation of China,the research team led by Dr.Liu Yuchen(刘宇辰)at the State Engineering Laboratory of Medical Key Technologies Application of Synthetic Biology,Shenzhen Second People’s Hospital,the First Affiliated Hospital of Shenzhen University,developed a type of CRISPR-based riboswitch,which was published in Nature Methods(2016,doi:10.展开更多
基金the National Natural Science Foundation of China(619320061772051).
文摘Background The redirected jumping(RDJ)technique is a new locomotion method that saves physical tracking area and enhances the body movement experience of users in virtual reality.In a previous study,the range of imperceptible manipulation gains in RDJ was discussed in an empty virtual environment(VE).Methods In this study,we conducted three tasks to investigate the influence of alley width on the detection threshold of jump redirection in a VE.Results The results demonstrated that the imperceptible distance gain range in RDJ was not associated with the width of the alleys.The imperceptible height and rotation gain ranges in RDJ are related to the width of the alleys.Conclusions We preliminarily summarized the relationship between the occlusion distance and manipulation range of the three gains in a complex environment.Simultaneously,the guiding principle for choosing three gains in RDJ according to the occlusion distance in a complex environment is provided.
基金the National Natural Science Foundation of China(61902012)the Young Talents Support Project of China Association for Science and Technology.
文摘Background Redirected jumping(RDJ)allows users to explore virtual environments(VEs)naturally by scaling a small real-world jump to a larger virtual jump with virtual camera motion manipulation,thereby addressing the problem of limited physical space in VR applications.Previous RDJ studies have mainly focused on detection threshold estimation.However,the effect VE or self representation(SR)has on the perception or performance of RDJs remains unclear.Methods In this paper,we report experiments to measure the perception(detection thresholds for gains,presence,embodiment,intrinsic motivation,and cybersickness)and physical performance(heart rate intensity,preparation time,and actual jumping distance)of redirected forward jumping under six different combinations of VE(low and high visual richness)and SRs(invisible,shoes,and human-like).Results Our results indicated that the detection threshold ranges for horizontal translation gains were significantly smaller in the VE with high rather than low visual richness.When different SRs were applied,our results did not suggest significant differences in detection thresholds,but it did report longer actual jumping distances in the invisible body case compared with the other two SRs.In the high visual richness VE,the preparation time for jumping with a human-like avatar was significantly longer than that with other SRs.Finally,some correlations were found between perception and physical performance measures.Conclusions All these findings suggest that both VE and SRs influence users'perception and performance in RDJ and must be considered when designing locomotion techniques.
文摘Background: Mesh expansion and fixation at retro-rectus plane through multiples stabs produces good results. But these stabs cause cosmetic disorders for the patients and doctors. So, we find some modification to do this procedure without these stabbing wounds in midline hernial repair. Patients and methods: This technique was used to fix the mesh at retro-rectus plane in 50 patients suffering from midline hernias, from January 2008 through January 2010 at Zagazig university Hospital, Egypt. Laparotomy incision was done over the hernial sac or at old incision;the contents were then released and reduced into peritoneal cavity without much subcutaneous dissection. The suitable sheet of polypropylene mesh to cover the hernial defect and any weak area was prepared and fixed at retro-rectus plane percutaneously without stabbing wounds by using redirecting suture hook. The mean period of follow up was 26 months. Results: There was no recurrence during the period of follow up. Five patients developed subcutaneous bluish discoloration at the site of some stitches, which disappear within two weeks with conservative treatment. Conclusion: Percutaneous mesh expansion and fixation at retro-rectus plane by using redirecting suture hook procedure has good results in recurrence rate and cosmetic appearance.
文摘Locomotion is a fundamental interaction technique that allows free navigation in virtual scenes.A large body of literature has demonstrated that natural locomotion experience can significantly improve the sense of presence and help users achieve better performance in tasks such as searching and training.In the upcoming metaverse era,locomotion will play a critical role in the success of large-scale interactive applications.Perception and redirection are two tightly connected problems in virtual locomotion.Given a limited physical condition and a target virtual scene,how to make the perceived locomotion as natural as possible,and further unknowingly redirect the user in the physical world is an open question.In this special issue,we have selected five papers that provide their latest updates for research problems of view control,virtual jumping,climbing,and searching.
基金supported by the National Natural Science Foundation of China(Nos.32070940 and 81991491)the China Postdoctoral Science Foundation(No.2021M700115)+2 种基金the Postdoctoral Innovation Talents Support Program(No.BX20220189,China)the Science and Technology Planning Project of Fujian Province(No.2022L3080,China)the CAMS Innovation Fund for Medical Sciences(No.2019RU022,China).
文摘T cell-redirecting bispecific antibodies are specifically designed to bind to tumor-associated antigens,thereby engaging with CD3 on the T cell receptor.This linkage between tumor cells and T cells actively triggers T cell activation and initiates targeted killing of the identified tumor cells.These antibodies have emerged as one of the most promising avenues within tumor immunotherapy.However,despite success in treating hematological malignancies,significant advancements in solid tumors have yet to be explored.In this review,we aim to address the critical challenges associated with T cellredirecting bispecific antibodies and explore novel strategies to overcome these obstacles,with the ultimate goal of expanding the application of this therapy to include solid tumors.
基金supported by the National Key Research and Development Program of China under Grant No.2023YFF0905104the National Natural Science Foundation of China under Grant No.62361146854Tsinghua-Tencent Joint Laboratory for Internet Innovation Technology.
文摘As the virtual reality(VR)technology strives to provide immersive and natural user experiences,the challenge of aligning vast virtual environments with limited physical spaces remains significant.This survey comprehensively explores the advancements in redirected walking(RDW)techniques aimed at overcoming spatial constraints in VR.RDW addresses this by subtly manipulating users’physical movements to allow for seamless navigation within constrained areas.The survey delves into gain perception mechanisms,detailing how slight discrepancies between virtual and real-world movements can be utilized without user awareness,thus extending the effective navigable space.Various RDW control algorithms for gain-based RDW are analyzed,highlighting their implementation and effectiveness in maintaining immersion and minimizing perceptual disturbances.Furthermore,novel methods extending beyond traditional gain-based techniques are discussed,showcasing innovative approaches that further refine VR interactions.The practical implications of RDW in enhancing safety and reducing physical collisions in VR environments are underscored,alongside its potential to improve user experience by aligning virtual exploration more closely with natural human behavior patterns.Through a thorough review of existing literature and recent advancements,this survey provides a systematic understanding for researchers,developers,and industry professionals.It underscores the importance of RDW in the future of VR,emphasizing RDW's role in making VR more accessible and practical across various applications,from education and training to therapy and entertainment.The paper concludes with a forward-looking perspective on the continued evolution and potential of RDW in revolutionizing virtual reality experiences.
文摘目的对运用反应中断再定向干预孤独症谱系障碍(ASD)儿童刻板语言的研究进行Scoping综述分析。方法检索EBSCO、PubMed、Web of Science、中国知网、万方数据库中使用反应中断再定向的方法对ASD儿童的刻板语言进行干预的相关文献,提取文献中的数据信息对其进行Scoping综述。结果最终纳入16篇英文文献,均采用单一受试时间序列研究设计。共涉及41例ASD儿童,出现刻板语言行为的ASD儿童基本语言功能有显著差异。刻板语言表现为语言和非语言声音两种形式。多数研究使用实验功能评价来确认刻板语言的功能,绝大多数ASD儿童刻板语言的功能为自动强化。实验功能评价以Iwata等的范式为主,其他评价范式在此范式基础上进行一定的改变,使操作更简洁。反应中断再定向常在个别化的情境中进行,少数研究尝试在特殊教育班级中进行。因刻板语言和其他行为的障碍程度不同,干预时长和频率差异较大。通过比较传统反应中断再定向与其变形程序对刻板语言的改善效果发现,改变再定向任务内容,减少再定向任务数量及不同执行时长对其效果没有显著影响。反应中断再定向与匹配刺激的非后效强化、反应代价、语言操作训练、药物治疗等方法进行比较的结果认为,反应中断再定向及其他方法(除药物治疗)都可以在一定程度上减少ASD儿童的刻板语言,并促进适当行为的出现,但反应中断再定向与匹配刺激、反应代价等其他方法共同使用会更有效。结论伴有刻板语言的ASD儿童具有不同功能性语言表现,其刻板语言表现形式包括语言和非语言的声音。刻板语言绝大多数功能为自动强化。反应中断再定向作为一种行为干预,均在个别化的情境下进行,干预时长和频率根据ASD儿童的刻板语言及其他行为障碍的严重程度等进行调整。改变再定向指令内容、数量等的变形反应中断再定向不会对行为改善结果有显著影响,匹配刺激和反应代价等其他干预方法也能够有效地减少刻板语言,但反应中断再定向与这些方法一同使用可能效果更好。反应中断再定向干预不仅可以有效改善ASD儿童语言功能,减少刻板语言,还能增加适当语言、任务参与、指令服从。
基金This workis supported by Natural Science Foundation of Jiangsu Province (BK2004218 ,BK2003106) Pandeng Project of Nanjing Universities of Postsand Telecommunications.
文摘Honeypot is a recent developed computer security concept which uses active offense to against attacks from hackers . It lures hackers to attack a seemly vulnerable fake network where they could be well observed in order to learn about the tactics and tools used by the attackers, so that we may improve the system security accordingly later. In this paper, we propose a novel approach for redirecting technique in honeypot system. First, we introduce briefly concepts of the honeypot system. Then we describe a redirection technique and an implementation algorithm. Finally, using the IDS Snort and the firewall IPTable, we set up a testing environment and give some simulations results. We also discuss some future research topics.
文摘Novel biologics that redirect cytotoxic T lymphocytes (CTLs) to kill tumor cells bearing a tumor associated antigen hold great promise in the clinic. However, the ability to safely and potently target CD3 on CTL toward tumor associated antigens (TAA) expressed on tumor cells remains a challenge of both technology and biol- ogy. Herein we describe the use of a Half DVD-Ig format that can redirect CTL to kill tumor cells. Notably, Half DVD-Ig molecules that are monovalent for each speci- ficity demonstrated reduced non-specific CTL activation and conditional CTL activation upon binding to TAA compared to intact tetravalent DVD-Ig molecules that are bivalent for each specificity, while maintaining good drug like properties and appropriate PK properties.
基金the National Natural Science Foundation of China under Grant Nos.61902012 and 61932003Frank Steinicke was supported by funds from the BMBF,BMWi,DFG,and EU.
文摘Virtual reality(VR)allows users to explore and experience a computer-simulated virtual environment so that VR users can be immersed in a totally artificial virtual world and interact with arbitrary virtual objects.However,the limited physical tracking space usually restricts the exploration of large virtual spaces,and VR users have to use special locomotion techniques to move from one location to another.Among these techniques,redirected walking(RDW)is one of the most natural locomotion techniques to solve the problem based on near-natural walking experiences.The core idea of the RDW technique is to imperceptibly guide users on virtual paths,which might vary from the paths they physically walk in the real world.In a similar way,some RDW algorithms imperceptibly change the structure and layout of the virtual environment such that the virtual environment fits into the tracking space.In this survey,we first present a taxonomy of existing RDW work.Based on this taxonomy,we compare and analyze both contributions and shortcomings of the existing methods in detail,and find view manipulation methods offer satisfactory visual effect but the experience can be interrupted when users reach the physical boundaries,while virtual environment manipulation methods can provide users with consistent movement but have limited application scenarios.Finally,we discuss possible future research directions,indicating combining artificial intelligence with this area will be effective and intriguing.
文摘With the support by the National Natural Science Foundation of China,the research team led by Dr.Liu Yuchen(刘宇辰)at the State Engineering Laboratory of Medical Key Technologies Application of Synthetic Biology,Shenzhen Second People’s Hospital,the First Affiliated Hospital of Shenzhen University,developed a type of CRISPR-based riboswitch,which was published in Nature Methods(2016,doi:10.