Oxidation and reduction are important chemical and biological processes. The redox state is related with physical functions and health. Thus, it is meaningful to develop tools for study the redox process.Fluorescence ...Oxidation and reduction are important chemical and biological processes. The redox state is related with physical functions and health. Thus, it is meaningful to develop tools for study the redox process.Fluorescence is a powerful method to connecting the microcosm and macrocosm. In this review, we discuss the recent progress of reversible fluorescent probes for chemical and biological redox process according to different active centers.展开更多
The vicinal dithiol motif is widely present in proteins, and is critical for proteins’ structures and functions.In recent years, a variety of fluorescent probes with high specificity and outstanding optical propertie...The vicinal dithiol motif is widely present in proteins, and is critical for proteins’ structures and functions.In recent years, a variety of fluorescent probes with high specificity and outstanding optical properties for sensing protein vicinal dithiols have been developed. In this review, we summarized the fluorescent probes of protein vicinal dithiols in literature. These probes are classified into four types based on their acceptor sites, i.e., biarsenical probes, monoarsenical probes, dimaleimide probes and diacrylate probes.Through analyzing the properties of different probes, we expect that this review would help readers further understand the structural factors of these probes and provide the design strategy for novel fluorescent probes with improved properties.展开更多
基金the National Nature Science Foundation of China (No. 21402120)the Shanghai Municipal Education Commission (No. 13CG48)the Ministry of Education of China (No. PCSIRT_IRT_16R49)
文摘Oxidation and reduction are important chemical and biological processes. The redox state is related with physical functions and health. Thus, it is meaningful to develop tools for study the redox process.Fluorescence is a powerful method to connecting the microcosm and macrocosm. In this review, we discuss the recent progress of reversible fluorescent probes for chemical and biological redox process according to different active centers.
基金financial supports from the National Natural Science Foundation of China (Nos. 21572093 & 21778028)the 111 Project
文摘The vicinal dithiol motif is widely present in proteins, and is critical for proteins’ structures and functions.In recent years, a variety of fluorescent probes with high specificity and outstanding optical properties for sensing protein vicinal dithiols have been developed. In this review, we summarized the fluorescent probes of protein vicinal dithiols in literature. These probes are classified into four types based on their acceptor sites, i.e., biarsenical probes, monoarsenical probes, dimaleimide probes and diacrylate probes.Through analyzing the properties of different probes, we expect that this review would help readers further understand the structural factors of these probes and provide the design strategy for novel fluorescent probes with improved properties.
