Main observation and conclusion A divergent and novel protocol for the preparation of both pyrido[2,3,4-kl]acridine and pyrido[4,3,2-kl]acridine alkaloids was developed.This method featured the remote palladium-cataly...Main observation and conclusion A divergent and novel protocol for the preparation of both pyrido[2,3,4-kl]acridine and pyrido[4,3,2-kl]acridine alkaloids was developed.This method featured the remote palladium-catalyzed reductive cyclization with Mo(CO)_(6) as reductant.A wide range of substrates including three types of nitro arenes were tolerated and afforded corresponding products in good to excellent yields.展开更多
A catalytic two-component three-centered(2C3C)Ugi-type reaction was developed for the synthesis of L-1-deoxynojirimycin(DNJ)isomers using a chiron approach.This new and quite mild catalytic system,comprised of phenylp...A catalytic two-component three-centered(2C3C)Ugi-type reaction was developed for the synthesis of L-1-deoxynojirimycin(DNJ)isomers using a chiron approach.This new and quite mild catalytic system,comprised of phenylphosphinic acid/Nal,was used to synthesize both the L-allo-DNJ and L-altro-DNJ in high yield.展开更多
The intermolecular reductive cyclization of o-nitrobenzene-sulfonamides with aliphatic ketones induced by TiCl4/Sm system was studied and a series of 3, 3-disubstituted-3,4-dihydro(2H)-1,2, 4-benzothiadiazine-1,1-diox...The intermolecular reductive cyclization of o-nitrobenzene-sulfonamides with aliphatic ketones induced by TiCl4/Sm system was studied and a series of 3, 3-disubstituted-3,4-dihydro(2H)-1,2, 4-benzothiadiazine-1,1-dioxides were synthesized in moderate to high yields under mild and neutral conditions.展开更多
Bis-silicon-bridged stilbene derivatives were synthesized in a modified procedure that combined the preparation of bis[2- (silyl)phenyl]acetylene and its intramolecular reductive cyclization in one pot. The results ...Bis-silicon-bridged stilbene derivatives were synthesized in a modified procedure that combined the preparation of bis[2- (silyl)phenyl]acetylene and its intramolecular reductive cyclization in one pot. The results indicated that the one pot approach produced target products in a comparable yield to that of the two-step method reported previously.展开更多
Dihydro-(2H)-1 .2.4-benzothiadizine-1. 1-dioixdes were prepared in good yields via reductive cyclization of o-nitrobenzenesulfonamidcs with aldchydes promoted by Sml2 under mild and neutral condition.
The intermolecular reductive coupling cyclization reactions of 1,1-dicyanoalkenes promoted by Sm-0/cat. HgCl2 were studied. A possible reaction mechanism was proposed.
Stannous chloride dihydrate is used as an efficient catalyst in reductive cyclization of 2-nitro-5- substituted aniline Schiff base leading to stable 2,5-disubstitued benzimidazole derivatives in excellent yields with...Stannous chloride dihydrate is used as an efficient catalyst in reductive cyclization of 2-nitro-5- substituted aniline Schiff base leading to stable 2,5-disubstitued benzimidazole derivatives in excellent yields with good purity. It provides a novel method of synthesis of 2,5-disubstitued benzimidazole under reductive system at room temperature.展开更多
Catalytic hydrogenation of 2-cyano-2-(2-nitrophenyl)acetates bearing an electron withdrawing substituent to the nitrile, using Hantzsch ester catalyzed by Pd/C, affords 2-aminoindoles in good to excellent yields.
基金This project is financially supported by the National Key Research and Development Program of China(No.2018YFC0310900)the National Natural Science Foundation of China(Nos.81903499 and 41729002)the Innovative Research Team of High-Level Local Universities in Shanghai(No.SSMU-ZLCX20180702).
文摘Main observation and conclusion A divergent and novel protocol for the preparation of both pyrido[2,3,4-kl]acridine and pyrido[4,3,2-kl]acridine alkaloids was developed.This method featured the remote palladium-catalyzed reductive cyclization with Mo(CO)_(6) as reductant.A wide range of substrates including three types of nitro arenes were tolerated and afforded corresponding products in good to excellent yields.
文摘A catalytic two-component three-centered(2C3C)Ugi-type reaction was developed for the synthesis of L-1-deoxynojirimycin(DNJ)isomers using a chiron approach.This new and quite mild catalytic system,comprised of phenylphosphinic acid/Nal,was used to synthesize both the L-allo-DNJ and L-altro-DNJ in high yield.
基金Project supported by the National Natural Science Foundation of China (No. 29872010)Natural Science Foundation of Zhejiang Province, China
文摘The intermolecular reductive cyclization of o-nitrobenzene-sulfonamides with aliphatic ketones induced by TiCl4/Sm system was studied and a series of 3, 3-disubstituted-3,4-dihydro(2H)-1,2, 4-benzothiadiazine-1,1-dioxides were synthesized in moderate to high yields under mild and neutral conditions.
文摘Bis-silicon-bridged stilbene derivatives were synthesized in a modified procedure that combined the preparation of bis[2- (silyl)phenyl]acetylene and its intramolecular reductive cyclization in one pot. The results indicated that the one pot approach produced target products in a comparable yield to that of the two-step method reported previously.
文摘Dihydro-(2H)-1 .2.4-benzothiadizine-1. 1-dioixdes were prepared in good yields via reductive cyclization of o-nitrobenzenesulfonamidcs with aldchydes promoted by Sml2 under mild and neutral condition.
基金ProjectsupportedbytheNationalNaturalScienceFoundationofChina (No .2 0 0 72 0 33)andtheNaturalScienceFoundationofZhejiangProvince (No .2 980 6 7) .
文摘The intermolecular reductive coupling cyclization reactions of 1,1-dicyanoalkenes promoted by Sm-0/cat. HgCl2 were studied. A possible reaction mechanism was proposed.
基金supported by Shanghai Municipal Natural Science Foundation(No.12ZR1434900)International Collabora-tion on Drugs and Diagnostics Innovation of Tropical Diseases in China(International S&T Cooperation 2010DFB73280)
文摘Stannous chloride dihydrate is used as an efficient catalyst in reductive cyclization of 2-nitro-5- substituted aniline Schiff base leading to stable 2,5-disubstitued benzimidazole derivatives in excellent yields with good purity. It provides a novel method of synthesis of 2,5-disubstitued benzimidazole under reductive system at room temperature.
基金We thank the National Natural Science Foundation of China
文摘Catalytic hydrogenation of 2-cyano-2-(2-nitrophenyl)acetates bearing an electron withdrawing substituent to the nitrile, using Hantzsch ester catalyzed by Pd/C, affords 2-aminoindoles in good to excellent yields.