Background: Gastroesophageal reflux disease (GERD) is a disorder resulting from the reversed flow of gastroduodenal contents into the esophagus, and producing different symptoms, while laryngopharyngeal reflux (LPR) i...Background: Gastroesophageal reflux disease (GERD) is a disorder resulting from the reversed flow of gastroduodenal contents into the esophagus, and producing different symptoms, while laryngopharyngeal reflux (LPR) is a disorder resulting from the reversed flow of gastric contents into the hypopharynx. The aim of this work is to evaluate LPR in cases of GERD. Methods: The present study was performed on fifty GERD patients diagnosed by gastroscope. LPR was assessed by reflux symptoms score (RSI) and reflux finding score (RFS). Accordingly, patients are classified into: Group I = 25 patients with manifest LPR, and Group II = 25 control patients without LPR symptoms. Results: GERD accounts for 17.4% of attendants of gastroscope unit, where manifest LPR accounts for 29.1% of GERD cases recording mean RSI and RFS 16.48 and 8.44 respectively. Silent LPR accounts for 8% recording mean RFS 7. Conclusion: There is a significant direct proportional relationship between severity of GERD and the RSI and RFS (p = 0.015 and 0.005 respectively).展开更多
目的初步研究白细胞介素-8(IL-8)在兔动物模型中的表达,并探讨其在咽喉反流发病中的作用。方法将20只普通级新西兰兔随机分为实验组和对照组,每组各10只。实验组采用扩张食管上、下括约肌的制作咽喉反流动物模型,对照组为假操作组。建...目的初步研究白细胞介素-8(IL-8)在兔动物模型中的表达,并探讨其在咽喉反流发病中的作用。方法将20只普通级新西兰兔随机分为实验组和对照组,每组各10只。实验组采用扩张食管上、下括约肌的制作咽喉反流动物模型,对照组为假操作组。建模完成后定期对动物进行24 h pH监测和反流体征量表(RFS)评分,并取上呼吸道不同部位组织进行免疫组化染色检测IL-8的表达水平。结果24 h pH监测结果显示实验组动物出现了明显的咽喉反流,与对照组相比,两组间Ryan指数阳性率差异具有统计学意义(P<0.001);实验组与对照组的RFS评分阳性率差异具有统计学意义(P=0.029)。实验组与对照组在声带部位的组间IL-8免疫组化染色评分差异具有统计学意义(P=0.015),在咽鼓管、扁桃体、下鼻甲部位差异无统计学意义(P>0.05)。结论咽喉反流可导致喉部IL-8的高表达,IL-8可能在咽喉反流的发生发展中起重要作用。展开更多
文摘Background: Gastroesophageal reflux disease (GERD) is a disorder resulting from the reversed flow of gastroduodenal contents into the esophagus, and producing different symptoms, while laryngopharyngeal reflux (LPR) is a disorder resulting from the reversed flow of gastric contents into the hypopharynx. The aim of this work is to evaluate LPR in cases of GERD. Methods: The present study was performed on fifty GERD patients diagnosed by gastroscope. LPR was assessed by reflux symptoms score (RSI) and reflux finding score (RFS). Accordingly, patients are classified into: Group I = 25 patients with manifest LPR, and Group II = 25 control patients without LPR symptoms. Results: GERD accounts for 17.4% of attendants of gastroscope unit, where manifest LPR accounts for 29.1% of GERD cases recording mean RSI and RFS 16.48 and 8.44 respectively. Silent LPR accounts for 8% recording mean RFS 7. Conclusion: There is a significant direct proportional relationship between severity of GERD and the RSI and RFS (p = 0.015 and 0.005 respectively).
文摘目的初步研究白细胞介素-8(IL-8)在兔动物模型中的表达,并探讨其在咽喉反流发病中的作用。方法将20只普通级新西兰兔随机分为实验组和对照组,每组各10只。实验组采用扩张食管上、下括约肌的制作咽喉反流动物模型,对照组为假操作组。建模完成后定期对动物进行24 h pH监测和反流体征量表(RFS)评分,并取上呼吸道不同部位组织进行免疫组化染色检测IL-8的表达水平。结果24 h pH监测结果显示实验组动物出现了明显的咽喉反流,与对照组相比,两组间Ryan指数阳性率差异具有统计学意义(P<0.001);实验组与对照组的RFS评分阳性率差异具有统计学意义(P=0.029)。实验组与对照组在声带部位的组间IL-8免疫组化染色评分差异具有统计学意义(P=0.015),在咽鼓管、扁桃体、下鼻甲部位差异无统计学意义(P>0.05)。结论咽喉反流可导致喉部IL-8的高表达,IL-8可能在咽喉反流的发生发展中起重要作用。
