Courtyard house is one of the symbols of Beijing's traditional culture.However,illegal self-constructions,over population and the phenomenon of multiple families crowding in one courtyard house have seriously dama...Courtyard house is one of the symbols of Beijing's traditional culture.However,illegal self-constructions,over population and the phenomenon of multiple families crowding in one courtyard house have seriously damaged the traditional courtyard houses and urban texture of Beijing.This article insists that due attention should be paid to the traditional cultures of the original residents and their actual requirements in the preservation and regeneration of the courtyard houses.It proposes a new prototype of multi-family courtyard house which might be a feasible mode for the preservation and regeneration of Beijing's traditional courtyard houses.In addition,based on the typology methods,the article analyzes the evolution of multi-family courtyard houses through investigating the layout of courtyards,and brings forward an idea for its preservation and regeneration.Finally,taking some specific areas of Hutongs and courtyard houses as examples,it also presents a simulation model to validate the feasibility of this mode.展开更多
Levodopa is the gold-standard treatment for Parkinson＇s disease. However, although it alleviates the clinical symptoms, it cannot delay the progressive apoptosis of dopaminergic neurons or prevent motor complications...Levodopa is the gold-standard treatment for Parkinson＇s disease. However, although it alleviates the clinical symptoms, it cannot delay the progressive apoptosis of dopaminergic neurons or prevent motor complications in the long term. In the present study, we investigated the effect of Shudipingchan granule on neuronal apoptosis in a rat model of Parkinson＇s disease, established by injecting 6-hydroxydopamine into the substantia nigra pars compacta and ventral tegmental area. We then administered levodopa （20 mg/kg intraperitoneally, twice daily） with or without Shudipingchan granule （7.5 mL/kg intragastrically, twice daily）, for 4 weeks. The long-term use of levodopa accel- erated apoptosis of nigral cells and worsened behavioral symptoms by activating the extracellular signal-regulated kinase pathway and downstream apoptotic factors. However, administration of Shudipingchan granule with levodopa reduced expression of phosphorylated extracellular signal-regulated kinase 1/2 and Bax, increased tyrosine hydroxylase and Bcl-2, reduced apoptosis in the substantia nigra, and markedly improved dyskinesia. These findings suggest that Shudipingchan granule suppresses neuronal apoptosis by inhibiting the hyper- phosphorylation of extracellular signal-regulated kinase and downregulating expression of anti-apoptotic genes. Shudipingchan granule, used in combination with levodopa, can effectively reduce the symptoms of Parkinson＇s disease.展开更多
It is understood from the Jiangxi Industry and Information Technology Committee that Jiangxi has started and signed for another batch of key non-ferrous metals projects in March.
文摘Courtyard house is one of the symbols of Beijing's traditional culture.However,illegal self-constructions,over population and the phenomenon of multiple families crowding in one courtyard house have seriously damaged the traditional courtyard houses and urban texture of Beijing.This article insists that due attention should be paid to the traditional cultures of the original residents and their actual requirements in the preservation and regeneration of the courtyard houses.It proposes a new prototype of multi-family courtyard house which might be a feasible mode for the preservation and regeneration of Beijing's traditional courtyard houses.In addition,based on the typology methods,the article analyzes the evolution of multi-family courtyard houses through investigating the layout of courtyards,and brings forward an idea for its preservation and regeneration.Finally,taking some specific areas of Hutongs and courtyard houses as examples,it also presents a simulation model to validate the feasibility of this mode.
基金financially supported by the National Natural Science Foundation of China,No.81302926,30472207the Major Project of Shanghai Science and Technology Commission of China,No.15401970100the Shanghai Municipal Commission of Health and Family Planning of China,No.ZY3-RCPY-2-2005
文摘Levodopa is the gold-standard treatment for Parkinson＇s disease. However, although it alleviates the clinical symptoms, it cannot delay the progressive apoptosis of dopaminergic neurons or prevent motor complications in the long term. In the present study, we investigated the effect of Shudipingchan granule on neuronal apoptosis in a rat model of Parkinson＇s disease, established by injecting 6-hydroxydopamine into the substantia nigra pars compacta and ventral tegmental area. We then administered levodopa （20 mg/kg intraperitoneally, twice daily） with or without Shudipingchan granule （7.5 mL/kg intragastrically, twice daily）, for 4 weeks. The long-term use of levodopa accel- erated apoptosis of nigral cells and worsened behavioral symptoms by activating the extracellular signal-regulated kinase pathway and downstream apoptotic factors. However, administration of Shudipingchan granule with levodopa reduced expression of phosphorylated extracellular signal-regulated kinase 1/2 and Bax, increased tyrosine hydroxylase and Bcl-2, reduced apoptosis in the substantia nigra, and markedly improved dyskinesia. These findings suggest that Shudipingchan granule suppresses neuronal apoptosis by inhibiting the hyper- phosphorylation of extracellular signal-regulated kinase and downregulating expression of anti-apoptotic genes. Shudipingchan granule, used in combination with levodopa, can effectively reduce the symptoms of Parkinson＇s disease.
文摘It is understood from the Jiangxi Industry and Information Technology Committee that Jiangxi has started and signed for another batch of key non-ferrous metals projects in March.
