Significant advances in regional groundwater flow modeling have been driven by the demand to predict regional impacts of human inferences on groundwater systems and associated environment. The wide availability of pow...Significant advances in regional groundwater flow modeling have been driven by the demand to predict regional impacts of human inferences on groundwater systems and associated environment. The wide availability of powerful computers, user friendly modeling systems and GIS stimulates an exponential growth of regional groundwater modeling. Large scale transient groundwater models have been built to analyze regional flow systems, to simulate water budget components changes, and to optimize groundwater develop- ment scenarios. This paper reviews the historical development of regional groundwater modeling. Examples of Death Valley and Great Artesian Basin transient groundwater models are introduced to show the application of large scale regional groundwater flow models. Specific methodologies for regional groundwater flow modeling are descried and special issues in regional groundwater flow modeling are discussed.展开更多
With continuous urbanization,cities are undergoing a sharp expansion within the regional space.Due to the high cost,the prediction of regional traffic flow is more difficult to extend to entire urban areas.To address ...With continuous urbanization,cities are undergoing a sharp expansion within the regional space.Due to the high cost,the prediction of regional traffic flow is more difficult to extend to entire urban areas.To address this challenging problem,we present a new deep learning architecture for regional epitaxial traffic flow prediction called GACNet,which predicts traffic flow of surrounding areas based on inflow and outflow information in central area.The method is data-driven,and the spatial relationship of traffic flow is characterized by dynamically transforming traffic information into images through a two-dimensional matrix.We introduce adversarial training to improve performance of prediction and enhance the robustness.The generator mainly consists of two parts:abstract traffic feature extraction in the central region and traffic prediction in the extended region.In particular,the feature extraction part captures nonlinear spatial dependence using gated convolution,and replaces the maximum pooling operation with dynamic routing,finally aggregates multidimensional information in capsule form.The effectiveness of the method is evaluated using traffic flow datasets for two real traffic networks:Beijing and New York.Experiments on highly challenging datasets show that our method performs well for this task.展开更多
Debris-flow disasters occurred frequently after the Mw 8.0 Wenchuan earthquake on 12 May 2008 in Sichuan Province, China. Based on historical accounts of debris-flow disaster events, it found that debris flow occurren...Debris-flow disasters occurred frequently after the Mw 8.0 Wenchuan earthquake on 12 May 2008 in Sichuan Province, China. Based on historical accounts of debris-flow disaster events, it found that debris flow occurrence is closely related to the impact of earthquakes and droughts, because earthquakedrought activities can increase the loose solid materials, which can transform into debris flows under the effect of rainstorms. Based on the analysis of historical earthquake activity(frequency, magnitude and location), drought indexes and the trend of climate change(amount of rainfall), a prediction method was established, and the regional debris flow susceptibility was predicted. Furthermore, in a debris flow-susceptible site, effective warning and monitoring are essential not only from an economicpoint of view but are also considered as a frontline approach to alleviate hazards. The advantages of the prediction and early monitoring include(1) the acquired results being sent to the central government for policy making;(2) lives and property in mountainous areas can be protected, such as the 570 residents in the Aizi valley, who evacuated successfully before debris flows in 2012;(3) guiding the government to identify the areas of disasters and the preparation for disaster prevention and mitigation, such as predicting disasters in high-risk areas in the period 2012-2017, helping the government to recognize the development trend of disasters;(4) the quantitative prediction of regional debris-flow susceptibility, such as after the Wenchuan earthquake, can promote scientific and sustainable development and socioeconomic planning in earthquake-struck areas.展开更多
Solutions for radial flow of a Bingham fluid are analyzed in this paper.It aims to eliminate confusions in the literature concerning the plug flow region in different solutions for analysis and design of grouting in r...Solutions for radial flow of a Bingham fluid are analyzed in this paper.It aims to eliminate confusions in the literature concerning the plug flow region in different solutions for analysis and design of grouting in rock fractures.The analyses based on the force balance equation reveal that the plug flow region in Bingham radial flow is independent of the fracture radius,and is not a growth function adapted from the solution of one-dimensional(1D)slit flow according to‘similarity’.Based on the shear stress distribution,we analytically proposed that a non-uniform plug flow region cannot exist.The Bingham fluid(grout)penetration and flowrate evolution as functions of grouting time are given using the correct expression for the plug flow region.The radius-independent plug flow region and the presented flowrate evolution equation are also verified numerically.For radial flow,the relative penetration length is equal to the relative width of plug flow region,which is the same as that for 1D channel flow.Discrepancies in analytical solutions for grout penetration and flowrate evolution were also illustrated.The clarification of the plug flow region and evaluation of discrepancies in analytical solutions presented in this work could simplify modeling and design of grouting in rock engineering applications.展开更多
Objective To evaluate in vivo stability of ethylenedylbis cysteine diethylester (ECD) brain SPECT. Methods Each of 13 normal volunteers (31. 2 ± 11. 8 years) has 12 dynamic SPECK scans ac-quired in 60min 1h after...Objective To evaluate in vivo stability of ethylenedylbis cysteine diethylester (ECD) brain SPECT. Methods Each of 13 normal volunteers (31. 2 ± 11. 8 years) has 12 dynamic SPECK scans ac-quired in 60min 1h after an injection of 99mTc-ECD using a triple headed gamma camera equipped with ultra high resolution fan beam collimators. Average counts per pixel were measured from frontal, temporal, parie-tal, occipital regions, cerebellum, basal ganglia, thalamus and white matter. Regional ECD clearance rates, regional gray-to-white matter (G/W) ratios and the change of the G/W ratio were calculated. Results The average ECD clearance rate was 4. 2% /h, ranged from 3. 03% /h to 5. 41% /h corresponding to white matter and occipital. There was no significant difference between regional ECD clearance rates. Regional G 7W ratio was between 1.27 to 1.75. The G/W ratio of temporal lobe was lower than the occipital ( P <0.05). The change of regional G/W ratio with time is slow. Conclusion Regional ECD distribution is stable in normal brain. ECD clearance from brain is slow and no significant regional difference.展开更多
Background Autism spectrum disorders (ASD), which include autism, asperger syndrome (AS) and pervasive developmental disorder-not otherwise specified (PDD-NOS), are devastating neurodevelopmental disorders of ch...Background Autism spectrum disorders (ASD), which include autism, asperger syndrome (AS) and pervasive developmental disorder-not otherwise specified (PDD-NOS), are devastating neurodevelopmental disorders of childhood resulting in deficits in social interaction, repetitive patterns of behaviors, and restricted interests and activities. Single photon emission computed tomography (SPECT) is a common technique used to measure regional cerebral blood flow (rCBF). Several studies have measured rCBF in children with ASD using SPECT, however, findings are discordant. In addition, the majority of subjects used in these studies were autistic. In this study, we aimed to investigate changes in rCBF in children with ASD using SPECT.Methods A Technetium-99m-ethyl cysteinate dimmer (99mTc-ECD) brain SPECT study was performed on an ASD group consisting of 23 children (3 girls and 20 boys; mean age (7.2±3.0) years) who were diagnosed according to Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSM-Ⅳ) criteria and an age-matched control group with 8children (1 girl and 7 boys, mean age (5.5±2.4) years). Image data were evaluated with Statistical Parametric Mapping,5th version (SPM5). A Student's t test for unpaired data was used to compare rCBF and asymmetry in the autism and corresponding control group. The covariance analysis, taking age as covariance, was performed between the ASD and control group.Results There was a significant reduction in rCBF in the bilateral frontal lobe (frontal poles, arcula frontal gyrus) and the bilateral basal ganglia in the autism group, and a reduction in the bilateral frontal, temporal, parietal, legumina nucleus and cerebellum in the AS group compared to the control. In addition, asymmetry of hemispheric hypoperfusion in the ASD group was observed. Inner-group comparison analysis revealed that rCBF decreased significantly in the bilateral frontal lobe (42.7%), basal nucleus (24.9%) and temporal lobe (22.8%) in the autism group, and in the bilateral cerebellum (22.8%), basal nucleus (19.3%) and right thalamencephalon (16.6%)in the AS group (P <0.05).Conclusions The decrease in rCBF in ASD is a global event, which involves the bilateral frontal, temporal, limbic system and basal ganglias. Asymmetry of hemispheric hypoperfusion was more obvious in the AS group than the autism group, which indicates a different neurobiological mechanism from that of autism.展开更多
Background Standard superficial temporal artery-middle cerebral artery (STA-MCA) bypass surgery is an effective treatment for moyamoya disease, but recent evidence suggests that postoperative cerebral hyperperfusion...Background Standard superficial temporal artery-middle cerebral artery (STA-MCA) bypass surgery is an effective treatment for moyamoya disease, but recent evidence suggests that postoperative cerebral hyperperfusion can occur. In this study, the trendline of changes in regional cerebral blood flow (rCBF) after surgery were continually monitored near the site of anastomosis in order to investigate both the efficacy of the procedure for improving rCBF and the possible risk of hyperperfusion . Methods Standard STA-MCA bypass surgery was performed on 13 patients, rCBF was measured continually using laser Doppler flowmetry (LDF) until the 5th day after the operation with the LDF probe implanted adjacent to the area of the anastomosis. The trendline of rCBF changes postoperatively was recorded for the analysis performed using SPSS 13.0. Results The baseline LDF value of cortical rCBF was (84.68±14.39) perfusion unit (PU), which was linear relative to absolute perfusion volume before anastomosis and (88.90±11.26) PU immediately after anastomosis (P 〉0.05). The value changed significantly from before to after anastomosis (P 〈0.05); it was (417.72±21.35) PU on the 1st day after surgery, and (358.99±18.01) PU, (323.46±17.38) PU, (261.60±16.38) PU and (375.72±18.45) PU on the following 4 days, respectively. The rCBF decreased gradually from the 2nd day until the 4th postoperative day, but still was at a high level (P 〈0.05). However, on the 5th postoperative day the rCBF increased again to the second highest level, which was significantly different compared with the baseline value (P 〈0.05), but not significantly different compared with the values on the other 4 days (P〉0.05). Conclusions STA-MCA anastomosis improves the cerebral blood supply significantly in the early stage after surgery, however, the risk of symptomatic hyperperfusion may exist, which may possibly occur on the 1st day and 5th day after surgery. A LDF is useful for postoperative monitoring for both the efficacy of bypass and possible risk of neurologic deterioration or bleeding from hyperperfusion.展开更多
Recent reports have shown that apolipoprotein E (APOE) polymorphisms are involved in neurodegenerative disease. However, it is unclear whether APOE affects post-stroke depression. Accordingly, we hypothesized that A...Recent reports have shown that apolipoprotein E (APOE) polymorphisms are involved in neurodegenerative disease. However, it is unclear whether APOE affects post-stroke depression. Accordingly, we hypothesized that APOE polymorphisms modify the risk of post-stroke depression. Here, we performed a hospital-based case-control study (including 76 cerebral infarction cases with post-stroke depression, 88 cerebral infarction cases without post-stroke depression, and 109 controls without any evidence of post-stroke depression or cerebral infarction) to determine possible association between APOE rs429358 and rs7412 polymorphisms and risk of post-stroke depression. Our findings show no difference among the groups with regards genotype distribution of the rs7412 polymorphism. In contrast, APOE genotypes with rs429358-C alleles increased the risk of post-stroke depression. Further, the rs429358 polymorphism was associated with significantly decreased regional cerebral blood flow values in the left temporal lobe of post-stroke depression cases. Additionally, the rs429358 polymorphism was not only associated with depression severity, but with increasing serum levels of total cholesterol. These resuits suggest that the APOE rs429358 polymorphism is associated with increased risk of developing post-stroke depression, and that APOE rs429358-C allele genotypes may be detrimental to recovery of nerve function after stoke. Indeed, these findings provide clinical data for future post-stroke depression gene interventions.展开更多
Objective To investigate pre- and postoperative changes of regional cerebral cortical blood flow in patients with cerebral arteriovenous malformation. Method Twenty-two adult patients with arteriovenous malformatio...Objective To investigate pre- and postoperative changes of regional cerebral cortical blood flow in patients with cerebral arteriovenous malformation. Method Twenty-two adult patients with arteriovenous malformation(AVM) were recruited into this study at Beijing Tiantan Hospital from September 2001 to May 2002. Eight patients had giant cerebral AVM and the other 14 had a small one. Cortical cerebral blood flow (CBF) was measured by laser Doppler flowmetry (LDF) before and after AVM resections. After surgery,the probe of LDF was implanted adjacent to the area of AVM and monitored for 24 hours.Results CBF increased significantly after the resection in all patients regardless of AVM size. In patients with small AVM,CBF returned to the baseline level within 4 hours,but in patients with giant AVM,CBF remained high even after 24 hours.Conclusions Monitoring CBF is helpful to understand pre- and postoperative changes of regional cortical CBF in patients with cerebral AVM.展开更多
AIM:To evaluate the possible effects of phacoemulsification cataract surgery on ocular hemodynamics.·METHODS:In this prospective study,intraocular pressure(IOP),pulsatile ocular blood flow(POBF),and ocular pulse ...AIM:To evaluate the possible effects of phacoemulsification cataract surgery on ocular hemodynamics.·METHODS:In this prospective study,intraocular pressure(IOP),pulsatile ocular blood flow(POBF),and ocular pulse amplitude(OPA) were measured pre-operatively(baseline) and at 1 week and 3 weeks postoperation in 52 eyes of 26 patients(mean age 63.15±10.25 years) scheduled for unilateral phacoemulsification cataract surgery with intraocular lens implantation.In all of the eyes,a blood flow analyzer(Paradigm DICON;Paradigm Medical Industries Inc.;USA) was used to obtain measurements of IOP,POBF,and OPA.The data obtained from operated eyes were compared statistically to untreated fellow phakic eyes of the patients.·RESULTS:For operated eyes,the mean baseline IOP,POBF,and OPA values were 15.9±4.64mmHg,17.41±4.84μL/s,and 2.91 ±1.12mmHg,respectively.The IOP,POBF,and OPA values were 17.19 ±4.34mmHg,17.56 ±6.46μL/s,and3.12 ±1.1mmHg,respectively,in the nonoperated control eyes.Statistically significant differences from baseline measurements were not observed 1 week and 3 weeks postoperation for the operated or nonoperated eyes.There were also no statistically significant differences in any measurements between the operated and nonoperated eyes in all the examination periods(P 】0.05for all).·CONCLUSION:Uncomplicated phacoemulsification surgery does not affect ocular hemodynamics in normotensive eyes with cataracts.展开更多
BACKGROUND: Presently, clinic memory scale is used to evaluate learning memory ability in most studies, and the influence of difference in measurement condition of individuals exists. OBJECTIVE: To study the correla...BACKGROUND: Presently, clinic memory scale is used to evaluate learning memory ability in most studies, and the influence of difference in measurement condition of individuals exists. OBJECTIVE: To study the correlation between regional cerebral blood flow (rCBF) perfusion and learning memory function in special brain regions of patients with cerebral infarction at convalescent period, and to try to find out a method which can quantitatively evaluate learning ability. DESIGN: Case observation, and correlation analysis. SETTINGS: Shandong Institute for Behavioral Medicine; the Affiliated Hospital of Jining Medical College. PARTICIPANTS: Totally 70 patients with cerebral infarction admitted to Department of Neurology, Jining Medical College between January 2004 and December 2005 were involved. The involved patients, 58 male and 12 female, were averaged (52±3) years, and they were all right handed. They all met the diagnosis criteria instituted by the Fourth National Conference on Cerebrovascular Disease, and were confirmed as cerebral infarction by skull CT or MRI. Informed consents of detected items were obtained from all the patients and relatives. METHODS: When the patients were at convalescent period, their learning and memory ability were measured with “ clinic memory scale (set A)”. The 18 patients whose total mark over 100 were regarded as good learning memory function group; The 23 cases whose total mark less than 70 were regarded as poor learning memory function group. RCBF of hippocampus, nucleus amygdalae, temporal cortex and prefrontal lobe of patients between two groups were measured and compared by single photon emission computed tomography (SPECT). The total scores of the 18 good learning memory patients and 23 poor learning memory patients were taken as dependent variable Y, and their rCBFs of hippocampus, nucleus amygdale, temporal cortex and prefrontal lobe respectively as independent variable X for linear correlation analysis. MAIN OUTCOME MEASURES: Correlation of rCBF in different brain regions and learning memory ability in patients with cerebral infarction. RESULTS: ①The rCBF of hippocampus, nucleus amygdale, temportal cortex and prefrontal cortex of good learning memory function group were significantly higher than those of poor learning memory function group (P 〈 0.05). ②In the good learning memory function group, rCBF of hippocampus, nucleus amygdale, temportal cortex and prefrontal cortex were significantly positively correlated with memory scale scores ( r = 0.961, 0.926, 0.954, 0.907, P 〈 0.05 ) , and also in the poor learning memory function group (r = 0.979, 0.976, 0.991, 0.953, P 〈 0.05 ) . CONCLUSION: The rCBF of hippocampus, nucleus amygdale, temportal cortex and prefrontal cortex of patients with cerebral infarction are significantly positively correlated with memory scale scores. Predicting learning memory ability of patients by quantitative determination of rCBF provides a quantitative and objective method for evaluating learning memory ability.展开更多
Background: Few previous studies have described other than age- and gender related changes in regional cerebral blood flow (rCBF) in healthy elderly. What is the influence of other common clinically relevant variables...Background: Few previous studies have described other than age- and gender related changes in regional cerebral blood flow (rCBF) in healthy elderly. What is the influence of other common clinically relevant variables such as ache, education, MMSE, and smoking history? Purpose: To study rCBF in Swedish healthy elderly by single-photon emission computed tomography (SPECT) and evaluate the influence on rCBF of age, gender, education, MMSE, ache, and smoking with a focus on education in relation to the ‘cognitive reserve’. Methods: Healthy subjects (n = 45, 50 -75 y), sampled from a large longitudinal aging study took part in an extensive examination of health and memory, including cognitive testing and socio-economic survey. After injection of 99 mTc-hexamethylpropylene amine oxime (HMPAO) followed by SPECT the rCBF-SPECT images were analyzed using statistical parametric mapping (SPM). Results: Age-related decreases in uptake were seen in interhemispheric and interlobar regions. There was a positive rCBF correlation with education in the inferior frontal lobe and a higher uptake in the left temporal lobe in an age-gender-matched high education subgroup. Conclusion: The localization of the age related findings except for the medial temporal lobe differs markedly from typical dementia related findings. A reduction close to interhemispheric or interlobar space should always be related to chronological age. Education seems to have an influence on basal brain function at a resting-state condition. Knowledge of normal rCBF variations for variables such as age and education should be considered when making clinical diagnosis. The findings could be interpreted as further support for the theory of cognitive reserve.展开更多
Objective: To investigate the effects of CO2 pneumo-peritoneum on blood flow volume of abdominal organs of rabbits with controlled hemorrhagic shock model and liver impact injuries.Methods: After controlled hemorrhagi...Objective: To investigate the effects of CO2 pneumo-peritoneum on blood flow volume of abdominal organs of rabbits with controlled hemorrhagic shock model and liver impact injuries.Methods: After controlled hemorrhagic shock and liver impact injuries, the rabbit model was established. Eighteen rabbits subjected to hemorrhagic shock and liver impact inju-ries were divided into 3 groups randomly according to the volume of lost blood: light hemorrhagic shock (blood loss volume was 10%, 6 ml/kg), moderate hemorrhagic shock (20%, 12 ml/kg) and severe hemorrhagic shock (40%, 22 ml/kg). Intraabdominal pressures of CO2 pneumoperitoneum was 10 mmHg. Color-labeled microspheres were used to mea-sure the blood flow volume of the liver, kidney and stomach before pneumoperitoneum at 30 minutes and 2 hours after pneumoperitoneum and 30 minutes after deflation. And the mortality and hepatic traumatic condition of rabbits were recorded.Results: Of the 18 rabbits, there were 9 with liver impact injuries at Grade Ⅰ, 8 at Grade Ⅱ and Ⅰ at Grade Ⅲ (according to AIS-2005). The mortality rate in light hemorrhagic shock group was 33.33%, and that in moderate or severe hemor-rhagic shock group was 100% within 30 minutes and 2 hours after pneumoperitoneum, respectively. The blood flow vol-ume in the organs detected decreased at 30 minutes under pneumoperitoneum in light and moderate hemorrhagic shock groups. At the same time, the blood flow volume of the liver in moderate hemorrhagic shock group decreased more sig-nificantly than that in light hemorrhagic shock group.Conclusions: The blood flow volume of abdominal organs in rabbits is decreased obviously under CO2 pneumoperitoneum, with fairly high mortality rate. It is be-lieved that CO2 pneumoperitoneum should cautiously be used in abdominal injury accompanied with hemorrhagic shock, especially under non-resuscitation conditions.展开更多
Background:Bipolar electro-coagulation has a reported efficacy in treating epilepsy involving functional cortex by pure electro-coagulation or combination with resection.However,the mechanisms of bipolar electro-coag...Background:Bipolar electro-coagulation has a reported efficacy in treating epilepsy involving functional cortex by pure electro-coagulation or combination with resection.However,the mechanisms of bipolar electro-coagulation are not completely known.We studied the acute cortical blood flow and histological changes after bipolar electro-coagulation in 24 patients with intractable temporal lobe epilepsy.Methods:Twenty-four patients were consecutively enrolled,and divided into three groups according to the date of admission.The regional cortical blood flow (rCBF),electrocorticography,the depth of cortex damage,and acute histological changes (H and E staining,neuronal staining and neurofilament (NF) staining) were analyzed before and after the operation.The t-test analysis was used to compare the rCBF before and after the operation.Results:The rCBF after coagulation was significantly reduced (P 〈 0.05).The spikes were significantly reduced after electro-coagulation.For the temporal cortex,the depth of cortical damage with output power of 2-9 W after electro-coagulation was 0.34 ± 0.03,0.48 ± 0.06,0.69 ± 0.06,0.84 ± 0.09,0.98 ± 0.08,1.10 ± 0.1 l,1.11 ± 0.09,and 1.22 ± 0.11 mm,respectively.Coagulation with output power of 4-5 W completely damaged the neurons and NF protein in the molecular layer,external granular layer,and external pyramidal layer.Conclusions:The electro-coagulation not only destroyed the neurons and NF protein,but also reduced the rCBF.We concluded that the injuries caused by electro-coagulation would prevent horizontal synchronization and spread of epileptic discharges,and partially destroy the epileptic focus.展开更多
To study the influence of back feeding particles on gas-solid flow in the riser, this paper investigated the flow asymmetry in the solid entrance region of a fluidized bed by particle concentration/velocity measuremen...To study the influence of back feeding particles on gas-solid flow in the riser, this paper investigated the flow asymmetry in the solid entrance region of a fluidized bed by particle concentration/velocity measurements in a cold square circulating fluidized beds (CFB). The pressure drop distribution along the riser and the saturation carrying capacity of gas for Geldart-B type particles were first analyzed. Under the condition of u0 = 4 m/s and Gs = 21 kg/(m^2 s), the back feeding particles were found to penetrate the lean gas-solid flow near the entrance (rear) wall before reaching the opposite (front) wall, thus leading to a relatively denser region near the front wall in the bottom bed. Higher solid circulation rate (u0 =4 m/s, Gs = 33 kg/(m^2 s)) resulted in a higher particle concentration in the riser. However the back feeding particles with higher momentum increased the asymmetry of the particle concentration/velocity profile in the solid entrance region. Lower air velocity (u0 =3.2 m/s) and Gs =21 kg/(m2 s), beyond the saturation carrying capacity of gas, induced an S-shaped axial solid distribution with a denser bottom zone. This limited the penetration of the back feeding particles and forced the flnidizing air to flow in the central region, thus leading to a higher solid holdup near the rear wall. Under the conditions of uo = 4 m/s and Gs = 21 kg/(m^2 s), addition of coarse particles (dp= 1145 μm) into the bed made the radial distribution of solids more symmetrical.展开更多
In the present work,a slot-type flip bucket with separated flows,called SFS-type flip bucket,is developed,and flow regime and energy dissipation are experimentally investigated.Comparing with the circular-shaped or sl...In the present work,a slot-type flip bucket with separated flows,called SFS-type flip bucket,is developed,and flow regime and energy dissipation are experimentally investigated.Comparing with the circular-shaped or slot-type flip bucket buckets,the present SFS-type flip bucket has better flow regime and larger energy dissipation since the three branches of the flows are separated through the outlet of the flip bucket.Meanwhile,the energy dissipation for this flip bucket is estimated.展开更多
During multi-jet cooling,the complex hydrodynamic characteristics caused by the interaction between jets will affect the heat transfer of the plate.To further clarify the heat transfer characteristics in different flo...During multi-jet cooling,the complex hydrodynamic characteristics caused by the interaction between jets will affect the heat transfer of the plate.To further clarify the heat transfer characteristics in different flow regions,the double-jet cooling experiments were completed on a 50-mm-thick plate with the initial cooling temperature and jet angle in the range of 300–900°C and 0°–60°,respectively.The inverse heat conduction was used to calculate the surface temperature and heat flux.Furthermore,the rewetting phenomenon,maximum heat flux and maximum cooling speed were studied.The results show that increasing the angle between jet and wall normal would increase the wetting front’s width downstream of the jet point.When the jet angle was 60°,the maximum value increased by 37.29 mm compared with that when the angle was 0.The correlation between the width of the wetting front and the radial temperature gradient was further confirmed.In addition,it was found that the maximum heat flux would be affected by the duration of transition boiling,but not affected by complete wetting time.The results clarified the heat transfer mechanisms under various initial cooling temperature and inclination angle conditions on plate cooling in different flow regions,and provided valuable data for controlling heat transfer efficiency and improving cooling uniformity.展开更多
Background The solitary pulmonary nodule (SPN) is one of the most common findings on chest radiographs. The objectives of clinical practice are to differentiate malignant nodules from benign nodules in the least inv...Background The solitary pulmonary nodule (SPN) is one of the most common findings on chest radiographs. The objectives of clinical practice are to differentiate malignant nodules from benign nodules in the least invasive way and to make a specific diagnosis. This study was aimed to evaluate the correlation between perfusion imaging features and microvessel density (MVD) and vascular endothelial growth factors (VEGF) in SPNs using multi-slice computed tomography (MSCT); and to provide the theoretical basis for SPN blood flow pattern and blood flow quantitative features. Also, the study called for the discussion of the method's clinical application value in the differential diagnosis of benign and malignant SPNs.Methods Sixty-eight patients with SPN underwent multi-location dynamic contrast enhanced (nonionic contrast material was administrated via the antecubital vein at a rate of 4 ml/s) MSCT. Precontrast and postcontrast attenuations on every scan was studied. Perfusion, peak height, and the ratio of the peak height of the SPN to that of the aorta were analyzed. Perfusion was calculated using the maximum gradient of the time-density curves (TDC) and the peak height of the aorta. The quantitative parameters (perfusion, peak height, ratio of peak height of the SPN to that of the aorta) of the blood flow pattern were compared with MVD and the VEGF expression of immunohistochemistry. Results The perfusion peak heights of malignant ((96.15±11.55) HU) and inflammatory ((101.15±8.41) HU) SPNs were significantly higher than those of benign ((47.24±9.15) HU) SPNs (P 〈0.05, P 〈0.05). Ratios of SPN-to-aorta of malignant and inflammatory SPNs were significantly higher than those of benign SPNs (P 〈0.05, P 〈0.05). No significant differences were found between the peak height and SPN-to-aorta ratio of malignant SPNs and inflammatory SPNs (P 〉0.05, P 〉0.05). The precontrast densities of inflammatory SPNs were lower than those of malignant SPNs (P 〈0.05). Perfusion values of malignant and inflammatory SPNs were significantly higher than those of the benign SPNs (P 〈0.05, P 〈0.05). The VEGF positive expressions appeared in 32 patients with malignant SPNs and 2 patients with benign SPNs, and the average value of the MVD was higher in patients with malignant SPNs (36.88±6.76) than in patients with either benign (4.51±0.60) or inflammatory (26.11±5.43) SPNs (P 〈0.05, P 〈0.05). There were statistically significant correlations between the CT perfusion feature and the MVD. The highest correlation was between the peak height of SPN and the MVD (r=0.657, P 〈0.05).Conclusions Tumor microvessel density and VEGF expression facilitate the exploration of the pathophysiological basis of CT perfusion in SPNs. Multi-slice CT perfusion has shown strong positive correlations with angiogenesis in SPNs.展开更多
文摘Significant advances in regional groundwater flow modeling have been driven by the demand to predict regional impacts of human inferences on groundwater systems and associated environment. The wide availability of powerful computers, user friendly modeling systems and GIS stimulates an exponential growth of regional groundwater modeling. Large scale transient groundwater models have been built to analyze regional flow systems, to simulate water budget components changes, and to optimize groundwater develop- ment scenarios. This paper reviews the historical development of regional groundwater modeling. Examples of Death Valley and Great Artesian Basin transient groundwater models are introduced to show the application of large scale regional groundwater flow models. Specific methodologies for regional groundwater flow modeling are descried and special issues in regional groundwater flow modeling are discussed.
基金This work was funded by the National Natural Science Foundation of China under Grant(Nos.61762092 and 61762089).
文摘With continuous urbanization,cities are undergoing a sharp expansion within the regional space.Due to the high cost,the prediction of regional traffic flow is more difficult to extend to entire urban areas.To address this challenging problem,we present a new deep learning architecture for regional epitaxial traffic flow prediction called GACNet,which predicts traffic flow of surrounding areas based on inflow and outflow information in central area.The method is data-driven,and the spatial relationship of traffic flow is characterized by dynamically transforming traffic information into images through a two-dimensional matrix.We introduce adversarial training to improve performance of prediction and enhance the robustness.The generator mainly consists of two parts:abstract traffic feature extraction in the central region and traffic prediction in the extended region.In particular,the feature extraction part captures nonlinear spatial dependence using gated convolution,and replaces the maximum pooling operation with dynamic routing,finally aggregates multidimensional information in capsule form.The effectiveness of the method is evaluated using traffic flow datasets for two real traffic networks:Beijing and New York.Experiments on highly challenging datasets show that our method performs well for this task.
基金funded by National Natural Science Foundation of China(Grant No.41671112 and 41861134008)National Key Research and Development Plan(Grant No.2018YFC1505202)Sichuan Province Science and Technology Plan Project Key research and development projects(Grant No.18ZDYF0329)
文摘Debris-flow disasters occurred frequently after the Mw 8.0 Wenchuan earthquake on 12 May 2008 in Sichuan Province, China. Based on historical accounts of debris-flow disaster events, it found that debris flow occurrence is closely related to the impact of earthquakes and droughts, because earthquakedrought activities can increase the loose solid materials, which can transform into debris flows under the effect of rainstorms. Based on the analysis of historical earthquake activity(frequency, magnitude and location), drought indexes and the trend of climate change(amount of rainfall), a prediction method was established, and the regional debris flow susceptibility was predicted. Furthermore, in a debris flow-susceptible site, effective warning and monitoring are essential not only from an economicpoint of view but are also considered as a frontline approach to alleviate hazards. The advantages of the prediction and early monitoring include(1) the acquired results being sent to the central government for policy making;(2) lives and property in mountainous areas can be protected, such as the 570 residents in the Aizi valley, who evacuated successfully before debris flows in 2012;(3) guiding the government to identify the areas of disasters and the preparation for disaster prevention and mitigation, such as predicting disasters in high-risk areas in the period 2012-2017, helping the government to recognize the development trend of disasters;(4) the quantitative prediction of regional debris-flow susceptibility, such as after the Wenchuan earthquake, can promote scientific and sustainable development and socioeconomic planning in earthquake-struck areas.
基金funding for this study is provided by the BeFo Rock Engineering Research Foundation(Grant No.392)。
文摘Solutions for radial flow of a Bingham fluid are analyzed in this paper.It aims to eliminate confusions in the literature concerning the plug flow region in different solutions for analysis and design of grouting in rock fractures.The analyses based on the force balance equation reveal that the plug flow region in Bingham radial flow is independent of the fracture radius,and is not a growth function adapted from the solution of one-dimensional(1D)slit flow according to‘similarity’.Based on the shear stress distribution,we analytically proposed that a non-uniform plug flow region cannot exist.The Bingham fluid(grout)penetration and flowrate evolution as functions of grouting time are given using the correct expression for the plug flow region.The radius-independent plug flow region and the presented flowrate evolution equation are also verified numerically.For radial flow,the relative penetration length is equal to the relative width of plug flow region,which is the same as that for 1D channel flow.Discrepancies in analytical solutions for grout penetration and flowrate evolution were also illustrated.The clarification of the plug flow region and evaluation of discrepancies in analytical solutions presented in this work could simplify modeling and design of grouting in rock engineering applications.
文摘Objective To evaluate in vivo stability of ethylenedylbis cysteine diethylester (ECD) brain SPECT. Methods Each of 13 normal volunteers (31. 2 ± 11. 8 years) has 12 dynamic SPECK scans ac-quired in 60min 1h after an injection of 99mTc-ECD using a triple headed gamma camera equipped with ultra high resolution fan beam collimators. Average counts per pixel were measured from frontal, temporal, parie-tal, occipital regions, cerebellum, basal ganglia, thalamus and white matter. Regional ECD clearance rates, regional gray-to-white matter (G/W) ratios and the change of the G/W ratio were calculated. Results The average ECD clearance rate was 4. 2% /h, ranged from 3. 03% /h to 5. 41% /h corresponding to white matter and occipital. There was no significant difference between regional ECD clearance rates. Regional G 7W ratio was between 1.27 to 1.75. The G/W ratio of temporal lobe was lower than the occipital ( P <0.05). The change of regional G/W ratio with time is slow. Conclusion Regional ECD distribution is stable in normal brain. ECD clearance from brain is slow and no significant regional difference.
基金This study was supported by a grant from the National Natural Science Foundation of China (No. 30872130).
文摘Background Autism spectrum disorders (ASD), which include autism, asperger syndrome (AS) and pervasive developmental disorder-not otherwise specified (PDD-NOS), are devastating neurodevelopmental disorders of childhood resulting in deficits in social interaction, repetitive patterns of behaviors, and restricted interests and activities. Single photon emission computed tomography (SPECT) is a common technique used to measure regional cerebral blood flow (rCBF). Several studies have measured rCBF in children with ASD using SPECT, however, findings are discordant. In addition, the majority of subjects used in these studies were autistic. In this study, we aimed to investigate changes in rCBF in children with ASD using SPECT.Methods A Technetium-99m-ethyl cysteinate dimmer (99mTc-ECD) brain SPECT study was performed on an ASD group consisting of 23 children (3 girls and 20 boys; mean age (7.2±3.0) years) who were diagnosed according to Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSM-Ⅳ) criteria and an age-matched control group with 8children (1 girl and 7 boys, mean age (5.5±2.4) years). Image data were evaluated with Statistical Parametric Mapping,5th version (SPM5). A Student's t test for unpaired data was used to compare rCBF and asymmetry in the autism and corresponding control group. The covariance analysis, taking age as covariance, was performed between the ASD and control group.Results There was a significant reduction in rCBF in the bilateral frontal lobe (frontal poles, arcula frontal gyrus) and the bilateral basal ganglia in the autism group, and a reduction in the bilateral frontal, temporal, parietal, legumina nucleus and cerebellum in the AS group compared to the control. In addition, asymmetry of hemispheric hypoperfusion in the ASD group was observed. Inner-group comparison analysis revealed that rCBF decreased significantly in the bilateral frontal lobe (42.7%), basal nucleus (24.9%) and temporal lobe (22.8%) in the autism group, and in the bilateral cerebellum (22.8%), basal nucleus (19.3%) and right thalamencephalon (16.6%)in the AS group (P <0.05).Conclusions The decrease in rCBF in ASD is a global event, which involves the bilateral frontal, temporal, limbic system and basal ganglias. Asymmetry of hemispheric hypoperfusion was more obvious in the AS group than the autism group, which indicates a different neurobiological mechanism from that of autism.
文摘Background Standard superficial temporal artery-middle cerebral artery (STA-MCA) bypass surgery is an effective treatment for moyamoya disease, but recent evidence suggests that postoperative cerebral hyperperfusion can occur. In this study, the trendline of changes in regional cerebral blood flow (rCBF) after surgery were continually monitored near the site of anastomosis in order to investigate both the efficacy of the procedure for improving rCBF and the possible risk of hyperperfusion . Methods Standard STA-MCA bypass surgery was performed on 13 patients, rCBF was measured continually using laser Doppler flowmetry (LDF) until the 5th day after the operation with the LDF probe implanted adjacent to the area of the anastomosis. The trendline of rCBF changes postoperatively was recorded for the analysis performed using SPSS 13.0. Results The baseline LDF value of cortical rCBF was (84.68±14.39) perfusion unit (PU), which was linear relative to absolute perfusion volume before anastomosis and (88.90±11.26) PU immediately after anastomosis (P 〉0.05). The value changed significantly from before to after anastomosis (P 〈0.05); it was (417.72±21.35) PU on the 1st day after surgery, and (358.99±18.01) PU, (323.46±17.38) PU, (261.60±16.38) PU and (375.72±18.45) PU on the following 4 days, respectively. The rCBF decreased gradually from the 2nd day until the 4th postoperative day, but still was at a high level (P 〈0.05). However, on the 5th postoperative day the rCBF increased again to the second highest level, which was significantly different compared with the baseline value (P 〈0.05), but not significantly different compared with the values on the other 4 days (P〉0.05). Conclusions STA-MCA anastomosis improves the cerebral blood supply significantly in the early stage after surgery, however, the risk of symptomatic hyperperfusion may exist, which may possibly occur on the 1st day and 5th day after surgery. A LDF is useful for postoperative monitoring for both the efficacy of bypass and possible risk of neurologic deterioration or bleeding from hyperperfusion.
基金supported in part by the National Natural Science Foundation of China,No.81160146
文摘Recent reports have shown that apolipoprotein E (APOE) polymorphisms are involved in neurodegenerative disease. However, it is unclear whether APOE affects post-stroke depression. Accordingly, we hypothesized that APOE polymorphisms modify the risk of post-stroke depression. Here, we performed a hospital-based case-control study (including 76 cerebral infarction cases with post-stroke depression, 88 cerebral infarction cases without post-stroke depression, and 109 controls without any evidence of post-stroke depression or cerebral infarction) to determine possible association between APOE rs429358 and rs7412 polymorphisms and risk of post-stroke depression. Our findings show no difference among the groups with regards genotype distribution of the rs7412 polymorphism. In contrast, APOE genotypes with rs429358-C alleles increased the risk of post-stroke depression. Further, the rs429358 polymorphism was associated with significantly decreased regional cerebral blood flow values in the left temporal lobe of post-stroke depression cases. Additionally, the rs429358 polymorphism was not only associated with depression severity, but with increasing serum levels of total cholesterol. These resuits suggest that the APOE rs429358 polymorphism is associated with increased risk of developing post-stroke depression, and that APOE rs429358-C allele genotypes may be detrimental to recovery of nerve function after stoke. Indeed, these findings provide clinical data for future post-stroke depression gene interventions.
文摘Objective To investigate pre- and postoperative changes of regional cerebral cortical blood flow in patients with cerebral arteriovenous malformation. Method Twenty-two adult patients with arteriovenous malformation(AVM) were recruited into this study at Beijing Tiantan Hospital from September 2001 to May 2002. Eight patients had giant cerebral AVM and the other 14 had a small one. Cortical cerebral blood flow (CBF) was measured by laser Doppler flowmetry (LDF) before and after AVM resections. After surgery,the probe of LDF was implanted adjacent to the area of AVM and monitored for 24 hours.Results CBF increased significantly after the resection in all patients regardless of AVM size. In patients with small AVM,CBF returned to the baseline level within 4 hours,but in patients with giant AVM,CBF remained high even after 24 hours.Conclusions Monitoring CBF is helpful to understand pre- and postoperative changes of regional cortical CBF in patients with cerebral AVM.
文摘AIM:To evaluate the possible effects of phacoemulsification cataract surgery on ocular hemodynamics.·METHODS:In this prospective study,intraocular pressure(IOP),pulsatile ocular blood flow(POBF),and ocular pulse amplitude(OPA) were measured pre-operatively(baseline) and at 1 week and 3 weeks postoperation in 52 eyes of 26 patients(mean age 63.15±10.25 years) scheduled for unilateral phacoemulsification cataract surgery with intraocular lens implantation.In all of the eyes,a blood flow analyzer(Paradigm DICON;Paradigm Medical Industries Inc.;USA) was used to obtain measurements of IOP,POBF,and OPA.The data obtained from operated eyes were compared statistically to untreated fellow phakic eyes of the patients.·RESULTS:For operated eyes,the mean baseline IOP,POBF,and OPA values were 15.9±4.64mmHg,17.41±4.84μL/s,and 2.91 ±1.12mmHg,respectively.The IOP,POBF,and OPA values were 17.19 ±4.34mmHg,17.56 ±6.46μL/s,and3.12 ±1.1mmHg,respectively,in the nonoperated control eyes.Statistically significant differences from baseline measurements were not observed 1 week and 3 weeks postoperation for the operated or nonoperated eyes.There were also no statistically significant differences in any measurements between the operated and nonoperated eyes in all the examination periods(P 】0.05for all).·CONCLUSION:Uncomplicated phacoemulsification surgery does not affect ocular hemodynamics in normotensive eyes with cataracts.
基金the Grant from Bureau of Science and Technology of Jining City, No.2004JH006
文摘BACKGROUND: Presently, clinic memory scale is used to evaluate learning memory ability in most studies, and the influence of difference in measurement condition of individuals exists. OBJECTIVE: To study the correlation between regional cerebral blood flow (rCBF) perfusion and learning memory function in special brain regions of patients with cerebral infarction at convalescent period, and to try to find out a method which can quantitatively evaluate learning ability. DESIGN: Case observation, and correlation analysis. SETTINGS: Shandong Institute for Behavioral Medicine; the Affiliated Hospital of Jining Medical College. PARTICIPANTS: Totally 70 patients with cerebral infarction admitted to Department of Neurology, Jining Medical College between January 2004 and December 2005 were involved. The involved patients, 58 male and 12 female, were averaged (52±3) years, and they were all right handed. They all met the diagnosis criteria instituted by the Fourth National Conference on Cerebrovascular Disease, and were confirmed as cerebral infarction by skull CT or MRI. Informed consents of detected items were obtained from all the patients and relatives. METHODS: When the patients were at convalescent period, their learning and memory ability were measured with “ clinic memory scale (set A)”. The 18 patients whose total mark over 100 were regarded as good learning memory function group; The 23 cases whose total mark less than 70 were regarded as poor learning memory function group. RCBF of hippocampus, nucleus amygdalae, temporal cortex and prefrontal lobe of patients between two groups were measured and compared by single photon emission computed tomography (SPECT). The total scores of the 18 good learning memory patients and 23 poor learning memory patients were taken as dependent variable Y, and their rCBFs of hippocampus, nucleus amygdale, temporal cortex and prefrontal lobe respectively as independent variable X for linear correlation analysis. MAIN OUTCOME MEASURES: Correlation of rCBF in different brain regions and learning memory ability in patients with cerebral infarction. RESULTS: ①The rCBF of hippocampus, nucleus amygdale, temportal cortex and prefrontal cortex of good learning memory function group were significantly higher than those of poor learning memory function group (P 〈 0.05). ②In the good learning memory function group, rCBF of hippocampus, nucleus amygdale, temportal cortex and prefrontal cortex were significantly positively correlated with memory scale scores ( r = 0.961, 0.926, 0.954, 0.907, P 〈 0.05 ) , and also in the poor learning memory function group (r = 0.979, 0.976, 0.991, 0.953, P 〈 0.05 ) . CONCLUSION: The rCBF of hippocampus, nucleus amygdale, temportal cortex and prefrontal cortex of patients with cerebral infarction are significantly positively correlated with memory scale scores. Predicting learning memory ability of patients by quantitative determination of rCBF provides a quantitative and objective method for evaluating learning memory ability.
基金Financial support was provided by Lion’s Cancer Research Foundation in Northern Sweden,the Swedish Knowledge Foundation,the Faculty of Medicine at Umea University,the Swedish research council and Borger-skapet in Umea research foundation.
文摘Background: Few previous studies have described other than age- and gender related changes in regional cerebral blood flow (rCBF) in healthy elderly. What is the influence of other common clinically relevant variables such as ache, education, MMSE, and smoking history? Purpose: To study rCBF in Swedish healthy elderly by single-photon emission computed tomography (SPECT) and evaluate the influence on rCBF of age, gender, education, MMSE, ache, and smoking with a focus on education in relation to the ‘cognitive reserve’. Methods: Healthy subjects (n = 45, 50 -75 y), sampled from a large longitudinal aging study took part in an extensive examination of health and memory, including cognitive testing and socio-economic survey. After injection of 99 mTc-hexamethylpropylene amine oxime (HMPAO) followed by SPECT the rCBF-SPECT images were analyzed using statistical parametric mapping (SPM). Results: Age-related decreases in uptake were seen in interhemispheric and interlobar regions. There was a positive rCBF correlation with education in the inferior frontal lobe and a higher uptake in the left temporal lobe in an age-gender-matched high education subgroup. Conclusion: The localization of the age related findings except for the medial temporal lobe differs markedly from typical dementia related findings. A reduction close to interhemispheric or interlobar space should always be related to chronological age. Education seems to have an influence on basal brain function at a resting-state condition. Knowledge of normal rCBF variations for variables such as age and education should be considered when making clinical diagnosis. The findings could be interpreted as further support for the theory of cognitive reserve.
文摘Objective: To investigate the effects of CO2 pneumo-peritoneum on blood flow volume of abdominal organs of rabbits with controlled hemorrhagic shock model and liver impact injuries.Methods: After controlled hemorrhagic shock and liver impact injuries, the rabbit model was established. Eighteen rabbits subjected to hemorrhagic shock and liver impact inju-ries were divided into 3 groups randomly according to the volume of lost blood: light hemorrhagic shock (blood loss volume was 10%, 6 ml/kg), moderate hemorrhagic shock (20%, 12 ml/kg) and severe hemorrhagic shock (40%, 22 ml/kg). Intraabdominal pressures of CO2 pneumoperitoneum was 10 mmHg. Color-labeled microspheres were used to mea-sure the blood flow volume of the liver, kidney and stomach before pneumoperitoneum at 30 minutes and 2 hours after pneumoperitoneum and 30 minutes after deflation. And the mortality and hepatic traumatic condition of rabbits were recorded.Results: Of the 18 rabbits, there were 9 with liver impact injuries at Grade Ⅰ, 8 at Grade Ⅱ and Ⅰ at Grade Ⅲ (according to AIS-2005). The mortality rate in light hemorrhagic shock group was 33.33%, and that in moderate or severe hemor-rhagic shock group was 100% within 30 minutes and 2 hours after pneumoperitoneum, respectively. The blood flow vol-ume in the organs detected decreased at 30 minutes under pneumoperitoneum in light and moderate hemorrhagic shock groups. At the same time, the blood flow volume of the liver in moderate hemorrhagic shock group decreased more sig-nificantly than that in light hemorrhagic shock group.Conclusions: The blood flow volume of abdominal organs in rabbits is decreased obviously under CO2 pneumoperitoneum, with fairly high mortality rate. It is be-lieved that CO2 pneumoperitoneum should cautiously be used in abdominal injury accompanied with hemorrhagic shock, especially under non-resuscitation conditions.
文摘Background:Bipolar electro-coagulation has a reported efficacy in treating epilepsy involving functional cortex by pure electro-coagulation or combination with resection.However,the mechanisms of bipolar electro-coagulation are not completely known.We studied the acute cortical blood flow and histological changes after bipolar electro-coagulation in 24 patients with intractable temporal lobe epilepsy.Methods:Twenty-four patients were consecutively enrolled,and divided into three groups according to the date of admission.The regional cortical blood flow (rCBF),electrocorticography,the depth of cortex damage,and acute histological changes (H and E staining,neuronal staining and neurofilament (NF) staining) were analyzed before and after the operation.The t-test analysis was used to compare the rCBF before and after the operation.Results:The rCBF after coagulation was significantly reduced (P 〈 0.05).The spikes were significantly reduced after electro-coagulation.For the temporal cortex,the depth of cortical damage with output power of 2-9 W after electro-coagulation was 0.34 ± 0.03,0.48 ± 0.06,0.69 ± 0.06,0.84 ± 0.09,0.98 ± 0.08,1.10 ± 0.1 l,1.11 ± 0.09,and 1.22 ± 0.11 mm,respectively.Coagulation with output power of 4-5 W completely damaged the neurons and NF protein in the molecular layer,external granular layer,and external pyramidal layer.Conclusions:The electro-coagulation not only destroyed the neurons and NF protein,but also reduced the rCBF.We concluded that the injuries caused by electro-coagulation would prevent horizontal synchronization and spread of epileptic discharges,and partially destroy the epileptic focus.
基金supported financially by the Ministry of Science of China under the National Key Technology R&D Program of China (Contract No.:2006BAA03B01-07)
文摘To study the influence of back feeding particles on gas-solid flow in the riser, this paper investigated the flow asymmetry in the solid entrance region of a fluidized bed by particle concentration/velocity measurements in a cold square circulating fluidized beds (CFB). The pressure drop distribution along the riser and the saturation carrying capacity of gas for Geldart-B type particles were first analyzed. Under the condition of u0 = 4 m/s and Gs = 21 kg/(m^2 s), the back feeding particles were found to penetrate the lean gas-solid flow near the entrance (rear) wall before reaching the opposite (front) wall, thus leading to a relatively denser region near the front wall in the bottom bed. Higher solid circulation rate (u0 =4 m/s, Gs = 33 kg/(m^2 s)) resulted in a higher particle concentration in the riser. However the back feeding particles with higher momentum increased the asymmetry of the particle concentration/velocity profile in the solid entrance region. Lower air velocity (u0 =3.2 m/s) and Gs =21 kg/(m2 s), beyond the saturation carrying capacity of gas, induced an S-shaped axial solid distribution with a denser bottom zone. This limited the penetration of the back feeding particles and forced the flnidizing air to flow in the central region, thus leading to a higher solid holdup near the rear wall. Under the conditions of uo = 4 m/s and Gs = 21 kg/(m^2 s), addition of coarse particles (dp= 1145 μm) into the bed made the radial distribution of solids more symmetrical.
基金Project supported by the National Natural Science Foundation of China(Grant No.51579076).
文摘In the present work,a slot-type flip bucket with separated flows,called SFS-type flip bucket,is developed,and flow regime and energy dissipation are experimentally investigated.Comparing with the circular-shaped or slot-type flip bucket buckets,the present SFS-type flip bucket has better flow regime and larger energy dissipation since the three branches of the flows are separated through the outlet of the flip bucket.Meanwhile,the energy dissipation for this flip bucket is estimated.
基金the National Key Research and Development Programs of China(Grant No.2017YFB0305102).
文摘During multi-jet cooling,the complex hydrodynamic characteristics caused by the interaction between jets will affect the heat transfer of the plate.To further clarify the heat transfer characteristics in different flow regions,the double-jet cooling experiments were completed on a 50-mm-thick plate with the initial cooling temperature and jet angle in the range of 300–900°C and 0°–60°,respectively.The inverse heat conduction was used to calculate the surface temperature and heat flux.Furthermore,the rewetting phenomenon,maximum heat flux and maximum cooling speed were studied.The results show that increasing the angle between jet and wall normal would increase the wetting front’s width downstream of the jet point.When the jet angle was 60°,the maximum value increased by 37.29 mm compared with that when the angle was 0.The correlation between the width of the wetting front and the radial temperature gradient was further confirmed.In addition,it was found that the maximum heat flux would be affected by the duration of transition boiling,but not affected by complete wetting time.The results clarified the heat transfer mechanisms under various initial cooling temperature and inclination angle conditions on plate cooling in different flow regions,and provided valuable data for controlling heat transfer efficiency and improving cooling uniformity.
文摘Background The solitary pulmonary nodule (SPN) is one of the most common findings on chest radiographs. The objectives of clinical practice are to differentiate malignant nodules from benign nodules in the least invasive way and to make a specific diagnosis. This study was aimed to evaluate the correlation between perfusion imaging features and microvessel density (MVD) and vascular endothelial growth factors (VEGF) in SPNs using multi-slice computed tomography (MSCT); and to provide the theoretical basis for SPN blood flow pattern and blood flow quantitative features. Also, the study called for the discussion of the method's clinical application value in the differential diagnosis of benign and malignant SPNs.Methods Sixty-eight patients with SPN underwent multi-location dynamic contrast enhanced (nonionic contrast material was administrated via the antecubital vein at a rate of 4 ml/s) MSCT. Precontrast and postcontrast attenuations on every scan was studied. Perfusion, peak height, and the ratio of the peak height of the SPN to that of the aorta were analyzed. Perfusion was calculated using the maximum gradient of the time-density curves (TDC) and the peak height of the aorta. The quantitative parameters (perfusion, peak height, ratio of peak height of the SPN to that of the aorta) of the blood flow pattern were compared with MVD and the VEGF expression of immunohistochemistry. Results The perfusion peak heights of malignant ((96.15±11.55) HU) and inflammatory ((101.15±8.41) HU) SPNs were significantly higher than those of benign ((47.24±9.15) HU) SPNs (P 〈0.05, P 〈0.05). Ratios of SPN-to-aorta of malignant and inflammatory SPNs were significantly higher than those of benign SPNs (P 〈0.05, P 〈0.05). No significant differences were found between the peak height and SPN-to-aorta ratio of malignant SPNs and inflammatory SPNs (P 〉0.05, P 〉0.05). The precontrast densities of inflammatory SPNs were lower than those of malignant SPNs (P 〈0.05). Perfusion values of malignant and inflammatory SPNs were significantly higher than those of the benign SPNs (P 〈0.05, P 〈0.05). The VEGF positive expressions appeared in 32 patients with malignant SPNs and 2 patients with benign SPNs, and the average value of the MVD was higher in patients with malignant SPNs (36.88±6.76) than in patients with either benign (4.51±0.60) or inflammatory (26.11±5.43) SPNs (P 〈0.05, P 〈0.05). There were statistically significant correlations between the CT perfusion feature and the MVD. The highest correlation was between the peak height of SPN and the MVD (r=0.657, P 〈0.05).Conclusions Tumor microvessel density and VEGF expression facilitate the exploration of the pathophysiological basis of CT perfusion in SPNs. Multi-slice CT perfusion has shown strong positive correlations with angiogenesis in SPNs.