Burden of mental disorders and risk factors in the Western Pacific region from 1990 to 2021

BACKGROUND The burden of mental disorders(MD)in the Western Pacific Region(WPR)re-mains a critical public health concern,with substantial variations across demogra-phics and countries.AIM To analyze the burden of MD in the WPR from 1990 to 2021,along with associated risk factors,to reveal changing trends and emerging challenges.METHODS We used data from the Global Burden of Disease 2021,analyzing prevalence,incidence,and disability-adjusted life years(DALYs)of MD from 1990 to 2021.Statistical methods included age-standardisation and uncertainty analysis to address variations in population structure and data completeness.RESULTS Between 1990 and 2021,the prevalence of MD rose from 174.40 million cases[95%uncertainty interval(UI):160.17-189.84]to 234.90 million cases(95%UI:219.04-252.50),with corresponding DALYs increasing from 22.8 million(95%UI:17.22-28.79)to 32.07 million(95%UI:24.50-40.68).During this period,the burden of MD shifted towards older age groups.Depressive and anxiety disorders were predominant,with females showing higher DALYs for depressive and anxiety disorders,and males more affected by conduct disorders,attention-deficit hyperactivity disorder,and autism spectrum disorders.Australia,New Zealand,and Malaysia reported the highest burdens,whereas Vietnam,China,and Brunei Darussalam reported the lowest.Additionally,childhood sexual abuse and bullying,and intimate partner violence emerged as significant risk factors.CONCLUSION This study highlights the significant burden of MD in the WPR,with variations by age,gender,and nation.The coronavirus disease 2019 pandemic has exacerbated the situation,emphasizing the need for a coordinated response.

Addressing inclusion,innovation,and sustainability challenges through the lens of economic geography:Introducing the hierarchical regional innovation system

The world is facing dramatic challenges related to environmental sustainability at an accelerating pace.In this context,the field of economic geography(EG)has been playing an important role in understanding both the socioeconomic and technological dimensions of these challenges,as it deals with a variety of complementary notions and perspectives.Departing from this lens,our aim is to explore a conceptual framework that can help us to understand environmental changes relating to multi-dimensional territorial development,notably in eco-nomic contexts where inequality is high,and stratification based on hierarchies regulate social and economic life.Based on the territory concept,we propose the original notion of a hierarchical regional innovation system(HRIS)that emphasises the pervasive role of hierarchies(powers)in regional innovation systems and illustrate its value with evidence and case studies from extant literature on sustainability transitions.The HRIS can help us understand and promote development paths considering the contribution of inclusive eco-innovations(another original conceptual amalgam).Through some empirical cases from other studies in low-carbon transitions,we show the application of the HRIS(and inclusive eco-innovation)framework.In conclusion,we provide incen-tives to explore new regional innovation systems,alongside the HRIS,adapted to different regions worldwide and centred on the inclusiveness of people and places.

Coupling coordinated development among digital economy,regional innovation,and talent employment:A case study in the Hangzhou Metropolitan Circle,China

Coordinative development across various systems,particularly the economic,social,cultural,and human resources subsystems,is a key aspect of urban sustainability and has a direct impact on the quality of urbanization.The Hangzhou Metropolitan Circle,comprising Hangzhou City,Huzhou City,Jiaxing City,and Shaoxing City,was the first metropolitan circle approved by the National Development and Reform Commission(NDRC)as a demonstration of economic transformation in China.To evaluate the coupling coordination degree of the four cities and analyze the coordinative development in three systems(including digital economy,regional innovation,and talent employment),we collected panel data during 2015–2022 from these four cities.The development level of the three systems was evaluated by the standard deviation method and comprehensive development index.The results are as follows:(1)the level of coupling coordinated development of the three systems in the Hangzhou Metropolitan Circle was relatively low;(2)the coupling coordination degree of the four cities in the Hangzhou Metropolitan Circle showed significant regional differences,among which Hangzhou City was in the leading position,and Huzhou,Jiaxing,and Shaoxing cities made steady but slow progress in the coupling development of the three systems;and(3)the development of digital economy and talent employment needs to be strengthened.This study contributes to the coordinative development of Hangzhou Metropolitan Circle by innovatively focusing on the coupling coordination relationship among digital economy,regional innovation,and talent employment,which also meets the industrial layout of Hangzhou Metropolitan Circle.In this way,the optimal allocation and sustainable development of digital economy,regional innovation,and talent employment in the Hangzhou Metropolitan Circle can be achieved.

Differentiated Paths of Regional Green Development Driven by Industrial Enterprise Innovation

A fundamental shift in the regional development pattern is crucial to achieving a comprehensive green transformation in China.Currently,innovation-driven green development is a significant strategic option for regional development.As the main body of innovation and the basic unit of regional composition,enterprises have a profound impact on the development of regional economy,society,ecology,and other aspects.However,considering China’s vast territory and significant regional differences in natural environment and industrial structure,it’s necessary to further explore the specific impact paths of regional green development driven by enterprise innovation.Therefore,taking industrial enterprises as an example,based on the panel data of 30 provinces in China from 2016 to 2020,this study verifies the impact of industrial enterprise innovation on the regional green development level by constructing a parallel multiple mediating effect model and dividing the economy into eastern,central,and western regions to discuss the specific impact paths.The results show that industrial enterprise innovation has a significant positive effect on regional green development level,via different influencing paths in each region:(1)The eastern region improves the regional green development level by narrowing the urban-rural income gap;(2)The central region improves the regional green development level by reducing resource dependence;and(3)The western region raises the regional green development level by improving the rationalization of industrial structure.

Recent Strengthening of the Regional Hadley Circulation over the Western Pacific during Boreal Spring

Previous studies suggested that there are large discrepancies in the intensity trend of the zonally averaged Hadley circulation (ZAHC) among different reanalyses. As the land, ocean, and topography are not evenly distributed, the ZAHC may mask the regional variability. Changes in the regional HC have important implications for regional climate change. Here, we detect the long-term trend of the boreal spring regional Hadley circulation intensity over the western Pacific (WPHC) since 1979 in both hemispheres using six reanalysis datasets. Unlike the ZAHC, we find that the trend of the spring WPHC intensity is consistent among various reanalysis datasets. All reanalyses show pronounced strengthening trends for the WPHC in both the Northern and Southern Hemisphere, which may be partly attributable to the robust warming trends of sea surface temperature in the tropical western Pacific. The result could improve our understanding of Hadley circulation variability at the regional scale and has implications for regional climate changes.

REGIONAL FEATURES OF LONG-TERM SST VARIATION IN THE WESTERN PACIFIC WARM POOL AREA

The main features of SST interannual and long term variations in the Western Pacific Warm Pool area were studied by using regression analysis, running t test and spectral analysis methods based on monthly mean SST data in the Pacific during 1950-1998. The results showed that the SST inter annual and long term variations in the Western Pacific Warm Pool area had evident regional features. There were significant differences in variation range, phase, period, occurrence time of abrupt variation between SST in the eastern area (east of 160°E) and SST in the western area (west of 160°E).

Does regional air–sea coupling improve the simulation of the summer monsoon over the western North Pacific in the WRF4 model?

A new regional coupled ocean–atmosphere model,WRF4-LICOM,was used to investigate the impacts of regional air–sea coupling on the simulation of the western North Pacific summer monsoon(WNPSM),with a focus on the normal WNPSM year 2005.Compared to WRF4,WRF4-LICOM improved the simulation of the summer mean monsoon rainfall,circulations,sea surface net heat fluxes,and propagations of the daily rainband over the WNP.The major differences between the models were found over the northern South China Sea and east of the Philippines.The warmer SST reduced the gross moist stability of the atmosphere and increased the upward latent heat flux,and then drove local ascending anomalies,which led to the increase of rainfall in WRF4-LICOM.The resultant enhanced atmospheric heating drove a low-level anomalous cyclone to its northwest,which reduced the simulated circulation biases in the stand-alone WRF4 model.The local observed daily SST over the WNP was a response to the overlying summer monsoon.In the WRF4 model,the modeled atmosphere exhibited passive response to the underlying daily SST anomalies.With the inclusion of regional air–sea coupling,the simulated daily SST–rainfall relationship was significantly improved.WRF4-LICOM is recommended for future dynamical downscaling of simulations and projections over this region.

Regional disparities of phytoplankton in relation to environmental factors in the western Arctic Ocean during summer of 2010

Global warming has caused Arctic sea ice to rapidly retreat,which is affecting phytoplankton,the primary producers at the base of the food chain,as well as the entire ecosystem.However,few studies with large spatial scales related to the Arctic Basin at high latitude have been conducted.This study aimed to investigate the relationship between changes in phytoplankton community structure and ice conditions.Fifty surface and 41 vertically stratified water samples from the western Arctic Ocean（67.0°–88°26′N,152°–178°54′W） were collected by the Chinese icebreaker R/V Xuelong from July 20 to August 30,2010 during China＇s fourth Arctic expedition.Using these samples,the species composition,spatial distribution,and regional disparities of phytoplankton during different stages of ice melt were assessed.A total of 157 phytoplankton taxa（〉5 μm） belonging to 69 genera were identified in the study area.The most abundant species were Navicula pelagica and Thalassiosira nordenskioeldii,accounting for 31.23% and 14.12% of the total phytoplankton abundance,respectively.The average abundance during the departure trip and the return trip were 797.07×10~2 cells/L and 84.94×10~2 cells/L,respectively.The highest abundance was observed at Sta.R09 in the north of Herald Shoal,where Navicula pelagica was the dominant species accounting for 59.42% of the abundance.The vertical distribution of phytoplankton abundance displayed regional differences,and the maximum abundances were confined to the lower layers of the euphotic zone near the layers of the halocline,thermocline,and nutricline.The species abundance of phytoplankton decreased from the low-latitude shelf to the high-latitude basin on both the departure and return trips.The phytoplankton community structure in the shallow continental shelf changed markedly during different stages of ice melt,and there was shift in dominant species from centric to pennate diatoms.Results of canonical correspondence analysis（CCA） showed that there were two distinct communities of phytoplankton in the western Arctic Ocean,and water temperature,ice coverage and silicate concentration were the most important environmental factors affecting phytoplankton distribution in the surveyed sea.These findings will help predict the responses of phytoplankton to the rapid melting of Arctic sea ice.

Regional Innovation System: Theoretical Approach and Empirical Study of ChinaAPPROACH AND EMPIRICAL STUDY OF CHINA

Regional innovation system (RIS) is the new research field of modern economicgeography in the age of knowledge economy. Based on the researches of regional economic geography,the authors of the paper consider RIS as the integrated and interactive systems with innovationmilieu, elements, units, structure and functions. Five aspects of evaluation indicators includinginnovation input scale and output scale, innovation milieu transition, innovation inner operation,as well as innovation outer impact are worked out for final indicators of RIS scale and quality.According to different RIS situations, three patterns of independent, imitative and cooperativedevelopment are put forward for choosing. At the latter part of the paper, we select 12 provincialregions (including three municipalities and one autonomous region) of China for empirical study. Theresults show that there exists great difference among each region from the aspects of innovationscale and quality mainly owning to the diversification of RIS social and economic milieu, the majorinnovative units of enterprises, universities and R&D institutes. Finally, the paper points out theinnovation development decisions for each region.

Exploring Regional Innovation Growth Through A Network Approach:A Case Study of the Yangtze River Delta Region,China

As the leading urban agglomeration in China,the Yangtze River Delta(YRD)is experiencing a factor-driven to innovationdriven transition.However,the dynamics of regional innovation growth are not yet fully understood.This paper combines the complex network methodology with spatial econometrics to disentangle the contributions of innovation endowments,innovation network flows,and innovation network positions to regional innovation growth,as well as their spatial spillover effects.The primary findings suggest that regional innovation growth results from the networked agglomeration economies,which is shaped by the interactions between agglomeration factors and network factors.Specifically,agglomeration factors play a fundamental role in regional innovation growth.In contrast,network factors,such as the network flows and network positions,may contribute to new path creation by promoting access to external innovation resources.Additionally,the institutional factors show multiplexity in fostering regional innovation patterns.Such findings indicate that the YRD region should shift the innovation growth pattern from competitive involution to mutually beneficial cooperation to reduce regional disparities.In this regard,the institutional capacity of organizing network flows and fostering reciprocal inter-city partnerships has become increasingly critical for promoting sustainable innovation and regional development.

Empirical Research on the Competence of Intellectual Property Rights in Shenzhen Based on Regional Industrial Innovation

Based on statistical data of the regional industry and the level of intellectual property right （IPR） development, this paper adopts the ways such as regression analysis and description statistics, trying to analyze the intrinsic linkage among the regional industry innovation, regional competence and IPR competence. A conclusion was drawn that IPR competence can assuredly upgrade the industrial competence and regional competence, but the supporting from perfect institutional environment and service system of intellectual property rights （IPR） is yet needed. According to the analysis, this paper gives some suggestions on how to improve the IPR competence of Shenzhen,

Analysis of educational factor in regional innovation and the corresponding policy implications

Education is a basic factor in regional innovation system. The impact of the scale, structure and pattern of education on regional innovation Performance has long been an important matter in innovation economics. With the method of econometric analysis, it is found that regional innovation ability of China's provinces (autonomous regions and municipalities) has a strong correlativity with public educational outlay and the number of people who hold a diploma higher than junior college. Meanwhile, mechanisms of education that exert impact on regional innovation ability through function such as forming human capital. diffusing knowledge and knowledge overflow are analyzed. Moreover,some policy implications for China are given.

THE REGIONAL DEVELOPMENT IN A MULTI-CULTURAL BACKGROUND──The Studies of Minority Regions in the Western China

China is a country with many nationalities. Each of them has formed its own special culture, which is different from the mainstream of majority Han nationality, by adapting to geo-environment during history. Due to different backgrounds, the regional developmental model of minorities in the western China is different from the Han nationality and western countries. Combining a knowledge-based civilization and sustainable development, the minority areas can seek the systematic integration of culture-economy-ecology. Based on this, the paper suggests that the minority areas in western China should take the way of emphasizing developmental quality rather than developmental quantity for a harmonious system of culture-economy-ecology. Some approaches for developing minority areas in western China have been put foreword.

Regional Innovation Policies for High-Technology Firms： The Importance of the Cluster Life Cycle

The present work makes an in-depth analysis of an aspect not yet sufficiently examined by the studies into regional innovation systems, relating to why the policy makers must adopt regional innovation policies in accordance with the development cycle of the active clusters in the territory. The analysis carried out in the course of the work contributes towards understanding the validity of an evolutionary-type development model for which the regional innovation policies for the growth of high-tech firms should dynamically change in relation to the various cluster stages. The development model proposed provides a framework for the policy makers in order to state more efficiently through time the regional innovation strategies.

An Evaluation on the Effects of the Policy of the Great Campaign of Western Development of China in the First 10 Years Based on the Kuznets Regional Inverted-U Theory

In order to reduce the regional differentials or narrow the gap in economic development between eastern and western areas and prevent the intensification of contradictions resulting from the regional inequality during the development process, the government of China launched the Great Campaign of Western Development （GCWD） in 2000. In this paper, we will evaluate the effects of the first 10 years＇ GCWD and use the latest Chinese annual data from 1978 to 2010 to investigate the problem of regional differentials in the development process, evaluate the effects of GCWD policy and test whether there is a regional Kuznets inverted-U curve in the regional development of China. The result shows that there are both good and bad news： the good news is that the inverted U-shaped curve of absolute differential between eastern and western areas finally emerges （the previous studies showed that the inverted-U curve did not appear and the differentials between eastern and western areas became worse） and the bad news is that the differential is in the first half of the inverted U-shaped curve in our choice of time span （1978-2010）, that is, it is still in the situation of deterioration, and the turning better point will emerge in 2025. Although the western areas have benefitted from GCWD, the absolute gap has been still widened. To narrow the gap, the western areas should accelerate the industrial development and the government should adjust the policy and make more efforts to support the development of the industry in the western areas, especially cultivate and support the development of the western characteristic and advantageous industry rather than just supporting the construction of infrastructure in the western areas.

How Will Different Types of Regional Innovation Policy and Their Mixes Affect the Innovation Performance of Enterprises: An Empirical Study Based on Shenzhen

Evaluating the functional boundary of different types of innovation policy instruments and their mixes on innovation performance of enterprises is an important but unresolved key issue.This paper,based on the systematically carding the quantization of 155 innovation policies issued by Shenzhen governmental departments from 2011 to 2019,analyzed the characteristics from different types of innovation instruments and their mixes.The results show that Shenzhen governmental has constantly enriched innovation policy instruments for encouraging enterprise innovation,but there are structural unbalances in the issued innovation policy manifested as follows:firstly supply-side policy and environmental-side policy were promulgated more than demand-side policy;secondly the specific instruments employed by Shenzhen governmental were also uneven in different type of innovation policy,like supply-side policy focused on the instruments of government procurement and R&D outsourcing,demand-side policy employed human resource training,innovation infrastructure and fiscal support most,and environmental-side policy main used target planning,intellectual property protection and financial support.This study expands and understanding empirical implementation of different reginal innovation policy instruments,and has implication for Shenzhen governmental in improving the applicability ability of policies in the enterprises innovation.

Research on the Innovation and Development of Regional Industrial Chain in the Context of Guangzhou-Foshan City

Based on the research on regional industrial chain innovation and development in the context of Guangzhou-Foshan City,this paper examines the industrial complementarity between Guangzhou and Foshan and finds that while Guangzhou-Foshan City is developing,there are still some issues,such as the homogenization and competition of industrial development,a lack of profound integration of industrial chain with innovation chain,and the need to optimize the innovative coordination system.Finally,it proposes some countermeasures to promote the innovation and development of Guangzhou-Foshan regional industrial chain from several aspects,including implementing regional advanced industrial base and modern industrial chain,promoting the deep integration of industrial chain with innovation chain,and optimizing the spatial layout of collaborative innovation.

Temporal Variability of Tropospheric NO_(2) over Cities in the United States,Western Europe and China from 2005 to 2022

Anthropogenic Nitrogen oxides(NO_(x)=NO_(2)+NO)emissions are highly concentrated in urban area,and the weekly cycles,seasonal patterns and long-term trends of tropospheric NO_(2) columns over cities differ from region to region due to different emission sectoral compositions and human activities.In this study,we used satellite observed tropospheric NO_(2) column data to compare the longand short-term NO_(2) column density time series over cities in the United Sates(the U.S.),western Europe and China.The results showed that in all the targeted cities,the outbreak of the Corona Virus Disease in 2019(COVID-19)moved the December peak of the city-level NO_(2)columns forward to November and October or even earlier in 2020 and 2021.On weekly level,cities in the U.S.show the lowest NO_(2) columns ratio on weekend/work day,then come the western European cities,and a weak weekly pattern is seen in Chinese cities.For all the cites,we find a higher weekend/work day NO_(2) ratio in cold seasons than in warm seasons,indicating a higher contribution from NOx emission sectors of residential,industry and power plants in the warm seasons.In the long-term,NO_(2) columns over the U.S.and western European cities declined by a fraction twice that of the regional mean level from 2004 to 2021.In China,NO_(2) columns started to decrease since 2012,at a similar rate between the city and regional level.This work confirms the importance to quantify and control NOx emissions from cities.

Does Industry-University-Research Cooperation Matter? An Analysis of Its Coupling Effect on Regional Innovation and Economic Development

The dislocation between regional innovation and economic development directly influences the economic effect of regional innovation. However, no in-depth researches have been made on how to solve this problem. Using data from Henan Province, China,employing geographical detector technology, this paper focuses on testing whether the industry-university-research cooperation can contribute to coordinating the relation between regional innovation and economic development. It is shown that: 1) the industry-universityresearch cooperation in Henan Province is increasing gradually, and the network presents a core-edge structure, and the coupling degree between regional innovation and economic development is spatially unbalanced, which is similar to the spatial distribution of the intensity of industry-university-research cooperation;2) as an important approach to effectively connect scientific researches with market demands, the industry-university-research cooperation can help form an interactive, interconnected, coupled and coordinated virtuous relation between regional innovation and economic development. Compared with the cooperation between organizations of the same type and the separate innovation of organizations, the improvement of the industry-university-research cooperation level can better coordinate the relation between regional innovation and economic development;3) the cooperative innovation model between enterprises and universities can better promote the coupling between regional innovation and economic development, compared with many industryuniversity-research cooperation models. For underdeveloped areas lacking local knowledge base, industry-university-research cooperation should be considered as a long-term development strategy, especially using the knowledge sources of external universities and scientific research institutions to enhance innovation capability and achieve economic growth.

Introduction to the Regional Coupled Model WRF4-LICOM: Performance and Model Intercomparison over the Western North Pacific

Regional coupled modeling is one of the frontiers of regional climate modeling,but intercomparison has not been well coordinated.In this study,a community regional climate model,WRF4,with a resolution of 15 km,was coupled with a high-resolution(0.1°)North Pacific Ocean model(LICOM_np).The performance of the regional coupled model,WRF4_LICOM,was compared to that of another regional coupled model,RegCM4_LICOM,which was a coupling of version 4 of the Regional Climate Model(RegCM4)with LICOM_np.The analysis focused on the 2005 western North Pacific summer monsoon rainfall.The results showed that the regional coupled models with either RegCM4 or WRF4 as their atmospheric model component simulated the broad features over the WNP reasonably well.Quantitative intercomparison of the regional coupled simulations exhibited different biases for different climate variables.RegCM4_LICOM exhibited smaller biases in its simulation of the averaged June–July–August SST and rainfall,while WRF4_LICOM better captured the tropical cyclone(TC)intensity,the percentage contributions of rainfall induced by TCs to the total rainfall,and the diurnal cycle of rainfall and stratiform percentages,especially over land areas.The different behaviors in rainfall simulated by the two models were partly ascribed to the behaviors in the simulated western North Pacific subtropical high(WNPSH).The stronger(weaker)WNPSH in WRF4_LICOM(RegCM4_LICOM)was driven by overestimated(underestimated)diabatic heating,which peaked at approximately 450 hPa over the region around the Philippines in association with different condensation–radiation processes.Coupling of WRF4 with LIOCM is a crucial step towards the development of the next generation of regional earth system models at the Chinese Academy of Sciences.