Gray Matter-Based Age Prediction Characterizes Different Regional Patterns

Dear Editor,The brain experiences ongoing changes across different ages to support brain development and functional reorganization.During the span of adulthood,although the brain has matured from a neurobiological perspective,it is still continuously shaped by external factors such as habits,the family setting,socioeconomic status,and the work environment [1].In contrast to chronological age (CA),brain(or biological) age (BA) is conceptualized as an important index for characterizing the aging process and neuropsychological state,as well as individual cognitiveperformance.Growing evidence indicates that BA can be assessed by neuroimaging techniques,including MRI [2].

Coseismic fault model of the 2017 M_(W)6.5 Jiuzhaigou earthquake and implications for the regional fault slip pattern

On August 8,2017,an M_(W)6.5 earthquake occurred in Jiuzhaigou County,Sichuan Province,China,on the eastern margin of the Qinghai-Tibet Plateau.This study investigates the coseismic deformation field and fault model with ascending and descending Sentinel-1 synthetic aperture radar(SAR)images,aftershock distribution,and elastic half-space dislocation model.The regional fault slip pattern is then quantita-tively examined using the boundary element method.The results show that the ascending and descending interferometric synthetic aperture radar(InSAR)coseismic deformation fields display an overall NNW-SSE trend,with more significant deformation on the southwest side of the fault.The coseismic fault geometry is divided into NW and SE sub-faults with strikes of 162.1°and 149.3°,respectively.The coseismic fault slip is dominated by a left-lateral strike-slip movement with an average rake of-2.31°,mainly occurring at a depth of 0-13.04 km with a shape of an approximately inverted triangle.The fault slip features two peak slip zones,with a maximum of 1.39 m.The total seismic moment is 6.34×10^(18) N·m(M_(W)6.47).The boundary element calculation quantitatively indicates that the regional fault slip pattern may be mainly attributable to the changing strike and dip.The strike changes from NNWeSSE to nearly NS direction,and the dip gradually decreases from the Jiuzhaigou earthquake fault in the north to the Huya fault in the south.With these characteristics,the Huya and the Jiuzhaigou earthquake faults form the eastern boundary of the Minshan uplift zone and accommodate the accumulated deformation.

Comment on “The diurnal variation pattern of choroidal thickness in macular region of young healthy female individuals using spectral domain optical coherence tomography”

Dear Editor,We have read and reviewed the article entitled'The diurnal variation pattern of choroidal thickness in macular region of young healthy female individuals using spectral domain optical coherence tomography'by Zhao et al^([1])with great interest.The authors evaluated the pattern of diurnal variations

Regional features of pollen R-values in China

Establishing a quantitative relationship between modern pollen and vegetation remains a pivotal but intricate pursuit within the field of Quaternary palynology.The R-value,a well-established and traditional metric characterized by its simplicity and direct applicability,serves to calibrate the nonlinear disparities between surface pollen and modern vegetation.This study entails the construction of a comprehensive pollen R-value dataset for China derived from R-values published between 1987 and 2021.The dataset,compiled after rigorous screening,calibration,and standardization processes,encompasses 898 modern pollen sampling sites and 2115 pollen R-value data entries,encapsulating 152 pollen taxa spanning 65 families and 113 genera.Synthesizing the extracted R-values yielded the following insights:(1)A macrospatial analysis validates previously established knowledge at a site-specific scale.Evidently,pollen R-value variations across China are statistically significant.Approximately two-thirds of pollen taxa exhibit underrepresentation(e.g.,Taxodiaceae,Corylus,Nitraria,Tamarix,Cyperaceae,Poaceae,and Fabaceae),while the remaining one-third display overrepresentation(e.g.,Pinus,Picea,Betula,Ephedra,Chenopodiaceae,and Artemisia).The degree of underrepresentation surpasses that of overrepresentation,and the representation patterns of Castanea,Quercus,Polygonaceae,and Asteraceae are contingent upon vegetation types.(2)Pollen R-values follow distinct spatial distribution patterns within China.In the woody vegetation region of eastern China,R-values progressively decline from north to south,correlating with rising temperatures and precipitation.Conversely,in herbaceous vegetation regions of northern and western China,R-values decrease from east to west and from northeast to southwest,corresponding to increased aridity.Nevertheless,pollen R-values manifest variation contingent on pollen taxa,vegetation types,and climatic regions,even differing for the same taxa across varying vegetation types and climatic conditions.This highlights the intricate nature of pollen R-values and their interpretation of pollen-vegetation relationships.(3)Pollen R-values and relative pollen production estimates exhibit resemblances and a modest positive correlation.However,adjudicating between them as representatives of vegetation requires nuanced consideration,as both metrics convey pollen representation within vegetation,demonstrating the multifaceted relationships they share with modern vegetation.Further recommendations suggest that when assessing pollen representation in modern vegetation,fossil pollen content should be weighted using either the median or log-transformed R-value.This approach underscores the necessity of comprehensively accounting for divergences and convergences across various spatial scales and vegetation types,particularly the disparities observed within identical pollen taxa across dissimilar regions.

Highly Regional Genes:graph-based gene selection for single-cell RNA-seq data

Gene selection is an indispensable step for analyzing noisy and high-dimensional single-cell RNA-seq(scRNA-seq)data.Compared with the commonly used variance-based methods,by mimicking the human maker selection in the 2D visualization of cells,a new feature selection method called HRG(Highly Regional Genes)is proposed to find the informative genes,which show regional expression patterns in the cell-cell similarity network.We mathematically find the optimal expression patterns that can maximize the proposed scoring function.In comparison with several unsupervised methods,HRG shows high accuracy and robustness,and can increase the performance of downstream cell clustering and gene correlation analysis.Also,it is applicable for selecting informative genes of sequencing-based spatial transcriptomic data.

The Situation and Pattern of East Asian Region In the 1990s

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Historical Evolution of Relationship between China and the Gulf Region

The Gulf region is in unique geo-political position.The relationship between China and the Gulf region is deeply impacted by the international system and regional patterns,as well as the adjustments of China’s own diplomatic strategies.This article tries to analyze the historical evolution of the relationship between China and the Gulf Region from these three perspectives.At present,this study is very important for China to rightly understand the strategic environment of the“One Belt and one Road”constructions in the Gulf Region.In the period of Cold War,the relationship between China and the Gulf region is deeply affected by the Cold War system,which can be proved by the fact during that time,China’s policies toward the Gulf region depended on the relationship between China and the US and the Soviet Union.Changes in regional patterns in the Gulf Region and China’s own strategic adjustments also have influence on China’s policies toward the Gulf.After the end of the Cold War,many factors,including the changes in the international system,changes in the situation of the Gulf region and the adjustments of China’s development and diplomatic strategies,had influenced the relationship between China and the Gulf.However,in this period,the mutual interdependence between China and the Gulf,and the impact of the adjustments of China’s diplomatic strategies on China’s Gulf policies are increasing.In the future,jointly building the“One Belt and One Road”initiative will be the mainstream of the cooperation between China and the Gulf countries.