Epidemiology, Diagnosis and Survival of Breast Cancer: Data from the Population-Based Cancer Registry of the City of Parakou from 2017 to 2021

Background: Breast cancer mortality remains high in the majority of developing countries. The Ministry of Health has established two population-based cancer registries in Benin: the first one in Cotonou in 2014 and the second one in Parakou in 2017. However, there is a scarcity of data on breast cancer survival and prognosis in Benin Republic. Objective: This study sought to investigate epidemiological, diagnostic, and survival aspects of breast cancer in Parakou, based on data from its population-based cancer registry from 2017 to 2021. Method: For descriptive and analytical purposes, we used a retrospective cohort design. From January 24, 2022 to August 31, 2022, data were collected in all health facilities covered by the Parakou population-based cancer registry using an individual questionnaire. Survival and prognosis analysis were performed using KAPLAN MEIER method and David COX proportional hazard model respectively. Result: A total of 81 patients have been included in this study. The incidence rate of breast cancer in Parakou was 17.5 per 100,000 person-years with a mortality rate of 2.76 per 100,000 person-years. The median age at diagnosis was 44.50 years with extremes ranging from 19 to 76 years and a predominance of 40 - 50 years age group. The median survival time was estimated at 30 months with an overall 5-year survival of 47%. Young age at diagnosis (p-value = 0.002) and advanced stage at diagnosis (p-value = 0.000) had a negative impact on survival in women. The combination of surgery and chemotherapy improved survival (p-value = 0.018). Conclusion: Breast cancer is still a public health issue in Parakou. It comes out mandatory that resources be made available to make screening, early diagnosis and appropriate treatment of breast cancer affordable.

How a Cancer Registry Was Set Up in Senegal: An Example to Follow for a Developing Country

Objectives: Senegal, with the support of WHO, had begun the establishment of a National Cancer Registry in 2009, although it had been at a standstill since 1969;the objective of this work was to test the reliability of data collection tools and feasibility stages necessary for the validation of media before the establishment of a national cancer registry. Methodology: We conducted a non-exhaustive preliminary study over a period of three months from the first of January to 31 March 2010 at four major hospitals in Dakar at the time. Results: Two hundred and eighty-nine cases had been identified: 44% of men (n = 127) and 56% of women (n = 162) with a sex ratio of 0.8. The ages ranged from 20 to 90 years with an average of 50 years. The main diagnostic mode was essentially histological, with 76% of cases (n = 219). The most frequent locations were: ORL (ENT meaning Ear, Nose and Throat) with 25% of cases, liver 7% and bronchopulmonary 4.5% of cases. In men, liver cancer was the most common location and women for cervical cancer with 16%. Squamous cell carcinoma was the most common histological type with 68% of cases followed by adenocarcinoma with 22% of cases. Thirty-eight percent of patients were classified as stage III and IV. A quarter of our patients had received palliative treatment. In contrast, 15 (15%) had received chemotherapy and 4% had received radiotherapy. Data collection was satisfactory. Conclusion: Cancer is a reality in Senegal but it remains underdiagnosed. The materials made it possible to make the cancer registry effective throughout the country.

面向领域UDDI Registry的服务注册和查找

作为WebServices三角架构的组成部分之一,UDDIRegistry承担着服务注册和查找的任务,它在开放和分布的WebServices环境中发挥着关键的作用.针对当前UDDIRegistry注册和查询方法的不足,本文给出了一个面向领域的UDDIReg-istry框架,介绍了service的属性模式、关联关系和约束条件等概念,在该框架下提出基于service属性、关系和约束的注册与查找,满足了某些应用领域中service注册和查找的需求.

基于UDDI Registry的智能检索引擎的研究

随着Web Services技术的不断成熟和发展,存储在UDDI Registry中的Web Service信息将会变得越来越庞大,如何从UDDI Registry浩如烟海的信息资源中为用户快速、方便、准确地检索出满足需求的Web Service,将变得十分重要。而传统的基于关键词匹配的检索技术已不能满足用户准确而全面定位信息的要求。因此,以WebService的文本描述信息为研究对象,运用文本挖掘相关方法,构建出用户概念空间,对用户提出的查询要求进行概念检索。着重介绍了用户概念空间的构建方法以及概念检索的匹配运算过程,并给出了应用于UDDI Registry的一种智能检索引擎系统模型。

《化学文摘》联机数据库中Registry文档的应用

STN 国际联机系统针对化合物结构的复杂性推出了登记号文档Registry File,作为书目文档 CA File 的补充,可解决若干 CA File 无法解决的有关化合物结构的问题。本文介绍了其主要用法和一些指令、符号等。

Registry(注册簿)的原理及其在Visual Basic 4.0中的应用

本文通过比较Windows95中Registry和Windows3.x中.INI文件的优缺点,介绍了Registry的基本构成及运作机制,并在此基础上介绍了Visual Basic 4.0开发者操作Registry的方法,并给出了应用实例。

VO-DAS Registry系统的设计与实现

为了给天文学家提供一个统一访问分布存储于世界各地数据中心的异构天文数据资源的方案,中国虚拟天文台项目组设计了虚拟天文台数据访问服务(VO-DAS)。VO-DAS支持国际虚拟天文台联盟(IVOA)制订的各项相关标准,使得它具有良好的互操作性。VO-DAS Registry系统是VO-DAS系统的重要组成部分,它为VO-DAS系统获取数据资源的元数据,从而使得VO-DAS更好的管理和应用这些数据资源。在这个过程中,此系统符合IVOA的相关标准。

Rate of anticoagulant use, and factors associated with not prescribing anticoagulant in older Thai adults with non-valvular atrial fibrillation: A multicenter registry

Objectives To investigate the rate of anticoagulant use,the reasons for not prescribing anticoagulant,and the factors associated with non-prescription of anticoagulant in older Thai adults with non-valvular atrial fibrillation.Methods A multicenter registry of patients with non-valvular atrial fibrillation was conducted during 2014 to 2017 in Thailand.Demographic,medical history,antithrombotic medication,non-antithrombotic medication,and laboratory data were collected and analyzed.Data were compared between the older adult (≥ 65 years) and younger adult (< 65 years) groups.The reasons why anticoagulant was not prescribed were collected,and predictive factors were identified.Results A total of 3218 patients (1873 males) with an average age of 67.3 ± 11.3 years were included.Almost two-thirds (61.0%) of patients were in the older adult group.Anticoagulant was prescribed in 2422 patients (75.3%): 81.4% in the older adult group and 65.7% in the younger adult group.The three main reasons for not prescribing anticoagulant were already taking antiplatelets,patient refusal,and bleeding risk.These reasons were more common in older adults as compared to younger adults.Multivariate analysis revealed current use of antiplatelets to be the most important factor that predict the non-prescription of anticoagulant in older population.Conclusions The prevalence of anticoagulant prescription among older Thai adults with atrial fibrillation is 81.4%.Taking antiplatelet drugs was found to be the strongest reason that predicts the non-prescription of anticoagulant in this patient population.A guideline should be developed to optimize the use of anticoagulant and antiplatelet in older adults.

STATISTICAL TESTS FOR THE COMPARISON OF THE INCIDENCE OR MORTALITY RATES IN CANCER REGISTRY AND DESCRIPTIVE EPIDEMIOLOGY──A MICROCOMPUTER PROGRAM IN BASIC

This paper describes the statistical methods of the comparison of the incidence or mortality rates in cancer registry and descriptive epidemiology, and the features of microcomputer program (CANTEST) which was designed to perform the methods. The program was written in IBM BASIC language. Using the program CANTEST we presented here the user can do several statistical tests or estimations as follow: 1. the comparison of the adjusted rates which were calculated by directly or indirectly standardized methods, 2. the calculation of the slope of regression line for testing the linear trends of the adjusted rates, 3. the estimation of the 95% or 99%conndence intervals of the directly adjusted rates, of the cumulative rates (0-64 and 0-74), and of the cumulative risk. Several examples are presented for testing the performances of the program.

Description of trauma among French service members in the Department of Defense Trauma Registry: Understanding the nature of trauma and the care provided

Background:Since 2001,the French Armed Forces have sustained many casualties during the Global War on Terror;however,even today,there is no French Military trauma registry.Some French service members(SMs)were treated in US Military Medical Treatment Facilities(MTFs)and were recorded in the US Department of Defense Trauma Registry(Do DTR).Our objective was to conduct a descriptive analysis of the injuries sustained by French SMs reported in the Do DTR and subsequent care provided to them to assist in understanding the importance of building a French Military trauma registry.Methods:Using Do DTR data collected from 2001 to 2017,a retrospective descriptive analysis was conducted.We identified 59 French SMs treated in US MTFs.The characteristics of the SMs’demographics,injuries,care provided to them,and discharge outcomes were summarized.Results:Among the 59 French SMs identified,46(78%)sustained battle injuries(BIs)and 13(22%)sustained nonbattle injuries(NBIs).There were 47(80%)SMs injured in Afghanistan(Opération Pamir),while 12(20%)were injured in Opération Chammal in Iraq and Syria.Explosives accounted for 52.5%of injuries,while 25.4%were due to gunshot wounds;all were BIs.The majority of reported injuries were penetrating(59.3%),most of which were BIs(71.7%).The mean Injury Severity Score for BIs was 12(SD=8.9)compared to 6(SD=1.7)for NBIs.Around half of SMs(n=30;51%)were injured in Afghanistan between the years 2008–2010.Among a total of 246 injuries sustained by 59 patients,extremities were the body part most prone to BIs followed by the head and face.Four SMs died after admission(6.8%).Conclusions:The Do DTR provides extensive data on trauma injuries that can be used to inform injury prevention and clinical care.The majority of injuries sustained by French SMs were BIs,caused by explosives,and predominantly occurring to the extremities;these findings are similar to those of other studies conducted in combat zones.There is a need to establish a French Military trauma registry to improve the combat casualty care provided to French SMs,and its creation may benefit from the Do DTR model.

Variations in non-ST-elevation myocardial infarction care across three levels of hospitals in China:analysis from the China Acute Myocardial Infarction Registry

Objective To explore the variation of treatment and outcomes for NSTEMI across different-level hospitals, which potentially influenced by unbalanced economy and disparate medical care.Methods The China AMI registry consists of 108 hospitals across three levels (province, prefecture and county) throughout China.

Epidemiological characteristics of Asian children with inflammatory bowel disease at diagnosis: Insights from an Asian-Pacific multicentre registry network

BACKGROUND There remains a dearth of Asian epidemiological literature for paediatric inflammatory bowel disease(PIBD).AIM To describe the presenting features of PIBD from 7 Asia-Pacific pediatric gastroenterology centers via a central standardised electronic data platform.METHODS Clinical,endoscopic and radiologic data at diagnosis from the registry were extracted between 1^(st) January 1995 to 31^(st) December 2019.Disease phenotypic characteristics were classified as per the Paris classification system.RESULTS There was a distinct rise in new PIBD cases:Nearly half(48.6%)of the cohort was diagnosed in the most recent 5 years(2015-2019).The ratio of Crohn’s disease(CD):Ulcerative colitis(UC):IBDUnclassified was 55.9%:38.3%:5.8%.The mean age was 9.07 years with a high proportion of very early onset IBD(VEO-IBD)(29.3%)and EO-IBD(52.7%).An over-representation of the Indian/South Asian ethnic group was observed which accounted for 37.0% of the overall Singapore/Malaysia subcohort(6.8%-9.0%Indians in census).Indian/South Asian CD patients were also most likely to present with symptomatic perianal disease(P=0.003).CD patients presented with significantly more constitutional symptoms(fever,anorexia,malaise/fatigue and muscle-wasting)than UC and higher inflammatory indices(higher C-reactive protein and lower albumin levels).CONCLUSION We observed a high incidence of VEO-IBD and an over-representation of the Indian ethnicity.South Asian CD patients were more likely to have symptomatic perianal disease.

Secular decreasing trends in gastric cancer incidence in Taiwan:A population-based cancer registry study

BACKGROUND Gastric cancer remains a leading cause of cancer death worldwide.In Taiwan,gastric cancer is the sixth leading cause of cancer mortality in both males and females.AIM To evaluate secular trends in gastric cancer incidence according to age,sex,and Helicobacter pylori(H.pylori)treatment in Taiwan.METHODS In this population-based study,we used the national Taiwan Cancer Registry database.Annual percent changes in incidence rates were used to describe secular trends in incidence rates and sex ratios of gastric cancer in Taiwan.Pearson’s product-moment correlation coefficients were used to analyze the correlation between annual age-adjusted incidence rates and the annual number of patients treated with antibiotic therapy for H.pylori infection.RESULTS The annual percent changes showed continuously decreasing rates of gastric cancer among both males and females.However,the decreasing trends differed by sex,with an annual percent change of-2.58%in males and-2.14%in females.The age-specific incidence rates increased with age.Within the same age group,more recent time periods showed lower incidence rates than greater time periods.Similarly,the sex ratio was lower in later birth cohorts than in earlier birth cohorts.Age-adjusted incidence rates substantially decreased with increasing numbers of patients being treated with antibiotic therapy for H.pylori infection during 2005 to 2016(r=0.72).CONCLUSION We observed steadily decreasing trends with differential sex ratios in the incidence of gastric cancer in Taiwan.These results support H.pylori eradication programs in Taiwan.

Using Blockchain Technology in Mobile Network to create decentralized Home Location Registry(HLR)

Blockchain can mean many things to many people.It is a set of protocols and encryption technologies for securely storing data on a distributed network for the developers.It is a distributed ledger for business and finance and the technology underlying the explosion of new digital currencies.For technologists,it is the driving force behind the next generation of the internet.On the other hand,it is a transformational technology facilitating large-scale human progress in previously unimagined ways for the rest of the people,a tool for radically reshaping society and economy.Some view it as a disruptive technology that can be the source of a great deal of fraud,illegal activity,where others see opportunities to bring into existing systems by providing decentralization,transparency,and efficiency.This complex technological,economic,and social phenomenon has been the subject of fervent debate.It calls into question what might have been seen to be established parameters of the modern world like currency,economics,trust,value,and exchange.It is a revolutionary new computing paradigm and one of the most significant,fundamental digital platforms’advances since the internet.It is an emergent technology experiencing very rapid evolution,and so is our understanding of what it is and what it can be.This paper is subject to the use of Blockchain concepts in mobile networks to strengthen the Home Location Registry(HLR)database and make it decentralized for secure transactions and in banking and financial centers.Blockchain also holds potential implications for global commerce.It could make trade more efficient by removing the manual and paper-based processes and introducing streamlined and automated processes.

Horn of plenty:Value of the international registry for pediatric chronic myeloid leukemia

Chronic myeloid leukemia(CML)in minors is a rare disease which can be effectively treated by tyrosine kinase inhibitors(TKIs)since the year 2000.A majority of pediatricians will encounter one or two CML patients in the course of their careers and will typically have to rely on written information along with their own intuition to provide care.Knowledge of response to TKIs and of agespecific side effects has an impact on the design of pediatric CML trials in many ways aiming to contribute toward greater predictability of clinical improvements.Information from a registry on a rare disease like CML offers the enormous benefit of enabling treating physicians to interact and share their collective experience.The International Registry on Pediatric CML(IR-PCML)was founded at Poitiers/France almost 10 years ago.Since then,the number of collaboration centers and in parallel of registered patients continuously increased(>550 patients as of December 2019).Ideally,from a given treatment center in a country data are transferred to a national coordinator who interacts with the IR-PCML.In the sense of quality assurance,the registry can offer dissemination of knowledge on state-of-the-art diagnostics(including reference appraisal),optimal treatment approaches,and follow-up procedures within a network that is exerting its strength via participation.With continuous growth during the recent years,very rare subgroups of patients could be identified(e.g.,CML diagnosed at age<3 years,children presenting with specific problems at diagnosis or during course of treatment)which had not been described before.Publications coming from the IR-PCML disseminated this useful information derived from patients who robustly participate and share information about their disease,among themselves and with their caregivers and clinicians.Patient input driving the collection of data on this rare leukemia is the basis for the considerable success of bringing new therapeutics into clinical use.

Cerrado:Agricultural Production and Areas Designated for Environmental Preservation Registered in the Brazilian Rural Environmental Registry(Cadastro Ambiental Rural)

In this study,authors analyzed value,production and area used for producing Cerrado’s main agricultural products,and data on the farms located within this biome and registered in CAR up until April 2019,by microregion.The territory considered here comprised all microregions with at least 25%of its area covered by the Cerrado biome.The production,agricultural production,and planted area values used were the averages of the 2015 to 2017 harvests,and are shown in graphs and tables,as are maps of planted areas and groups of main annual crops,semi-perennial and perennial crops.The areas designated for environmental preservation(ADPs)are the result of the sum of permanent preservation areas(APP),legal reserves(RL)and additional vegetation areas within the farms.Authors’study shows that most of Brazilian cotton,eucalyptus for charcoal,orange,sugarcane,maize and soybean are produced in Cerrado,that 28%of Cerrado are ADPs within farms,and that 16%are areas planted with cotton,eucalyptus,orange,sugarcane,maize,soybean,coffee,beans,and potatoes.The territory occupied by agricultural areas and ADPs required by the Brazilian Forest Code shows that agricultural production and environmental preservation do coexist,and gather the maintenance of essential ecosystem services provided by the ADPs together with the development of the country’s relevant agricultural production.

Introducing a Trauma Registry in Mozambique: An Ethics Case Study

This paper presents a case study of implementing a trauma registry in Mozambique, a low-income country with limited current trauma surveillance. An outline of the importance of trauma registries is presented followed by an evidence-based approach to building a sustainable and ethical partnership with local stakeholders.

Synergetic role of integrating the departments of cancer registry and clinical research at an academic comprehensive cancer center

Integration of the cancer registry and clinical research departments can have a significant impact on the accreditation process of a Commission on Cancer(Co C) Program.Here in we demonstrate that the integration of both departments will benefit as there is increased knowledge, manpower and crossover in job responsibilities in our Co C-accredited Academic Comprehensive Cancer Center.In our model this integration has led to a more successful cooperative interaction among departments, which has in turn created an enhanced combined effect on overall output and productivity.More manpower for the cancer registry has led to increased caseloads, decreased time from date of first contact to abstraction, quality of data submissions, and timely follow-up of all patients from our reference date for accurate survival analysis along with completeness of data.In 2016, our Annual Facility report showed an additional 163 cases over prediction by the state of Maryland Cancer Registry and a 39% increase in case completeness.As proof of the synergetic effectiveness of our model within one year of its implementation, the cancer center was able to apply for, and was awarded membership from Alliance for Clinical Trials in Oncology, Central IRB, and in turn led to increased clinical trial accrual from 2.8% in 2014 compared to 13.2% currently.Our cancer registry in year one submitted over 150 more cases than predicted, improved quality outcome measures displayed by our Cancer Program Practice Profile reports and had more timely and complete data submissions to national and state registries.This synergetic integration has led to a better understanding, utilization and analysis of data by an integrated team with Clinical Research expertise.

Cataract Surgery in Germany: Data from a German Registry on Quality Outcomes for Cataract and Refractive Surgery in the Year 2018

Background: The German registry for cataract surgery was established in 2014. The main aim of this registry was to improve cataract surgery outcomes. Aim: The aim of this project is to offer a tool for benchmarking through the establishment of a reference database in Germany where surgeons could record and analyze their own outcomes. Methods: Data were collected between January 2018 and December 2018. The analyzed data included parameters of surgical technique, implanted intraocular lens (IOL), refractive and visual outcomes. Results: During the year of 2018, the German registry included 10,035 lens exchange surgeries and the complete follow-up was available for 9882 lens extractions. Approximately one third of the patients were between 76 and 80 years old and 60.6% of the cases had a best-corrected distance visual acuity (CDVA) before surgery of 0.5 or better. Parabulbar anesthesia was reported in 60.4% of the cases and phacoemulsification with implantation of a posterior chamber IOL was the chosen method in 92.2% of the cases. The power of the implanted IOL was between 21.0 - 22.9D in 29.4% of eyes. Surgical complications were reported in only 413 cases. After surgery, a CDVA of 0.5 or better was achieved in 90.8% of the cases. Most of the operated patients (64%) had a residual refractive error within ±0.5D (95% confidence interval 63.2 - 65.1). Conclusions: Our results show that the registry was implementedsuccessfully with results comparable to the ones reported in EUREQUO.