Regulated cell death is a genetically determined form of programmed cell death that commonly occurs during the development of living organisms.This process plays a crucial role in modulating homeostasis and is evoluti...Regulated cell death is a genetically determined form of programmed cell death that commonly occurs during the development of living organisms.This process plays a crucial role in modulating homeostasis and is evolutionarily conserved across a diverse range of living organisms.Ferroptosis is a classic regulatory mode of cell death.Extensive studies of regulatory cell death in Alzheimer’s disease have yielded increasing evidence that fe rroptosis is closely related to the occurrence,development,and prognosis of Alzheimer’s disease.This review summarizes the molecular mechanisms of ferroptosis and recent research advances in the role of ferro ptosis in Alzheimer’s disease.Our findings are expected to serve as a theoretical and experimental foundation for clinical research and targeted therapy for Alzheimer’s disease.展开更多
随着分布式能源与随机负荷的大量接入,配电台区三相负荷不平衡与变压器轻重载运行问题日益突出,这将威胁台区安全可靠运行。然而,既有关于互联台区的研究鲜有兼顾三相不平衡与轻重载运行问题的综合治理。对此,该文提出一种基于四桥臂智...随着分布式能源与随机负荷的大量接入,配电台区三相负荷不平衡与变压器轻重载运行问题日益突出,这将威胁台区安全可靠运行。然而,既有关于互联台区的研究鲜有兼顾三相不平衡与轻重载运行问题的综合治理。对此,该文提出一种基于四桥臂智能软开关(four-leg soft open point,F-SOP)的柔性互联配电台区三相不平衡与轻重载综合调控策略。首先,分析了F-SOP和变压器的综合损耗特性,结果表明不平衡度和负载率均会影响设备运行效率;其次,建立三相不平衡与轻重载综合调控策略模型,设立变压器输出功率不平衡度与负载率的指标约束,以系统综合损耗最小为优化目标求解F-SOP最优调控指令。接着,针对F-SOP拓扑架构及其功率调控的需求,提出一种改进对等控制方法,进一步提高F-SOP稳定性能与动态性能,确保综合调控策略的实现。最后,通过算例分析与仿真实验验证了所提综合调控策略的有效性和可行性。展开更多
基金supported by the National Natural Science Foundation of China,No.81501106(to CF)Fund of Taishan Scholar Project(to CF)+1 种基金the Natural Science Foundation of Shandong Province,No.ZR2020QH106(to YH)the Medical and Health Science and Technology Development Plan of Shandong Province,No.202203010799(to QS)。
文摘Regulated cell death is a genetically determined form of programmed cell death that commonly occurs during the development of living organisms.This process plays a crucial role in modulating homeostasis and is evolutionarily conserved across a diverse range of living organisms.Ferroptosis is a classic regulatory mode of cell death.Extensive studies of regulatory cell death in Alzheimer’s disease have yielded increasing evidence that fe rroptosis is closely related to the occurrence,development,and prognosis of Alzheimer’s disease.This review summarizes the molecular mechanisms of ferroptosis and recent research advances in the role of ferro ptosis in Alzheimer’s disease.Our findings are expected to serve as a theoretical and experimental foundation for clinical research and targeted therapy for Alzheimer’s disease.
文摘随着分布式能源与随机负荷的大量接入,配电台区三相负荷不平衡与变压器轻重载运行问题日益突出,这将威胁台区安全可靠运行。然而,既有关于互联台区的研究鲜有兼顾三相不平衡与轻重载运行问题的综合治理。对此,该文提出一种基于四桥臂智能软开关(four-leg soft open point,F-SOP)的柔性互联配电台区三相不平衡与轻重载综合调控策略。首先,分析了F-SOP和变压器的综合损耗特性,结果表明不平衡度和负载率均会影响设备运行效率;其次,建立三相不平衡与轻重载综合调控策略模型,设立变压器输出功率不平衡度与负载率的指标约束,以系统综合损耗最小为优化目标求解F-SOP最优调控指令。接着,针对F-SOP拓扑架构及其功率调控的需求,提出一种改进对等控制方法,进一步提高F-SOP稳定性能与动态性能,确保综合调控策略的实现。最后,通过算例分析与仿真实验验证了所提综合调控策略的有效性和可行性。
