“Focusing on treating the spirit(神)”is an important principle in acupuncture and moxibustion.It is a unique psychosomatic therapy involving the doctor and the patient,which includes regulating the spirit and the bo...“Focusing on treating the spirit(神)”is an important principle in acupuncture and moxibustion.It is a unique psychosomatic therapy involving the doctor and the patient,which includes regulating the spirit and the body.Traditional Chinese medicine attaches great importance to it.Focusing on treating the spirit is also a component of the standards of medical ethics.Only when doctors have noble medical ethics can they achieve clinical treatment of the mind and give full play to their skills to cure diseases.Focusing on treating the spirit runs through the entire clinical process of acupuncture and moxibustion.Before the treatment,it is necessary to focus on the spirit to distinguish the spirit and qi.During the treatment,attention should be paid to the mind to regulate the spirit and qi.It is the premise of clinical diagnosis and treatment of acupuncture and moxibustion and the key to the curative effect.Focusing on treating the spirit is also in the realm of doctor-patient double treatment,which requires doctor-patient communication before treatment and the preservation of the body and spirit after treatment.Therefore,concentration of the mind is the key to acupuncture and moxibustion treatment.展开更多
Acute infections,including those due to Coronaviridae and other viruses,often stimulate a febrile response.A mild fever appears to improve outcome;it appears to diminish viral replication by several mechanisms,includi...Acute infections,including those due to Coronaviridae and other viruses,often stimulate a febrile response.A mild fever appears to improve outcome;it appears to diminish viral replication by several mechanisms,including virion entry into host cells and genome transcription,and improving host defence mechanisms against the pathogen.However,a fever may also damage host cellular and tissue function and increase metabolic demands.At temperatures at the lower end of the febrile range,the benefit of the fever appears to outweigh the detrimental effects.However,at higher temperatures,the outcome worsens,suggesting that the disadvantages of fever on the host predominate.A non-infective fever is associated with a worse outcome at lower temperatures,suggesting that hyperthermia carries less benefit in the absence of infection.This review discusses the risks and benefits of a fever on the host response,focusing on the effects of a fever on viral replication and host response,and the detrimental effect on the host.展开更多
It is widely accepted that body weight and adipose mass are tightly regulated by homeostatic mechanisms, in which leptin plays a critical role through hypothalamic pathways, and obesity is a result of homeostatic diso...It is widely accepted that body weight and adipose mass are tightly regulated by homeostatic mechanisms, in which leptin plays a critical role through hypothalamic pathways, and obesity is a result of homeostatic disorder. However, in C57BL/6J mice, we found that Rcan2 increases food intake and plays an important role in the develop- ment of age- and diet-induced obesity through a leptin-independent mechanism. RCAN2 was initially identified as a thyroid hormone （T3）-responsive gene in human fibroblasts. Expression of RCAN2 is regulated by T3 through the PI3K-Akt/PKB-mTOR-Rps6kbl signaling pathway. Intriguingly, both Rcan2-/- and Rps6kb1-/- mutations were re- ported to result in lean phenotypes in mice. In this study we compared the effects of these two mutations on growth and body weight in C57BL/6J mice. We observed reduced body weight and lower fat mass in both Rcan2-/- and Rps6kb1-/- mice compared to the wild-type mice, and we reported other differences unique to either the Rcan2-/- or Rps6kb1-/- mice. Firstly, loss of Rcan2 does not directly alter body length; however, Rcan2-/- mice exhibit reduced food intake. In contrast, Rps6kb1-/- mice exhibit abnormal embryonic development, which leads to smaller body size and reduced food intake in adulthood. Secondly, when fed a normal chow diet, Rcan2-/- mice weigh significantly more than Rps6kb1-/- mice, but both Rcan2-/- and Rps6kbl-/- mice develop similar amounts of epididymal fat. On a high-fat diet, Rcan2-/- mice gain body weight and fat mass at slower rates than Rps6kb1-/- mice. Finally, using the double-knockout mice （Rcan2-/- Rps6kb1-/-）, we demonstrate that concurrent loss of Rcan2and Rps6kbl has an additive effect on body weight reduction in C57BL/6J mice. Our data suggest that Rcan2 and Rps6kbl mutations both affect growth and body weight of mice, though likely through different mechanisms.展开更多
Subject Code:C09 With the support by the National Natural Science Foundation of China,a research group led by Dr.Shen Wei(沈伟)from Shanghai Tech University has deconstructed a neural circuit for body temperature regu...Subject Code:C09 With the support by the National Natural Science Foundation of China,a research group led by Dr.Shen Wei(沈伟)from Shanghai Tech University has deconstructed a neural circuit for body temperature regulation,which was published in PNAS(2017,114:2042—2047).展开更多
OBJECTIVE: To evaluate the clinical effects of Xiyan-ping injection intervention in pediatric patients with mild hand foot and mouth disease(HFMD).METHODS: A total of 329 patients were stratified and block-randomized ...OBJECTIVE: To evaluate the clinical effects of Xiyan-ping injection intervention in pediatric patients with mild hand foot and mouth disease(HFMD).METHODS: A total of 329 patients were stratified and block-randomized for symptomatic treatment of HFMD and assigned to one of the following groups: Western Medicine(group A, n = 103), Xiyanping injection(group B, n = 109), or Xiyanping injection and symptomatic treatment using Western Medicine(group C, n = 117). During the trial, fever,rash, ulcers of the mouth were observed among participants in each group before and after treatment, and conversion rates from mild to severe HFMD were measured.RESULTS: After 3-7 days' treatment, no significant differences in the conversion rates from mild to severe HFMD were observed among the three groups(P > 0.05). There was a significantly low number of patients with the onset time of antifebrile effect,vanished time of hand and foot rashes and cumulative time for the ulcers in the mouth vanished,among the three groups(P < 0.05, P < 0.01). The onset time of antifebrile effect of patients in groups B and C were markedly shorter compared with those in group A(P < 0.05, P < 0.01); there was no statically significant difference observed between groups B and C(P > 0.05). No significant differences were observed in the time for body temperature recovery among the three groups(P > 0.05). There were no significant differences in adverse effects among the three groups(P > 0.05).CONCLUSION: Xiyanping injection together with use of Western Medicine is most effective for symptomatic treatment of mild HFMD. No severe adverse reactions were observed.展开更多
基金By a grant from the National Science Foundation of China(No.81674090).
文摘“Focusing on treating the spirit(神)”is an important principle in acupuncture and moxibustion.It is a unique psychosomatic therapy involving the doctor and the patient,which includes regulating the spirit and the body.Traditional Chinese medicine attaches great importance to it.Focusing on treating the spirit is also a component of the standards of medical ethics.Only when doctors have noble medical ethics can they achieve clinical treatment of the mind and give full play to their skills to cure diseases.Focusing on treating the spirit runs through the entire clinical process of acupuncture and moxibustion.Before the treatment,it is necessary to focus on the spirit to distinguish the spirit and qi.During the treatment,attention should be paid to the mind to regulate the spirit and qi.It is the premise of clinical diagnosis and treatment of acupuncture and moxibustion and the key to the curative effect.Focusing on treating the spirit is also in the realm of doctor-patient double treatment,which requires doctor-patient communication before treatment and the preservation of the body and spirit after treatment.Therefore,concentration of the mind is the key to acupuncture and moxibustion treatment.
文摘Acute infections,including those due to Coronaviridae and other viruses,often stimulate a febrile response.A mild fever appears to improve outcome;it appears to diminish viral replication by several mechanisms,including virion entry into host cells and genome transcription,and improving host defence mechanisms against the pathogen.However,a fever may also damage host cellular and tissue function and increase metabolic demands.At temperatures at the lower end of the febrile range,the benefit of the fever appears to outweigh the detrimental effects.However,at higher temperatures,the outcome worsens,suggesting that the disadvantages of fever on the host predominate.A non-infective fever is associated with a worse outcome at lower temperatures,suggesting that hyperthermia carries less benefit in the absence of infection.This review discusses the risks and benefits of a fever on the host response,focusing on the effects of a fever on viral replication and host response,and the detrimental effect on the host.
基金Project supported by the National Natural Science Foundation of China(Nos.31140091 and 31371495)Shandong Natural Science Foundation(No.ZR2013CM040),China
文摘It is widely accepted that body weight and adipose mass are tightly regulated by homeostatic mechanisms, in which leptin plays a critical role through hypothalamic pathways, and obesity is a result of homeostatic disorder. However, in C57BL/6J mice, we found that Rcan2 increases food intake and plays an important role in the develop- ment of age- and diet-induced obesity through a leptin-independent mechanism. RCAN2 was initially identified as a thyroid hormone （T3）-responsive gene in human fibroblasts. Expression of RCAN2 is regulated by T3 through the PI3K-Akt/PKB-mTOR-Rps6kbl signaling pathway. Intriguingly, both Rcan2-/- and Rps6kb1-/- mutations were re- ported to result in lean phenotypes in mice. In this study we compared the effects of these two mutations on growth and body weight in C57BL/6J mice. We observed reduced body weight and lower fat mass in both Rcan2-/- and Rps6kb1-/- mice compared to the wild-type mice, and we reported other differences unique to either the Rcan2-/- or Rps6kb1-/- mice. Firstly, loss of Rcan2 does not directly alter body length; however, Rcan2-/- mice exhibit reduced food intake. In contrast, Rps6kb1-/- mice exhibit abnormal embryonic development, which leads to smaller body size and reduced food intake in adulthood. Secondly, when fed a normal chow diet, Rcan2-/- mice weigh significantly more than Rps6kb1-/- mice, but both Rcan2-/- and Rps6kbl-/- mice develop similar amounts of epididymal fat. On a high-fat diet, Rcan2-/- mice gain body weight and fat mass at slower rates than Rps6kb1-/- mice. Finally, using the double-knockout mice （Rcan2-/- Rps6kb1-/-）, we demonstrate that concurrent loss of Rcan2and Rps6kbl has an additive effect on body weight reduction in C57BL/6J mice. Our data suggest that Rcan2 and Rps6kbl mutations both affect growth and body weight of mice, though likely through different mechanisms.
文摘Subject Code:C09 With the support by the National Natural Science Foundation of China,a research group led by Dr.Shen Wei(沈伟)from Shanghai Tech University has deconstructed a neural circuit for body temperature regulation,which was published in PNAS(2017,114:2042—2047).
基金Supported by State Administration of Traditional Chinese Medicine(No.200907001)Natural Science Foundation of China(No.81603574)
文摘OBJECTIVE: To evaluate the clinical effects of Xiyan-ping injection intervention in pediatric patients with mild hand foot and mouth disease(HFMD).METHODS: A total of 329 patients were stratified and block-randomized for symptomatic treatment of HFMD and assigned to one of the following groups: Western Medicine(group A, n = 103), Xiyanping injection(group B, n = 109), or Xiyanping injection and symptomatic treatment using Western Medicine(group C, n = 117). During the trial, fever,rash, ulcers of the mouth were observed among participants in each group before and after treatment, and conversion rates from mild to severe HFMD were measured.RESULTS: After 3-7 days' treatment, no significant differences in the conversion rates from mild to severe HFMD were observed among the three groups(P > 0.05). There was a significantly low number of patients with the onset time of antifebrile effect,vanished time of hand and foot rashes and cumulative time for the ulcers in the mouth vanished,among the three groups(P < 0.05, P < 0.01). The onset time of antifebrile effect of patients in groups B and C were markedly shorter compared with those in group A(P < 0.05, P < 0.01); there was no statically significant difference observed between groups B and C(P > 0.05). No significant differences were observed in the time for body temperature recovery among the three groups(P > 0.05). There were no significant differences in adverse effects among the three groups(P > 0.05).CONCLUSION: Xiyanping injection together with use of Western Medicine is most effective for symptomatic treatment of mild HFMD. No severe adverse reactions were observed.
