The output regulation control problem for the Markovian jump systems with colored-noise is proposed in this paper.Since the modes mismatch problem often exists in the Markovian switching system,the authors design a mo...The output regulation control problem for the Markovian jump systems with colored-noise is proposed in this paper.Since the modes mismatch problem often exists in the Markovian switching system,the authors design a modes asynchronous controller with an internal model form,which can not only deal with external disturbance,but also reduce the influence of stochastic noise on the system,such that the mean square of the regulation error can be made arbitrarily small by turning the designed parameters.Meanwhile,a criterion of the m-th moment noise-to-state exponential stability is presented for continuous-time Markovian jump systems under the asynchronous control.展开更多
The eradication of poliomyelitis is a landmark achievement in the history of public health, providing strong protection for children’s health. The introduction of the Chinese Regulations for the Manufacture and Contr...The eradication of poliomyelitis is a landmark achievement in the history of public health, providing strong protection for children’s health. The introduction of the Chinese Regulations for the Manufacture and Control of Live Poliovirus Vaccine is a prerequisite and safeguard for the large-scale production and use of domestically produced live poliovirus vaccines, serving as an indispensable component of vaccine safety. This article, based on archival documents, letters, collections of essays, and oral interviews, examines the historical experience of the development of Chinese Regulations for the Manufacture and Control of Live Poliovirus Vaccine. It contends that the emphasis on localization and the active engagement in international cooperation are critical factors in the swift introduction of Chinese Regulations for the Manufacture and Control of Live Poliovirus Vaccine.展开更多
The distributed AC microgrid(MG) voltage restoration problem has been extensively studied. Still, many existing secondary voltage control strategies neglect the co-regulation of the voltage at the point of common coup...The distributed AC microgrid(MG) voltage restoration problem has been extensively studied. Still, many existing secondary voltage control strategies neglect the co-regulation of the voltage at the point of common coupling(PCC) in the AC multi-MG system(MMS). When an MMS consists of sub-MGs connected in series, power flow between the sub-MGs is not possible if the PCC voltage regulation relies on traditional consensus control objectives. In addition, communication faults and sensor faults are inevitable in the MMS. Therefore, a resilient voltage regulation strategy based on containment control is proposed.First, the feedback linearization technique allows us to deal with the nonlinear distributed generation(DG) dynamics, where the PCC regulation problem of an AC MG is transformed into an output feedback tracking problem for a linear multi-agent system(MAS) containing nonlinear dynamics. This process is an indispensable pre-processing in control algorithm design. Moreover, considering the unavailability of full-state measurements and the potential faults present in the sensors, a novel follower observer is designed to handle communication faults. Based on this, a controller based on containment control is designed to achieve voltage regulation. In regulating multiple PCC voltages to a reasonable upper and lower limit, a voltage difference exists between sub-MGs to achieve power flow. In addition, the secondary control algorithm avoids using global information of directed communication network and fault boundaries for communication link and sensor faults. Finally, the simulation results verify the performance of the proposed strategy.展开更多
Most current studies about shield tunneling machine focus on the construction safety and tunnel structure stability during the excavation. Behaviors of the machine itself are also studied, like some tracking control o...Most current studies about shield tunneling machine focus on the construction safety and tunnel structure stability during the excavation. Behaviors of the machine itself are also studied, like some tracking control of the machine. Yet, few works concern about the hydraulic components, especially the pressure and flow rate regulation components. This research focuses on pressure control strategies by using proportional pressure relief valve, which is widely applied on typical shield tunneling machines. Modeling of a commercial pressure relief valve is done. The modeling centers on the main valve, because the dynamic performance is determined by the main valve. To validate such modeling, a frequency-experiment result of the pressure relief valve, whose bandwidth is about 3 Hz, is presented as comparison. The modeling and the frequency experimental result show that it is reasonable to regard the pressure relief valve as a second-order system with two low corner frequencies. PID control, dead band compensation control and adaptive robust control(ARC) are proposed and simulation results are presented. For the ARC, implements by using first order approximation and second order approximation are presented. The simulation results show that the second order approximation implement with ARC can track 4 Hz sine signal very well, and the two ARC simulation errors are within 0.2 MPa. Finally, experiment results of dead band compensation control and adaptive robust control are given. The results show that dead band compensation had about 30° phase lag and about 20% off of the amplitude attenuation. ARC is tracking with little phase lag and almost no amplitude attenuation. In this research, ARC has been tested on a pressure relief valve. It is able to improve the valve's dynamic performances greatly, and it is capable of the pressure control of shield machine excavation.展开更多
RBPjk-dependent Notch signaling regulates both the onset of chondrocyte hypertrophy and the progression to terminal chondrocyte maturation during endochondral ossification. It has been suggested that Notch signaling c...RBPjk-dependent Notch signaling regulates both the onset of chondrocyte hypertrophy and the progression to terminal chondrocyte maturation during endochondral ossification. It has been suggested that Notch signaling can regulate Sox9 transcription, although how this occurs at the molecular level in chondrocytes and whether this transcriptional regulation mediates Notch control of chondrocyte hypertrophy and cartilage development is unknown or controversial. Here we have provided conclusive genetic evidence linking RBPjk-dependent Notch signaling to the regulation of Sox9 expression and chondrocyte hypertrophy by examining tissuespecific Rbpjk mutant(Prx1Cre;Rbpjkf/f), Rbpjk mutant/Sox9 haploinsufficient(Prx1Cre;Rbpjkf/f;Sox9f/1),and control embryos for alterations in SOX9 expression and chondrocyte hypertrophy during cartilage development. These studies demonstrate that Notch signaling regulates the onset of chondrocyte maturation in a SOX9-dependent manner, while Notch-mediated regulation of terminal chondrocyte maturation likely functions independently of SOX9. Furthermore, our in vitro molecular analyses of the Sox9 promoter and Notch-mediated regulation of Sox9 gene expression in chondrogenic cells identified the ability of Notch to induce Sox9 expression directly in the acute setting, but suppresses Sox9 transcription with prolonged Notch signaling that requires protein synthesis of secondary effectors.展开更多
The Xinhua News Agency has released the full text of the No.340 order of the State Council signed by Premier Zhu Rongji, on the publication of the Regulations of the People’s Republic of China on the Control of Forei...The Xinhua News Agency has released the full text of the No.340 order of the State Council signed by Premier Zhu Rongji, on the publication of the Regulations of the People’s Republic of China on the Control of Foreign Funded Financial Institutions, which will take effect on the date of February 1 in 2002.展开更多
Recently,decision has been made by the State Council onthe amendments to the Regulations for foreign Exchange Controlof the People’s Republic of China".The following amendments to the "Regulations Foreign E...Recently,decision has been made by the State Council onthe amendments to the Regulations for foreign Exchange Controlof the People’s Republic of China".The following amendments to the "Regulations Foreign Ex-change Control of the People’s Republic of China" are decided bythe State Council:1.Add an article and become Article five "No restriction bythe State as to regular international payment and transfer".2.Article 13 Clause one become Article 14 Clause one,amendto read "Foreign exchange of private use by individuals can be pur-chased within the prescribed limit amount.Foreign exchange ofprivate use by individuals in excess of the prescribed limit amount,an application has to be filed with the Administration of ExchangeControl,and foreign exchange can be purchased after展开更多
With the advancements in voltage source converter(VSC)technology,VSC based high voltage direct current(VSCHVDC)systems provide system operators with a prospective approach to enhance system operating stability and res...With the advancements in voltage source converter(VSC)technology,VSC based high voltage direct current(VSCHVDC)systems provide system operators with a prospective approach to enhance system operating stability and resilience.In addition to long-distance transmission,the VSC-HVDC system can also provide multiple ancillary services,such as frequency regulation,due to its power controllability.However,if a time delay exists in the control signal,the VSC-HVDC system may bring destabilizing influences to the system,which will decrease the system resilience under the disturbance.In order to reduce control deviation caused by time delay,in this paper,a small signal model is first conducted to analyze the impact of time delay on system stability.Then a time-delay correction control strategy for HVDC frequency regulation control is developed to reduce the influence of the time delay.The control performance of the proposed time-delay correction control is verified both in the established small signal model and the runtime simulation in a modified IEEE 39 bus system.The results indicate that the proposed time-delay correction control strategy shows significant improvement in system stability.展开更多
The durability of three-way catalyst (TWC) and corresponding close-coupled catalyst (CCC) for Euro Ⅳ stage regulation was investigated through Vehicle Road Running Mode tests, whereas emissions of regulated pollu...The durability of three-way catalyst (TWC) and corresponding close-coupled catalyst (CCC) for Euro Ⅳ stage regulation was investigated through Vehicle Road Running Mode tests, whereas emissions of regulated pollutants of three car fleet were investigated at every 100,000 km miles. The results showed that HC, NOx, and CO emission values could meet Euro Ⅳ regulation limits at every point. The redox properties of TWC and CCC were measured by CO reduction during each isothermal. It was obvious that both aged TWC and aged CCC behaved a good redox property at 673 and 773 K. Based on XRD and BET measurement results, TWC and CCC washcoat were characterized with good thermal stability.展开更多
Discharge plasmas in air can be accompanied by ultraviolet(UV) radiation and electron impact,which can produce large numbers of reactive species such as hydroxyl radical(OH·),oxygen radical(O·),ozone...Discharge plasmas in air can be accompanied by ultraviolet(UV) radiation and electron impact,which can produce large numbers of reactive species such as hydroxyl radical(OH·),oxygen radical(O·),ozone(O3),and nitrogen oxides(NOx),etc.The composition and dosage of reactive species usually play an important role in the case of volatile organic compounds(VOCs) treatment with the discharge plasmas.In this paper,we propose a volume discharge setup used to purify formaldehyde in air,which is configured by a plate-to-plate dielectric barrier discharge(DBD) channel and excited by an AC high voltage source.The results show that the relative spectral-intensity from DBD cell without formaldehyde is stronger than the case with formaldehyde.The energy efficiency ratios(EERs) of both oxides yield and formaldehyde removal can be regulated by the gas flow velocity in DBD channel,and the most desirable processing effect is the gas flow velocity within the range from2.50 to 3.33 m s^-1.Moreover,the EERs of both the generated dosages of oxides(O3 and NO2) and the amount of removed formaldehyde can also be regulated by both of the applied voltage and power density loaded on the DBD cell.Additionally,the EERs of both oxides generation and formaldehyde removal present as a function of normal distribution with increasing the applied power density,and the peak of the function is appeared in the range from 273.5 to 400.0 W l-1.This work clearly demonstrates the regulation characteristic of both the formaldehyde removal and oxides yield by using volume DBD,and it is helpful in the applications of VOCs removal by using discharge plasma.展开更多
This paper examines the design concept and mobile control strategy of the human assistant robot I-PENTAR(inverted pendulum type assistant robot). The motion equation is derived considering the non-holonomic constraint...This paper examines the design concept and mobile control strategy of the human assistant robot I-PENTAR(inverted pendulum type assistant robot). The motion equation is derived considering the non-holonomic constraint of the twowheeled mobile robot. Different optimal control approaches are applied to a linearized model of I-PENTAR. These include linear quadratic regulator(LQR), linear quadratic Gaussian control(LQG), H_2 control and H_∞ control. Simulation is performed for all the approaches yielding good performance results.展开更多
How osteoblast cells are induced is a central question for understanding skeletal formation. Abnormal osteoblast differentiation leads to a broad range of devastating craniofacial diseases. Here we have investigated i...How osteoblast cells are induced is a central question for understanding skeletal formation. Abnormal osteoblast differentiation leads to a broad range of devastating craniofacial diseases. Here we have investigated intramembranous ossification during cranial bone development in mouse models of skeletal genetic diseases that exhibit craniofacial bone defects. The GNAS gene encodes Gαs that transduces GPCR signaling. GNAS activation or loss-of-function mutations in humans cause fibrous dysplasia(FD) or progressive osseous heteroplasia(POH) that shows craniofacial hyperostosis or craniosynostosis, respectively. We find here that, while Hh ligand-dependent Hh signaling is essential for endochondral ossification, it is dispensable for intramembranous ossification, where Gαsregulates Hh signaling in a ligand-independent manner. We further show that Gαscontrols intramembranous ossification by regulating both Hh and Wnt/β-catenin signaling. In addition, Gαsactivation in the developing cranial bone leads to reduced ossification but increased cartilage presence due to reduced cartilage dissolution, not cell fate switch. Small molecule inhibitors of Hh and Wnt signaling can effectively ameliorate cranial bone phenotypes in mice caused by loss or gain of Gnas function mutations, respectively. Our work shows that studies of genetic diseases provide invaluable insights in both pathological bone defects and normal bone development, understanding both leads to better diagnosis and therapeutic treatment of bone diseases.展开更多
A new control strategy based on modal energy criterion is proposed to demonstrate the effectiveness of the control system in reducing structural earthquake responses. The modal control algorithm combining LQR(linear q...A new control strategy based on modal energy criterion is proposed to demonstrate the effectiveness of the control system in reducing structural earthquake responses. The modal control algorithm combining LQR(linear quadratic regulator) control algorithm is adopted in the discrete time-history analysis. The various modal energy forms are derived by definition of the generalized absolute displacement vector. A preliminary numerical study of the effectiveness of this control strategy is carried out on a 20-storey framed steel structural model. The controlled performance of the model is studied from the perspectives of both response and modal energy. Results show that the modal energy-based control strategy is very effective in reducing structural responses as well as in consuming a large amount of modal energy,while augmentation of additional generalized control force corresponding to the modes that contain little modal energy is unnecessary,as it does little help to improve the controlled structural performance.展开更多
The simple dynamic model is often adopted to deal with control questions in research on semi-active suspension. The model has more theoretic meanings than authentic ones because of difference between practical and phy...The simple dynamic model is often adopted to deal with control questions in research on semi-active suspension. The model has more theoretic meanings than authentic ones because of difference between practical and physical models. The virtual prototype has remarkable advantages in its application simulation processes. It is not only faster and more veracious, but also of better visualization of the simulation results.展开更多
Small modular reactors(SMRs) are beneficial in providing electricity power safely and viable for specific applications such as seawater desalination and heat production. Due to its inherent safety feature, the modular...Small modular reactors(SMRs) are beneficial in providing electricity power safely and viable for specific applications such as seawater desalination and heat production. Due to its inherent safety feature, the modular high temperature gas-cooled reactor(MHTGR) is considered as one of the best candidates for SMR-based nuclear power plants. Since its dynamics presents high nonlinearity and parameter uncertainty, it is necessary to develop adaptive power-level control, which is beneficial to safe, stable, and efficient operation of MHTGR and is easy to be implemented. In this paper, based on the physically-based control design approach, an adaptive outputfeedback power-level control is proposed for MHTGRs. This control can guarantee globally bounded closedloop stability and has a simple form. Numerical simulation results show the correctness of the theoretical analysis and satisfactory regulation performance of this control.展开更多
With the prevailing and popular entertainment programs, it brought huge benefits to TV stations, but at the same time caused a variety problems of homogenization. The paper analyzes the causes of the entertainment pro...With the prevailing and popular entertainment programs, it brought huge benefits to TV stations, but at the same time caused a variety problems of homogenization. The paper analyzes the causes of the entertainment programs, the root of homogenization, building game theory models between TV stations, TV station and audience to regulate and control the issue of homogeneity about entertainment programs.展开更多
Environmental regulation and industrial upgrading are the key to achieve win-win results for both economy and the environment. After environmental regulation tools are divided into market incentive and command control...Environmental regulation and industrial upgrading are the key to achieve win-win results for both economy and the environment. After environmental regulation tools are divided into market incentive and command control types,based on the provincial-level data of 30 provinces( cities and regions) in China from 2004 to 2016,the impact of environmental regulation on industrial upgrading and its transmission paths are empirically tested through an intermediary effect model. Technological innovation,FDI and capital market development all meet intermediary conditions,and the market incentive type is more dependent on technological innovation,while the command control type is more dependent on FDI and capital market development.The impact of the two environmental regulation tools on industrial upgrading is further studied. The results show that there is an " inverted U-shaped" relationship between the command control type and industrial upgrading,while there is a " U-shaped" relationship between the market incentive type and industrial upgrading,and there are also certain regional differences in the impact of environmental regulation on industrial upgrading.展开更多
Recently, Ministry of Foreign Trade and Economic Coop-eration issued a circular to the departments in charge of foreigntrade and economic cooperation under provinces, municipalitiesand autonomous regions, announcing t...Recently, Ministry of Foreign Trade and Economic Coop-eration issued a circular to the departments in charge of foreigntrade and economic cooperation under provinces, municipalitiesand autonomous regions, announcing that as of June 1, the Minis-try regulates its import license control on commodities and hasmade specific regulations.1. The import license control on agricultural chemical andcarbonate drink is removed and the control on "CD productionfacilities" is added. After the readjustment, totaling 35 commodi-ties are subject to import license control, and commodities undertariff lines are 374. Among them, 13 general commodities and 15mechanical and electrical commodities are subject to import quo-tas control; There are 7 commodities subject to import license butnon-quotas control.2. The import and export "CD production facilities" shall beconducted in accordance with the regulations as specified in展开更多
The resumption of production after the“suspension”caused by the COVID-19 has emerged as an urgent problem for many enterprises and the government.The resumption of production is actually a dynamic evolution problem ...The resumption of production after the“suspension”caused by the COVID-19 has emerged as an urgent problem for many enterprises and the government.The resumption of production is actually a dynamic evolution problem from 0 to 1(100%).This paper constructs a general game model and a dynamic replication system for the resumption of production and government support,and gives theorems for the construction of the model.It analyzes the evolution mechanism and scenario conditions for the convergence of enterprise strategies to the“resumption of production”strategy,takes the resumption of production of hog farmers as an example to carry out a study on the regulation of countermeasures to resume hog production,and explores systemic countermeasures and suggestions for the rapid convergence of farmers’strategies to the“resumption of work and production”strategy.The study found that the production resuming behavior system dynamics evolution game regulation model provides a systematic model and method for the study of resumption countermeasures,a general regulation model for the resumption ratio from 0 to 1(100%),and a systematic idea,method and model for exploring the“precise strategy”system to promote the rapid resumption of production.展开更多
Since the first demonstrations of radio-frequency(RF)circuits,the physics of the electromagnetic(EM)field and its regulation and control with codesigned circuits,have become essential competencies of RF circuit design...Since the first demonstrations of radio-frequency(RF)circuits,the physics of the electromagnetic(EM)field and its regulation and control with codesigned circuits,have become essential competencies of RF circuit designers.Leveraging advanced regulation or control methods,numerous high-performance circuits have been developed at RF and millimeter-wave(mm-wave)frequencies.Three main methods of electromagnetic regulation have been widely utilized,namely,the separation of electric and magnetic coupling paths,the manipulation of electromagnetic energy through the coupling of multiple tanks or multiple resonators,and the regulation of electromagnetic fields in air cavities or meta-substrates.The separated coupling paths of electric and magnetic fields provide guidance for designing a high-performance filter topology with a quasielliptical response through additional zeros.The manipulation of the EM field through electrical and magnetic intercouplings of multitanks or multiresonators,such as are used in oscillators,power amplifiers(PAs),etc.,results in remarkable power efficiency,size reduction,and wide bandwidth.The regulation of electromagnetism through an air cavity,patterned substrate,or metasubstrate reduces dielectric losses and size,especially when using a substrate integrated suspended line(SISL)platform.Many excellent circuits have been reported based on SISL with low loss,high integration,and self-packaging.Here,we present state-of-the-art cases that demonstrate the benefits of EM field regulation and control.展开更多
基金This work was partially supported by the National Natural Science Foundation of China under Grant No.U1966202.
文摘The output regulation control problem for the Markovian jump systems with colored-noise is proposed in this paper.Since the modes mismatch problem often exists in the Markovian switching system,the authors design a modes asynchronous controller with an internal model form,which can not only deal with external disturbance,but also reduce the influence of stochastic noise on the system,such that the mean square of the regulation error can be made arbitrarily small by turning the designed parameters.Meanwhile,a criterion of the m-th moment noise-to-state exponential stability is presented for continuous-time Markovian jump systems under the asynchronous control.
基金This work was supported by a key project of the 14th Five Year Plan of the Institute for the History of Natural Sciences,Chinese Academy of Sciences(E2291J01)the Youth Promotion Association of the Chinese Academy of Sciences(E3292G02).
文摘The eradication of poliomyelitis is a landmark achievement in the history of public health, providing strong protection for children’s health. The introduction of the Chinese Regulations for the Manufacture and Control of Live Poliovirus Vaccine is a prerequisite and safeguard for the large-scale production and use of domestically produced live poliovirus vaccines, serving as an indispensable component of vaccine safety. This article, based on archival documents, letters, collections of essays, and oral interviews, examines the historical experience of the development of Chinese Regulations for the Manufacture and Control of Live Poliovirus Vaccine. It contends that the emphasis on localization and the active engagement in international cooperation are critical factors in the swift introduction of Chinese Regulations for the Manufacture and Control of Live Poliovirus Vaccine.
基金supported in part by the National Key R&D Program of China(2018YFA0702200)the National Natural Science Foundation of China(62073065,U20A20190)。
文摘The distributed AC microgrid(MG) voltage restoration problem has been extensively studied. Still, many existing secondary voltage control strategies neglect the co-regulation of the voltage at the point of common coupling(PCC) in the AC multi-MG system(MMS). When an MMS consists of sub-MGs connected in series, power flow between the sub-MGs is not possible if the PCC voltage regulation relies on traditional consensus control objectives. In addition, communication faults and sensor faults are inevitable in the MMS. Therefore, a resilient voltage regulation strategy based on containment control is proposed.First, the feedback linearization technique allows us to deal with the nonlinear distributed generation(DG) dynamics, where the PCC regulation problem of an AC MG is transformed into an output feedback tracking problem for a linear multi-agent system(MAS) containing nonlinear dynamics. This process is an indispensable pre-processing in control algorithm design. Moreover, considering the unavailability of full-state measurements and the potential faults present in the sensors, a novel follower observer is designed to handle communication faults. Based on this, a controller based on containment control is designed to achieve voltage regulation. In regulating multiple PCC voltages to a reasonable upper and lower limit, a voltage difference exists between sub-MGs to achieve power flow. In addition, the secondary control algorithm avoids using global information of directed communication network and fault boundaries for communication link and sensor faults. Finally, the simulation results verify the performance of the proposed strategy.
基金Supported by National Natural Science Funds of China(Grant No.51275451)National Basic Research Program of China(973 Program,Grant No.2013CB035404)+1 种基金Science Fund for Creative Research Groups of National Natural Science Foundation of China(Grant No.51221004)National Hi-tech Research and Development Program of China(863 Program,Grant No.2013AA040203)
文摘Most current studies about shield tunneling machine focus on the construction safety and tunnel structure stability during the excavation. Behaviors of the machine itself are also studied, like some tracking control of the machine. Yet, few works concern about the hydraulic components, especially the pressure and flow rate regulation components. This research focuses on pressure control strategies by using proportional pressure relief valve, which is widely applied on typical shield tunneling machines. Modeling of a commercial pressure relief valve is done. The modeling centers on the main valve, because the dynamic performance is determined by the main valve. To validate such modeling, a frequency-experiment result of the pressure relief valve, whose bandwidth is about 3 Hz, is presented as comparison. The modeling and the frequency experimental result show that it is reasonable to regard the pressure relief valve as a second-order system with two low corner frequencies. PID control, dead band compensation control and adaptive robust control(ARC) are proposed and simulation results are presented. For the ARC, implements by using first order approximation and second order approximation are presented. The simulation results show that the second order approximation implement with ARC can track 4 Hz sine signal very well, and the two ARC simulation errors are within 0.2 MPa. Finally, experiment results of dead band compensation control and adaptive robust control are given. The results show that dead band compensation had about 30° phase lag and about 20% off of the amplitude attenuation. ARC is tracking with little phase lag and almost no amplitude attenuation. In this research, ARC has been tested on a pressure relief valve. It is able to improve the valve's dynamic performances greatly, and it is capable of the pressure control of shield machine excavation.
基金supported in part by the following United States National Institute of Health grants: R01 grants (AR057022 and AR063071), R21 grant (AR059733 to MJH), a P30 Core Center grant (AR061307), and a T32 training grant that supported both AK and TPR (AR053459 to Regis J.O’Keefe and Michael J.Zuscik)
文摘RBPjk-dependent Notch signaling regulates both the onset of chondrocyte hypertrophy and the progression to terminal chondrocyte maturation during endochondral ossification. It has been suggested that Notch signaling can regulate Sox9 transcription, although how this occurs at the molecular level in chondrocytes and whether this transcriptional regulation mediates Notch control of chondrocyte hypertrophy and cartilage development is unknown or controversial. Here we have provided conclusive genetic evidence linking RBPjk-dependent Notch signaling to the regulation of Sox9 expression and chondrocyte hypertrophy by examining tissuespecific Rbpjk mutant(Prx1Cre;Rbpjkf/f), Rbpjk mutant/Sox9 haploinsufficient(Prx1Cre;Rbpjkf/f;Sox9f/1),and control embryos for alterations in SOX9 expression and chondrocyte hypertrophy during cartilage development. These studies demonstrate that Notch signaling regulates the onset of chondrocyte maturation in a SOX9-dependent manner, while Notch-mediated regulation of terminal chondrocyte maturation likely functions independently of SOX9. Furthermore, our in vitro molecular analyses of the Sox9 promoter and Notch-mediated regulation of Sox9 gene expression in chondrogenic cells identified the ability of Notch to induce Sox9 expression directly in the acute setting, but suppresses Sox9 transcription with prolonged Notch signaling that requires protein synthesis of secondary effectors.
文摘The Xinhua News Agency has released the full text of the No.340 order of the State Council signed by Premier Zhu Rongji, on the publication of the Regulations of the People’s Republic of China on the Control of Foreign Funded Financial Institutions, which will take effect on the date of February 1 in 2002.
文摘Recently,decision has been made by the State Council onthe amendments to the Regulations for foreign Exchange Controlof the People’s Republic of China".The following amendments to the "Regulations Foreign Ex-change Control of the People’s Republic of China" are decided bythe State Council:1.Add an article and become Article five "No restriction bythe State as to regular international payment and transfer".2.Article 13 Clause one become Article 14 Clause one,amendto read "Foreign exchange of private use by individuals can be pur-chased within the prescribed limit amount.Foreign exchange ofprivate use by individuals in excess of the prescribed limit amount,an application has to be filed with the Administration of ExchangeControl,and foreign exchange can be purchased after
基金supported by National Natural Science Foundation of China(51977135,52207119).
文摘With the advancements in voltage source converter(VSC)technology,VSC based high voltage direct current(VSCHVDC)systems provide system operators with a prospective approach to enhance system operating stability and resilience.In addition to long-distance transmission,the VSC-HVDC system can also provide multiple ancillary services,such as frequency regulation,due to its power controllability.However,if a time delay exists in the control signal,the VSC-HVDC system may bring destabilizing influences to the system,which will decrease the system resilience under the disturbance.In order to reduce control deviation caused by time delay,in this paper,a small signal model is first conducted to analyze the impact of time delay on system stability.Then a time-delay correction control strategy for HVDC frequency regulation control is developed to reduce the influence of the time delay.The control performance of the proposed time-delay correction control is verified both in the established small signal model and the runtime simulation in a modified IEEE 39 bus system.The results indicate that the proposed time-delay correction control strategy shows significant improvement in system stability.
基金supported by the 863 Program (2006AA060305)China Postdoctoral Science Foundation (20070410196)+1 种基金Jiangsu Province Planned Projects for Postdoctoral Research Funds (0702054C)Jiangsu Province Natural Science Fund (BK2008532)
文摘The durability of three-way catalyst (TWC) and corresponding close-coupled catalyst (CCC) for Euro Ⅳ stage regulation was investigated through Vehicle Road Running Mode tests, whereas emissions of regulated pollutants of three car fleet were investigated at every 100,000 km miles. The results showed that HC, NOx, and CO emission values could meet Euro Ⅳ regulation limits at every point. The redox properties of TWC and CCC were measured by CO reduction during each isothermal. It was obvious that both aged TWC and aged CCC behaved a good redox property at 673 and 773 K. Based on XRD and BET measurement results, TWC and CCC washcoat were characterized with good thermal stability.
基金partially supported by the Fundamental Research Funds for the Central Universities(2017B15214)the Research Fund of Innovation and Entrepreneurship Education Reform for Chinese Universities(16CCJG01Z004)+2 种基金the Changzhou Science and Technology Program(CJ20160027)National Natural Science Foundation of China(11274092,61705058)the Natural Science Foundation of the Jiangsu Province(BK20170302)
文摘Discharge plasmas in air can be accompanied by ultraviolet(UV) radiation and electron impact,which can produce large numbers of reactive species such as hydroxyl radical(OH·),oxygen radical(O·),ozone(O3),and nitrogen oxides(NOx),etc.The composition and dosage of reactive species usually play an important role in the case of volatile organic compounds(VOCs) treatment with the discharge plasmas.In this paper,we propose a volume discharge setup used to purify formaldehyde in air,which is configured by a plate-to-plate dielectric barrier discharge(DBD) channel and excited by an AC high voltage source.The results show that the relative spectral-intensity from DBD cell without formaldehyde is stronger than the case with formaldehyde.The energy efficiency ratios(EERs) of both oxides yield and formaldehyde removal can be regulated by the gas flow velocity in DBD channel,and the most desirable processing effect is the gas flow velocity within the range from2.50 to 3.33 m s^-1.Moreover,the EERs of both the generated dosages of oxides(O3 and NO2) and the amount of removed formaldehyde can also be regulated by both of the applied voltage and power density loaded on the DBD cell.Additionally,the EERs of both oxides generation and formaldehyde removal present as a function of normal distribution with increasing the applied power density,and the peak of the function is appeared in the range from 273.5 to 400.0 W l-1.This work clearly demonstrates the regulation characteristic of both the formaldehyde removal and oxides yield by using volume DBD,and it is helpful in the applications of VOCs removal by using discharge plasma.
基金supported by the Deanship of Scientific Research(DSR)at the King Fahd University of Petroleum and Minerals(KFUPM)(141048)
文摘This paper examines the design concept and mobile control strategy of the human assistant robot I-PENTAR(inverted pendulum type assistant robot). The motion equation is derived considering the non-holonomic constraint of the twowheeled mobile robot. Different optimal control approaches are applied to a linearized model of I-PENTAR. These include linear quadratic regulator(LQR), linear quadratic Gaussian control(LQG), H_2 control and H_∞ control. Simulation is performed for all the approaches yielding good performance results.
基金supported by the NIH grants R01DE025866 from NIDCRR01AR070877 from NIAMSsupported by the 111 Project, MOE (B14038), China
文摘How osteoblast cells are induced is a central question for understanding skeletal formation. Abnormal osteoblast differentiation leads to a broad range of devastating craniofacial diseases. Here we have investigated intramembranous ossification during cranial bone development in mouse models of skeletal genetic diseases that exhibit craniofacial bone defects. The GNAS gene encodes Gαs that transduces GPCR signaling. GNAS activation or loss-of-function mutations in humans cause fibrous dysplasia(FD) or progressive osseous heteroplasia(POH) that shows craniofacial hyperostosis or craniosynostosis, respectively. We find here that, while Hh ligand-dependent Hh signaling is essential for endochondral ossification, it is dispensable for intramembranous ossification, where Gαsregulates Hh signaling in a ligand-independent manner. We further show that Gαscontrols intramembranous ossification by regulating both Hh and Wnt/β-catenin signaling. In addition, Gαsactivation in the developing cranial bone leads to reduced ossification but increased cartilage presence due to reduced cartilage dissolution, not cell fate switch. Small molecule inhibitors of Hh and Wnt signaling can effectively ameliorate cranial bone phenotypes in mice caused by loss or gain of Gnas function mutations, respectively. Our work shows that studies of genetic diseases provide invaluable insights in both pathological bone defects and normal bone development, understanding both leads to better diagnosis and therapeutic treatment of bone diseases.
基金Project (No. G20050452) supported by the Education Bureau of Zhejiang Province, China
文摘A new control strategy based on modal energy criterion is proposed to demonstrate the effectiveness of the control system in reducing structural earthquake responses. The modal control algorithm combining LQR(linear quadratic regulator) control algorithm is adopted in the discrete time-history analysis. The various modal energy forms are derived by definition of the generalized absolute displacement vector. A preliminary numerical study of the effectiveness of this control strategy is carried out on a 20-storey framed steel structural model. The controlled performance of the model is studied from the perspectives of both response and modal energy. Results show that the modal energy-based control strategy is very effective in reducing structural responses as well as in consuming a large amount of modal energy,while augmentation of additional generalized control force corresponding to the modes that contain little modal energy is unnecessary,as it does little help to improve the controlled structural performance.
文摘The simple dynamic model is often adopted to deal with control questions in research on semi-active suspension. The model has more theoretic meanings than authentic ones because of difference between practical and physical models. The virtual prototype has remarkable advantages in its application simulation processes. It is not only faster and more veracious, but also of better visualization of the simulation results.
文摘Small modular reactors(SMRs) are beneficial in providing electricity power safely and viable for specific applications such as seawater desalination and heat production. Due to its inherent safety feature, the modular high temperature gas-cooled reactor(MHTGR) is considered as one of the best candidates for SMR-based nuclear power plants. Since its dynamics presents high nonlinearity and parameter uncertainty, it is necessary to develop adaptive power-level control, which is beneficial to safe, stable, and efficient operation of MHTGR and is easy to be implemented. In this paper, based on the physically-based control design approach, an adaptive outputfeedback power-level control is proposed for MHTGRs. This control can guarantee globally bounded closedloop stability and has a simple form. Numerical simulation results show the correctness of the theoretical analysis and satisfactory regulation performance of this control.
文摘With the prevailing and popular entertainment programs, it brought huge benefits to TV stations, but at the same time caused a variety problems of homogenization. The paper analyzes the causes of the entertainment programs, the root of homogenization, building game theory models between TV stations, TV station and audience to regulate and control the issue of homogeneity about entertainment programs.
文摘Environmental regulation and industrial upgrading are the key to achieve win-win results for both economy and the environment. After environmental regulation tools are divided into market incentive and command control types,based on the provincial-level data of 30 provinces( cities and regions) in China from 2004 to 2016,the impact of environmental regulation on industrial upgrading and its transmission paths are empirically tested through an intermediary effect model. Technological innovation,FDI and capital market development all meet intermediary conditions,and the market incentive type is more dependent on technological innovation,while the command control type is more dependent on FDI and capital market development.The impact of the two environmental regulation tools on industrial upgrading is further studied. The results show that there is an " inverted U-shaped" relationship between the command control type and industrial upgrading,while there is a " U-shaped" relationship between the market incentive type and industrial upgrading,and there are also certain regional differences in the impact of environmental regulation on industrial upgrading.
文摘Recently, Ministry of Foreign Trade and Economic Coop-eration issued a circular to the departments in charge of foreigntrade and economic cooperation under provinces, municipalitiesand autonomous regions, announcing that as of June 1, the Minis-try regulates its import license control on commodities and hasmade specific regulations.1. The import license control on agricultural chemical andcarbonate drink is removed and the control on "CD productionfacilities" is added. After the readjustment, totaling 35 commodi-ties are subject to import license control, and commodities undertariff lines are 374. Among them, 13 general commodities and 15mechanical and electrical commodities are subject to import quo-tas control; There are 7 commodities subject to import license butnon-quotas control.2. The import and export "CD production facilities" shall beconducted in accordance with the regulations as specified in
文摘The resumption of production after the“suspension”caused by the COVID-19 has emerged as an urgent problem for many enterprises and the government.The resumption of production is actually a dynamic evolution problem from 0 to 1(100%).This paper constructs a general game model and a dynamic replication system for the resumption of production and government support,and gives theorems for the construction of the model.It analyzes the evolution mechanism and scenario conditions for the convergence of enterprise strategies to the“resumption of production”strategy,takes the resumption of production of hog farmers as an example to carry out a study on the regulation of countermeasures to resume hog production,and explores systemic countermeasures and suggestions for the rapid convergence of farmers’strategies to the“resumption of work and production”strategy.The study found that the production resuming behavior system dynamics evolution game regulation model provides a systematic model and method for the study of resumption countermeasures,a general regulation model for the resumption ratio from 0 to 1(100%),and a systematic idea,method and model for exploring the“precise strategy”system to promote the rapid resumption of production.
文摘Since the first demonstrations of radio-frequency(RF)circuits,the physics of the electromagnetic(EM)field and its regulation and control with codesigned circuits,have become essential competencies of RF circuit designers.Leveraging advanced regulation or control methods,numerous high-performance circuits have been developed at RF and millimeter-wave(mm-wave)frequencies.Three main methods of electromagnetic regulation have been widely utilized,namely,the separation of electric and magnetic coupling paths,the manipulation of electromagnetic energy through the coupling of multiple tanks or multiple resonators,and the regulation of electromagnetic fields in air cavities or meta-substrates.The separated coupling paths of electric and magnetic fields provide guidance for designing a high-performance filter topology with a quasielliptical response through additional zeros.The manipulation of the EM field through electrical and magnetic intercouplings of multitanks or multiresonators,such as are used in oscillators,power amplifiers(PAs),etc.,results in remarkable power efficiency,size reduction,and wide bandwidth.The regulation of electromagnetism through an air cavity,patterned substrate,or metasubstrate reduces dielectric losses and size,especially when using a substrate integrated suspended line(SISL)platform.Many excellent circuits have been reported based on SISL with low loss,high integration,and self-packaging.Here,we present state-of-the-art cases that demonstrate the benefits of EM field regulation and control.