The small and scattered enterprise pattern in the county economy has formed numerous sporadic pollution sources, hindering the centralized treatment of the water environment, increasing the cost and difficulty of trea...The small and scattered enterprise pattern in the county economy has formed numerous sporadic pollution sources, hindering the centralized treatment of the water environment, increasing the cost and difficulty of treatment. How enterprises can make reasonable decisions on their water environment behavior based on the external environment and their own factors is of great significance for scientifically and effectively designing water environment regulation mechanisms. Based on optimal control theory, this study investigates the design of contractual mechanisms for water environmental regulation for small and medium-sized enterprises. The enterprise is regarded as an independent economic entity that can adopt optimal control strategies to maximize its own interests. Based on the participation of multiple subjects including the government, enterprises, and the public, an optimal control strategy model for enterprises under contractual water environmental regulation is constructed using optimal control theory, and a method for calculating the amount of unit pollutant penalties is derived. The water pollutant treatment cost data of a paper company is selected to conduct empirical numerical analysis on the model. The results show that the increase in the probability of government regulation and public participation, as well as the decrease in local government protection for enterprises, can achieve the same regulatory effect while reducing the number of administrative penalties per unit. Finally, the implementation process of contractual water environmental regulation for small and medium-sized enterprises is designed.展开更多
An alternating current(AC)microgrid is a system that integrates renewable power,power converters,controllers and loads.Hierarchical control can manage the frequency of the microgrid to prevent imbalance and collapse o...An alternating current(AC)microgrid is a system that integrates renewable power,power converters,controllers and loads.Hierarchical control can manage the frequency of the microgrid to prevent imbalance and collapse of the system.The existing frequency control methods use traditional proportion integration(PI)controllers,which cannot adjust PI parameters in real-time to respond to the status changes of the system.Hierarchical control driven by fuzzy logic allows real-time adjustment of the PI parameters and the method used a two-layer control structure.The primary control used droop control to adjust power distribution,and fuzzy logic was used in the voltage loop of the primary control.The secondary control was added to make up for frequency deviation caused by droop control,and fuzzy logic was used in the secondary frequency control to deal with the dynamic change of frequency caused by the disturbances of loads.The proposed method was simulated in Matlab/Simulink.In the primary control,the proposed method reduced the total harmonic distortion(THD)of two cycles of the output voltage from 4.19%to 3.89%;in the secondary control,the proposed method reduced the frequency fluctuation of the system by about 0.03 Hz and 0.04 Hz when the load was increased and decreased,respectively.The results show that the proposed methods have a better effect on frequency maintenance and voltage control of the AC microgrid.展开更多
With the increasing prevalence of high-order systems in engineering applications, these systems often exhibitsignificant disturbances and can be challenging to model accurately. As a result, the active disturbance rej...With the increasing prevalence of high-order systems in engineering applications, these systems often exhibitsignificant disturbances and can be challenging to model accurately. As a result, the active disturbance rejectioncontroller (ADRC) has been widely applied in various fields. However, in controlling plant protection unmannedaerial vehicles (UAVs), which are typically large and subject to significant disturbances, load disturbances andthe possibility of multiple actuator faults during pesticide spraying pose significant challenges. To address theseissues, this paper proposes a novel fault-tolerant control method that combines a radial basis function neuralnetwork (RBFNN) with a second-order ADRC and leverages a fractional gradient descent (FGD) algorithm.We integrate the plant protection UAV model’s uncertain parameters, load disturbance parameters, and actuatorfault parameters and utilize the RBFNN for system parameter identification. The resulting ADRC exhibits loaddisturbance suppression and fault tolerance capabilities, and our proposed active fault-tolerant control law hasLyapunov stability implications. Experimental results obtained using a multi-rotor fault-tolerant test platformdemonstrate that the proposed method outperforms other control strategies regarding load disturbance suppressionand fault-tolerant performance.展开更多
With large-scale engineering projects being carried out in China, a large number of fossil localities have been discovered and excavated by responsible agencies, but still some important fossils of great value have be...With large-scale engineering projects being carried out in China, a large number of fossil localities have been discovered and excavated by responsible agencies, but still some important fossils of great value have been removed and smuggled into foreign countries. In the last three years, more than 1345 fossil specimens have been intercepted by Customs in Shenzhen, Shanghai, Tianjin, Beijing and elsewhere, and more than 5000 fossils, most of which are listed as key fossils,展开更多
Osteoarthritis(OA)is a prevalent joint disease with no effective treatment strategies.Aberrant mechanical stimuli was demonstrated to be an essential factor for OA pathogenesis.Although multiple studies have detected ...Osteoarthritis(OA)is a prevalent joint disease with no effective treatment strategies.Aberrant mechanical stimuli was demonstrated to be an essential factor for OA pathogenesis.Although multiple studies have detected potential regulatory mechanisms underlying OA and have concentrated on developing novel treatment strategies,the epigenetic control of OA remains unclear.Histone demethylase JMJD3 has been reported to mediate multiple physiological and pathological processes,including cell differentiation,proliferation,autophagy,and apoptosis.However,the regulation of JMJD3 in aberrant force-related OA and its mediatory effect on disease progression are still unknown.In this work,we confirmed the upregulation of JMJD3 in aberrant forceinduced cartilage injury in vitro and in vivo.Functionally,inhibition of JMJD3 by its inhibitor,GSK-J4,or downregulation of JMJD3 by adenovirus infection of sh-JMJD3 could alleviate the aberrant force-induced chondrocyte injury.Mechanistic investigation illustrated that aberrant force induces JMJD3 expression and then demethylates H3K27me3 at the NR4A1 promoter to promote its expression.Further experiments indicated that NR4A1 can regulate chondrocyte apoptosis,cartilage degeneration,extracellular matrix degradation,and inflammatory responses.In vivo,anterior cruciate ligament transection(ACLT)was performed to construct an OA model,and the therapeutic effect of GSK-J4 was validated.More importantly,we adopted a peptide-si RNA nanoplatform to deliver si-JMJD3 into articular cartilage,and the severity of joint degeneration was remarkably mitigated.Taken together,our findings demonstrated that JMJD3 is flow-responsive and epigenetically regulates OA progression.Our work provides evidences for JMJD3 inhibition as an innovative epigenetic therapy approach for joint diseases by utilizing p5RHH-si RNA nanocomplexes.展开更多
Article 1 These Regulations have been formulated under the Copyright Law of the People's Republic of China (hereinafter referred to as the Copyright Law) with a view to protecting the right of communication throug...Article 1 These Regulations have been formulated under the Copyright Law of the People's Republic of China (hereinafter referred to as the Copyright Law) with a view to protecting the right of communication through information network enjoyed by copyright owners, performers and producers of sound recordings and video recordings (hereinafter collectively referred to as the right owners) and to encouraging creation and communication of works conducive to the building of a socialist society that is advanced ethically and materially.展开更多
According to experiments in many years in Hebei Province, the research explored weed comprehensive control technology on millet fields in terms of application range, prevention rules, prevention object, agricultural c...According to experiments in many years in Hebei Province, the research explored weed comprehensive control technology on millet fields in terms of application range, prevention rules, prevention object, agricultural control, physical control, and chemical control and proposed specific methods and technological indices in order to provide technological references for comprehensive control on weeds of millet fields.展开更多
Spinal cord injury is a serious disease of the central nervous system involving irreversible nerve injury and various organ system injuries.At present,no effective clinical treatment exists.As one of the artificial hi...Spinal cord injury is a serious disease of the central nervous system involving irreversible nerve injury and various organ system injuries.At present,no effective clinical treatment exists.As one of the artificial hibernation techniques,mild hypothermia has preliminarily confirmed its clinical effect on spinal cord injury.However,its technical defects and barriers,along with serious clinical side effects,restrict its clinical application for spinal cord injury.Artificial hibernation is a futureoriented disruptive technology for human life support.It involves endogenous hibernation inducers and hibernation-related central neuromodulation that activate particular neurons,reduce the central constant temperature setting point,disrupt the normal constant body temperature,make the body adapt"to the external cold environment,and reduce the physiological resistance to cold stimulation.Thus,studying the artificial hibernation mechanism may help develop new treatment strategies more suitable for clinical use than the cooling method of mild hypothermia technology.This review introduces artificial hibernation technologies,including mild hypothermia technology,hibernation inducers,and hibernation-related central neuromodulation technology.It summarizes the relevant research on hypothermia and hibernation for organ and nerve protection.These studies show that artificial hibernation technologies have therapeutic significance on nerve injury after spinal co rd injury through inflammatory inhibition,immunosuppression,oxidative defense,and possible central protection.It also promotes the repair and protection of res pirato ry and digestive,cardiovascular,locomoto r,urinary,and endocrine systems.This review provides new insights for the clinical treatment of nerve and multiple organ protection after spinal cord injury thanks to artificial hibernation.At present,artificial hibernation technology is not mature,and research fa ces various challenges.Neve rtheless,the effort is wo rthwhile for the future development of medicine.展开更多
The problem of designing a feedback controller to achieve asymptotic disturbance rejection / attenuation while maintaining good transient response in the RTAC system is known as a benchmark nonlinear control problem, ...The problem of designing a feedback controller to achieve asymptotic disturbance rejection / attenuation while maintaining good transient response in the RTAC system is known as a benchmark nonlinear control problem, which has been an intensive research subject since 1995. In this paper, we will further investigate the solvability of the robust disturbance rejection problem of the RTAC system by the measurement output feedback control based on the robust output regulation method. We have obtained a design by overcoming two major obstacles: find a closed-form solution of the regulator equations; and devise a nonlinear internal model to account for non-polynomial nonlinearities.展开更多
A robust partial-state feedback asymptotic regulating control scheme is developed for a class of cascade systems with both nonlinear uncertainties and unknown control directions. A parameter separation technique is in...A robust partial-state feedback asymptotic regulating control scheme is developed for a class of cascade systems with both nonlinear uncertainties and unknown control directions. A parameter separation technique is introduced to separate the time-varying uncertainty and the unmeasurable state from nonlinear functions. Then, the Nussbaum-type gain method together with the idea of changing supply functions is adopted in the design of a smooth partial-state regulator that can ensure all the signals of the closed-loop system are globally uniformly bounded. Especially, the system state asymptotically converges to zero. The design procedure is illustrated through an example and the simulation results show that the controller is feasible and effective.展开更多
With the rapid development of computer technology, cloud-based services have become a hot topic. They not only provide users with convenience, but also bring many security issues, such as data sharing and privacy issu...With the rapid development of computer technology, cloud-based services have become a hot topic. They not only provide users with convenience, but also bring many security issues, such as data sharing and privacy issue. In this paper, we present an access control system with privilege separation based on privacy protection(PS-ACS). In the PS-ACS scheme, we divide users into private domain(PRD) and public domain(PUD) logically. In PRD, to achieve read access permission and write access permission, we adopt the Key-Aggregate Encryption(KAE) and the Improved Attribute-based Signature(IABS) respectively. In PUD, we construct a new multi-authority ciphertext policy attribute-based encryption(CP-ABE) scheme with efficient decryption to avoid the issues of single point of failure and complicated key distribution, and design an efficient attribute revocation method for it. The analysis and simulation result show that our scheme is feasible and superior to protect users' privacy in cloud-based services.展开更多
RBPjk-dependent Notch signaling regulates both the onset of chondrocyte hypertrophy and the progression to terminal chondrocyte maturation during endochondral ossification. It has been suggested that Notch signaling c...RBPjk-dependent Notch signaling regulates both the onset of chondrocyte hypertrophy and the progression to terminal chondrocyte maturation during endochondral ossification. It has been suggested that Notch signaling can regulate Sox9 transcription, although how this occurs at the molecular level in chondrocytes and whether this transcriptional regulation mediates Notch control of chondrocyte hypertrophy and cartilage development is unknown or controversial. Here we have provided conclusive genetic evidence linking RBPjk-dependent Notch signaling to the regulation of Sox9 expression and chondrocyte hypertrophy by examining tissuespecific Rbpjk mutant(Prx1Cre;Rbpjkf/f), Rbpjk mutant/Sox9 haploinsufficient(Prx1Cre;Rbpjkf/f;Sox9f/1),and control embryos for alterations in SOX9 expression and chondrocyte hypertrophy during cartilage development. These studies demonstrate that Notch signaling regulates the onset of chondrocyte maturation in a SOX9-dependent manner, while Notch-mediated regulation of terminal chondrocyte maturation likely functions independently of SOX9. Furthermore, our in vitro molecular analyses of the Sox9 promoter and Notch-mediated regulation of Sox9 gene expression in chondrogenic cells identified the ability of Notch to induce Sox9 expression directly in the acute setting, but suppresses Sox9 transcription with prolonged Notch signaling that requires protein synthesis of secondary effectors.展开更多
This job focuses on the stroke regulation of a class of high-precision metering pumps.A parametertuning method of robust non-fragile PID(proportional-integral-derivative)controllers is proposed with the assumption t...This job focuses on the stroke regulation of a class of high-precision metering pumps.A parametertuning method of robust non-fragile PID(proportional-integral-derivative)controllers is proposed with the assumption that a PID controller has additive gain perturbations.An H-infinite robust PID controller can be obtained by solving a linear matrix inequality.This approach can guarantee that the closed-loop control systems is asymptotically stable and the H-infinite norm of the transfer function from the disturbance to the output of a controlled system is less than a given constant to attenuate disturbances.The simulation case shows that the control performance of the proposed strategy is significantly better than the traditional PID approach in the situation with perturbations of controller parameters.展开更多
This paper addresses the control design for automatic train operation of high-speed trains with protection constraints.A new resilient nonlinear gain-based feedback control approach is proposed,which is capable of gua...This paper addresses the control design for automatic train operation of high-speed trains with protection constraints.A new resilient nonlinear gain-based feedback control approach is proposed,which is capable of guaranteeing,under some proper non-restrictive initial conditions,the protection constraints control raised by the distance-to-go(moving authority)curve and automatic train protection in practice.A new hyperbolic tangent function-based model is presented to mimic the whole operation process of high-speed trains.The proposed feedback control methods are easily implementable and computationally inexpensive because the presence of only two feedback gains guarantee satisfactory tracking performance and closed-loop stability,no adaptations of unknown parameters,function approximation of unknown nonlinearities,and attenuation of external disturbances in the proposed control strategies.Finally,rigorous proofs and comparative simulation results are given to demonstrate the effectiveness of the proposed approaches.展开更多
Effects of shading at the flowering and grain filling stages on osmotic regulation substance content and protective enzyme activities in the leaves of different rice genotypes (e.g., Ilyou 498, Gangyou 188, Dexiang 4...Effects of shading at the flowering and grain filling stages on osmotic regulation substance content and protective enzyme activities in the leaves of different rice genotypes (e.g., Ilyou 498, Gangyou 188, Dexiang 4103, Gangyou 527 and Chuanxiang 9838) were investigated. The results showed that the malondialdehyde content of Gangyou 188 significantly increased under shading, whereas those of Ilyou 498, Dexiang 4103, Gangyou 527 and Chuanxiang 9838 showed no significant differences compared to the control. The soluble sugar content significantly decreased in Ilyou 498, Gangyou 188, Dexiang 4103 and Chuanxiang 9838, whereas it did not significantly increase in Gangyou 527 under the weak light conditions (shading). Moreover, the soluble protein content in the leaves of different genotypes tended to decrease under shading. Further, the protective enzyme activities in the leaves varied in different rice genotypes under the shading treatment. Based on the osmotic regulation substance content and the protective enzyme activities in the leaves of different rice genotypes, it was concluded that Gangyou 188 and Gangyou 527 had strong abilities to adapt to the low light conditions. In addition, the mechanism of damage to rice leaves in different genotypes under shading was discussed.展开更多
Most current studies about shield tunneling machine focus on the construction safety and tunnel structure stability during the excavation. Behaviors of the machine itself are also studied, like some tracking control o...Most current studies about shield tunneling machine focus on the construction safety and tunnel structure stability during the excavation. Behaviors of the machine itself are also studied, like some tracking control of the machine. Yet, few works concern about the hydraulic components, especially the pressure and flow rate regulation components. This research focuses on pressure control strategies by using proportional pressure relief valve, which is widely applied on typical shield tunneling machines. Modeling of a commercial pressure relief valve is done. The modeling centers on the main valve, because the dynamic performance is determined by the main valve. To validate such modeling, a frequency-experiment result of the pressure relief valve, whose bandwidth is about 3 Hz, is presented as comparison. The modeling and the frequency experimental result show that it is reasonable to regard the pressure relief valve as a second-order system with two low corner frequencies. PID control, dead band compensation control and adaptive robust control(ARC) are proposed and simulation results are presented. For the ARC, implements by using first order approximation and second order approximation are presented. The simulation results show that the second order approximation implement with ARC can track 4 Hz sine signal very well, and the two ARC simulation errors are within 0.2 MPa. Finally, experiment results of dead band compensation control and adaptive robust control are given. The results show that dead band compensation had about 30° phase lag and about 20% off of the amplitude attenuation. ARC is tracking with little phase lag and almost no amplitude attenuation. In this research, ARC has been tested on a pressure relief valve. It is able to improve the valve's dynamic performances greatly, and it is capable of the pressure control of shield machine excavation.展开更多
This article studies the adaptive optimal output regulation problem for a class of interconnected singularly perturbed systems(SPSs) with unknown dynamics based on reinforcement learning(RL).Taking into account the sl...This article studies the adaptive optimal output regulation problem for a class of interconnected singularly perturbed systems(SPSs) with unknown dynamics based on reinforcement learning(RL).Taking into account the slow and fast characteristics among system states,the interconnected SPS is decomposed into the slow time-scale dynamics and the fast timescale dynamics through singular perturbation theory.For the fast time-scale dynamics with interconnections,we devise a decentralized optimal control strategy by selecting appropriate weight matrices in the cost function.For the slow time-scale dynamics with unknown system parameters,an off-policy RL algorithm with convergence guarantee is given to learn the optimal control strategy in terms of measurement data.By combining the slow and fast controllers,we establish the composite decentralized adaptive optimal output regulator,and rigorously analyze the stability and optimality of the closed-loop system.The proposed decomposition design not only bypasses the numerical stiffness but also alleviates the high-dimensionality.The efficacy of the proposed methodology is validated by a load-frequency control application of a two-area power system.展开更多
This paper firstly reviews the recent development in power system protection and control, with special attention paid to the wide-area and integrated protection, in order to look into future development of integration...This paper firstly reviews the recent development in power system protection and control, with special attention paid to the wide-area and integrated protection, in order to look into future development of integration of protection and control for smart grids. This paper mainly reports on the development of integrated wide area protection and control for power systems. The concept of integrated wide area protection and control is introduced, in which a hierarchical protection and control system provides the protection and control of wide area or regional power substations/ plants and their associated power network. The system is mainly divided into three levels, the local, the substation/plant and the wide area/regional protection and control. The integrated functions at each level are described in details with an aim to develop an optimal coordination mechanism between the levels. One of the core elements in the system is the synchronised wide area communication network between the substations and the protection and control system, in which latest communication technology is employed. Another important player in the system is the wide area synchronized protection and control information platform, which not only enables the fusion three line of defence for power system protection and control, but also provides a perfect tool for the application of cloud computing to substations and power networks.展开更多
This paper investigates the robust cooperative output regulation problem for a class of heterogeneousuncertain linear multi-agent systems with an unknown exosystem via event-triggered control (ETC). By utilizingthe in...This paper investigates the robust cooperative output regulation problem for a class of heterogeneousuncertain linear multi-agent systems with an unknown exosystem via event-triggered control (ETC). By utilizingthe internal model approach and the adaptive control technique, a distributed adaptive internal model isconstructed for each agent. Then, based on this internal model, a fully distributed ETC strategy composed ofa distributed event-triggered adaptive output feedback control law and a distributed dynamic event-triggeringmechanism is proposed, in which each agent updates its control input at its own triggering time instants. It isshown that under the proposed ETC strategy, the robust cooperative output regulation problem can be solvedwithout requiring either the global information associated with the communication topology or the bounds ofthe uncertain or unknown parameters in each agent and the exosystem. A numerical example is provided toillustrate the effectiveness of the proposed control strategy.展开更多
Applying pre-stress in glulam beam can reduce its deformation and make full use of the compressive strength of wood.However,when the glulam with low strength and the pre-stressed steel with high strength form combined...Applying pre-stress in glulam beam can reduce its deformation and make full use of the compressive strength of wood.However,when the glulam with low strength and the pre-stressed steel with high strength form combined members,materials of high strength can’t be fully utilized.Therefore,this study puts forward the idea of regulating and controlling string beam of pre-stressed glulam.By regulating and controlling the pre-stress,a part of the load borne by the wood is allocated to the pre-stressed tendon,which is equivalent to completing a redistribution of internal force,thus realizing the repeated utilization of the wood strength and the full utilization of the strength of the high-strength pre-stressed tendon.The bending experiments of 10 beams under 5 working conditions are carried out.The failure mode,bearing capacity and deformation of the beams are analyzed.The results show that 90%of beams are deformed under compression.The ultimate load of the regulated and controlled beam is obviously larger than that of the unregulated beam,and the ultimate load of the beam increases with the increase of the degree of regulation and control.Compared with that of the unregulated beams,the ultimate load of beams regulated by 7.5%-30%increases by 25.42%-65.08%,and the regulated and controlled effect is obvious.With the increase of the regulation and control amplitude of pre-stress,the stiffness of string beam of pre-stressed glulam increases.In addition,with the increase of the regulation and control amplitude,the compression height of the beam increases before the failure,and it reaches the state of full-section compression at the time of failure,giving full play to the compressive property of the glulam.At the end of the experiment,the constitutive relation which can reflect the anisotropy of the wood is established combined with the experimental data.The finite element analysis of the beam under 7 working conditions is carried out by using ABAQUS finite element program,and the influence of the regulation and control amplitude on the stress distribution and ultimate bearing capacity of the beam is discussed.展开更多
文摘The small and scattered enterprise pattern in the county economy has formed numerous sporadic pollution sources, hindering the centralized treatment of the water environment, increasing the cost and difficulty of treatment. How enterprises can make reasonable decisions on their water environment behavior based on the external environment and their own factors is of great significance for scientifically and effectively designing water environment regulation mechanisms. Based on optimal control theory, this study investigates the design of contractual mechanisms for water environmental regulation for small and medium-sized enterprises. The enterprise is regarded as an independent economic entity that can adopt optimal control strategies to maximize its own interests. Based on the participation of multiple subjects including the government, enterprises, and the public, an optimal control strategy model for enterprises under contractual water environmental regulation is constructed using optimal control theory, and a method for calculating the amount of unit pollutant penalties is derived. The water pollutant treatment cost data of a paper company is selected to conduct empirical numerical analysis on the model. The results show that the increase in the probability of government regulation and public participation, as well as the decrease in local government protection for enterprises, can achieve the same regulatory effect while reducing the number of administrative penalties per unit. Finally, the implementation process of contractual water environmental regulation for small and medium-sized enterprises is designed.
基金National Natural Science Foundation of China(No.62303107)Fundamental Research Funds for the Central Universities,China(Nos.2232022G-09 and 2232021D-38)Shanghai Sailing Program,China(No.21YF1400100)。
文摘An alternating current(AC)microgrid is a system that integrates renewable power,power converters,controllers and loads.Hierarchical control can manage the frequency of the microgrid to prevent imbalance and collapse of the system.The existing frequency control methods use traditional proportion integration(PI)controllers,which cannot adjust PI parameters in real-time to respond to the status changes of the system.Hierarchical control driven by fuzzy logic allows real-time adjustment of the PI parameters and the method used a two-layer control structure.The primary control used droop control to adjust power distribution,and fuzzy logic was used in the voltage loop of the primary control.The secondary control was added to make up for frequency deviation caused by droop control,and fuzzy logic was used in the secondary frequency control to deal with the dynamic change of frequency caused by the disturbances of loads.The proposed method was simulated in Matlab/Simulink.In the primary control,the proposed method reduced the total harmonic distortion(THD)of two cycles of the output voltage from 4.19%to 3.89%;in the secondary control,the proposed method reduced the frequency fluctuation of the system by about 0.03 Hz and 0.04 Hz when the load was increased and decreased,respectively.The results show that the proposed methods have a better effect on frequency maintenance and voltage control of the AC microgrid.
基金the 2021 Key Project of Natural Science and Technology of Yangzhou Polytechnic Institute,Active Disturbance Rejection and Fault-Tolerant Control of Multi-Rotor Plant ProtectionUAV Based on QBall-X4(Grant Number 2021xjzk002).
文摘With the increasing prevalence of high-order systems in engineering applications, these systems often exhibitsignificant disturbances and can be challenging to model accurately. As a result, the active disturbance rejectioncontroller (ADRC) has been widely applied in various fields. However, in controlling plant protection unmannedaerial vehicles (UAVs), which are typically large and subject to significant disturbances, load disturbances andthe possibility of multiple actuator faults during pesticide spraying pose significant challenges. To address theseissues, this paper proposes a novel fault-tolerant control method that combines a radial basis function neuralnetwork (RBFNN) with a second-order ADRC and leverages a fractional gradient descent (FGD) algorithm.We integrate the plant protection UAV model’s uncertain parameters, load disturbance parameters, and actuatorfault parameters and utilize the RBFNN for system parameter identification. The resulting ADRC exhibits loaddisturbance suppression and fault tolerance capabilities, and our proposed active fault-tolerant control law hasLyapunov stability implications. Experimental results obtained using a multi-rotor fault-tolerant test platformdemonstrate that the proposed method outperforms other control strategies regarding load disturbance suppressionand fault-tolerant performance.
文摘With large-scale engineering projects being carried out in China, a large number of fossil localities have been discovered and excavated by responsible agencies, but still some important fossils of great value have been removed and smuggled into foreign countries. In the last three years, more than 1345 fossil specimens have been intercepted by Customs in Shenzhen, Shanghai, Tianjin, Beijing and elsewhere, and more than 5000 fossils, most of which are listed as key fossils,
基金supported by National Natural Science Foundation of China(11932012,81870790 and 31801233)Science and Technology Commission of Shanghai Municipality(18441903600)+1 种基金Clinical Research Plan of SHDC(No.SHDC2020CR3009A)Innovative Research Team of High-level Local Universities in Shanghai(SSMU-ZDCX20180902)。
文摘Osteoarthritis(OA)is a prevalent joint disease with no effective treatment strategies.Aberrant mechanical stimuli was demonstrated to be an essential factor for OA pathogenesis.Although multiple studies have detected potential regulatory mechanisms underlying OA and have concentrated on developing novel treatment strategies,the epigenetic control of OA remains unclear.Histone demethylase JMJD3 has been reported to mediate multiple physiological and pathological processes,including cell differentiation,proliferation,autophagy,and apoptosis.However,the regulation of JMJD3 in aberrant force-related OA and its mediatory effect on disease progression are still unknown.In this work,we confirmed the upregulation of JMJD3 in aberrant forceinduced cartilage injury in vitro and in vivo.Functionally,inhibition of JMJD3 by its inhibitor,GSK-J4,or downregulation of JMJD3 by adenovirus infection of sh-JMJD3 could alleviate the aberrant force-induced chondrocyte injury.Mechanistic investigation illustrated that aberrant force induces JMJD3 expression and then demethylates H3K27me3 at the NR4A1 promoter to promote its expression.Further experiments indicated that NR4A1 can regulate chondrocyte apoptosis,cartilage degeneration,extracellular matrix degradation,and inflammatory responses.In vivo,anterior cruciate ligament transection(ACLT)was performed to construct an OA model,and the therapeutic effect of GSK-J4 was validated.More importantly,we adopted a peptide-si RNA nanoplatform to deliver si-JMJD3 into articular cartilage,and the severity of joint degeneration was remarkably mitigated.Taken together,our findings demonstrated that JMJD3 is flow-responsive and epigenetically regulates OA progression.Our work provides evidences for JMJD3 inhibition as an innovative epigenetic therapy approach for joint diseases by utilizing p5RHH-si RNA nanocomplexes.
文摘Article 1 These Regulations have been formulated under the Copyright Law of the People's Republic of China (hereinafter referred to as the Copyright Law) with a view to protecting the right of communication through information network enjoyed by copyright owners, performers and producers of sound recordings and video recordings (hereinafter collectively referred to as the right owners) and to encouraging creation and communication of works conducive to the building of a socialist society that is advanced ethically and materially.
基金Supported by Special Fund for Agro-scientific Research in the Public Interest(20120304201)Hebei Province Key Technology Research and Development Program(09250307D)~~
文摘According to experiments in many years in Hebei Province, the research explored weed comprehensive control technology on millet fields in terms of application range, prevention rules, prevention object, agricultural control, physical control, and chemical control and proposed specific methods and technological indices in order to provide technological references for comprehensive control on weeds of millet fields.
基金supported by the Key Projects of the National Natural Science Foundation of China,No.11932013(to XC)Key Military Logistics Research Projects,No.B WJ21J002(to XC)+4 种基金the Key projects of the Special Zone for National Defence Innovation,No.21-163-12-ZT006002-13(to XC)the National Nature Science Foundation of China No.82272255(to XC)the National Defense Science and Technology Outstanding Youth Science Fund Program,No.2021-JCIQ-ZQ-035(to XC)the Scientific Research Innovation Team Project of Armed Police Characteristic Medical Center,No.KYCXTD0104(to ZL)the National Natural Science Foundation of China Youth Fund,No.82004467(to BC)。
文摘Spinal cord injury is a serious disease of the central nervous system involving irreversible nerve injury and various organ system injuries.At present,no effective clinical treatment exists.As one of the artificial hibernation techniques,mild hypothermia has preliminarily confirmed its clinical effect on spinal cord injury.However,its technical defects and barriers,along with serious clinical side effects,restrict its clinical application for spinal cord injury.Artificial hibernation is a futureoriented disruptive technology for human life support.It involves endogenous hibernation inducers and hibernation-related central neuromodulation that activate particular neurons,reduce the central constant temperature setting point,disrupt the normal constant body temperature,make the body adapt"to the external cold environment,and reduce the physiological resistance to cold stimulation.Thus,studying the artificial hibernation mechanism may help develop new treatment strategies more suitable for clinical use than the cooling method of mild hypothermia technology.This review introduces artificial hibernation technologies,including mild hypothermia technology,hibernation inducers,and hibernation-related central neuromodulation technology.It summarizes the relevant research on hypothermia and hibernation for organ and nerve protection.These studies show that artificial hibernation technologies have therapeutic significance on nerve injury after spinal co rd injury through inflammatory inhibition,immunosuppression,oxidative defense,and possible central protection.It also promotes the repair and protection of res pirato ry and digestive,cardiovascular,locomoto r,urinary,and endocrine systems.This review provides new insights for the clinical treatment of nerve and multiple organ protection after spinal cord injury thanks to artificial hibernation.At present,artificial hibernation technology is not mature,and research fa ces various challenges.Neve rtheless,the effort is wo rthwhile for the future development of medicine.
基金This work was supported by the Hong Kong Research Grants Council(No.CUHK4316/02E)the National Natural Science Foundations of China(No.60374038)
文摘The problem of designing a feedback controller to achieve asymptotic disturbance rejection / attenuation while maintaining good transient response in the RTAC system is known as a benchmark nonlinear control problem, which has been an intensive research subject since 1995. In this paper, we will further investigate the solvability of the robust disturbance rejection problem of the RTAC system by the measurement output feedback control based on the robust output regulation method. We have obtained a design by overcoming two major obstacles: find a closed-form solution of the regulator equations; and devise a nonlinear internal model to account for non-polynomial nonlinearities.
基金supported by the National Natural Science Foundation of China (No.60774010,60574080)the research startup Foundation of Qufu Normal University
文摘A robust partial-state feedback asymptotic regulating control scheme is developed for a class of cascade systems with both nonlinear uncertainties and unknown control directions. A parameter separation technique is introduced to separate the time-varying uncertainty and the unmeasurable state from nonlinear functions. Then, the Nussbaum-type gain method together with the idea of changing supply functions is adopted in the design of a smooth partial-state regulator that can ensure all the signals of the closed-loop system are globally uniformly bounded. Especially, the system state asymptotically converges to zero. The design procedure is illustrated through an example and the simulation results show that the controller is feasible and effective.
基金financially supported by the National Natural Science Foundation of China(No.61303216,No.61272457,No.U1401251,and No.61373172)the National High Technology Research and Development Program of China(863 Program)(No.2012AA013102)National 111 Program of China B16037 and B08038
文摘With the rapid development of computer technology, cloud-based services have become a hot topic. They not only provide users with convenience, but also bring many security issues, such as data sharing and privacy issue. In this paper, we present an access control system with privilege separation based on privacy protection(PS-ACS). In the PS-ACS scheme, we divide users into private domain(PRD) and public domain(PUD) logically. In PRD, to achieve read access permission and write access permission, we adopt the Key-Aggregate Encryption(KAE) and the Improved Attribute-based Signature(IABS) respectively. In PUD, we construct a new multi-authority ciphertext policy attribute-based encryption(CP-ABE) scheme with efficient decryption to avoid the issues of single point of failure and complicated key distribution, and design an efficient attribute revocation method for it. The analysis and simulation result show that our scheme is feasible and superior to protect users' privacy in cloud-based services.
基金supported in part by the following United States National Institute of Health grants: R01 grants (AR057022 and AR063071), R21 grant (AR059733 to MJH), a P30 Core Center grant (AR061307), and a T32 training grant that supported both AK and TPR (AR053459 to Regis J.O’Keefe and Michael J.Zuscik)
文摘RBPjk-dependent Notch signaling regulates both the onset of chondrocyte hypertrophy and the progression to terminal chondrocyte maturation during endochondral ossification. It has been suggested that Notch signaling can regulate Sox9 transcription, although how this occurs at the molecular level in chondrocytes and whether this transcriptional regulation mediates Notch control of chondrocyte hypertrophy and cartilage development is unknown or controversial. Here we have provided conclusive genetic evidence linking RBPjk-dependent Notch signaling to the regulation of Sox9 expression and chondrocyte hypertrophy by examining tissuespecific Rbpjk mutant(Prx1Cre;Rbpjkf/f), Rbpjk mutant/Sox9 haploinsufficient(Prx1Cre;Rbpjkf/f;Sox9f/1),and control embryos for alterations in SOX9 expression and chondrocyte hypertrophy during cartilage development. These studies demonstrate that Notch signaling regulates the onset of chondrocyte maturation in a SOX9-dependent manner, while Notch-mediated regulation of terminal chondrocyte maturation likely functions independently of SOX9. Furthermore, our in vitro molecular analyses of the Sox9 promoter and Notch-mediated regulation of Sox9 gene expression in chondrogenic cells identified the ability of Notch to induce Sox9 expression directly in the acute setting, but suppresses Sox9 transcription with prolonged Notch signaling that requires protein synthesis of secondary effectors.
基金Supported by the National Natural Science Foundation of China(60604015) the Key Research Program of Education Department of Zhejiang Province(Z200803521)
文摘This job focuses on the stroke regulation of a class of high-precision metering pumps.A parametertuning method of robust non-fragile PID(proportional-integral-derivative)controllers is proposed with the assumption that a PID controller has additive gain perturbations.An H-infinite robust PID controller can be obtained by solving a linear matrix inequality.This approach can guarantee that the closed-loop control systems is asymptotically stable and the H-infinite norm of the transfer function from the disturbance to the output of a controlled system is less than a given constant to attenuate disturbances.The simulation case shows that the control performance of the proposed strategy is significantly better than the traditional PID approach in the situation with perturbations of controller parameters.
基金supported jointly by the National Natural Science Foundation of China(61703033,61790573)Beijing Natural Science Foundation(4192046)+1 种基金Fundamental Research Funds for Central Universities(2018JBZ002)State Key Laboratory of Rail Traffic Control and Safety(RCS2018ZT013),Beijing Jiaotong University
文摘This paper addresses the control design for automatic train operation of high-speed trains with protection constraints.A new resilient nonlinear gain-based feedback control approach is proposed,which is capable of guaranteeing,under some proper non-restrictive initial conditions,the protection constraints control raised by the distance-to-go(moving authority)curve and automatic train protection in practice.A new hyperbolic tangent function-based model is presented to mimic the whole operation process of high-speed trains.The proposed feedback control methods are easily implementable and computationally inexpensive because the presence of only two feedback gains guarantee satisfactory tracking performance and closed-loop stability,no adaptations of unknown parameters,function approximation of unknown nonlinearities,and attenuation of external disturbances in the proposed control strategies.Finally,rigorous proofs and comparative simulation results are given to demonstrate the effectiveness of the proposed approaches.
基金supported by the 11th 5-year Major Project of National Science and Technology Support Plan(Grant No. 2011BAD16B05)Youth Foundation Project of Sichuan Agricultural University in ChinaOutstanding Master’s Thesis Foundation Project of Sichuan Agricultural University in China
文摘Effects of shading at the flowering and grain filling stages on osmotic regulation substance content and protective enzyme activities in the leaves of different rice genotypes (e.g., Ilyou 498, Gangyou 188, Dexiang 4103, Gangyou 527 and Chuanxiang 9838) were investigated. The results showed that the malondialdehyde content of Gangyou 188 significantly increased under shading, whereas those of Ilyou 498, Dexiang 4103, Gangyou 527 and Chuanxiang 9838 showed no significant differences compared to the control. The soluble sugar content significantly decreased in Ilyou 498, Gangyou 188, Dexiang 4103 and Chuanxiang 9838, whereas it did not significantly increase in Gangyou 527 under the weak light conditions (shading). Moreover, the soluble protein content in the leaves of different genotypes tended to decrease under shading. Further, the protective enzyme activities in the leaves varied in different rice genotypes under the shading treatment. Based on the osmotic regulation substance content and the protective enzyme activities in the leaves of different rice genotypes, it was concluded that Gangyou 188 and Gangyou 527 had strong abilities to adapt to the low light conditions. In addition, the mechanism of damage to rice leaves in different genotypes under shading was discussed.
基金Supported by National Natural Science Funds of China(Grant No.51275451)National Basic Research Program of China(973 Program,Grant No.2013CB035404)+1 种基金Science Fund for Creative Research Groups of National Natural Science Foundation of China(Grant No.51221004)National Hi-tech Research and Development Program of China(863 Program,Grant No.2013AA040203)
文摘Most current studies about shield tunneling machine focus on the construction safety and tunnel structure stability during the excavation. Behaviors of the machine itself are also studied, like some tracking control of the machine. Yet, few works concern about the hydraulic components, especially the pressure and flow rate regulation components. This research focuses on pressure control strategies by using proportional pressure relief valve, which is widely applied on typical shield tunneling machines. Modeling of a commercial pressure relief valve is done. The modeling centers on the main valve, because the dynamic performance is determined by the main valve. To validate such modeling, a frequency-experiment result of the pressure relief valve, whose bandwidth is about 3 Hz, is presented as comparison. The modeling and the frequency experimental result show that it is reasonable to regard the pressure relief valve as a second-order system with two low corner frequencies. PID control, dead band compensation control and adaptive robust control(ARC) are proposed and simulation results are presented. For the ARC, implements by using first order approximation and second order approximation are presented. The simulation results show that the second order approximation implement with ARC can track 4 Hz sine signal very well, and the two ARC simulation errors are within 0.2 MPa. Finally, experiment results of dead band compensation control and adaptive robust control are given. The results show that dead band compensation had about 30° phase lag and about 20% off of the amplitude attenuation. ARC is tracking with little phase lag and almost no amplitude attenuation. In this research, ARC has been tested on a pressure relief valve. It is able to improve the valve's dynamic performances greatly, and it is capable of the pressure control of shield machine excavation.
基金supported by the National Natural Science Foundation of China (62073327,62273350)the Natural Science Foundation of Jiangsu Province (BK20221112)。
文摘This article studies the adaptive optimal output regulation problem for a class of interconnected singularly perturbed systems(SPSs) with unknown dynamics based on reinforcement learning(RL).Taking into account the slow and fast characteristics among system states,the interconnected SPS is decomposed into the slow time-scale dynamics and the fast timescale dynamics through singular perturbation theory.For the fast time-scale dynamics with interconnections,we devise a decentralized optimal control strategy by selecting appropriate weight matrices in the cost function.For the slow time-scale dynamics with unknown system parameters,an off-policy RL algorithm with convergence guarantee is given to learn the optimal control strategy in terms of measurement data.By combining the slow and fast controllers,we establish the composite decentralized adaptive optimal output regulator,and rigorously analyze the stability and optimality of the closed-loop system.The proposed decomposition design not only bypasses the numerical stiffness but also alleviates the high-dimensionality.The efficacy of the proposed methodology is validated by a load-frequency control application of a two-area power system.
文摘This paper firstly reviews the recent development in power system protection and control, with special attention paid to the wide-area and integrated protection, in order to look into future development of integration of protection and control for smart grids. This paper mainly reports on the development of integrated wide area protection and control for power systems. The concept of integrated wide area protection and control is introduced, in which a hierarchical protection and control system provides the protection and control of wide area or regional power substations/ plants and their associated power network. The system is mainly divided into three levels, the local, the substation/plant and the wide area/regional protection and control. The integrated functions at each level are described in details with an aim to develop an optimal coordination mechanism between the levels. One of the core elements in the system is the synchronised wide area communication network between the substations and the protection and control system, in which latest communication technology is employed. Another important player in the system is the wide area synchronized protection and control information platform, which not only enables the fusion three line of defence for power system protection and control, but also provides a perfect tool for the application of cloud computing to substations and power networks.
基金the National Natural Science Foundation of China(NSFC)-Excellent Young Scientists Fund(Hong Kong and Macao)under Grant 62222318.
文摘This paper investigates the robust cooperative output regulation problem for a class of heterogeneousuncertain linear multi-agent systems with an unknown exosystem via event-triggered control (ETC). By utilizingthe internal model approach and the adaptive control technique, a distributed adaptive internal model isconstructed for each agent. Then, based on this internal model, a fully distributed ETC strategy composed ofa distributed event-triggered adaptive output feedback control law and a distributed dynamic event-triggeringmechanism is proposed, in which each agent updates its control input at its own triggering time instants. It isshown that under the proposed ETC strategy, the robust cooperative output regulation problem can be solvedwithout requiring either the global information associated with the communication topology or the bounds ofthe uncertain or unknown parameters in each agent and the exosystem. A numerical example is provided toillustrate the effectiveness of the proposed control strategy.
基金In the process,this project was supported by the Fundamental Research Funds for the Central Universities(2572017DB02)Natural Science Foundation of Heilongjiang Province(JJ2019LH0696)by Postdoctoral Scientific Research Developmental Fund of Heilongjiang Province in 2016(LBH-Q16011).
文摘Applying pre-stress in glulam beam can reduce its deformation and make full use of the compressive strength of wood.However,when the glulam with low strength and the pre-stressed steel with high strength form combined members,materials of high strength can’t be fully utilized.Therefore,this study puts forward the idea of regulating and controlling string beam of pre-stressed glulam.By regulating and controlling the pre-stress,a part of the load borne by the wood is allocated to the pre-stressed tendon,which is equivalent to completing a redistribution of internal force,thus realizing the repeated utilization of the wood strength and the full utilization of the strength of the high-strength pre-stressed tendon.The bending experiments of 10 beams under 5 working conditions are carried out.The failure mode,bearing capacity and deformation of the beams are analyzed.The results show that 90%of beams are deformed under compression.The ultimate load of the regulated and controlled beam is obviously larger than that of the unregulated beam,and the ultimate load of the beam increases with the increase of the degree of regulation and control.Compared with that of the unregulated beams,the ultimate load of beams regulated by 7.5%-30%increases by 25.42%-65.08%,and the regulated and controlled effect is obvious.With the increase of the regulation and control amplitude of pre-stress,the stiffness of string beam of pre-stressed glulam increases.In addition,with the increase of the regulation and control amplitude,the compression height of the beam increases before the failure,and it reaches the state of full-section compression at the time of failure,giving full play to the compressive property of the glulam.At the end of the experiment,the constitutive relation which can reflect the anisotropy of the wood is established combined with the experimental data.The finite element analysis of the beam under 7 working conditions is carried out by using ABAQUS finite element program,and the influence of the regulation and control amplitude on the stress distribution and ultimate bearing capacity of the beam is discussed.