目的:系统评价口服补肾活血中药治疗老年桡骨远端骨折的临床疗效。方法:应用计算机检索中国知网、万方数据库、维普网、中国生物医学文献数据库、PubMed、Cochrane Library、Web of science、EBSCO、EMbase建库至2020年1月收录的有关闭...目的:系统评价口服补肾活血中药治疗老年桡骨远端骨折的临床疗效。方法:应用计算机检索中国知网、万方数据库、维普网、中国生物医学文献数据库、PubMed、Cochrane Library、Web of science、EBSCO、EMbase建库至2020年1月收录的有关闭合复位夹板固定或切开复位内固定术联合口服补肾活血中药(试验组)和单纯闭合复位夹板固定或切开复位内固定术(对照组)治疗老年桡骨远端骨折的随机对照临床研究文献。由2名研究者按照纳入、排除标准独立进行文献筛选和数据提取,采用Cochrane偏倚风险评估工具对纳入研究文献的质量进行评价,采用RevMan5.3软件进行Meta分析。结果:共检索出1569篇文献,最终纳入12篇文献,共涉及1039例老年桡骨远端骨折患者,其中对照组519例、试验组520例。Meta分析结果显示,试验组骨折愈合时间短于对照组[I^(2)=0%,P=1.000,MD=-0.77,95%CI(-0.94,-0.59)],Gartland-Werley腕关节功能评分低于对照组[I^(2)=26%,P=0.190,MD=-2.21,95%CI(-2.43,-1.98)],腕关节患者自评量表评分低于对照组[I^(2)=0%,P=1.000,MD=-3.97,95%CI(-4.85,-3.10)],桡骨骨折愈合评分系统(radius union scoring system,RUSS)评分高于对照组[I^(2)=99%,P=0.000,MD=0.53,95%CI(0.09,0.98)];按补肾活血中药的剂量及药物组成进行亚组分析,补肾活血汤高、低剂量组RUSS评分均高于对照组[I^(2)=0%,P=0.830,MD=0.50,95%CI(0.41,0.59);I^(2)=60%,P=0.110,MD=1.03,95%CI(0.81,1.24)],其他补肾活血中药(非补肾活血汤)组RUSS评分高于对照组[I^(2)=0%,P=0.410,MD=0.83,95%CI(0.74,0.93)]。结论:现有的证据表明,采用口服补肾活血中药治疗老年桡骨远端骨折,能促进骨折愈合、改善腕关节功能。展开更多
Objective: To observe the effects of Bushen Huoxue Formula (Formula for reinforcing the kidney and activating blood circulation) on the learning and memory function and the cerebral neurotransmitters in diabetic mice....Objective: To observe the effects of Bushen Huoxue Formula (Formula for reinforcing the kidney and activating blood circulation) on the learning and memory function and the cerebral neurotransmitters in diabetic mice. Methods: Forty ICR mice were randomized into the normal control group, model group, Nimotop group and Chinese medicine group, 10 mice in each group. Tail intravenous injection of alloxan was applied to prepare diabetic model. Four weeks later, intragastric administration of Bushen Huoxue Formula for the Chinese medicine group, Nimotop for the Nimotop group, and isometric distilled water for the other two groups were respectively given for 8 weeks. The changes in the blood sugar level were observed; the learning and memory function was detected by Morris labyrinth test; and the contents of norepinephrine (NE), dopamine (DA), 5-hydroxyltryptamine (5-HT) and 5-hydroxyl indole acetic acid (5-HIAA) in cerebral cortex were determined in mice of all the groups. Results: The blood sugar levels in the diabetic model mice significantly increased as compared with those of the normal control group determined 72 h and 12 weeks later (P<0.05 or P<0.01). Latencies for Morris labyrinth test in the Nimotop group and the Chinese medicine group were significantly shortened as compared with that in the model group (P<0.01). The contents of cortical NE in the Chinese medicine group was significantly higher than that in the model group (P<0.01). Conclusion: Bushen Huoxue Formula can improve the learning and memory function in the diabetic mice, and the mechanism is possibly related with change of the cortical NE content.展开更多
文摘目的:系统评价口服补肾活血中药治疗老年桡骨远端骨折的临床疗效。方法:应用计算机检索中国知网、万方数据库、维普网、中国生物医学文献数据库、PubMed、Cochrane Library、Web of science、EBSCO、EMbase建库至2020年1月收录的有关闭合复位夹板固定或切开复位内固定术联合口服补肾活血中药(试验组)和单纯闭合复位夹板固定或切开复位内固定术(对照组)治疗老年桡骨远端骨折的随机对照临床研究文献。由2名研究者按照纳入、排除标准独立进行文献筛选和数据提取,采用Cochrane偏倚风险评估工具对纳入研究文献的质量进行评价,采用RevMan5.3软件进行Meta分析。结果:共检索出1569篇文献,最终纳入12篇文献,共涉及1039例老年桡骨远端骨折患者,其中对照组519例、试验组520例。Meta分析结果显示,试验组骨折愈合时间短于对照组[I^(2)=0%,P=1.000,MD=-0.77,95%CI(-0.94,-0.59)],Gartland-Werley腕关节功能评分低于对照组[I^(2)=26%,P=0.190,MD=-2.21,95%CI(-2.43,-1.98)],腕关节患者自评量表评分低于对照组[I^(2)=0%,P=1.000,MD=-3.97,95%CI(-4.85,-3.10)],桡骨骨折愈合评分系统(radius union scoring system,RUSS)评分高于对照组[I^(2)=99%,P=0.000,MD=0.53,95%CI(0.09,0.98)];按补肾活血中药的剂量及药物组成进行亚组分析,补肾活血汤高、低剂量组RUSS评分均高于对照组[I^(2)=0%,P=0.830,MD=0.50,95%CI(0.41,0.59);I^(2)=60%,P=0.110,MD=1.03,95%CI(0.81,1.24)],其他补肾活血中药(非补肾活血汤)组RUSS评分高于对照组[I^(2)=0%,P=0.410,MD=0.83,95%CI(0.74,0.93)]。结论:现有的证据表明,采用口服补肾活血中药治疗老年桡骨远端骨折,能促进骨折愈合、改善腕关节功能。
基金supported by the Foundation of Peking Union Medical College Hospital, China (XH-020042)
文摘Objective: To observe the effects of Bushen Huoxue Formula (Formula for reinforcing the kidney and activating blood circulation) on the learning and memory function and the cerebral neurotransmitters in diabetic mice. Methods: Forty ICR mice were randomized into the normal control group, model group, Nimotop group and Chinese medicine group, 10 mice in each group. Tail intravenous injection of alloxan was applied to prepare diabetic model. Four weeks later, intragastric administration of Bushen Huoxue Formula for the Chinese medicine group, Nimotop for the Nimotop group, and isometric distilled water for the other two groups were respectively given for 8 weeks. The changes in the blood sugar level were observed; the learning and memory function was detected by Morris labyrinth test; and the contents of norepinephrine (NE), dopamine (DA), 5-hydroxyltryptamine (5-HT) and 5-hydroxyl indole acetic acid (5-HIAA) in cerebral cortex were determined in mice of all the groups. Results: The blood sugar levels in the diabetic model mice significantly increased as compared with those of the normal control group determined 72 h and 12 weeks later (P<0.05 or P<0.01). Latencies for Morris labyrinth test in the Nimotop group and the Chinese medicine group were significantly shortened as compared with that in the model group (P<0.01). The contents of cortical NE in the Chinese medicine group was significantly higher than that in the model group (P<0.01). Conclusion: Bushen Huoxue Formula can improve the learning and memory function in the diabetic mice, and the mechanism is possibly related with change of the cortical NE content.
