Late Quaternary Activity of the Huashan Piedmont Fault and Associated Hazards in the Southeastern Weihe Graben,Central China

The Weihe Graben is not only an important Cenozoic fault basin in China but also a significant active seismic zone. The Huashan piedmont fault is an important active fault on the southeast side of the Weihe Graben and has been highly active since the Cenozoic. The well–known Great Huaxian County Earthquake of 1556 occurred on the Huashan piedmont fault. This earthquake, which claimed the lives of approximately 830000 people, is one of the few large earthquakes known to have occurred on a high–angle normal fault. The Huashan piedmont fault is a typical active normal fault that can be used to study tectonic activity and the associated hazards. In this study, the types and characteristics of late Quaternary deformation along this fault are discussed from geological investigations, historical research and comprehensive analysis. On the basis of its characteristics and activity, the fault can be divided into three sections, namely eastern, central and western. The eastern and western sections display normal slip. Intense deformation has occurred along the two sections during the Quaternary; however, no deformation has occurred during the Holocene. The central section has experienced significant high–angle normal fault activity during the Quaternary, including the Holocene. Holocene alluvial fans and loess cut by the fault have been identified at the mouths of many stream valleys of the Huashan Mountains along the central section of the Huashan piedmont fault zone. Of the three sections of the Huashan piedmont fault, the central section is the most active and was very active during the late Quaternary. The rate of normal dip–slip was 1.67–2.71±0.11 mm/a in the Holocene and 0.61±0.15 mm/a during the Mid–Late Pleistocene. As is typical of normal faults, the late Quaternary activity of the Huashan piedmont fault has produced a set of disasters, which include frequent earthquakes, collapses, landslides, mudslides and ground fissures. Ground fissures mainly occur on the hanging–wall of the Huashan piedmont fault, with landslides, collapses and mudslides occurring on the footwall.

Spatial Genetic Structure of Two HIV-I-resistant Polymorphisms (CCR2-64 Ⅰ and SDF1-3’A) Alleles in Population of Shandong Province, China

To explore the spatial genetic structure of two HIV-Ⅰ-resistant polymorphisms （CCR2-64 Ⅰ and SDF1-3＇A） alleles in the population of Shandong Province, China. Methods Using the techniques of spatial stratified sampling and spatial statistics, the spatial genetic structure of the locus （CCR2-64 Ⅰ and SDF1-3＇A）, which was shown to be important co-receptor for HIV infection, was quantified from the populations of 36 sampled counties of Shandong Province, and a total of 3147 and 3172 samples were taken for testing CCR2-64Ⅰ and SDF1-3＇A respectively from individuals without known history of HIV-Ⅰ infection and AIDS symptoms. Results There were significantly spatial genetic structures of the two alleles at different spatial distance classes on the scale of populations, but on the scale of individuals, no spatial structure was found in either the whole area of Shandong Province or the area of each sampled county. Although the change of frequencies of the two alleles with geographic locations in Shandong Province both showed gradual increase trends, their changing directions were inverse. The frequency of CCR2-64Ⅰallele gradually increased from the southwest to the northeast, while the frequency of SDF1-3＇A allele gradually increased from the northeast to the southwest. However the RH to AIDS of combined types of their different genotypes did not represent obvious geographic diversity on the whole area of the Province. Conclusion The frequency of allele usually has some spatial genetic structures or spatial autocorrelation with different spatial distance classes, but the genotypes of individuals have random distribution in the same geographic area. Evaluating spatial distribution of the genetic susceptibility of HIV （AIDS） to CCR2-64Ⅰand SDF1-3＇A alleles, should focus on the frequencies of combined genotypes of CCR2 and SDFI based on the two-locus genotypes of each individual rather than the frequencies of CCR2-641 and SDF1-3＇A alleles.