Characterizing permeability-porosity relationships of porous rocks using a stress sensitivity model in consideration of elastic-structural deformation and tortuosity sensitivity

Clarifying the relationship between stress sensitivities of permeability and porosity is of great significance in guiding underground resource mining.More and more studies focus on how to construct stress sensitivity models to describe the relationship and obtain a comprehensive stress sensitivity of porous rock.However,the limitations of elastic deformation calculation and incompleteness of considered tortuosity sensitivity lead to the fact that the existing stress sensitivity models are still unsatisfactory in terms of accuracy and generalization.Therefore,a more accurate and generic stress sensitivity model considering elastic-structural deformation of capillary cross-section and tortuosity sensitivity is proposed in this paper.The elastic deformation is derived from the fractal scaling model and Hooke's law.Considering the effects of elastic-structural deformation on tortuosity sensitivity,an empirical formula is proposed,and the conditions for its applicability are clarified.The predictive performance of the proposed model for the permeability-porosity relationships is validated in several sets of publicly available experimental data.These experimental data are from different rocks under different pressure cycles.The mean and standard deviation of relative errors of predicted stress sensitivity with respect to experimental data are 2.63%and 1.91%.Compared with other models,the proposed model has higher accuracy and better predictive generalization performance.It is also found that the porosity sensitivity exponent a,which can describe permeability-porosity relationships,is 2 when only elastic deformation is considered.a decreases from 2 when structural deformation is also considered.In addition,a may be greater than 3 due to the increase in tortuosity sensitivity when tortuosity sensitivity is considered even if the rock is not fractured.

Different mechanisms underlie similar species-area relationships in two tropical archipelagoes

Despite much research in the field of island biogeography,mechanisms regulating insular diversity remain elusive.Here,we aim to explore mechanisms underlying plant species-area relationships in two tropical archipelagoes in the South China Sea.We found positive plant species-area relationships for both coral and continental archipelagoes.However,our results showed that different mechanisms contributed to similar plant species-area relationships between the two archipelagoes.For coral islands,soil nutrients and spatial distance among communities played major roles in shaping plant community structure and species diversity.By contrast,the direct effect of island area,and to a lesser extent,soil nutrients determined plant species richness on continental islands.Intriguingly,increasing soil nutrients availability(N,P,K)had opposite effects on plant diversity between the two archipelagoes.In summary,the habitat quality effect and dispersal limitation are important for regulating plant diversity on coral islands,whereas the passive sampling effect,and to a lesser extent,the habitat quality effect are important for regulating plant diversity on continental islands.More generally,our findings indicate that island plant species-area relationships are outcomes of the interplay of both niche and neutral processes,but the driving mechanisms behind these relationships depends on the type of islands.

Modern pollen-vegetation relationships along altitudinal vegetation belts in the Leigong Mountain of southwestern China

Understanding the distribution,dispersal,and correlation of modern pollen with vegetation in mountainous regions is essential for establishing accurate modern analogs for fossil pollen records.This study,conducted in Leigong Mountain on the YunnanGuizhou Plateau of southwestern China,involved the collection of 35 surface soil samples from diverse vegetation communities along an elevational gradient ranging from 1210 to 1875 meters.The results reveal a close correspondence between modern pollen assemblages and vegetation zones.Principal Component Analysis(PCA)results indicate that pollen assemblages can effectively distinguish between subtropical montane evergreen broad-leaved forest(SEBF)and subtropical montane deciduous broadleaved forest(SDBF).However,both SEBF and SDBF show significant overlap with subtropical montane evergreen-deciduous broad-leaved mixed forest(SEMF).Detrended Correspondence Analysis(DCA)results clearly distinguish the three vegetation zones,and the first axis of DCA shows a significant positive correlation with elevation(p<0.01,R=0.48).Discriminant Analysis(DA)successfully assigns 94.4%of the modern pollen samples to their respective vegetation zones.Pollen taxa such as Impatiens,Astertype,and Rosaceae exhibit significant indicative capabilities for the SEBF zone,effectively distinguishing this vegetation zone from others.Pinus and Alnus display overrepresentation in the Leigong Mountain region,while Quercus(D,deciduous-type)and Poaceae exhibit high representation in the SEBF zone.In the SEBF zone,both pollen diversity and richness are the lowest.Our study reveals the complex relationship between the richness and diversity of pollen and vegetation.The diversity and richness of tree and shrub pollen are found to be lower than those of the corresponding plants.The pollen-vegetation relationship elucidated in this study serves as a critical reference for reconstructing ancient environments from fossil pollen retrieved in this region.

The Risk Role of Defeat on the Mental Health of College Students:A Moderated Mediation Effect of Academic Stress and Interpersonal Relationships

Background:College students face significant academic and physiological changes,making them more susceptible to psychological issues such as depression,self-injury,and suicidal ideation.Feelings of defeat can exacerbate these risks by increasing academic stress.However,interpersonal relationships can moderate the impact of academic stress on students’mental health.Utilizing the presage–process–product model,this study aims to empirically investigate how feelings of defeat influence depression,self-injury,and suicidal ideation among college students.Additionally,it explores the mediating role of academic stress and the moderating role of various types of interpersonal relationships.Methods:A total of 1612 college students(750 females,862 males,mean age=19.64±0.62 years)were recruited through cluster sampling.Data were collected via offline questionnaires administered by a trained psychology teacher and a postgraduate student,ensuring high reliability with two examiners per class.Latent profile analysis(LPA)was used to examine the impact of defeat on mental health outcomes,while mediation analysis was conducted to assess the roles of academic stress and interpersonal relationships.Results:1.Defeat is identified as a significant risk factor for mental health issues among college students;2.Four distinct patterns of interpersonal relationships were identified:the interpersonal-relationship risk group,the father–child-relationship high-risk group,the general interpersonal-relationship group,and the superior interpersonal-relationship group;3.Academic stress partially mediates the relationship between defeat and mental health issues such as depression,self-injury,and suicidal ideation;4.Different interpersonal relationship models moderate the impact of academic stress on depression and suicidal ideation.Conclusion:Defeat is a significant risk factor for mental health problems in college students.Academic stress partially mediates the negative impact of defeat on mental health,while patterns of interpersonal relationships moderate this impact.Effective early prevention and intervention should focus on monitoring students’stress levels and fostering warm,positive parent–child relationships.

Studies on the Synthesis, Anticonvulsant Activity, and the Structure-Activity Relationships of Phenyl Pyridazinones and their GABA Derivatives

In searching for effective anticonvulsant agents,fourteen 6-aryl-4.5-di- hydro-3(2H)pyridazinones.fifteen 6-aryl-3(2H)pyridazinones,and seventeen 3-GABA derivatives of 6-aryIpyridazines have been synthesized,and evaluated in mice for the ability to antagonize maximal electroshock seizure(MES).The ED_(50) values showed that 6-(2′,4′- dichlorophenyt)-3(2H)pyridazinone was the most potent anticonvulsant among these corn- pounds(ED_(50)=10.15 mg/kg).The structure-activity relationships of the aryl pyridazinones were studied.The result showed that:(1)the higher the value of the hydrophobic parameter л of the substituent on the phenyl ring.the more potent the anticonvulsant activity of the corn- pound.and(2)only the compounds with an electron withdrawing substituent on the phenyl ring exhibited appreciable anticonvulsant activity.

Optimizing the Leadership Styles and Establishing a New Teacher-Student Relationship

There're mainly two kinds of behaviors-Task Behaviors(TBs) and Relationship Behaviors(RBs) among the school leadership styles. TBs contribute to achieving the goals, while RBs help to promote the interpersonal relationships. However, different perceptions of social values and morals will have a great influence on establishing the good leader-teacher relationship and the teacher-student relationship, which is also no exception for the leadership styles. Thus, optimizing the leadership styles will enhance the leader-teacher relationship, and also benefit the teacher-student relationship.

A review of the health effects and exposure-responsible relationship of diesel particulate matter for underground mines

The increasing use of diesel-powered equipment in confined spaces(underground mines) has the potential to over expose underground miners under the threat of diesel particulate matter(DPM). Miners in underground mines can be exposed to DPM concentrations far more than works in other industries. A great number of animal and epidemiological studies have shown that both short-term and long-term DPM exposure have adverse health effect. Based on reviews of related studies, especially some recent evidence, this paper investigated the long and short-term health effects based on animal studies and epidemiological studies. The exposure-response relationship studies were also explored and compared to the current DPM regulation or standards in some countries. This paper found that the DPM health effect studies specifically for miners are not sufficient to draw solid conclusions, and a recommendation limit of DPM concentration can be put in place for better protection of miners from DPM health risk. Current animal studies lack the use of species that have similar lung functions as human for understanding the cancer mode of action in human. And finally, the DPM health hazard will continue to be a challenging topic before the mode of action and reliable exposure-response relationship are established.

Numerical Method for Modeling the Constitutive Relationship of Sand under Different Stress Paths

A numerical method was used in order to establish the constitutive relationship of sands under different stress paths, Firstly, based on the numerical method modeling the constitutive law of sands, the elastoplastic constitutive relationship of sand was established for three paths： the constant proportion of principle stress path, the conventional triaxial compression （CTC） path, and the p=constant （TC） path. The yield lines of plastic volumetric strain and plastic generalized shear strain were given. Through visualization, the three dimensional surface of the stress-strain relationship in the whole stress field （p, q） obtained under the three paths was plotted. Also, by comparing the stress-strain surfaces and yield locus of the three stress paths, the differences were found to be obvious, which demonstrates that the influence of the stress paths on constitutive law was not neglected. The numerical modeling method overcame the difficulty of finding an analytical expression for plastic potential. The results simulated the experimental data with an accuracy of 90% on average, so the constitutive model established in this paper provides an effective constitutive equation for this kind of engineering, reflecting the effect of practical stress paths that occur in sands.

Relationship between self-directed learning readiness, learning attitude, and self-efficacy of nursing undergraduates

Objective: The purposes of this study were to analyze the influencing factors of self-directed learning readiness(SDLR) of nursing undergraduates and explore the impacts of learning attitude and self-efficacy on nursing undergraduates.Methods: A total of 500 nursing undergraduates were investigated in Tianjin, with the Chinese version of SDLR scale, learning attitude questionnaire of nursing college students, academic self-efficacy scale, and the general information questionnaire.Result: The score of SDLR was 149.99±15.73. Multiple stepwise regressions indicated that academic self-efficacy, learning attitude, attitudes to major of nursing, and level of learning difficulties were major influential factors and explained 48.1% of the variance in SDLR of nursing interns.Conclusions: The score of SDLR of nursing undergraduates is not promising. It is imperative to correct students' learning attitude, improve self-efficacy, and adopt appropriate teaching model to improve SDLR.

Relationship Between Diurnal Changes of Net Photosynthetic Rate and Influencing Factors in Rice under Saline Sodic Stress

The net photosynthetic rate of flag leaves and influencing factors under saline sodic soil conditions were investigated at the full heading stage of rice. The net photosynthetic rate of rice leaves showed a double-peak curve in a day in both non-saline sodic and saline sodic soil treatments. The first peak of the net photosynthetic rate appeared at 9：00-10：00 and 9：00 in the saline sodic and non-saline sodic soil treatments, respectively, whereas the second peak both at 14：00. The midday depression of the net photosynthetic rate always appeared regardless of non-saline sodic or saline sodic soil conditions. In addition, the net photosynthetic rate significantly decreased in all day under saline sodic conditions compared with that under non-saline sodic conditions. Some differences were observed in correlation characters between the net photosynthetic rate and all influencing factors during 9：00-13：00. Under non-saline sodic conditions, the diurnal changes of the net photosynthetic rate in a day were mainly caused by stomatal conductance, and the limitation value and the stomatal factors served as determinants; whereas under saline sodic stress, the diurnal changes of the net photosynthetic rate in a day were mainly caused by non stomatal factors including light intensity and air temperature.

Exercise,cognitive function, and the brain:Advancing our understanding of complex relationships

In recent years,scientists have shown a growing interest in the relationship between exercise,cognitive function,and the brain.The growing body of evidence supporting positive relationships is evidenced by the first mention of the beneficial effects of exercise on cognitive function appearing in the 9th edition of the American College of Sports Medicine's guidelines published in 2014.1 The strength of this evidence is further confirmed by recommendations relative to the benefits of exercise for cognitive performance and mental health being included in the 2nd edition of the Physical Activity Guidelines for Americans,a landmark policy statement released by the U.S.Department of Health and Human Services.

Molecular characteristics and structure–activity relationships of food-derived bioactive peptides

Peptides are functional active fragments of proteins which can provide nutrients needed for human growth and development,and they also have unique physiological activity characteristics relative to proteins.Bioactive peptides contain a great deal of development potential.More specifically,food-derived bioactive peptides have the advantages of a wide variety of sources,unique structures,high efficiency and safety,so they have broad development prospects.This review provides an overview of the current advances regarding the preparation,functional characteristics,and structure–activity relationships of food-derived bioactive peptides.Moreover,the prospects for the future development and application of food-derived bioactive peptides are discussed.This review may provide a better understanding of foodderived bioactive peptides,and some constructive inspirations for further research and applications in the food industry.

Oxygen Evolution Reaction in Energy Conversion and Storage: Design Strategies Under and Beyond the Energy Scaling Relationship

The oxygen evolution reaction(OER)is the essential module in energy conversion and storage devices such as electrolyzer,rechargeable metal–air batteries and regenerative fuel cells.The adsorption energy scaling relations between the reaction intermediates,however,impose a large intrinsic overpotential and sluggish reaction kinetics on OER catalysts.Developing advanced electrocatalysts with high activity and stability based on non-noble metal materials is still a grand challenge.Central to the rational design of novel and high-efficiency catalysts is the development and understanding of quantitative structure–activity relationships,which correlate the catalytic activities with structural and electronic descriptors.This paper comprehensively reviews the benchmark descriptors for OER electrolysis,aiming to give an in-depth understanding on the origins of the electrocatalytic activity of the OER and further contribute to building the theory of electrocatalysis.Meanwhile,the cutting-edge research frontiers for proposing new OER paradigms and crucial strategies to circumvent the scaling relationship are also summarized.Challenges,opportunities and perspectives are discussed,intending to shed some light on the rational design concepts and advance the development of more efficient catalysts for enhancing OER performance.

Spectrum-effect relationship of immunologic activity of Ganoderma lucidum by UPLC-MS/MS and component knock-out method

This study was designed to elucidate the immunoregulation of Ganoderma lucidum.HPLC fingerprint and spectrum-effect relationship of G.lucidum were established to predict the active compounds and BP neural network model was established to predict the efficacy.Then the target compounds were identified by high resolution mass spectrometry.The results indicated that there are both enhanced immunity and immunosuppressive components in G.lucidum.BP neural network was trained with the common peak area and immune effi cacy index of G.lucidum fi ngerprint as samples,and a combined evaluation system of G.lucidum fi ngerprint effi cacy was established.The correlation coeffi cient R of BP network model was 0.98643,and the error of pharmacodynamic prediction results was in the ideal range.Eight compounds were identifi ed by high resolution mass spectrometry.The compounds related to immune activity in G.lucidum were determined in this study.

COL1A1突变致Van der Hoeve综合征家系的遗传和表型分析并文献复习

目的对一个常染色体显性遗传的Van der Hoeve综合征家系进行详尽的临床表型分析及基因突变检测,明确该家系的致病基因突变位点及该突变对基因编码的影响。方法对收集到的Van der Hoeve综合征家系进行包括病史、体格检查及辅助检查在内的临床资料的收集及外周血液样本的采集,并对22位家系成员进行外显子组测序以及Sanger测序,利用生物信息学软件分析数据。结果该家系共五代,各代连续发病,且每一代男女均可患病,符合常染色体显性遗传特点。该家系中12例患者均自出生时巩膜即呈蓝色且身材矮小,8例患者有骨折病史,可正常愈合,3例患者考虑有Van der Hoeve综合征所致的听力下降,12例患者的COL1A1基因第17号外显子有一个碱基的缺失(c.1128delT),使第376位后的氨基酸编码改变,在第539位提前结束氨基酸编码,该家系中10例无症状者无此突变。结论该家系患者确定为由COL1A1基因c.1128delT突变导致的Van der Hoeve综合征。

Peplau's interpersonal relationship theory combined with bladder function training on patients with prostate cancer

BACKGROUND Prostate cancer is a major disease impacting men’s health worldwide.Peplau,who is known as“the mother of psychiatric society,”developed an interpersonal relationship theory for nursing.Implementation of this theory in practice has been shown to positively impact patients’quality of life and reduce adverse symptoms after surgery.AIM To investigate the effects of a nursing model based on Peplau’s interpersonal relationship theory combined with bladder function training on patients with prostate cancer.METHODS Eighty-nine patients with prostate cancer who underwent transurethral resection of the prostate(TURP)participated in this study.These patients were admitted to The First Affiliated Hospital of Soochow University or Dushu Lake Hospital Affiliated to Soochow University between January 2020 and April 2021.Patients were randomized into either the Peplau nursing group(n=44)or a routine nursing group(n=45).The routine nursing group received routine care and bladder function training,while the Peplau care group received care that integrated concepts from the Peplau interpersonal relationship theory as well as bladder function training.The urinary incontinence symptoms of the two groups were recorded,and the respective International Prostate Symptom Scores(IPSS),Functional Assessment of Chronic Illness Therapy-Spiritual Well-Being(FACIT-Sp)scores,and quality of life(QOL)scores for each group were compared before and after three months of nursing intervention.RESULTS During the intervention period,the duration of urinary incontinence,frequency,number and amount of urinary incontinence were significantly greater in the routine nursing group compared to the Peplau care group(P<0.05).The indicators of the routine nursing group were 7.13±2.42 days,8.23±2.75 times,and 1.24±0.42 L,while those of the Peplau care group were 4.74±1.85 d,4.21±1.26 times,and 0.56±0.11 L,respectively.After three months of intervention,the mean IPSS score of the routine nursing group was significantly reduced(P<0.05),while the mean FACIT-Sp and QOL scores were significantly increased(P<0.05).The mean IPSS score in the Peplau nursing group was significantly lower compared to the routine nursing group,while the FACIT-Sp and QOL scores were higher(P<0.05).CONCLUSION A nursing model based on Peplau’s interpersonal relationship theory combined with bladder function training can significantly improve prostate function and urinary symptoms,resulting in the restoration of physiological function and improvement in the QOL of patients with prostate cancer following TURP.

尘螨过敏原Der p 7新的IgE抗原表位鉴定及尘螨交叉反应性的研究

目的:尘螨过敏原Der p 7新的IgE抗原表位鉴定及尘螨交叉反应性的研究。方法:ELISA检测华东地区安徽省合肥市的尘螨过敏患者与尘螨过敏临床相关性较高的重组蛋白Der p 7的IgE结合率;通过ELISA和Dot Blot鉴定屋尘螨过敏原Der p 7的新IgE抗原表位;利用圆二色光谱法检测Der p 7和其突变体的结构及热稳定性;最后用ELISA和ELISA抑制实验鉴定尘螨新的交叉过敏物质。结果:通过ELISA实验检测发现,华东地区的合肥市内尘螨过敏患者体内IgE与Der p 7的结合率为36.2%,与华南地区的广州市(37.4%)和西班牙(34.7%)相近。然而,这一结合率受到地理区域、自然环境和生活方式等多种因素的影响,与华北地区的北京市(19.3%)、乌克兰(22.67%)、意大利(28%)相比明显较低,而与非洲(56%)和日本(超过60%)相比则显著不同。ELISA和Dot Blot鉴定出尘螨重要过敏原Der p 7的两个新IgE抗原结合表位,分别是第36位天冬氨酸和第100位天冬氨酸。用圆二色光谱实验证明了Der p 7的结构稳定性,且突变后结构未发生改变,并检测了其热稳定性特征。最后用ELISA和ELISA抑制实验新发现了两种与尘螨存在交叉过敏的物质(小麦和花生)。结论:基于尘螨过敏原Der p 7与华东地区安徽省合肥市内过敏患者IgE的结合率及新的IgE抗原表位的研究为预防、诊断、治疗过敏性疾病提供理论基础,对开发尘螨过敏原低敏疫苗具有参考价值。发现新的尘螨交叉过敏物质为交叉过敏反应的预防、治疗提供了科学依据。

Meteorological satellite stakeholder relationship network based on social network analysis

The meteorological satellite service range is extensive,and science and technology and related industries have become beneficiaries of it.The complex meteorological satellite stakeholder relationship warrants quantitative evaluation.This study investigates the meteorological satellite stakeholder relationship network to provide a new research perspective for meteorological satellites in the field of management.For literature analysis,16 meteorological satellite stakeholders are identified through keyword screening,classified,and coded.A meteorological satellite stakeholder relationship network model is then constructed through social network analysis(SNA).Ego,local,and overall networks are analyzed from three perspectives to measure the network principle and to form a relationship network coordination degree evaluation system.The improved analytic hierarchy process(AHP)-fuzzy comprehensive evaluation method is then used to determine index weights and evaluate the relationship network coordination process design comprehensively.In empirical analysis,data for the meteorological satellite Fengyun-4 are obtained through questionnaire survey and literature analysis.Ucinet6 is used to generate relationship networks and analyze various stakeholder roles and status,stakeholder relationship network coordination degree,and evaluation results.The results demonstrate that the competent meteorological satellite department,the meteorological administration,the National Meteorological Centre,and the government are in the center of the Fengyun-4 stakeholder relationship network,with coordination degree in an“average”state.Thus,establishing a stakeholder coordination mechanism may strengthen connection and promote the development of meteorological undertakings.

The new multistage water adsorption model of Longmaxi Formation shale considering the spatial configuration relationship between organic matter and clay minerals

The water adsorption by shale significantly affects shale gas content and its seepage capacity.However,the mechanism of water adsorption by shale is still unclear due to its strong heterogeneity and complicated pore structure.The relationship between the adsorbed water content at different relative humidities(RHs)and shale compositions,as well as shale pore structure and the spatial configuration relationship between organic matter(OM)and clay minerals,was investigated to clarify the controlling factors and mechanisms of water adsorption by Longmaxi Formation shale from the Southern Sichuan Basin in China.Consequently,the water adsorption process could be generally divided into three different stages from 0%RH to 99%RH.Furthermore,the Johnston’s clay mine ral interlayer pore structure model(JCM),the Freundlich model(FM)and the Dubinin-Astakhov model(DAM)were tested to fit the three water adsorption stages from low RH to high RH,respectively.The fitting results of the JCM and FM at lower RHs were far from good,while the fitting results of DAM at higher RHs were acceptable.Accordingly,two revised models(LRHM and MRHM)considering the spatial configuration relationship between OM and clay minerals were proposed for the two stages with lower RHs,and performed better fitting results indicating the pronounced effect of the spatial configuration relationship between OM and clay minerals on the water adsorption process of Longmaxi Formation shale.The outcomes of this study will contribute to clarifying the water distribution characteristics in the pore network of shale samples with variable water contents.

尘螨过敏原Der p 2线性表位肽及其硝基化产物与IgE结合能力

许多过敏原可以介导Ⅰ型超敏反应,通过与IgE特异性结合,引起过敏症状.过敏原与细胞表面的特异性IgE结合的部分叫做表位,其与IgE的结合能力可以表征过敏原致敏性的强弱.Der p 2是一种重要的屋尘螨过敏原,其线性表位中含有的酪氨酸可被空气中的NO_(2)和O_(3)硝基化,从而影响线性表位与IgE的结合能力.本实验研究了Der p 2的线性表位及其硝基化产物与IgE的结合能力.研究发现,Der p 2的两条表位多肽可以有效地结合IgE,硝基化表位多肽的IgE结合能力显著高于未硝基化的表位多肽,且不同位点的硝基化对于IgE结合能力的增强程度也不同.结果表明,硝基化能够位点特异性地增强Der p 2的致敏性.