Peri-implant gas accumulation in response to magnesium-based musculoskeletal biomaterials:Reframing current evidence for preclinical research and clinical evaluation

Historically,the rapid degradation and massive gas release from magnesium(Mg)implants resulted in severe emphysema and mechanical failure.With the advent of new alloys and surface treatment methods,optimized Mg implants have re-entered clinics since last decade with reliable performance.However,the optimization aims at slowing down the degradation process,rather than exemption of the gas release.This study involved a systematic evaluation of current preclinical and clinical evidence,regarding the physical signs,symptoms,radiological features,pathological findings and complications potentially associated with peri±implant gas accumulation(PIGA)after musculoskeletal Mg implantation.The literature search identified 196 potentially relevant publications,and 51 papers were enrolled for further analysis,including 22 preclinical tests and 29 clinical studies published from 2005 to 2023.Various Mg-based materials have been evaluated in animal research,and the application of pure Mg and Mg alloys have been reported in clinical follow-ups involving multiple anatomical sites and musculoskeletal disorders.Soft tissue and intraosseous PIGA are common in both animal tests and clinical follow-ups,and potentially associated with certain adverse events.Radiological examinations especially micro-CT and clinical CT scans provide valuable information for quantitative and longitudinal analysis.While according to simulation tests involving Mg implantation and chemical processing,tissue fixation could lead to an increase in the volume of gas cavity,thus the results obtained from ex vivo imaging or histopathological evaluations should be interpreted with caution.There still lacks standardized procedures or consensus for both preclinical and clinical evaluation of PIGA.However,by providing focused insights into the topic,this evidence-based study will facilitate future animal tests and clinical evaluations,and support developing biocompatible Mg implants for the treatment of musculoskeletal disorders.

Experimental and theoretical study on the dynamic effective stress of loaded gassy coal during gas release

In the process of mining coalbed methane(CBM),an unsteady state often arises due to the rapid extraction,release and pressure relief of CBM.In this case,the effective stress of coal changes dynamically,affecting the stability of the gassy coal seam.In this paper,gas release tests of gassy coal under conventional triaxial compression were performed,and the dynamic effective stress(DES)during gas release was obtained indirectly based on a constitutive equation and deformation of coal.The results show that the maximum increases in DES caused by the release of free gas and adsorbed gas under the stress of 1.1 MPa were 0.811 and 5.418 MPa,respectively,which seriously affected the stress state of the coal.During the gas release,the free gas pressure and the adsorbed gas volume were the parameters that directly affected the DES and showed a positive linear relationship with the DES with an intercept of zero.The DES of the coal sample increased exponentially with time,which was determined by the contents of free and adsorbed gas.Based on the experimental results and theoretical analysis,an effective stress model was obtained for loaded gassy coal during gas release.The results of verification indicated accuracy greater than 99%.

Experimental research into the effect of gas pressure,particle size and nozzle area on initial gas-release energy during gas desorption

Coal and gas outburst is a violent disaster driven by released energy from gas desorption.The initial expansion energy of released gas(IEERG)is a new method to predict coal and gas outburst.In this paper,an instrument for IEERG measurement was developed.Compared with previous setups,the new one which is equipped with three convergent nozzles and quick-release mechanism gets improved in data acquisition and gas sealing and releasing performance.To comprehensively know the effect of gas pressure,particle size,and nozzle area on IEERG,a series of experiments were carried out with this new setup.The variable control test results indicated that the gas pressure-IEERG curves remain the linear trend and the particle size-IEERG curves maintain the negative exponential trend for nozzle areas at 1.13,2.26,and3.39 mm2,respectively.The increase in nozzle area leads to deceases in value of IEERG and absolute value of slope of fitting curves in each test.In addition,the orthogonal experiment showed that the influence of gas pressure,nozzle area,and particle size on IEERG decreases in turn.Only gas pressure had a marked impact on IEERG.This work offers great importance in improving the accuracy of prediction of coal and gas outburst.

Modeling the Flow Regime Near the Source in Underwater Gas Releases

Recent progress in calculating gas bubble sizes in a plume, based on phenomenological approaches using the release conditions is a significant improvement to make the gas plume models self-reliant. Such calculations require details of conditions Near the Source of Plume （NSP）; （i.e. the plume/jet velocity and radius near the source）, which inspired the present work. Determining NSP conditions for gas plumes are far more complex than that for oil plumes due to the substantial density difference between gas and water. To calculate NSP conditions, modeling the early stage of the plume is important. A novel method of modeling the early stage of an underwater gas release is presented here. Major impact of the present work is to define the correct NSP conditions for underwater gas releases, which is not possible with available methods as those techniques are not based on the physics of flow region near the source of the plume/jet. We introduce super Gaussian profiles to model the density and velocity variations of the early stages of plume, coupled with the laws of fluid mechanics to define profile parameters. This new approach, models the velocity profile variation from near uniform, across the section at the release point to Gaussian some distance away. The comparisons show that experimental data agrees well with the computations.

Paleo-oil reservoir pyrolysis and gas release in the Yangtze Block imply an alternative mechanism for the Late Permian Crisis

The causes of the global mass extinction that occurred around the Permian-Triassic boundary have been widely studied through the geological record and in various locations.The results show that volcanic activity was a key factor in initiating the crisis during the Late Permian.Compared to other thermal events triggered by volcanic activity,pyrolysis of petroleum in Pre-Permian reservoirs has rarely been suggested as a significant source of the greenhouse gases that caused the mass extinction.In this study,geochemical analysis is carried out of a huge paleo-oil reservoir in the Yangtze Block(YB),South China.The detection of mineral inclusions and pyrobitumens is evidence of rapid pyrolysis of accumulated oil in the Ediacaran reservoir.New evidence from hydrothermal minerals and the presence of domain mesophase in the pyrobitumen suggest that the pyrolysis process occurred abruptly and that greenhouse gases were rapidly released through venting pipes.The dating of such a complex geological event in this old and deeply buried reservoir is inevitably difficult and potentially unreliable.However,cross-validation of the multiple evidence sources,including hydrothermal minerals and domain mesophase,indicates that the rapid oil pyrolysis must have been driven by a major thermal event.Reconstruction of burial and thermal histories suggests that the thermal event was most likely to have been triggered by the Emeishan Large Igneous Province(ELIP),which was in a period of significant volcanic activity during the Late Permian.Massive volumes of gases,including methane,carbon dioxide,and possibly hydrogen sulfide,were released,causing a significant increase in greenhouse gases that may have contributed to global warming and the resulting mass extinction during the Late Permian Crisis(LPC).

On-site raw gas cut-off during the shut down of Baosteel phaseⅠcoke ovens

The preparation and implementation of raw coke oven gas cut-off, which was the key process involved with shutting down the Baosteel phase I coke ovens, were investigated, and the main technical points and countermeasures are presented.

A multi-parameter-induced activation of gas therapeutic platform to remarkably amplify photodynamic therapy efficacy

Gas therapy(GT)combined with photodynamic therapy(PDT)is an effective strategy to compensate for the PDT limitation caused by the hypoxic tumor microenvironment,which can greatly improve PDT efficacy.The uncontrolled leakage of gas molecules during delivery seriously hinders its practical biological application.Herein,we report a multifunction nanomedicine that enables precise gas therapy(including carbon monoxide(CO)release and H_(2)S depletion)using a multi-parameter-induced activation gas release strategy,enlarging the PDT efficacy.This nanomedicine uses a disulfide bond to covalently link a photosensitizer with the CO donor 3-hydroxyflavone(3-HF).The disulfide bond can be specifically consumed in H_(2)S-rich tumor areas,releasing the CO donor(3-HF),and also depleting H_(2)S.More importantly,the photo-controlled production of^(1)O_(2)can induce 3-HF precise release of CO in the tumor location.Such H_(2)S,light,and^(1)O_(2)multi-parameter-induced activation of gas release strategy ensures the accuracy of GT to amplify PDT efficiency.As expected,in vitro and in vivo investigations show that GT makes up for the PDT limitation,exhibiting the highest tumor therapeutic effect.This multi-parameter-activated design strategy provides a new way to improve the precision and efficacy of multimodal synergistic therapy of tumors.

An experimental study on temperature increasing mechanism of satellitic thermo-infrared

Mixed gases (CO 2 and CH 4 etc .) in different ratio under the action of transient electric field may cause temperature to increase about 6℃, while under that of solar irradiation may lead temperature to rise around 3℃. The temperature increasing mechanism of satellitic thermo infrared of lower air is explained here based on an experimental study: thermo infrared temperature increasing of lower atmosphere may be caused by paroxysmal releasing of crustal gas and sudden changing of lower atmosphere electrostatic field. Therefore, appearance of the anomaly of thermo infrared temperature increasing prior to a moderate strong earthquake requires the concurrence of gas paroxysmal releasing and electrostatic field sudden changing at the same time.

Gas release characteristics during carbonization of iron coke hot briquette and influence of heating rate

The release characteristics of CH_(4),H_(2),CO and CO_(2) from iron coke hot briquette(ICHB)during carbonization were studied.The results show that compared with briquette without iron ore,Fe_(3)O_(4) can inhibit the release rate of H2 and promote the production of CO and CO_(2).In addition,when the heating rate increases from 3 to 7℃/min,the release rates of CH4 and H2 increase,while the release rates of CO and CO_(2) first increase and then decrease.The carbonization process of ICHB was segmented,and corresponding kinetic analysis was carried out.The results show that the activation energy of StageⅡand StageⅣis higher in the carbonization process of ICHB,and the active pyrolysis of coal and the reduction of iron ore occur in these two stages.In addition,the effect of heating rate on the kinetic parameters of ICHB carbonization process was investigated.It was found that when the heating rate increased,the reaction activation energy of StageⅣdecreased first and then increased,which was consistent with the release law of CO and CO_(2).The analysis showed that the increase in heating rate leads to more reactions at higher temperatures,resulting in an increase in the release rate of some gases.In addition,thermal hysteresis can also cause some processes to fail to fully react at the end of heating.It is also found that the apparent activation energy and preexponential factor have kinetic compensation effect during the car-bonization of ICHB.

Godunov-type solutions for gas-liquid two-phase transient flows with gas release effects

The gas-liquid two-phase homogenous flow has been extensively investigated without the effect of gas release.However,the dissolved gas will release when internal water pressure drops below saturation pressure during hydraulic transients.This results in inaccuracy or even invalidity of the existing model for homogenous flows,especially for the reproduction of two-phase mass transfer processes.To address this problem,this paper couples the gas release model with conservation equations of homogenous flows,which are numerically solved by the second-order Godunov-type scheme(GTS).Specifically,a virtual-cell method is adopted at system boundaries to achieve the same second-order accuracy as interior cells,which is realized by the monotonic upwind scheme for conservation laws(MUSCL-Hancock scheme).Simulated pressure curves by the proposed model are compared with a series of analytical,numerical and experimental results.It indicates that the proposed model with gas release effects reproduces actual pressure responses most accurately,with minimum relative error and root mean squared error compared with experimental data.Moreover,the gas release leads to dynamic synchronous fluctuations of void fraction,wave speed and pressure head,including the opposite trends of void fraction and pressure,and higher void fraction leading to greater wave speed depression.Furthermore,sensitivity analysis is concluded with recommended Courant number,and different gas release effects in different initial void fractions.Present research increases the basic understanding of two-phase mass transfer processes and their implications for hydraulic transients.

Anode Plasma Influence on Breakdown Formation in Explosive-Emission Electron Sources

Breakdown formation in the explosive-emission sources is related to the interelectrode gap filling with the cathode and anode plasma generated at the anode and in the gap under the beam influence. Under conditions of saturation of the cathode plasma emissive ability as well as when the measures on the emission boundary stabilization are taken, the anode plasma has the deciding part in the formation of the electron source breakdown. The paper presents the results of the anode plasma investigations obtained to solve the problem of the electron beam length increase in the explosive-emission sources. The data concerning the gas release from the anode, the mechanism of the anode plasma formation and the anode plasma influence on the parameters of the generated electron beam are presented as well.

New insight into fabrication of shaped Mg-X alloy foams with cellular structure via a gas release reaction powder metallurgy route

Shaped Mg alloy foams with closed-cell structure are highly interested for a great potential to be utilized in the fields where weight reduction is urgently required.A powder metallurgical method,namely gas release reaction powder metallurgy route to fabricate Mg-X(X=Al,Zn or Cu)alloy foams,was summarized.The principles on shaped Mg-X foams fabrication via the route were proposed.In addition,the effects of alloying elements,sintering treatment and foaming temperatures on fabrication of shaped Mg-X alloy foams were investigated experimentally.The results show that the key to ensure a successful foaming of Mg-X alloy foams is to add alloying metals alloyed with Mg to form lower melting(<600℃)intermetallic compounds by the initial sintering treatment.The foaming mechanism of Mg-X alloy foams also has been clarified,that is,the low-melting-point Mg-based intermetallic compounds melt first,and then reactions between the melt and CaCO_(3),a foaming agent,release CO gas to make the precursor foamed and finally shaped Mg-X alloy foam with a promising cellular structure is prepared.This route has been verified by successful fabrication on shaped Mg-Al,Mg-Zn and Mg-Cu foams with cellular structure.