The activation of inert C(sp^3)–H bonds with control of reactivity and selectivity is one of the central topics in chemical sciences.In this context,alkoxy radical-mediated 1,5-hydrogen atom transfer allows the regio...The activation of inert C(sp^3)–H bonds with control of reactivity and selectivity is one of the central topics in chemical sciences.In this context,alkoxy radical-mediated 1,5-hydrogen atom transfer allows the regioselective transfor-展开更多
Chromone and flavone are both central backbones of natural products and clinical medicines.Synthesis of diversely functionalized chromones and flavones constitutes significant research contents of the modern synthetic...Chromone and flavone are both central backbones of natural products and clinical medicines.Synthesis of diversely functionalized chromones and flavones constitutes significant research contents of the modern synthetic science because abundant molecular libraries of such types are crucial in providing candidate compounds for the discovery of new pharmaceuticals and functional materials.The direct C—H bond activation or functionalization on these heterocyclic backbones provides highly powerful tools for the rapid accesses to densely functionalized chromone and flavone derivatives.Considering the importance of the functionalized chromone and flavone compounds as well as the notable advances in the synthesis of such products by direct C—H activation or functionalization,we review herein the research advances in the C—H bond activation and functionalization reactions of chro mone and flavones,in hope of showing the current states and promise of the research domain.展开更多
Transition-metal-catalyzed C–H bond activation represents one of the most attractive research areas in organic synthesis.In contrast to the great developments made in directed C–H bond functionalization of arenes,th...Transition-metal-catalyzed C–H bond activation represents one of the most attractive research areas in organic synthesis.In contrast to the great developments made in directed C–H bond functionalization of arenes,the directing group-assisted activation of non-aromatic vinylic C–H bonds still remains challenging.During the recent years,significant progress has been made in this fascinating field with various functionalized alkenes,heterocycles and carbocycles being obtained.This article will focus on the recent achievements in the field of directing-group-assisted vinylic C–H bond functionalization.展开更多
A new palladium-catalyzed oxidative conversion of N-arylpropiolamides and H2O to various indoline-2,3-diones and acids through the C≡C triple bond cleavage and C(sp2)–H functionalization is described,which is promot...A new palladium-catalyzed oxidative conversion of N-arylpropiolamides and H2O to various indoline-2,3-diones and acids through the C≡C triple bond cleavage and C(sp2)–H functionalization is described,which is promoted by a cooperative action of catalytic CuBr2,2,2,6,6-tetramethyl-1-piperidinyloxy(TEMPO)and O2.The method provides a practical tool for transformations of alkynes by means of a C–H functionalization strategy,which enables the formation of one C–C bond and multiple C–O bonds in a single reaction with high substrates compatibility and excellent functional group tolerance.展开更多
Selective C–H bond functionalization has been emerged as a versatile strategy for the construction of new chemical bonds. In the past decades, the directing group(DG)-assisted C–H bond activation has been developed ...Selective C–H bond functionalization has been emerged as a versatile strategy for the construction of new chemical bonds. In the past decades, the directing group(DG)-assisted C–H bond activation has been developed as one of the most efficient methods for selective C–H functionalization. Although a great progress has been made by utilizing this traditional method, developing new strategy for selective C–H bond functionalization is still highly demanded. Hence, a novel oxidation-induced C–H bond functionalization method was demonstrated in this work. By this new method, ortho-C(sp2)–H chlorination of N-substituted 2-naphthylamine was realized in a highly selective manner.展开更多
A copper-catalyzed decarboxylative oxidative coupling of α,β-unsaturated carboxylic acids with non-cyclic ethers is developed.This method provides a new approach for C(sp^3)–H bond functionalization of non-cyclic e...A copper-catalyzed decarboxylative oxidative coupling of α,β-unsaturated carboxylic acids with non-cyclic ethers is developed.This method provides a new approach for C(sp^3)–H bond functionalization of non-cyclic ethers. Mechanism study shows the reaction involves a radical process.展开更多
Organic electrochemistry has a rich history in organic synthesis and has been considered as a promising alternative to traditional chemical oxidants and reductants because it obviates the use of stoichiometric amount ...Organic electrochemistry has a rich history in organic synthesis and has been considered as a promising alternative to traditional chemical oxidants and reductants because it obviates the use of stoichiometric amount of dangerous and toxic reagents. In particular, the electrochemical C-H bonds functionalization is one of the most desirable approaches for the construction of carbon-carbon （C-C） and carbon-heteroatom （C-X） bonds. This review summarizes the substantial progress made in the last few years in C-H functionalization via organic electrochemistry. It is divided into sections on C-C, C-N, C-O, C-S, C-Halogen and C-P bond formation.展开更多
文摘The activation of inert C(sp^3)–H bonds with control of reactivity and selectivity is one of the central topics in chemical sciences.In this context,alkoxy radical-mediated 1,5-hydrogen atom transfer allows the regioselective transfor-
基金supported by the National Natural Science Foundation of China(No.21806018 and No.21873052)the Fundamental Research Funds for the Central Universities(DUT20RC(4)002)+1 种基金Scientific Research Grant of Ningbo University(No.215-432000282)Ningbo Top Talent Project(No.215-432094250)。
基金National Natural Science Foundation of China(Nos.21861019 and 21702091)for financial support。
文摘Chromone and flavone are both central backbones of natural products and clinical medicines.Synthesis of diversely functionalized chromones and flavones constitutes significant research contents of the modern synthetic science because abundant molecular libraries of such types are crucial in providing candidate compounds for the discovery of new pharmaceuticals and functional materials.The direct C—H bond activation or functionalization on these heterocyclic backbones provides highly powerful tools for the rapid accesses to densely functionalized chromone and flavone derivatives.Considering the importance of the functionalized chromone and flavone compounds as well as the notable advances in the synthesis of such products by direct C—H activation or functionalization,we review herein the research advances in the C—H bond activation and functionalization reactions of chro mone and flavones,in hope of showing the current states and promise of the research domain.
基金supported by the National Basic Research Program of China(2015CB856600)the National Natural Science Foundation of China(21332002,21272010)
文摘Transition-metal-catalyzed C–H bond activation represents one of the most attractive research areas in organic synthesis.In contrast to the great developments made in directed C–H bond functionalization of arenes,the directing group-assisted activation of non-aromatic vinylic C–H bonds still remains challenging.During the recent years,significant progress has been made in this fascinating field with various functionalized alkenes,heterocycles and carbocycles being obtained.This article will focus on the recent achievements in the field of directing-group-assisted vinylic C–H bond functionalization.
基金supported by the National Natural Science Foundation of China(21625203,21871126)the Opening Fund of KLCBTCMR,Ministry of Education(KLCBTCMR18-02)
文摘A new palladium-catalyzed oxidative conversion of N-arylpropiolamides and H2O to various indoline-2,3-diones and acids through the C≡C triple bond cleavage and C(sp2)–H functionalization is described,which is promoted by a cooperative action of catalytic CuBr2,2,2,6,6-tetramethyl-1-piperidinyloxy(TEMPO)and O2.The method provides a practical tool for transformations of alkynes by means of a C–H functionalization strategy,which enables the formation of one C–C bond and multiple C–O bonds in a single reaction with high substrates compatibility and excellent functional group tolerance.
基金supported by the National Natural Science Foundation of China (21390402, 21520102003, 21702150)the National Basic Research Program of China (2012CB725302)+1 种基金the CAS Interdisciplinary Innovation Team and the Hubei Province Natural Science Foundation of China (2017CFA010)China Postdoctoral Science Foundation (BX201600114, 2016M602340)
文摘Selective C–H bond functionalization has been emerged as a versatile strategy for the construction of new chemical bonds. In the past decades, the directing group(DG)-assisted C–H bond activation has been developed as one of the most efficient methods for selective C–H functionalization. Although a great progress has been made by utilizing this traditional method, developing new strategy for selective C–H bond functionalization is still highly demanded. Hence, a novel oxidation-induced C–H bond functionalization method was demonstrated in this work. By this new method, ortho-C(sp2)–H chlorination of N-substituted 2-naphthylamine was realized in a highly selective manner.
基金supported by the National Natural Science Foundation of China (21572240)
文摘A copper-catalyzed decarboxylative oxidative coupling of α,β-unsaturated carboxylic acids with non-cyclic ethers is developed.This method provides a new approach for C(sp^3)–H bond functionalization of non-cyclic ethers. Mechanism study shows the reaction involves a radical process.
文摘Organic electrochemistry has a rich history in organic synthesis and has been considered as a promising alternative to traditional chemical oxidants and reductants because it obviates the use of stoichiometric amount of dangerous and toxic reagents. In particular, the electrochemical C-H bonds functionalization is one of the most desirable approaches for the construction of carbon-carbon （C-C） and carbon-heteroatom （C-X） bonds. This review summarizes the substantial progress made in the last few years in C-H functionalization via organic electrochemistry. It is divided into sections on C-C, C-N, C-O, C-S, C-Halogen and C-P bond formation.
