SPACES OF ANALYTIC FUNCTIONS REPRESENTED BY DIRICHLET SERIES OF TWO COMPLEX VARIABLES

We consider the space X of all analytic functionsof two complex variables s1 and s2, equipping it with the natural locally convex topology and using the growth parameter, the order of f as defined recently by the authors. Under this topology X becomes a Frechet space Apart from finding the characterization of continuous linear functionals, linear transformation on X, we have obtained the necessary and sufficient conditions for a double sequence in X to be a proper bases.

COP28 Makes It Official: Fossil Fuels Cause Climate Change

On November 30,2023,amidst outrage over its leadership’s ties to the oil and gas industry[1],COP28—shorthand for the 28th United Nations(UN)“Conference of the Parties”Climate Change meeting—began in Dubai,United Arab Emirates(UAE).However,by the end of the conference on December 12,its attendees had surprisingly reached agreement on a handful of steps to address the challenges posed by climate change.The biggest surprise?Explicitly identifying fossil fuels as the root cause of climate change.For the first time in the summit’s 28-year history,delegates representing nearly 200 countries acknowledged the role of fossil fuels in driving climate change.They agreed to work on “transitioning away from fossil fuels in energy systems,in a just,orderly,and equitable manner,accelerating action in this critical decade,so as to achieve net zero by 2050 in keeping with the science”[2].

m^(1)A inhibition fuels oncolytic virus-elicited antitumor immunity via downregulating MYC/PD-L1 signaling

N^(1)-methyladenosine(m^(1)A)RNA methylation is critical for regulating mRNA translation;however,its role in the development,progression,and immunotherapy response of head and neck squamous cell carcinoma(HNSCC)remains largely unknown.Using Tgfbr1 and Pten conditional knockout(2cKO)mice,we found the neoplastic transformation of oral mucosa was accompanied by increased m^(1)A modification levels.Analysis of m^(1)A-associated genes identified TRMT61A as a key m^(1)A writer linked to cancer progression and poor prognosis.Mechanistically,TRMT61A-mediated tRNA-m^(1)A modification promotes MYC protein synthesis,upregulating programmed death-ligand 1(PD-L1)expression.Moreover,m^(1)A modification levels were also elevated in tumors treated with oncolytic herpes simplex virus(oHSV),contributing to reactive PD-L1 upregulation.Therapeutic m^(1)A inhibition sustained oHSV-induced antitumor immunity and reduced tumor growth,representing a promising strategy to alleviate resistance.These findings indicate that m^(1)A inhibition can prevent immune escape after oHSV therapy by reducing PD-L1 expression,providing a mutually reinforcing combination immunotherapy approach.

Editorial for the Special Issue on Natural Medicine

As the world continues to search for innovative therapeutic solutions,the field of natural medicines has emerged as a vibrant area of research.The potential of natural products to treat a wide range of diseases,coupled with the relatively low sideeffects of such products,has captured the attention of scientists,clinicians,and the general public alike.This Special Issue on Natural Medicine aims to present the latest advancements in this exciting field,highlighting both fundamental research and clinical applications.The collection of articles in this Special Issue covers a broad spectrum of topics,ranging from medicinal chemistry to biological mechanisms,and from the study of single botanic compounds to complex plant formulas.We are particularly pleased to include a comprehensive review by Yi Wang et al.on the bioactivities,mechanisms,production,and potential application of bile acids in preventing and treating infectious diseases.This review not only summarizes the current landscape of bile acids research but also highlights several promising compounds for future investigations,such as the recent interest in ursodeoxycholic acid.In a related topic,Shishan Yu’s team has developed artificial bear bile using synthetic chemistry and enzyme engineering,providing a sustainable substitute for natural bear bile.This innovation meets medical needs while addressing animal welfare issues,representing a notable progression in the field.

Cover Story

Traditional villages are cultural heritage sites representing stages of historical development,with unique regional cultural characteristics and significant cultural values,and their preservation should focus on integrity,authenticity,and egrity,au continuity,The protection and development of traditional villages should be guided by a scientifically sound approach.Post-disaster reconstruction is a topic of global concen,and trnditional villages,with their special heritage nttributes,face additional demands and obstacles in post-disaster reconstruction.Post-disaster reconstruction of traditional villages is a dynamic process of changing the production and livelihoods of affected residents while restoring and protecting heritage during this process,Concretely,it is urgent to identify thc main problems faced by post-disaster recovery and reconstruction of traditional vil lages based on the heritage attributes,and probes the protection planning design paths and revitalization strategies accor dingly.

Solving Quantum Many-Particle Models with Graph Attention Network

Deep learning methods have been shown to be effective in representing ground-state wavefunctions of quantum many-body systems,however the existing approaches cannot be easily used for non-square like or large systems.Here.we propose a variational ansatz based on the graph attention network(GAT)which learns distributed latent representations and can be used on non-square lattices.

Data-driven methods for predicting the representative temperature of bridge cable based on limited measured data

Cable-stayed bridges have been widely used in high-speed railway infrastructure.The accurate determination of cable’s representative temperatures is vital during the intricate processes of design,construction,and maintenance of cable-stayed bridges.However,the representative temperatures of stayed cables are not specified in the existing design codes.To address this issue,this study investigates the distribution of the cable temperature and determinates its representative temperature.First,an experimental investigation,spanning over a period of one year,was carried out near the bridge site to obtain the temperature data.According to the statistical analysis of the measured data,it reveals that the temperature distribution is generally uniform along the cable cross-section without significant temperature gradient.Then,based on the limited data,the Monte Carlo,the gradient boosted regression trees(GBRT),and univariate linear regression(ULR)methods are employed to predict the cable’s representative temperature throughout the service life.These methods effectively overcome the limitations of insufficient monitoring data and accurately predict the representative temperature of the cables.However,each method has its own advantages and limitations in terms of applicability and accuracy.A comprehensive evaluation of the performance of these methods is conducted,and practical recommendations are provided for their application.The proposed methods and representative temperatures provide a good basis for the operation and maintenance of in-service long-span cable-stayed bridges.

Assessing the impact of climate change on agricultural production in central Afghanistan

Afghanistan has faced extreme climatic crises such as drought,rising temperature,and scarce precipitation,and these crises will likely worsen in the future.Reduction in crop yield can affect food security in Afghanistan,where the majority of population and economy are completely dependent on agriculture.This study assessed the interaction between climate change and crop yield in Kabul of Afghanistan during the reference(1990–2020)and future(2025–2100)periods.Climate data(1990–2020)were collected from four meteorological stations and three local organizations,and wheat yield data(1990–2020)were acquired from the United States Agriculture Department.Data during the reference period(1990–2020)were used for the validation and calibration of the statistical downscaling models such as the Statistical Downscaling Model(SDSM)and Long Ashton Research Station Weather Generator(LARS-WG).Furthermore,the auto-regression model was used for trend analysis.The results showed that an increase in the average annual temperature of 2.15℃,2.89℃,and 4.13℃will lead to a reduction in the wheat yield of 9.14%,10.20%,and 12.00%under Representative Concentration Pathway(RCP)2.6,RCP4.5,and RCP8.5 during the future period(2025–2100),respectively.Moreover,an increase in the annual maximum temperature of 1.79℃,2.48℃,and 3.74℃also causes a significant reduction in the wheat yield of 2.60%,3.60%,and 10.50%under RCP2.6,RCP4.5,and RCP8.5,respectively.Furthermore,an increase in the annual minimum temperature of 2.98℃,2.23℃,and 4.30℃can result in an increase in the wheat yield of 6.50%,4.80%,and 9.30%under RCP2.6,RCP4.5,and RCP8.5,respectively.According to the SDSM,the decrease of the average monthly precipitation of 4.34%,4.10%,and 5.13%results in a decrease in the wheat yield of 2.60%,2.36%,and 3.18%under RCP2.6,RCP4.5,and RCP8.5,respectively.This study suggests that adaptation strategies can be applied to minimize the consequences of climate change on agricultural production.

From Major-Countries Coordination to Global Mechanisms:an Analysis of the Global Governance of Large AI Models

The global governance of large artificial intelligence(AI)models calls for urgent actions.Large models,representing a type of technological innovation,is advancing global technological progress and is also compelling the international community’s attention to the role of global governance system in coordinating the development of AI.In building a global governance mechanism for large models,both traditional governance system and new international system should be explored to construct Regime Complexes for the governance of large models.

Attica's Message to Chinese Tourists:We Will Pleasantly Surprise You-Exclusive Interview with Nikos Hardalias,Governor of Greece’s Attica Region

CHINA and Greece,representing two ancient civilizations,hold an enduring appeal for tourists due to their spectacular cultures.The Region of Attica in Greece has an enchantment of its own due to its place in history,when its primary city Athens was a center of learning in Europe.It is therefore no surprise that Greece-and the Region of Attica-would be present at a major tourism event in China.With international tourism warming up,the ITB China 2024.

Three working groups on commercial aerospace established

In order to implement the spirits of the Central Economic Work Conference and systematically promote the standardization work of commercial aerospace,SAC/TC 425,Space technology and operation,recently established three working groups for emerging fields and strategic emerging industries related to commercial aerospace.The work scope of WG 1 on commercial aircraft launching covers the standards research,development and revision for operation support,process,industrial chains,and other fields of launching.It is also responsible for the updating of standards documents published by correspondent international standardization organizations for further analysis and adoption.WG 2 on the application of satellite internet is responsible for the research,development and revision of standards in areas such as the application scenarios and demands,functions and process,interfaces and data forms of satellite internet.Its first batch of members consists of 29 service providers,operators,equipment manufacturers,and parties representing public interests in this field.

全球人工智能专家共同探讨挑战、趋势和标准化

With the rapid evolution of artificial intelligence(AI)and the race for governments to regulate it,the need for international consensus has never been greater.International standards can be valuable tools in the responsible deployment of AI,representing the needs and requirements of all stakeholders and providing global best practice.

Enduring Importance

On 5 March,national and global spotlight turned to the Great Hall of the People in Beijing where around 3,000 deputies gathered to open the second session of the 14th National People’s Congress(NPC).Over a span of seven days,the deputies,representing all of China’s ethnic groups,regions and sectors,discussed and decided on a range of issues critical for the country’s development.

News: JES well represented at the recent Gordon Research Conference on Drinking Water Disinfection By-products

The Gordon Research Conference （GRC） on Drinking Water Disinfection By-products （DBPs） was recently held in Mount Holyoke College, South Hadley, Massachusetts, United States, on July 30-August 4, 2017. The theme of this year＇s GRC on DBPs was ＂Disinfection 2100： Linking Engineering, Chemistry, Toxicology, and Epidemiology to Reduce Exposure to Toxicity Drivers while Curtailing Pathogens＂ （GRC, 2017）. More than one hundred and fifty scientists from around the world actively participated in the week-long conference.

PIKFYVE inhibition mitigates disease in models of diverse forms of ALS

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that results from many diverse genetic causes.Although therapeutics specifically targeting known causal mutations may rescue individual types of ALS, these approaches cannottreat most cases since they have unknown genetic etiology. Thus, there is a pressing need for therapeutic strategies that rescuemultiple forms of ALS. Here, we show that pharmacological inhibition of PIKFYVE kinase activates an unconventional proteinclearance mechanism involving exocytosis of aggregation-prone proteins. Reducing PIKFYVE activity ameliorates ALSpathology and extends survival of animal models and patient-derived motor neurons representing diverse forms of ALS includingC9ORF72, TARDBP, FUS, and sporadic. These findings highlight a potential approach for mitigating ALS pathogenesis that doesnot require stimulating macroautophagy or the ubiquitin-proteosome system.

Future meteorological drought conditions in southwestern Iran based on the NEX-GDDP climate dataset

Investigation of the climate change effects on drought is required to develop management strategies for minimizing adverse social and economic impacts.Therefore,studying the future meteorological drought conditions at a local scale is vital.In this study,we assessed the efficiency of seven downscaled Global Climate Models(GCMs)provided by the NASA Earth Exchange Global Daily Downscaled Projections(NEX-GDDP),and investigated the impacts of climate change on future meteorological drought using Standard Precipitation Index(SPI)in the Karoun River Basin(KRB)of southwestern Iran under two Representative Concentration Pathway(RCP)emission scenarios,i.e.,RCP4.5 and RCP8.5.The results demonstrated that SPI estimated based on the Meteorological Research Institute Coupled Global Climate Model version 3(MRI-CGCM3)is consistent with the one estimated by synoptic stations during the historical period(1990-2005).The root mean square error(RMSE)value is less than 0.75 in 77%of the synoptic stations.GCMs have high uncertainty in most synoptic stations except those located in the plain.Using the average of a few GCMs to improve performance and reduce uncertainty is suggested by the results.The results revealed that with the areas affected by wetness decreasing in the KRB,drought frequency in the North KRB is likely to increase at the end of the 21st century under RCP4.5 and RCP8.5 scenarios.At the seasonal scale,the decreasing trend for SPI in spring,summer,and winter shows a drought tendency in this region.The climate-induced drought hazard can have vast consequences,especially in agriculture and rural livelihoods.Accordingly,an increasing trend in drought during the growing seasons under RCP scenarios is vital for water managers and farmers to adopt strategies to reduce the damages.The results of this study are of great value for formulating sustainable water resources management plans affected by climate change.

The Three Cs:China,Culture and Civilization

Steeped in a civilization featuring inclusivity and peaceful nature,China seeks exchanges and mutual learning among civilizations rather than cultural hegemony.WHILE claiming its preeminent global economic status,China has also come to assert its equivalent position in world politics and diplomacy,typically representing the interests of the developing world.

Epigenetic patterns in a complete human genome

The completion of a telomere-to-telomere human reference genome,T2T-CHM13,has resolved complex regions of the genome,including repetitive and homologous regions.Here,we present a high-resolution epigenetic study of previously unresolved sequences,representing entire acrocentric chromosome short arms,gene family expansions,and a diverse collection of repeat classes.This resource precisely maps CpG methylation(32.28 million CpGs),DNA accessibility,and short-read datasets(166,058 previously unresolved chromatin immunoprecipitation sequencing peaks)to provide evidence of activity across previously unidentified or corrected genes and reveals clinically relevant paralog-specific regulation.Probing CpG methylation across human centromeres from six diverse individuals generated an estimate of variability in kinetochore localization.This analysis provides a framework with which to investigate the most elusive regions of the human genome,granting insights into epigenetic regulation.

捕梦网

The dreamcatcher may be the perfect gift for anyone who always has nightmares.对于那些总是做噩梦的人来说,捕梦网可能是最完美的礼物。Dreamcatchers are round.Inside the loop1 thread2 is arranged3 in such a way that resembles4 a spider’s web.Feathers are attached5 to the bottom.Beads6 are often used.Some choose to have one bead in the middle representing7 the spider.Others prefer to have the hole in the middle empty.

Healthcare Across Borders

Due to the shortage of health personnel in Malawi,some communities often find it difficult to access healthcare service.Some of the people most a!ected are those in orphanages,as it’s not easy to find medical personnel to visit them,resulting in spreading infections and sometimes negative outcomes in critical illness.Matilda Dambula,representing one of the orphanages in the Central Region of Malawi,said she gave up.