Neurophysiological, histological, and behavioral characterization of animal models of distraction spinal cord injury: a systematic review

Distraction spinal cord injury is caused by some degree of distraction or longitudinal tension on the spinal cord and commonly occurs in patients who undergo corrective operation for severe spinal deformity.With the increased degree and duration of distraction,spinal cord injuries become more serious in terms of their neurophysiology,histology,and behavior.Very few studies have been published on the specific characteristics of distraction spinal cord injury.In this study,we systematically review 22 related studies involving animal models of distraction spinal cord injury,focusing particularly on the neurophysiological,histological,and behavioral characteristics of this disease.In addition,we summarize the mechanisms underlying primary and secondary injuries caused by distraction spinal cord injury and clarify the effects of different degrees and durations of distraction on the primary injuries associated with spinal cord injury.We provide new concepts for the establishment of a model of distraction spinal cord injury and related basic research,and provide reference guidelines for the clinical diagnosis and treatment of this disease.

Static-to-kinematic modeling and experimental validation of tendon-driven quasi continuum manipulators with nonconstant subsegment stiffness

Continuum robots with high flexibility and compliance have the capability to operate in confined and cluttered environments. To enhance the load capacity while maintaining robot dexterity, we propose a novel non-constant subsegment stiffness structure for tendon-driven quasi continuum robots(TDQCRs) comprising rigid-flexible coupling subsegments.Aiming at real-time control applications, we present a novel static-to-kinematic modeling approach to gain a comprehensive understanding of the TDQCR model. The analytical subsegment-based kinematics for the multisection manipulator is derived based on screw theory and product of exponentials formula, and the static model considering gravity loading,actuation loading, and robot constitutive laws is established. Additionally, the effect of tension attenuation caused by routing channel friction is considered in the robot statics, resulting in improved model accuracy. The root-mean-square error between the outputs of the static model and the experimental system is less than 1.63% of the arm length(0.5 m). By employing the proposed static model, a mapping of bending angles between the configuration space and the subsegment space is established. Furthermore, motion control experiments are conducted on our TDQCR system, and the results demonstrate the effectiveness of the static-to-kinematic model.

Hubble Tension Explanation from This Cosmological Model AΛΩ (Slow Bang Model, SB)

In this article we present a model of Hubble-Lemaître law using the notions of a transmitter (galaxy) and a receiver (MW) coupled to a model of the universe (Slow Bang Model, SB), based on a quantum approach of the evolution of space-time as well as an equation of state that retains all the infinitesimal terms. We find an explanation of the Hubble tension H0. Indeed, we have seen that this constant depends on the transceiver pair which can vary from the lowest observable value, from photons of the CMB (theoretical [km/s/Mpc]) to increasingly higher values depending on the earlier origin of the formation of the observed galaxy or cluster (ETG ~0.3 [Gy], ~74 [km/s/Mpc]). We have produced a theoretical table of the values of the constant according to the possible pairs of transmitter/receiver in the case where these galaxies follow the Hubble flow without large disturbance. The calculated theoretical values of the constant are in the order of magnitude of all values mentioned in past studies. Subsequently, we applied the models to 9 galaxies and COMA cluster and found that the models predict acceptable values of their distances and Hubble constant since these galaxies mainly follow the Hubble flow rather than the effects of a galaxy cluster or a group of clusters. In conclusion, we affirm that this Hubble tension does not really exist and it is rather the understanding of the meaning of this constant that is questioned.

JWST Discoveries and the Hypersphere World-Universe Model: Transformative New Cosmology

Twenty-six years ago, a small committee report built upon earlier studies to articulate a compelling and poetic vision for the future of astronomy. This vision called for an infrared-optimized space telescope with an aperture of at least four meters. With the support of their governments in the US, Europe, and Canada, 20,000 people brought this vision to life as the 6.5-meter James Webb Space Telescope (JWST). The telescope is working perfectly, delivering much better image quality than expected [1]. JWST is one hundred times more powerful than the Hubble Space Telescope and has already captured spectacular images of the distant universe. A view of a tiny part of the sky reveals many well-formed spiral galaxies, some over thirteen billion light-years away. These observations challenge the standard Big Bang Model (BBM), which posits that early galaxies should be small and lack well-formed spiral structures. JWST’s findings are prompting scientists to reconsider the BBM in its current form. Throughout the history of science, technological advancements have led to new results that challenge established theories, sometimes necessitating their modification or even abandonment. This happened with the geocentric model four centuries ago, and the BBM may face a similar reevaluation as JWST provides more images of the distant universe. In 1937, P. Dirac proposed the Large Number Hypothesis and the Hypothesis of Variable Gravitational Constant, later incorporating the concept of Continuous Creation of Matter in the universe. The Hypersphere World-Universe Model (WUM) builds on these ideas, introducing a distinct mechanism for matter creation. WUM is proposed as an alternative to the prevailing BBM. Its main advantage is the elimination of the “Initial Singularity” and “Inflation”, offering explanations for many unresolved problems in Cosmology. WUM is presented as a natural extension of Classical Physics with the potential to bring about a significant transformation in both Cosmology and Classical Physics. Considering JWST’s discoveries, WUM’s achievements, and 87 years of Dirac’s proposals, it is time to initiate a fundamental transformation in Astronomy, Cosmology, and Classical Physics. The present paper is a continuation of the published article “JWST Discoveries—Confirmation of World-Universe Model Predictions” [2] and a summary of the paper “Hypersphere World-Universe Model: Digest of Presentations John Chappell Natural Philosophy Society” [3]. Many results obtained there are quoted in the current work without full justification;interested readers are encouraged to view the referenced papers for detailed explanations.

Electrostatic Attraction and Repulsion Explained and Modelled Mathematically Using Classical Physics—A Detailed Mechanism Based on Particle Wave Functions

The phenomenon of electrical attraction and repulsion between charged particles is well known, and described mathematically by Coulomb’s Law, yet until now there has been no explanation for why this occurs. There has been no mechanistic explanation that reveals what causes the charged particles to accelerate, either towards or away from each other. This paper gives a detailed explanation of the phenomena of electrical attraction and repulsion based on my previous work that determined the exact wave-function solutions for both the Electron and the Positron. It is revealed that the effects are caused by wave interactions between the wave functions that result in Electromagnetic reflections of parts of the particle’s wave functions, causing a change in their momenta.

Mathematical Wave Functions and 3D Finite Element Modelling of the Electron and Positron

The wave/particle duality of particles in Physics is well known. Particles have properties that uniquely characterize them from one another, such as mass, charge and spin. Charged particles have associated Electric and Magnetic fields. Also, every moving particle has a De Broglie wavelength determined by its mass and velocity. This paper shows that all of these properties of a particle can be derived from a single wave function equation for that particle. Wave functions for the Electron and the Positron are presented and principles are provided that can be used to calculate the wave functions of all the fundamental particles in Physics. Fundamental particles such as electrons and positrons are considered to be point particles in the Standard Model of Physics and are not considered to have a structure. This paper demonstrates that they do indeed have structure and that this structure extends into the space around the particle’s center (in fact, they have infinite extent), but with rapidly diminishing energy density with the distance from that center. The particles are formed from Electromagnetic standing waves, which are stable solutions to the Schrödinger and Classical wave equations. This stable structure therefore accounts for both the wave and particle nature of these particles. In fact, all of their properties such as mass, spin and electric charge, can be accounted for from this structure. These particle properties appear to originate from a single point at the center of the wave function structure, in the same sort of way that the Shell theorem of gravity causes the gravity of a body to appear to all originate from a central point. This paper represents the first two fully characterized fundamental particles, with a complete description of their structure and properties, built up from the underlying Electromagnetic waves that comprise these and all fundamental particles.

Calculation of Particle Decay Times in the Standard Model

We present here a two-step method of classification and calculation for decay rates in the Standard Model. The first step is a phenomenological classification method, which is an extended and improved schematic experimental formula for decay width originally introduced by Chang. This schematic formula separates decays into seven classes. Furthermore, from it is derived a process-specific interaction energy mX. The second step is a numerical calculation method, which calculates this interaction energy mX numerically by minimization of action from the Lagrangian of the process, from which follows the decay width via the phenomenological formula. The Lagrangian is based on an extension of the Standard Model, the extended SU(4)-preon-model. A comparison of numerically calculated and observed decay widths for a large selection of decays shows a good agreement.

基于修正断裂分析模型的混凝土劈拉强度预测

数值分析是规避试验短板、实现理论预期的重要研究手段。该文采用细观尺度数值试验方法,对建立的基于绕晶失效模式的混凝土三维细观断裂理论分析模型进行修正。采用的混凝土数值分析模型由砂浆、界面及骨料组成,与理论分析模型保持一致。为模拟普通强度混凝土的力学行为,采用塑性损伤本构模型表征砂浆和界面的力学性能,骨料则设为弹性球体。采用自编骨料投放程序,建立了截面尺寸分别为100 mm(一级配)、150 mm(二级配)、300 mm(三级配)和450 mm(四级配)的三维模型混凝土标准立方体试件。通过开展不同界面强度条件下标准立方体试件劈裂拉伸加载数值试验,对理论分析模型进行了修正,建立了用于不同级配混凝土劈拉强度预测的半理论-半经验修正计算公式。与数值试验及物理试验结果对比表明:修正后的理论分析模型能够有效表征混凝土宏观力学性能随细观组成材料力学特性和结构特性的变化规律。该文提出的基于重叠效应和结构效应分析的理论模型修正方法,可为后续建立基于修正断裂分析模型的混凝土力学性能半理论-半经验预测公式奠定基础。

基于GMM的湿筛混凝土轴拉损伤演化机制研究

为研究不同加载阶段下的二级配湿筛混凝土开裂模式与损伤演化过程,将声发射技术(AE)与高斯混合模型(GMM)进行结合作为损伤识别手段,以3种加载速率(1×10^(-6)、5×10^(-6)、25×10^(-6)s^(-1))作为试验变量,对二级配湿筛混凝土开展单轴拉伸损伤时空演化机制试验研究。结果表明:随着加载速率增大,湿筛混凝土试件内部裂缝开展更加密集,并且裂缝种类随机性更高;利用GMM法对声发射数据进行处理分类结果显示,拉伸裂缝为试验加载过程的主要开裂模式,加载速率升高会导致剪切裂缝占比增大;随着加载速率增大,拉伸裂缝频率分布明显扩大,而剪切裂缝与混合裂缝频率分布基本不变;随着加载进行,拉伸裂缝与剪切裂缝概率密度区域均向AF轴趋近;GMM法所得裂缝开裂模式有拉伸裂缝、剪切裂缝与混合裂缝3种类别,并且随着加载进行,混合断裂区所处位置也会发生变化;相较于常规裂缝模式分类方法,GMM法提供了更好的裂缝分类近似值分析,对裂缝开裂模式表述更加可靠。

Indirect tension test of epoxy asphalt mixtureusing microstructural finite-element model

A finite-element model of the thermosetting epoxy asphalt mixture（EAM） microstructure is developed to simulate the indirect tension test（IDT）.Image techniques are used to capture the EAM microstructure which is divided into two phases：aggregates and mastic.A viscoelastic constitutive relationship,which is obtained from the results of a creep test,is used to represent the mastic phase at intermittent temperatures.Model simulation results of the stiffness modulus in IDT compare favorably with experimental data.Different loading directions and velocities are employed in order to account for their influence on the modulus and the localized stress of the microstructure model.It is pointed out that the modulus is not consistent when the loading direction changes since the heterogeneous distribution of the mixture internal structure,and the loading velocity affects the localized stress as a result of the viscoelasticity of the mastic.The study results can provide a theoretical basis for the finite-element method,which can be extended to the numerical simulations of asphalt mixture micromechanical behavior.

Calculating models on surface tension of RE_2O_3-Mg O-SiO_2(RE=La, Nd, Sm, Gd and Y) melts

A thermodynamic model was developed for determining the surface tension of RE2O3-MgO-SiO2(RE=La, Nd, Sm, Gd and Y) melts considering the ionic radii of the components and Butler's equation. The temperature and composition dependence of the surface tensions in molten RE2O3-MgO-SiO2 slag systems was reproduced by the present model using surface tensions and molar volumes of pure oxides, as well as the anionic and cationic radii of the melt components. The iso-surface tension lines of La2O3-MgO-SiO2 slag melt at 1873 K were calculated and the effects of slag composition on the surface tension were also investigated. The surface tensions of La2O3, Gd2O3, Nd2O3 and Y2O3 at 1873 K were evaluated as 686, 677, 664 and 541 m N/m, respectively. The surface tension of pure rare earth oxide melts linearly decreases with increasing cationic field strength, except for Y2O3 oxide, while Y2O3 has a much weaker surface tension. The evaluated results of the surface tension show good agreements with literature data, and the mean deviation of the present model is found to be 1.05% at 1873 K.

无粘结环锚预应力衬砌张拉工艺足尺模型试验研究

针对预应力衬砌张拉过程中易出现应力集中而导致张拉裂缝的现象,通过开展洞外地面足尺模型试验,提出了分级分步张拉顺序和质量控制指标。首先根据钢绞线摩阻测试计算出摩擦系数,随后应用上述张拉顺序和质量控制方法进行自动张拉,并采用磁通量传感器和混凝土应变计分别对钢绞线和内衬混凝土的应力变化开展实测。现场张拉试验结果表明:①钢绞线沿程预应力损失约16.3%,采用的双层钢绞线在实践中可保证较高的有效预应力;②对锚具槽进行分级分步张拉,可使内衬混凝土获得较均匀的封闭环向压应力环,平均压应力达-10.9 MPa;③提出的3项控制指标可进行量化管理,结合自动张拉技术可有效地保证张拉质量。

常温养护超高性能混凝土弯拉性能及轴拉本构模型

根据水化反应方程和紧密堆积理论确定了常温养护下超高性能混凝土(UHPC)的基础配合比,基于此考虑水胶比和钢纤维掺量设计了8组UHPC抗弯试件。通过四点弯曲试验,分析了试件的受弯破坏形态、荷载-挠度曲线、弯拉特征参数和弯曲韧性等;基于试验结果采用倒推方法得到了UHPC轴拉应力-应变曲线,采用回归分析提出了考虑纤维特征的轴拉本构模型,并经过材料和构件两个层次的验证。结果表明:掺加钢纤维可抑制主裂缝的发展,从而明显改善UHPC的抗弯韧性,钢纤维掺量为2.0%的UHPC弯曲韧性指数达到116.9 J;随着水胶比增大,试件抗折强度和峰值挠度均呈下降趋势;增大钢纤维掺量明显提升了试件弯曲性能,掺入2.0%钢纤维的UHPC与未掺纤维相比,其初裂挠度和抗折强度分别提升157.14%和148.63%;当纤维含量为1.5%~2.0%时,试件具有良好的弯拉性能;水胶比对曲线平台段趋势影响不大,纤维掺量大于1.0%时曲线具有较明显的应变硬化特征,可保证UHPC良好的抗拉性能,其应变硬化特征随着纤维掺量增大而变得更明显;所提模型对UHPC受拉应力-应变关系具有较好的预测性。

不同侧张力性气胸对猪血流动力学的影响

目的探讨不同侧张力性气胸对猪血流动力学的影响,为优化气胸现场一线救治流程提供数据支持。方法12只巴马猪随机分为左侧张力性气胸组与右侧张力性气胸组,每组6只。通过脉搏指示连续心输出量监测(PICCO)技术在气胸及以1 mmHg为单位逐渐增大的胸膜腔压力下采集相关指标,包括血流动力学指标[全心射血分数(GEF)、心输出量(CO)、全心舒张末容量(GEDV)、胸腔内血容量(ITBV)、每搏量(SV)、平均动脉压(MAP)]、基础生命体征指标[心率(HR)、舒张压(DBP)、收缩压(SBP)]及动脉血气指标[氧分压(PO_(2))、二氧化碳分压(PCO_(2))],随后使用X线片进行纵隔定位。通过两组之间互相比较及组内前后比较的方式探究其差异性。结果通过比较血流动力学变化及X线片检查结果,12只巴马猪张力性气胸模型均构建成功。血流动力学分析结果显示,左侧张力性气胸在胸膜腔压力为8 mmHg时,与同侧气胸时相比,SBP、DBP、MAP、CO、GEF、SV、GEDV及ITBV明显下降(P<0.05)。右侧张力性气胸在胸膜腔压力为3 mmHg时,与同侧气胸时相比,SBP、DBP、MAP、SV、GEDV及ITBV明显下降(P<0.05)。血气分析结果显示,左侧张力性气胸(胸膜腔压力为8 mmHg)及右侧张力性气胸(胸膜腔压力为3 mmHg)时,与各自同侧气胸时相比,PO_(2)明显降低(P<0.05),PCO_(2)明显升高(P<0.05)。结论不同侧张力性气胸存在差异性,在较小的胸膜腔压力下右侧张力性气胸较左侧更易导致严重后果。进行张力性气胸相关实验时可根据实际情况构建不同侧张力性气胸模型。

热转印系统色带传动过程张力分析与建模

为保证热转印过程中薄膜色带传动稳定进而实现高质量转印,建立正确的热转印色带传动张力模型十分关键。首先,研究了热转印色带传动系统组成及转印原理,并根据色带传动路径分辊间段、放卷段和收卷段3阶段对色带传动系统张力进行了建模与分析。然后,结合热转印色带卷材的黏弹性分析张力形成机制,改进了卷绕系统经典张力公式,建立了辊间段薄膜色带张力模型。针对传动系统的放卷区域,分析了摩擦对薄膜色带传动张力的影响,提出张力下降系数以评估张力损失。考虑色带张力非线性时变的特点,利用步进电动机负载模型求解收卷区域色带张力。最后,通过对比仿真与实验所得的色带张力变化曲线,验证了模型的准确性,为后续张力控制方案设计奠定了基础。

基于SOA优化的ADRC胎面卷取张力控制系统

胎面卷取张力控制的精度直接影响后期成型工序的精度和硫化成品质量。为保证胎面成品的质量,以挤出联动线卷取时的张力控制为研究对象,针对胎面制品卷取速度和时变卷径引起的张力波动问题,首先分析系统张力产生机理,建立张力系统的数学模型,设计了系统启动和运行阶段的张力观测算法。其次建立仿真模型在系统启动-运行阶段通过对比自抗扰控制器(active disturbance rejection control,ADRC)与比例-积分-微分(proportional integral derivative,PID)的控制性能,验证了自抗扰控制响应速度快,能够稳定地控制张力,并且具备出色的抗干扰性和抗内部参数扰动能力。最后采用人群搜索算法(seeker optimization algorithm,SOA)筛选控制器参数最优值,将控制器应用到张力系统模型,仿真验证了所设计的人群搜索自抗扰控制策略的有效性和准确性。结果表明:SOA优化性能较好且与ADRC相结合的控制方式控制效果较佳。研究结果在桂林橡胶设计院的工艺方法及性能指标体系上进行控制算法设计,对实际生产具有一定的参考价值。

主动激励声波在后张法混凝土传播机理可视化及影响研究

当激振器作为主动激励信号时,不同的激励频率和激励幅值的声波在后张法混凝土结构内的传播机理及影响因素对实际工程提供主动激励信号波形参数选取及声发射传感器布置方式具有重要意义。该文利用COMSOL数值模拟方法可视化了激振器激励声波在后张法混凝土梁内的传播机理,提出了激振器主动激励信号波形参数确定的方法。结果表明:数值模拟方法可视化了激振器激励声波在后张法混凝土结构内的传播路径;构建了不同激励频率和激励幅值声波在后张法混凝土结构内衰减模型,可作为稳定的主动激励信号波形参数选取和声发射传感器布置方式的理论基础,当激励幅值相同,激励频率为10 kHz时,激励声波在后张法混凝土结构内衰减系数最小,实际工程中为保证信噪比,较大的激励幅值更有优势。

铝粒尺寸及入炉高度对运动轨迹的影响

二次精炼过程中,铝是钢液进行脱氧及合金化的主要物料之一,但纯铝的密度小于钢液,能否穿越渣层与钢液接触及接触时间对铝的脱氧效果和钢中溶解铝的含量有直接影响。在忽略铝的熔化、溶解及化学反应的情况下,通过对铝粒运动过程受力分析,建立铝粒在气-渣-钢相内的三维运动数学模型,明晰铝粒尺寸及入炉高度对铝粒运动轨迹的影响。结果表明:在渣层厚度为70 mm且入炉高度为1~1.5 m的情况下,1 mm和5 mm的铝粒在渣钢界面处波动;入炉高度为1 m时,粒径为10 mm的铝粒停留在渣钢界面处,但在入炉高度为1.5 m及以上时可以进入钢液;20 mm及以上尺寸的铝粒可以进入钢液。在入炉高度为1 m时、30 mm尺寸的铝粒在钢液中的停留时间与深度相较于20 mm的基础上分别增加22.86%和50.00%;在铝粒尺寸为20 mm时、入炉高度为1.5 m时的铝粒在钢液中的停留时间与深度在1 m的基础上分别增加5.71%和10.00%。增加钢渣界面张力、减小钢铝界面张力或增加渣铝界面张力有利于铝粒进入钢液,而铝粒的尺寸大于20 mm,界面张力对铝块运动几乎没有影响;增大密度会使钢芯铝在钢液中停留更长时间,有利于钢液脱氧。

考虑张力制度影响的碳纤维缠绕容器爆破性能预测与仿真插件开发

针对缠绕张力对碳纤维缠绕容器承载性能影响规律尚不明确的问题,基于ABAQUSTM软件开发了一套用户友好、自主选择性好且高效的插件工具,能够自动化完成模型建立和相关设置工作,实现了考虑多种缠绕工艺参数的容器结构精细化建模。基于该插件工具,对碳纤维缠绕容器在不同缠绕张力制度下的爆破性能进行了参数化分析,通过爆破试验验证了数值模型的有效性。对于直径为Ф155 mm和Ф474 mm的容器,90 N-80 N-60 N和200 N-180 N-160 N逐层减小的缠绕张力制度将提高容器的爆破性能;对于20 N和30 N递减张力制度,直径Ф474 mm容器的爆破压强随着内层张力的减小逐渐降低,当张力递减幅度增加时,容器的爆破压强趋于稳定,其下降幅度由16.79%减小到3.05%。此外,容器封头段与筒身段过渡区域的应变水平最高,为碳纤维缠绕容器的薄弱位置。

拉压复合型锚杆锚固机理的数值及模型试验应用研究

针对全长注浆锚杆在深部隧洞中支护作用的局限性,为有效控制隧洞围岩变形、增强锚杆承载性能,本文采用有限元数值模拟法深入研究拉压复合型锚杆支护结构在岩石隧道加固过程中受到拉拔荷载作用下的界面失效特征及力学传递机制,并将锚杆应用在超载模型试验中,探究锚杆的支护性能。研究结果表明:锚固体与围岩相互作用接触界面的力学演化共经历了弹性阶段、塑性软化阶段、完全滑移阶段的渐进式失效过程。界面剪切力的传递也是从拉拔荷载较小时出现在承载板处,随拉拔荷载增大,向锚固段两侧转移,呈现双峰趋势。根据锚杆界面剪切力分布规律,提出了复合锚杆在低荷载和高荷载拉拔作用下的剪切力分布模型,此模型具有普遍性,进行的室内超载模型试验得出复合锚杆支护效果优于普通锚杆的结论,此研究可为复合锚杆在深埋隧洞等地下工程中的应用提供一定的参考价值。