Research on Technology Opportunity Identification of Small and Medium-sized Vaccine Enterprises Based on Patent Analysis

Objective To propose a method for identifying cooperation partners and technology opportunities based on technological similarity and technological capability analysis at the critical moment for the survival of small and medium-sized vaccine companies.This method can provide a direction for small and medium-sized enterprises that lack human and financial resources to make full use of its existing technologies.Methods Data analysis was carried out based on patent data.First,through cosine similarity and patent index evaluation,companies with high technological similarity and strong technological capabilities were selected as the target of cooperation.Then evaluation index system of technological development potential was built from three dimensions:technological competitiveness,technological creativity,and potential for industrialization.AHP-CRITIC method was used to determine the comprehensive development potential of each technology.Finally,technology opportunities based on K-means and text mining were identified.Results and Conclusion This method can help small and medium vaccine companies in China to identify technological opportunities and provide directions for product development.

Development Trend and Prediction of Stem Cell Technology in China from the Perspective of Patent

Objective To provide new ideas for the effective treatment of many serious diseases and to solve many major medical problems faced by mankind.Methods In this paper,the invention patents in the field of stem cells in China from 2010 to 2020 were taken as the research object,and the technology status quo in the field of stem cells was analyzed to predict the future development direction through quantitative analysis method.Results and Conclusion The development of stem cell technology in China is in a period of growth with great potential.Therefore,it is necessary to strengthen the ability of Chinese universities to combine production,education and research.Nowadays,the hotspots in stem cell technology are using culture medium to improve cell proliferation ability,production efficiency,and to induce differentiated cells.Meanwhile,the production efficiency of embryonic stem cells should be improved,and the immunomodulatory effect of embryonic stem cells can be exerted to screen drugs.Besides,the function of hematopoietic stem cells should be enhanced and apply mesenchymal cells in therapy.Since the potential technological gaps are the improvement of therapy,induced differentiation and efficiency of pluripotent stem cells,the improvement of progenitor cell proliferation and the control of cost,we should strengthen R&D investment in culture medium,embryonic stem cells and other technical fields,and achieve the purpose of reducing R&D costs and improving R&D efficiency.

Patent Citations Analysis and Its Value in Research Evaluation： A Review and a New Approach to Map Technology-relevant Research

Purpose： First, to review the state-of-the-art in patent citation analysis, particularly characteristics of patent citations to scientific literature （scientific non-patent references, SNPRs）. Second, to present a novel mapping approach to identify technology-relevant research based on the papers cited by and referring to the SNPRs. Design/methodology/approach： In the review part we discuss the context of SNPRs such as the time lags between scientific achievements and inventions. Also patent-to-patent citation is addressed particularly because this type of patent citation analysis is a major element in the assessment of the economic value of patents. We also review the research on the role of universities and researchers in technological development, with important issues such as universities as sources of technological knowledge and inventor-author relations. We conclude the review part of this paper with an overview of recent research on mapping and network analysis of the science and technology interface and of technological progress in interaction with science. In the second part we apply new techniques for the direct visualization of the cited and citing relations of SNPRs, the mapping of the landscape around SNPRs by bibliographic coupling and co-citation analysis, and the mapping of the conceptual environment of SNPRs by keyword co-occurrence analysis. Findings： We discuss several properties of SNPRs. Only a small minority of publications covered by the Web of Science or Scopus are cited by patents, about 3%-4%. However, for publications based on university-industry collaboration the number of SNPRs is considerably higher, around 15%. The proposed mapping methodology based on a ＂second order SNPR approach＂ enables a better assessment of the technological relevance of research. Research limitations： The main limitation is that a more advanced merging of patent and publication data, in particular unification of author and inventor names, in still a necessity. Practical implications： The proposed mapping methodology enables the creation of a database of technology-relevant papers （TRPs）. In a bibliometric assessment the publications of research groups, research programs or institutes can be matched with the TRPs and thus the extent to which the work of groups, programs or institutes are relevant for technological development can be measured. Originality/value： The review part examines a wide range of findings in the research of patent citation analysis. The mapping approach to identify a broad range of technologyrelevant papers is novel and offers new opportunities in research evaluation practices.

Meru University of Science and Technology Research Ethics Review System: A SWOT Analysis

The objectives of this article are as follows: 1) to propose a university research ethics system framework, 2) to provide a brief anatomy of the Meru University of Science and Technology (MUST) Institutional Research Ethics Review Committee (MIRERC), 3) to perform a SWOT (Strengths, Weaknesses, Opportunities, and Threats) analysis of MIRERC, and 4) to make recommendations for improving its performance. The 13-member multi-disciplinary MIRERC was established in April 2017 to provide effective ethical oversight of research undertaken by the University’s scholarly community. Strengths of the MUST research ethics review system include a functional MIRERC, a pertinent national law and ethical guidelines, an Innovation and Enterprise Centre that could house a dedicated MIRERC Secretariat, and a supportive University Management Board. The weaknesses include lack of graduate schools to assure scientific rigor of proposals before submission to the MIRERC, lack of research ethics training in most school’s curricula, absence of a dedicated MIRERC Secretariat, undergraduate research proposals being not ethically reviewed, dearth of faculty trained in research ethics, and lack of an operating budget for MIRERC work. The opportunities include existence of about 22 accredited Institutional Research Ethics Review Committees (IRERC) in Kenya, existence of international standards and operational guidance for ethics review, availability of guidelines and codes of best ethical practices in research, existence of a free automated platform called Research for Health Innovation Organizer (RHInnO) Ethics for managing the ethics review process, and availability of external resources for strengthening IRERCs. In order to improve the performance and sustainability of the MUST research ethics system, there is need to include research ethics training in all undergraduate and post-graduate curricula, create a dynamic database of potential research ethics reviewers, allocate a percentage of the annual MUST research budget for MIRERC operations, charge a graduated fee for proposal ethics review, require all students’ and faculties’ internal and external research proposals be cleared by the MIRERC, and use the RHInnO Ethics platform to manage the ethics review process.

Research on technology cluster evolution of global MEMS sensors based on patent co-occurrence analysis

At present, microelectro mechanical systems (MEMS) sensors have gradually replaced traditional mechanical sensors and are applied to several fields. Many developed countries pay high attention to technological innovation of MEMS sensors, and have applied a large number of patents since 2000. In this study, the patents of MEMS sensor from 2000 to 2015 are researched, the patents data is collected from Derwent Innovation Index (DII), and the method of co-classification analysis is used to investigate the technology cluster evolution of MEMS sensors. Results show that the technology diffusion occurrs in each technical field and the technology relevance between different technical fields is changed over time. On the whole, the evolution process of MEMS sensor is the manufacture and material of sensor chip, the electronic components and measuring function, the computing and control technology, and applications to biochemical field and communication.

The Preparation Technology Research and Composition Analysis of Anti-fatigue Yikangshu Granules

[Objectives]To optimize the preparation technology of Yikangshu granule,an anti-fatigue health food.[Methods]The process was studied from three aspects(raw material extraction,excipient selection and forming process),and then it was verified in pilot production,and the content of the three components of the product was determined.[Results]The optimum production process of the formula granules was as follows:raw materials were extracted(adding 1∶9 water,extracting twice,2.5 h each time);vacuum concentration;adding excipients and mixing after vacuum drying,crushing and sieving;granulation of 75%ethanol sifted by a 20-mesh sieve;drying at 60℃,sifting through 14-mesh,and packaging.The average content of products obtained was as follows:crude polysaccharides(3204 mg/100 g),total saponins(2295 mg/100 g),astragaloside A(21 mg/100 g).[Conclusions]The optimized preparation technology is stable and feasible,and has a quality that can be controlled,which can provide a reference for the development of health food in food industry.

Analysis and Research of Core Technology in Wisdom Libraries

Combining the wisdom library management plan, recognize the importance of modern wisdom library construction, summarize the core technologies in the construction of smart libraries, aiming to demonstrate the innovative value of smart library construction through the innovation of construction programs, and to provide guarantee for the design of modern libraries.

Analysis of Renewable Energy Research Hotspots and Trends Based on Bibliometric and Patent Survey

In recent years,renewable energy has taken on an increasingly important role as a result of the depletion of traditional fossil fuels and the pressure of climate change.Due to the advantages of clean energy production and wide availability,research on renewable energy has increased worldwide.We collected data from the Web of Science and the Derwent Innovations Index to analyze research trends in the field of renewable energy.It was found that the number of research achievements in this field has developed rapidly worldwide since 2005.The United States ranks first in the quantity and quality of literature and fourth in the number of authorized patents.China ranks second and first regarding the quantity of literature and authorized patents,respectively.Biomass energy,wind energy,and solar energy are trending research topics in various stages of development.China has maintained close cooperation with the United States,the United Kingdom,Australia,and other countries.

Patent Analysis and Research on Mars Sampling Technology

This article reviews Mars sampling and return technology,by retrieving and analyzing the patents of domestic and foreign sampling equipment and mechanism technology,Mars surface removal technology and ultra-highspeed light and small sample return technology.It conducts patent analysis from the macro-technical view down to the micro-specific content view using statistical,quantitative and qualitative analysis methods.In the process of macro-analysis,it analyzes patent data from multiple perspectives such as time,region,technical composition,and applicants,and establishes the development trends for Mars sampling and return technology at home and abroad.In the process of micro-analysis,through the analysis and interpretation of key patents,we can learn the development priorities and development direction of foreign Mars sampling and return technology.This paper also proposes China’s Mars sampling and return technology development suggestions.

Forecasting promising technology using analysis of patent information:Focused on next generation mobile communications

In order to forecast promising technologies in the field of next generation mobile communication, various patent indicators were analyzed such as citation per patent, patent family information, patent share, increase rate, and patent activity. These indicators were quantified into several indexes and then integrated into an evaluation score to provide promising technologies. As a result of the suggested patent analysis, four technologies out of twenty two in details classification were selected, which showed outstanding technology competitiveness, high patent share and increasing rates as well as high recent-patent-ratios and triad-patent-family-ratios. Each of the selected technologies scored more than 10 points in total, and the following four technologies were suggested as promising ones in the field of next generation mobile communication: 1) 3GPP based mobile communication, 2) beyond 4G mobile communication, 3) IEEE 802.16 based mobile communication, which are in medium classification of broadband mobile communication system, and 4) testing/certification system of mobile communication, which is in medium classification of mobile communication testing/certification system.

Comparison of administrative and regulatory green technologies development between China and the U.S.based on patent analysis

With the increasing importance of computer intelligence in the new round of the industrial revolution,administrative,regulatory,or design(ARD)green technology contributes to improving national technological competitiveness and promoting the transformation of green technology,which is becoming an important field under sustainable development goals.The U.S.and China ranked top two in terms of paper influence and patent applications in the field of ARD green technology.However,few comparative studies have been conducted in these two countries.This study presents the evolution and landscapes of ARD green technology between China and the U.S.,focusing on comparing development priorities and technical layouts in each five-year plan period.According to the“International Patent Classification(IPC)Green Inventory”launched by the World Intellectual Property Organization(WIPO),we retrieved 69,412 patents published between 2001 and 2020 from the PatSnap database.Descriptive,content,and thematic network analyses were conducted using latent dirichlet allocation(LDA)and community detection algorithms.The results show that both China and the U.S.strategically focus on ARD green technology development.The technical topics in this field can be divided into three themes:data processing systems,traffic control systems,and building designs.The emphasis on technology research and development(R&D)differs between China and the U.S.There is also evidence that the U.S.has advantages in terms of technological innovation and capabilities.However,China has an advantage in terms of data volume,and the gap between China and the U.S.is gradually narrowing.We also highlight the contributions and limitations of this study.

Proposals to Promote the Development of Virtual Reality in China—Based on Patent Econometric Analysis

Virtual reality technology has great potential for development and application space. On the one hand, this paper makes use of the data of Derwent Patent Database to carry out statistical analysis of the information, and analyzes the basic situation of the patent of virtual reality technology. On the other hand, this paper uses the Citespace software to analyze and process the retrieval records, and then obtains the relation of intermediary center, frequency of occurrence, burst term and other related data. According to these data, it analyzes and forecasts the core technologies, cutting-edge and hot technologies of virtual reality, which makes the future development of virtual reality technology more clear. At the same time, combined with the current development of virtual reality, this paper makes recommendations for the future development of China’s virtual reality technology to promote the development of virtual reality industry in China.

An SAO-based approach to technology evolution analysis using patent information: Case study—graphene sensors

Purpose: This paper introduces an approach to technology evolution analysis using patent information based on Subject-Action-Object(SAO) structures.Design/methodology/approach: First, SAO structures were extracted from patent documents and were cleaned. Second, several dimension-reduction techniques were used to generate technology topics. Then, the hierarchical relationships between technology topics were calculated based on patent clustering. Finally, technology evolution maps were drawn by adding a timeline.Findings: This approach can reveal technology evolution processes from multiple perspectives than other approaches.Research limitations: The semantic annotation of an SAO type is not very accurate and the semantic types of technology topics need to be enriched.Practical implications: The approach can be applied to draw technology evolution maps using different types of technology topics such as problem or solution.Originality/value: This approach offers an analytical dimension and more details than existing techniques, and it helps identify fundamental and emerging technologies more accurately and comprehensively.

Quantitative Characteristics of Patentable Applications in Japan： An Analysis Using Bibliographic Information of Application Documents

This study examined Japanese patents in terms of the quantitative characteristics of application documents that resulted in the acquisition of rights in order to clarify the relationship between the features and patentability of applications. The groups of approved applications and those that had not been approved were compared for 12 variables： publication time lag; numbers of inventors, classifications, pages, figures, tables, claims, priority claims, countries for priority claims, cited patents, and cited non-patent documents; and median of citation age. Furthermore, the authors carried out the experiments in which patent applications were automatically classified into two groups by the machine learning method, random forests. As a result, statistically significant differences between the two groups were observed for the following variables （p 〈 .001）： the numbers of inventors, pages, figures, claims, priority claims, and countries for priority claims were significantly larger in the group of approved applications, while the time lag until publication was smaller. In particular, the publication time lag and the numbers of inventors, pages, and figures were variables representing the features that largely contribute to discriminating approved applications in the classification using random forests, which implies that these have relatively strong relationships with patentability.

Analysis of Strategy for Extending Patent Protection of Rucaparib

As a knowledge-intensive and promising strategic emerging industry, the biomedical industry has high entry thresholds, large R&D investment, long cycle, high risk and high return. In all technical fields, the biomedical industry has the highest dependence on intellectual property rights, and the protection of pharmaceutical intellectual property rights by domestic and foreign biomedical enterprises also runs through the whole process of drug research and development. Extending the patent protection period of drugs as well as forming and strengthening patent fortresses requires a patent network that surrounds drugs to maximize the value of intellectual property protection, which is also the focus of every pharmaceutical company with patent rights. By analyzing the patent portfolio of Clovis Oncology Company in the United States on Rucaparib and the patent portfolio of other companies or applicants on Rucaparib, we can have a clearer understanding of the strategy of extending the patent protection period of a new drug product.

The Progress of Biomechanical Researches in Kayaking

In this review we summarized literatures about biomechanical researches in kayaking. Biomechanical methods provide data on a number of analytical techniques and kayak moving posture for coaches and athletes. 3-D kinematic analysis, on-water dynamic analysis and surface electromyography measurement are the most common methods through which we can assess and describe effects of paddling techniques and training. The purposes of numerous current studies are to identify the factors which restrict kayak performance, make improvement of techniques, prevent and correct mistakes, and develop new type of practical instrument. As a result, we found that although researchers realized the importance of kayaking balance ability and core stability, but balance ability and core stability haven’t been considered yet in mechanics analysis and instrument design fields, nor have the research of muscle working status under unsteady state. Our findings through this literature review reveal important directions for further study in the biomechanical researches in kayaking.

Examining the nexus of blockchain technology and digital twins:Bibliometric evidence and research trends

The integration of Blockchain Technology(BT)with Digital Twins(DTs)is becoming increasingly recognized as an effective strategy to enhance trust,interoperability,and data privacy in virtual spaces such as the metaverse.Although there is a significant body of research at the intersection of BT and DTs,a thorough review of the field has not yet been conducted.This study performs a systematic literature review on BT and DTs,using the CiteSpace analytic tool to evaluate the content and bibliometric information.The review covers 976 publications,identifying the significant effects of BT on DTs and the integration challenges.Key themes emerging from keyword analysis include augmented reality,smart cities,smart manufacturing,cybersecurity,lifecycle management,Ethereum,smart grids,additive manufacturing,blockchain technology,and digitalization.Based on this analysis,the study proposes a development framework for BTenhanced DTs that includes supporting technologies and applications,main applications,advantages and functionalities,primary contexts of application,and overarching goals and principles.Additionally,an examination of bibliometric data reveals three developmental phases in cross-sectional research on BT and DTs:technology development,technology use,and technology deployment.These phases highlight the research field’s evolution and provide valuable direction for future studies on BTenhanced DTs.

竞争对手技术相似性与技术能力的企业技术机会识别

[研究目的]在激烈的市场竞争中,企业如何实现高水平科技自立自强至关重要,在竞争对手视角下进行技术机会识别有助于企业实现创新突破,提升核心竞争力。[研究方法]构建技术相似性和技术能力二维矩阵选择竞争对手,在竞争对手视角下使用关联规则挖掘算法识别技术机会,最后利用对手关注度对技术机会进行评估,获取对手关注度较低的技术机会。[研究结果/结论]通过对比实验,证明在技术相似性与技术能力的基础上进行竞争对手选择能够提升识别机会的准确率。使用自然语言处理领域专利数据,以腾讯科技有限公司为例,识别出数据处理和计算模型、信息和通信技术应用、图像和视频处理与识别三个方向的技术机会,为企业的研发创新提供了参考依据。

基于主路径分析和引文文本挖掘的关键核心技术基础研究结构识别

[研究目的]准确识别关键核心技术的基础研究结构,为聚力突破“卡脖子”关键核心技术提供参考。[研究方法]提出了一套用以识别关键核心技术基础研究结构的理论框架--科技知识树,构建了针对“纯基础研究-应用型基础研究-关键核心技术-常规技术”关联的分析方法,通过综合应用复杂网络分析与文本挖掘技术,理清了基础研究与应用研究间的知识流动关系,识别出了关键核心技术的基础研究结构。[研究结果/结论]以集成电路技术为例进行实证分析,识别得到关键核心技术分布于21个领域,涵盖11类应用型基础研究,包括Petri网、算法优化、光子学原理等;14类纯基础研究,包括半导体原理、数字电路建构原理等。经验证,提出的方法能够有效识别支撑技术研发的基础研究结构,为成果转化、技术攻关与基础研究布局提供了参考。