China's landscape in oncology drug research:perspectives from research collaboration networks

Objective： Better understanding of China＇s landscape in oncology drug research is of great significance for discovering anti-cancer drugs in future. This article differs from previous studies by focusing on Chinese oncology drug research communities in co-publication networks at the institutional level. Moreover, this research aims to explore structures and behaviors of relevant research units by thematic community analysis and to address policy recommendations. Methods： This research used social network analysis to define an institutions network and to identify a community network which is characterized by thematic content. Results： A total of 675 sample articles from 2008 through 2012 were retrieved from the Science Citation Index Expanded （SCIE） database of Web of Science, and top institutions and institutional pairs are highlighted for further discussion. Meanwhile, this study revealed that institutions based in the Chinese mainland are located in a relatively central position, Taiwan＇s institutions are closely assembled on the side, and Hong Kong＇s units located in the middle of the Chinese mainland＇s and Taiwan＇s. Spatial division and institutional hierarchy are still critical barriers to research collaboration in the field of anti-cancer drugs in China. In addition, the communities focusing on hot research areas show the higher nodal degree, whereas communities giving more attention to rare research subjects are relatively marginalized to the periphery of network. Conclusions= This paper offers policy recommendations to accelerate cross-regional cooperation, such as through developing information technology and increasing investment. The brokers should focus more on outreach to other institutions. Finally, participation in topics of common interest is conducive to improved efficiency in research and development （R＆D） resource allocation.

Chinese Ecosystem Research Network

The article analyzes the development of the Chinese Ecosystem Research Network, and its mission, mandate, and management mechanisms, with examples of research, demonstration and consultation for policy-setting.

Research Status of Network Attachment Subsystem in NGN

The Network Attachment Subsystem (NASS) is introduced to the Next Generation Network (NGN) architecture to enable services independent from access networks and support nomadism for fixed terminals. The NASS is responsible for managing the users attached to the access network in terms of user authentication, allocation of the IP address, and location management. In NGN R1, Telecommunications and Internet Converged Services and Protocols for Advanced Networking (TISPAN) studied the internal architecture and external interface protocols of NASS and published the relevant technical specifications. In NGN R2, TISPAN focuses on the study of mobility and nomadism as well as the ability to support various access network architectures. There still remain several issues that need further study.

EQUATOR Network Library for health research reporting

Introduction EQUATOR Network provides unique access to collated expertise and resources for good reporting of health research, The resources are aimed at researchers （authors of research articles）, journal editors, peer reviewers, and developers of reporting guidelines,

Research on Traffic Identification Technologies for Peer-to-Peer Networks

The Peer-to-Peer(P2P)network traffic identification technology includes Transport Layer Identification(TLI)and Deep Packet Inspection(DPI)methods.By analyzing packets of the transport layer and the traffic characteristic in the P2P system,TLI can identify whether or not the network data flow belongs to the P2P system.The DPI method adopts protocol analysis technology and reverting technology.It picks up data from the P2P application layer and analyzes the characteristics of the payload to judge if the network traffic belongs to P2P applications.Due to its accuracy,robustness and classifying ability,DPI is the main method used to identify P2P traffic.Adopting the advantages of TLI and DPI,a precise and efficient technology for P2P network traffic identification can be designed.

Research and Design of IPv6 Network Management and Operations Support System

IPv6 is the foundation of the development of Next Generation Internet (NGI). An IPv6 network management and operations support system is necessary for real operable NGI. Presently there are no approved standards yet and relevant equipment interfaces are not perfect. A Network Management System (NMS) at the network layer helps implement the integrated management of a network with equipment from multiple vendors, including the network resources and topology, end-to-end network performance, network failures and customer Service Level Agreement (SLA) management. Though the NMS will finally realize pure IPv6 network management, it must be accommodated to the management of relevant IPv4 equipment. Therefore, modularized and layered structure is adopted for the NMS in order to implement its smooth transition.

Emerging molecular classifications and therapeutic implications for gastric cancer

Gastric cancer(GC) is a highly aggressive and life-threatening malignancy.Even with radical surgical removal and front-line chemotherapy,more than half of GCs locally relapse and metastasize at a distant site.The dismal outcomes reflect the ineffectiveness of a one-size fits-all approach for a highly heterogeneous disease with diverse etiological causes and complex molecular underpinnings.The recent comprehensive genomic and molecular profiling has led to our deepened understanding of GC.The emerging molecular classification schemes based on the genetic,epigenetic,and molecular signatures are providing great promise for the development of more effective therapeutic strategies in a more personalized and precise manner.To this end,the Cancer Genome Atlas(TCGA) research network conducted a comprehensive molecular evaluation of primary GCs and proposed a new molecular classification dividing GCs into four subtypes:Epstein-Barr virus-associated tumors,microsatellite unstable tumors,genomically stable tumors,and tumors with chromosomal instability.This review primarily focuses on the TCGA molecular classification of GCs and discusses the implications on novel targeted therapy strategies.We believe that these fundamental findings will support the future application of targeted therapies and will guide our efforts to develop more efficacious drugs to treat human GCs.

Nitrate in shallow groundwater in typical agricultural and forest ecosystems in China,2004-2010

The nitrate-nitrogen（NO 3-N） concentrations from shallow groundwater wells situated in 29 of the Chinese Ecosystem Research Network field stations,representing typical agroand forest ecosystems,were assessed using monitoring data collected between 2004 and 2010.Results from this assessment permit a national scale assessment of nitrate concentrations in shallow groundwater,and allow linkages between nitrate concentrations in groundwater and broad land use categories to be made.Results indicated that most of the NO 3--N concentrations in groundwater from the agroand forest ecosystems were below the Class 3 drinking water standard stated in the Chinese National Standard：Quality Standard for Ground Water（≤ 20 mg/L）.Over the study period,the average NO 3--N concentrations were significantly higher in agro-ecosystems（4.1 ± 0.33 mg/L） than in forest ecosystems（0.5 ± 0.04 mg/L）.NO 3-N concentrations were relatively higher（〉 10 mg N /L） in 10 of the 43 wells sampled in the agricultural ecosystems.These elevated concentrations occurred mainly in the Ansai,Yucheng,Linze,Fukang,Akesu,and Cele field sites,which were located in arid and semiarid areas where irrigation rates are high.We suggest that improvements in N fertilizer application and irrigation management practices in the arid and semi-arid agricultural ecosystems of China are the key to managing groundwater nitrate concentrations.

Health Emergency and Disaster Risk Management: Five Years into Implementation of the Sendai Framework

The Sendai Framework for Disaster Risk Reduction 2015–2030 recognizes health at the heart of disaster risk management(DRM)at the global policy level.Five years on,it has catalyzed the rapid development of the field of Health Emergency and Disaster Risk Management(Health EDRM)by providing a mandate for building partnerships as well as enhancing scientific research.Key milestones achieved include publication of the World Health Organization’s Health EDRM Framework,development of the WHO Thematic Platform for Health EDRM and the WHO Health EDRM Research Network,and further application of health information principles to DRM.Furthermore,health actors at all levels have continued to engage in the Sendai Framework processes and have had a key role in its implementation and proposed monitoring.There have been significant gains made through the partnership of health and DRM,but the relationship has not been without its challenges.Many national,regional,and global initiatives continue to operate with a lack of consistency and of linkages to respond to the Sendai Framework’s call for embedding health resilience in DRM,and conversely,embedding DRM in health resilience.Overcoming this hurdle is important,and doing so will be a key marker of success of the next 10 years of partnership under the Sendai Framework.

Total phosphorus concentrations in surface water of typical agro- and forest ecosystems in China, 2004-2010

The concentrations of total phosphorus （TP） from 83 surface water sampling sites in 29 of the Chinese Ecosystem Research Network （CERN） monitored ecosystems, representing typical agro- and forest ecosystems, were assessed using monitoring data collected between 2004 and 2010 from still and flowing surface water. Results showed that, TP concentrations were significantly higher in agro-ecosystems than those in forest ecosystems both for still and flowing surface water. For agro- ecosystems, TP concentrations in the southern area were significantly higher than those in the northern and north- western areas for both still and flowing surface water, however no distinct spatial pattern was observed for forest ecosystems. In general, the median values of TP within agro- and forest ecosystems did not exceed the Class V guideline for still （0.2mg.L-1） or flowing （0.4mg.L-1） surface water, however, surface water at some agro- ecosystem sampling sites was frequently polluted by TE Elevated concentrations were mainly found in still surface water at the Changshu, Fukang, Linze and Naiman monitored ecosystems, where exceedance （〉 0.2 mg.L-1） frequencies varied from 43% to 78%. For flowing water, elevated TP concentrations were found at the Hailun, Changshu and Shapotou monitored ecosystems, where exceedance （〉 0.4 mg. L-1） frequencies varied from 29% to 100%. Irrational fertilization, frequent irrigation and livestock manure input might be the main contributors of high TP concentrations in these areas, and reduced fertilizer applications, improvements in irrigation practices and centralized treatment of animal waste are necessary to control P loss in these TP vulnerable zones.