Early gastric composite tumor comprising signet-ring cell carcinoma and mucosa-associated lymphoid tissue lymphoma:A case report

BACKGROUND Composite tumors are neoplasms comprising two distinct,yet intermingling,cell populations.This paper reports a rare phenomenon where early gastric signet-ring cell carcinoma(SRCC)and gastric mucosa-associated lymphoid tissue(MALT)lymphoma coexist within the same lesion.CASE SUMMARY A 40-year-old woman presented to the West China Hospital for examination,which revealed a whitish,shallow,and uneven mucosal lesion in the stomach.The lesion was diagnosed as a poorly differentiated adenocarcinoma,including SRCC with atypical lymphoid hyperplasia associated with Helicobacter pylori infection,based on histopathological examination of the biopsy specimen.The lesion was excised using segmental gastrectomy.However,histological exami-nation of the surgical specimen confirmed that it was a poorly differentiated gastric adenocarcinoma with features of SRCC and MALT lymphoma.These two entities were stage I and coexisted in the same lesion.CONCLUSION It is uncommon for gastric SRCC and MALT lymphoma to coexist without distinct borders.Surgical resection is effective for these lesions.

Hemophagocytic lymphohistiocytosis secondary to composite lymphoma:Two case reports

BACKGROUND Hemophagocytic lymphohistiocytosis(HLH)is a rare and life-threatening disease caused by inherited pathogenic mutations and acquired dysregulations of the immune system.Composite lymphoma is defined as two or more morphologically and immunophenotypically distinct lymphomas that occur in a single patient.Here,we report two cases of HLH secondary to composite lymphoma with mixed lineage features of T-and B-cell marker expression both in the bone marrow and lymph nodes in adult patients.CASE SUMMARY Two patients were diagnosed with HLH based on the occurrence of fever,pancytopenia,lymphadenopathy,splenomegaly,hemophagocytosis and hyperferritinemia.Immunohistochemical staining of the axillary lymph node and bone marrow in case 1 showed typical features of combined B-cell and T-cell lymphoma.In addition,a lymph node gene study revealed rearrangement of the T-cell receptor chain and the immunoglobulin gene.Morphology and immunohistochemistry studies of a lymph node biopsy in case 2 showed typical features of T cell lymphoma,but immunophenotyping by flow cytometry analysis of bone marrow aspirate showed B cell lymphoma involvement.The patients were treated with high-dose methylprednisolone combined with etoposide to control aggressive HLH progression.The patients also received immunochemotherapy with the R-CHOP(rituximab,cyclophosphamide,doxorubicin,vincristine,and prednisone)regimen immediately after diagnosis.Both patients presented with highly aggressive lymphoma,and died of severe infection or uncontrolled HLH.CONCLUSION We present two rare cases with overwhelming hemophagocytosis along with composite T-and B-cell lymphoma,which posed a diagnostic dilemma.HLH caused by composite lymphoma was characterized by poor clinical outcomes.

The Finite Element Analysis and Computer Simulation of the Composite Case

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Study of the Bearing Capacity at the Variable Cross-Section of A Riser- Surface Casing Composite Pile

Reducing the cost of offshore platform construction is an urgent issue for marginal oilfield development.The offshore oil well structure includes a riser and a surface casing.The riser,surface casing and oil well cement can be considered special variable cross-section piles.Replacing or partially replacing the steel pipe pile foundation with a variable cross-section pile to provide the required bearing capacity for an offshore oil platform can reduce the cost of foundation construction and improve the economic efficiency of production.In this paper,the finite element analysis method is used to investigate the variable cross-section bearing mode of composite piles composed of a riser and a surface casing in saturated clay under a vertical load.The calculation formula of the bearing capacity at the variable section is derived based on the theory of spherical cavity expansion,the influencing factors of the bearing capacity coefficient N_(c) are revealed,and the calculation method of N_(c) is proposed.By comparing the calculation results with the results of the centrifuge test,the accuracy and applicability of the calculation method are verified.The results show that the riser composite pile has a rigid core in the soil under the variable cross-section,which increases the bearing capacity at the variable cross-section.

Diverse microbiota in palatal radicular groove analyzed by Illumina sequencing:Four case reports

BACKGROUND A palatal radicular groove is an unusual developmental deformity of the tooth,which may serve as a channel linking the periodontal and periapical inflammation,and yet no literature could be obtained analyzing microbiota within the palatal radicular grooves.CASE SUMMARY Four patients diagnosed with palatal radicular groove and concomitant periodontal-endodontic deformity in permanent maxillary lateral incisors were enrolled in this work.Twelve bacterial samples from 4 patients were collected from different parts of the palatal radicular groove during intentional replantation surgery.Illumina sequencing was performed to analyze the taxonomical composition and microbiome structure inside the palatal grooves,and 1162 operational taxonomic units were obtained.The phyla of Firmicutes and Proteobacteria predominated in most of the samples.An unknown genus from the Bacillaceae family,Lactococcus,and Porphyromonas were the most abundant genera identified.There was no difference in the microbiota richness and diversity in three sections of the groove.CONCLUSION The unique ecological niches inside the palatal grooves harbored bacterial communities that shared some component features of both the endodontic and periodontal infections.The existence of palatal groove may play an interaction bridge between the root apex and tooth cervix and thus impair the outcome of traditional therapeutic methods such as root canal treatment and periodontal management.

Focal nodular hyperplasia associated with a giant hepatocellular adenoma:A case report and review of literature

BACKGROUND Focal nodular hyperplasia(FNH)and hepatocellular adenoma(HCA)are wellknown benign liver lesions.Surgical treatment is usually chosen for symptomatic patients,lesions more than 5 cm,and uncertainty of diagnosis.CASE SUMMARY We described the case of a large liver composite tumor in an asymptomatic 34-year-old female under oral contraceptive for 17-years.The imaging work-out described two components in this liver tumor;measuring 6 cm×6 cm and 14 cm×12 cm×6 cm.The multidisciplinary team suggested surgery for this young woman with an unclear HCA diagnosis.She underwent a laparoscopic left liver lobectomy,with an uneventful postoperative course.Final pathological examination confirmed FNH associated with a large HCA.This manuscript aimed to make a literature review of the current management in this particular situation of large simultaneous benign liver tumors.CONCLUSION The simultaneous presence of benign composite liver tumors is rare.This case highlights the management in a multidisciplinary team setting.

Aware Time in Bug Fix—A Novel Automatic Test Case Selection for Prioritization of Version Control

The supreme goal of the Automatic Test case selection techniques is to guarantee systematic coverage, to recognize the usual error forms and to lessen the test of redundancy. It is unfeasible to carry out all the test cases consistently. For this reason, the test cases are picked and prioritize it. The major goal of test case prioritization is to prioritize the test case sequence and finds faults as early as possible to improve the efficiency. Regression testing is used to ensure the validity and the enhancement part of the changed software. In this paper, we propose a new path compression technique (PCUA) for both old version and new version of BPEL dataset. In order to analyze the enhancement part of an application and to find an error in an enhancement part of an application, center of the tree has been calculated. Moreover in the comparative analysis, our proposed PCUA- COT technique is compared with the existing XPFG technique in terms of time consuming and error detection in the path of an enhancement part of BPEL dataset. The experimental results have been shown that our proposed work is better than the existing technique in terms of time consuming and error detection.

粉末套管法Ti/Al/Ti复合板的界面结合性能

采用粉末套管法,通过“热轧+中间退火+进一步冷轧”工艺制备Ti/Al/Ti复合板。利用扫描电镜、电子探针、能谱仪、XRD分析以及万能实验机,研究不同制备参数下Ti/Al/Ti复合带材的界面形貌、元素分布、物相种类和界面结合强度。结果表明,单一脆性金属间化合物TiAl_(3)的产生会阻碍Ti/Al元素的扩散,扩散层厚度发生减薄。500℃退火,扩散层主要是由扩散形成的冶金结合层,局部区域有少量的金属间化合物TiAl_(3)生成,界面结合强度受冶金结合强度与机械结合强度的动态变化影响,随着压下率升高,结合强度先降低后升高再降低;550℃退火,界面反应增强,TiAl_(3)相逐渐增多,扩散层强度增加,冶金结合强度提高,由14.3 N/mm(500℃)增加至35.1 N/mm(550℃),随着压下率的增大,化合物层破碎程度增加,界面结合强度逐渐降低。

复合磨损套管爆裂失效机理及剩余强度预测

超深井、水平井、大位移井等复杂油气井服役工况异常恶劣,套管复合磨损严重,将对井筒完整性构成巨大威胁,且磨损套管剩余强度难以精准预测。为此,基于塔里木盆地塔中北坡顺南区块501井套管磨损数据及P110管材应力—应变本构关系,建立了充分考虑钻杆本体和接头联合造成的磨损模式、夹角、磨损重叠深度及磨损深度的复合磨损套管有限元力学模型,并开展了多种复合磨损模式下套管弹塑性变形、屈服、裂纹萌生、扩展及爆裂行为模拟,得到了不同复合磨损套管应力分布、剩余抗内压屈服强度及爆裂强度。研究结果表明:(1)月牙夹角在0°~90°时,应力干涉削弱应力集中,月牙夹角在90°~180°时,应力干涉增强应力集中,这种交互作用机制导致磨损套管剩余强度随着月牙夹角增加而先增加后降低;(2)裂纹萌生并起始于等效应力最大的位置即磨损月牙中心,并垂直于最大环向应力沿径向从套管内壁向外壁扩展,且裂纹一旦萌生,裂纹将迅速扩展并发生爆裂失效;(3)灰色关联度分析确定了复合磨损套管剩余强度对磨损深度、月牙夹角、复合磨损形式、月牙重叠深度的敏感性,分析结果表明磨损深度是决定套管剩余强度的主控因素。结论认为,该认识为套管强度设计与优化提供了技术参考,并对准确预测复合磨损套管剩余强度和确保井筒安全及完整性具有重要意义。

近千米大直径穿强厚含水层降温管井钻孔设计

制冷降温是深部矿井热害防治的有效技术手段。以核桃峪矿井制冷降温系统建设工程为背景,针对降温管井钻孔深度大,穿过洛河组巨厚强含水层,长距离输送冷媒保冷等技术难题,在分析工程及水文地质条件基础上,确定管井钻孔两次开孔分段设计参数;通过调研管路保冷材料性能,提出复合钢管、静态空气、玻璃微珠增强水泥、钢基复合保温套管四种保冷方法条件下基岩段护壁管设计方案;综合考虑保冷效果、固井可靠性、施工难度等因素,优选工作管采用钢基复合保温套管;并根据套管受力计算,校验护壁管规格参数。工程实施效果表明,井上下降温管始末端温度损失约1℃,可以满足冷媒长距离输送冷量损失要求,对于类似工程具有借鉴价值。

基于声发射技术的T800碳纤维复合材料拉伸失效机制分析

为揭示固体火箭发动机碳纤维缠绕复合材料壳体多载荷工况下的失效机理,开展了单向T800碳纤维复合材料试件不同偏轴角度下的拉伸实验。利用声发射(AE)无损测试技术获得了试件完整波形信号,结合Pearson相关系数选取了AE信号的特征参数,通过K-means聚类算法对AE信号进行了聚类分析,同时结合扫描电镜(SEM)拍摄的微观断口形貌将不同的损伤机制与声发射聚类组对应。进一步利用代表性体积单元并结合渐进损伤方法,实现了单向复合材料损伤过程的数值模拟。分析结果表明,AE信号的峰值频率与幅值两类参数的相关系数低于0.2。采用二者对AE信号进行聚类分析,同时结合数值仿真获得的应力-应变曲线,发现纤维断裂峰值频率最高,基体开裂峰值频率居中,界面脱粘峰值频率最低,试件宏观破坏时的AE信号幅值最高。

埋头弹复合药筒抽壳闭气性能分析与改进设计

针对埋头弹药的闭气和抽壳问题,设计复合药筒方案,并对方案的闭气性能进行分析。分析结果表明:在最大380 MPa膛压下,药筒底座与筒体和闩体之间闭气性能良好,但端盖与身管之间闭气性较差,且筒体前端塑性变形较大,易出现抽壳后筒体破损。在此基础上,提出复合药筒改进方案,并与改进前方案进行对比分析。对比结果表明:端盖与身管之间有效接触面积增大,闭气效果明显改善,且筒体前端塑性变形明显变小,局部破损情况得到明显改善,膛压卸载后端盖与底座均与药室脱离,可实现几乎零抽壳力。

高钢级套管复合载荷试验堵头焊接工艺研究

为了确保高钢级特殊螺纹套管在复合载荷试验过程中试样与堵头焊接的可靠性,分析高钢级特殊螺纹套管堵头材料的焊接性能,选择合适的焊材及焊接结构,制定高钢级特殊螺纹套管复合载荷试验堵头焊接工艺,采用2种焊条进行多层多道焊接并进行焊前预热、焊后热处理的工艺能有效提高焊缝强度及韧性。实践表明,制定的焊接工艺能够保证堵头焊接的连接强度,可满足API RP 5C5—2017规定的高钢级特殊螺纹套管CAL IV级复合载荷试验要求。

个案管理模式下减重代谢手术患者手术前后的人体成分变化

目的 探讨个案管理模式下代谢综合征患者行减重代谢手术前后的人体成分变化。方法 选取宁夏医科大学总医院胃肠外科2021年11月至2022年5月住院行减重代谢手术的患者,采用科室自行制定的个案管理模式对患者进行术后照护与随访,并对其手术前后的人体成分进行检测,观察患者不同时期部分人体参数的变化情况。结果 66例减重代谢手术患者经2个月术后体系化的个案管理后,将手术前与手术后的人体成分相比,患者的骨骼肌肉量和肌肉含量降低,部分营养物质在合理范围内有所减少,颈围、胸围、腹围、臀围变小,躯干、双下肢浮肿指数均降低(P均<0.05),患者左、右上肢的浮肿参数变化不明显(P>0.05)。结论 将个案管理模式应用于减重代谢术后患者的照护,有助于促进肥胖患者身体围度减小、浮肿指数降低。

冶金复合油套管技术的研究进展

回顾了冶金复合油套管的制造工艺、结合界面特性以及螺纹连接设计。讨论了冶金结合界面特征,发现现行制造工艺会使冶金结合界面产生成分、组织、性能梯度。现有公开的冶金复合油套管的螺纹设计均缺乏实际井下应用验证其安全性。展望了冶金复合油套管的研究方向:精确的界面梯度控制和检测,兼顾内外层性能的新型热处理工艺,基于避免自身电偶腐蚀的螺纹连接设计。

数控车床加工油/套管接箍用复合刀具结构设计与分析

为适应数控制造面临的产品多样化、生产效率高效化等要求,基于生产加工经验,提出一种适用于油/套管加工的三种刀具组合的复合刀具,系统阐述了其结构设计和工作原理,并针对关键特征开展分析研究。结果表明,本文所设计的复合刀具结构合理,可有效减少换刀次数,节省换刀时间,提高加工效率及加工精度。

2018—2022年某综合性三甲医院住院死亡病例分析

目的 分析2018—2022年某综合性三甲医院住院患者死亡病例特征,为科学合理配置医疗资源,加强医疗质量管理提供参考。方法 从该院病案信息系统中提取2018年1月1日至2022年12月31日的所有出院患者信息,对出院患者和死亡病例总数、年龄、性别分布以及疾病诊断等,采用Excel 2007和SPSS 18.0软件进行数据整理和统计分析。结果 675例死亡病例中,男性病例443例(65.63%),女性232例(34.37%),住院患者病死率0.64%;死亡原因居前3位的疾病为循环系统疾病、呼吸系统疾病、肿瘤,分别占总死亡病例数的28.44%、28.30%和27.56%;死亡病例男女性别比1.91∶1,病死率男性高于女性,差异有统计学意义(χ2=46.068,P<0.001)。年龄越大,病死率越高,50岁以上病死率迅速上升。结论 医院住院患者病死率总体较低,老年人是该院的死亡高危人群,循环系统疾病、恶性肿瘤和呼吸系统疾病是最主要的死亡原因。在医疗工作中,应根据患者年龄、性别、死亡高发病种等特点,科学合理配置医疗资源,降低住院患者病死率。

以经典科研案例为主线的断裂力学教学创新与实验设计

断裂力学课程知识体系复杂、重点难点分散,又偏重理论教学,因此针对性地提出以经典科研案例与理论知识串联、将特色性实验环节穿插其中的创新教学模式。基于高延性水泥基材料(ECC)发明过程中的断裂力学理论,建立脉络清晰、重点突出的知识框架,理论与实际问题结合,使断裂力学呈现出独特的工程魅力。借助与理论教学配合的实验教学,学生切身体验到理论知识的应用场景,培养前沿思考、创新意识和实操能力。同时,通过科研案例融入课程思政元素,鼓励学生聚焦国家重大工程需求,深入思考工程技术背后的科学逻辑。课程提升学生的学习兴趣、参与热情和研究主动性,取得较好的教学效果。

基于NSGA-Ⅱ的固体火箭发动机壳体不同开口比封头补强优化

封头补强工艺作为壳体封头承载能力提升的典型手段,其补强工艺参数对不同开口比壳体补强后应力水平、壳体质量的影响规律不明晰。为此,构建了?300 mm壳体分析模型,并结合径向基函数(RBF)神经网络分析方法拟合优化变量与优化目标间的映射关联,开展了补强角度、补强层数、补强区域对应力响应水平的影响规律研究。最后,基于非支配排序遗传算法(NSGA-Ⅱ)获得了最优开口比以及使壳体特性系数达到最大的最优补强参数。结果表明,优化后壳体的特性系数比未补强壳体提高16.28%,比未优化的编织布补强壳体提高6.53%。研究成果可以为不同开口比壳体补强工艺参数的选定提供理论依据。

涡轮增压器壳体的复合材料切削加工特性研究

涡轮增压器壳体的复合材料因其结构和性质在切削加工中面临独特的挑战。探讨了涡轮增压器壳体的功能、应用以及材料选择的重要性。详述了复合材料的基本性质,特别是其在涡轮增压器壳体中的应用和力学性质。进一步分析了切削过程中的挑战如切削力、角度的变化以及工具磨损问题。并提出了一系列的优化策略,涵盖了工具选择、切削角度参数以及冷却液和润滑策略。旨在提高切削效率,确保工件的质量,并延长工具的使用寿命。