Objective： To explore the expression of resistin protein in abdominal subeutaneons adipose tissue and placental tissue in pregnant women and the relationship between pregnant physiological insulin resistance （IR） a...Objective： To explore the expression of resistin protein in abdominal subeutaneons adipose tissue and placental tissue in pregnant women and the relationship between pregnant physiological insulin resistance （IR） and gestational diabetes ruellitus （GDM）. Methods： The expression of resistin protein in abdominal subcutaneous adipose tissue of pregnant and nonpregnant women and placental tissue was rueasured using western blotting method. Fasting serum glucose concentration was rueasured by glucose oxidase assay. Systohc blood pressure （SBP） and diastohc blood pressure （ DBP ） were rueasured. Results ： Resistin protein expression in placental tissue （67905±8441）（arbitrary OD units）was much higher than that in abdominal subcutaneous fat tissue in pregnant women （40718±3818） （ P 〈 0.01 ） and nonpregnant women （ 38288 ± 2084 ） （ P 〈 0.01 ） respectively, and there was no significant difference in abdominal subcutaneous fat tissue among pregnant and nonpregnant women. Conclusion： Resistin protein expressign in placental tissue is much higher than that in abdominal subcutaneous fat tissue in pregnant and nonpregnant women. Resistin protein is secreted from hmnan placental tissue. Resistin is one of the factors which lead to pregnant physiological IR and GDM.展开更多
文摘Objective： To explore the expression of resistin protein in abdominal subeutaneons adipose tissue and placental tissue in pregnant women and the relationship between pregnant physiological insulin resistance （IR） and gestational diabetes ruellitus （GDM）. Methods： The expression of resistin protein in abdominal subcutaneous adipose tissue of pregnant and nonpregnant women and placental tissue was rueasured using western blotting method. Fasting serum glucose concentration was rueasured by glucose oxidase assay. Systohc blood pressure （SBP） and diastohc blood pressure （ DBP ） were rueasured. Results ： Resistin protein expression in placental tissue （67905±8441）（arbitrary OD units）was much higher than that in abdominal subcutaneous fat tissue in pregnant women （40718±3818） （ P 〈 0.01 ） and nonpregnant women （ 38288 ± 2084 ） （ P 〈 0.01 ） respectively, and there was no significant difference in abdominal subcutaneous fat tissue among pregnant and nonpregnant women. Conclusion： Resistin protein expressign in placental tissue is much higher than that in abdominal subcutaneous fat tissue in pregnant and nonpregnant women. Resistin protein is secreted from hmnan placental tissue. Resistin is one of the factors which lead to pregnant physiological IR and GDM.
