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Effects of Three Typical Resistivity Models on Pulsed Inductive Plasma Acceleration Modeling 被引量:1
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作者 孙新锋 贾艳辉 +6 位作者 张天平 吴宸辰 温晓东 郭宁 金海 柯于俊 郭伟龙 《Chinese Physics Letters》 SCIE CAS CSCD 2017年第12期46-50,共5页
The effects of three different typical resistivity models(Spitzer, Z&L and M&G) on the performance of pulsed inductive acceleration plasma are studied. Numerical results show that their influences decrease with th... The effects of three different typical resistivity models(Spitzer, Z&L and M&G) on the performance of pulsed inductive acceleration plasma are studied. Numerical results show that their influences decrease with the increase of the plasma temperature. The significant discriminations among them appear at the plasma temperature lower than 2.5 eV, and the maximum gap of the pulsed inductive plasma accelerated efficiency is approximately 2.5%.Moreover, the pulsed inductive plasma accelerated efficiency is absolutely related to the dynamic impedance parameters, such as voltage, inductance, capacitance and flow rate. However, the distribution of the efficiency as a function of plasma temperature with three resistivity models has nothing to do with the dynamic impedance parameter. 展开更多
关键词 In Effects of Three Typical resistivity models on Pulsed Inductive Plasma Acceleration modeling
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Study on theoretical model for electrical explosion resistivity of Al/Ni reactive multilayer foil
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作者 Zehao Wang Tao Wang +2 位作者 Pengfei Xue Mingyu Li Qingxuan Zeng 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2024年第2期348-356,共9页
Al/Ni reactive multilayer foil(RMF)possesses excellent comprehensive properties as a promising substitute for traditional Cu bridge.A theoretical resistivity model of Al/Ni RMF was developed to guide the optimization ... Al/Ni reactive multilayer foil(RMF)possesses excellent comprehensive properties as a promising substitute for traditional Cu bridge.A theoretical resistivity model of Al/Ni RMF was developed to guide the optimization of EFIs.Al/Ni RMF with different bilayer thicknesses and bridge dimensions were prepared by MEMS technology and electrical explosion tests were carried out.According to physical and chemical reactions in bridge,the electrical explosion process was divided into 5 stages:heating of condensed bridge,vaporization and diffusion of Al layers,intermetallic combination reaction,intrinsic explosion,ionization of metal gases,which are obviously shown in measured voltage curve.Effects of interface and grain boundary scattering on the resistivity of film metal were considered.Focusing on variations of substance and state,the resistivity was developed as a function of temperature at each stage.Electrical explosion curves were calculated by this model at different bilayer thicknesses,bridge dimensions and capacitor voltages,which showed an excellent agreement with experimental ones. 展开更多
关键词 Al/Ni reactive multilayer foil Electrical explosion resistivity model Phase transition CALCULATION
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2.5-D DC Resistivity Modeling Considering Flexibility and Accuracy 被引量:1
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作者 汤井田 王飞燕 +1 位作者 肖晓 张林成 《Journal of Earth Science》 SCIE CAS CSCD 2011年第1期124-130,共7页
We highlighted the flexibility of using unstructured mesh together with the local refinement by a resistivity model with complicated topography. The effect of topography is emphasized. Based on this, we calculated a s... We highlighted the flexibility of using unstructured mesh together with the local refinement by a resistivity model with complicated topography. The effect of topography is emphasized. Based on this, we calculated a specific class of layered models and found that the accuracy is not always satisfactory by utilizing the standard approach. As an improvement, we employed the layered earth as the reference model to calculate the wavenumbers. The comparison demonstrates that the accuracy is considerably improved by using this enhanced approach. 展开更多
关键词 2-D topography 2.5-D DC resistivity modeling layered earth.
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SPICE model of trench-gate MOSFET device
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作者 刘超 张春伟 +1 位作者 刘斯扬 孙伟锋 《Journal of Southeast University(English Edition)》 EI CAS 2016年第4期408-414,共7页
A novel simulation program with an integrated circuit emphasis(SPICE) model developed for trench-gate metal-oxide-semiconductor field-effect transistor(M OSFET)devices is proposed. The drift region resistance was ... A novel simulation program with an integrated circuit emphasis(SPICE) model developed for trench-gate metal-oxide-semiconductor field-effect transistor(M OSFET)devices is proposed. The drift region resistance was modeled according to the physical characteristics and the specific structure of the trench-gate MOSFET device. For the accurate simulation of dynamic characteristics, three important capacitances, gate-to-drain capacitance Cgd, gate-to-source capacitance Cgsand drain-to-source capacitance Cds, were modeled, respectively, in the proposed model. Furthermore,the self-heating effect, temperature effect and breakdown characteristic were taken into account; the self-heating model and breakdown model were built in the proposed model; and the temperature parameters of the model were revised. The proposed model is verified by experimental results, and the errors between measured data and simulation results of the novel model are less than 5%. Therefore, the model can give an accurate description for both the static and dynamic characteristics of the trench-gate MOSFET device. 展开更多
关键词 trench-gate metal-oxide-semiconductor field-effect transistor(MOSFET) simulation program with integrated circuit emphasis(SPICE) model drift region resistance model dynamic model
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Relationship of Resistivity with Water Content and Fissures of Unsaturated Expansive Soils 被引量:7
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作者 CHEN Liang YIN Zong-ze ZHANG Pei 《Journal of China University of Mining and Technology》 EI 2007年第4期537-540,共4页
The development of fissures in expansive soils has a great effect on the stability of slope. Of the three phases of soils,the gas phase and solid phase are relatively insulated,so the average resistivity of soils can ... The development of fissures in expansive soils has a great effect on the stability of slope. Of the three phases of soils,the gas phase and solid phase are relatively insulated,so the average resistivity of soils can be calculated from the resistivity of the liquid phase. On this basis,the two-part model of resistivity changing with the water saturation of the expansive soil can be deduced. A 2-D resistance grid model is established based on simulating the resistance of ver-tically developed fissures. Variation in measured resistance of vertically developed fissures at different positions can be calculated from this model. Fissure development can be inversely determined from the variation in the measured resis-tance. Finally,the model is verified by an indoor resistivity test for remolded soil samples,indicating that the test result agrees well with that of the model established. 展开更多
关键词 unsaturated expansive soil resistivity fissure development degree of saturation resistivity structural model
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Application of 2-D geoelectrical resistivity tomography for subsurface cavity detection in the eastern part of Saudi Arabia 被引量:3
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作者 Mohamed Metwaly Fouzan AlFouzan 《Geoscience Frontiers》 SCIE CAS CSCD 2013年第4期469-476,共8页
The presence of natural voids and cavities in subsurface karstic limestones causes severe problem for civil engineering and environmental management. The presence of such features hinders the extension of urbanization... The presence of natural voids and cavities in subsurface karstic limestones causes severe problem for civil engineering and environmental management. The presence of such features hinders the extension of urbanizations particularly in the new metropolitan. The eastern part of Saudi Arabia contains various types of karstic limestone, sinkholes, solution cavities and voids. In this context, geophysical methods particularly electrical resistivity technique is used as a cost-effective solution for investigating subsurface caves, voids, and shallow weathered zones. 2-D electrical resistivity data sets have been acquired along seven profiles in the new urbanization at AI Hassa area. Data processing has been carried out taking into consideration the response of synthetic models, which simulates physical models of the most common karstic features in the area. The results are very useful to determine the extension of shallow weathered zones and to locate different cavities underneath them. The hard limestone bedrock can also be detected and traced along the surveyed profiles. 展开更多
关键词 Cavity detectionElectrical resistivity tomographySynthetic modeling
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Ecological Land Suitability for Arid Region at River Basin Scale:Framework and Application Based on Minmum Cumulative Resistance(MCR) Model 被引量:2
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作者 WEI Wei LIU Congying +2 位作者 MA Libang ZHANG Xueyuan XIE Binbin 《Chinese Geographical Science》 SCIE CSCD 2022年第2期312-323,共12页
As an important and typical arid inland region in China,Shiyang River Basin plays an important role in maintaining the sustainable development of eco-environment,whose ecological land suitability restricts the develop... As an important and typical arid inland region in China,Shiyang River Basin plays an important role in maintaining the sustainable development of eco-environment,whose ecological land suitability restricts the development of the local human activities.Therefore,Shiyang River Basin was selected as the case study,the minimum cumulative resistance(MCR)model and GIS technique were integrated to create land suitability evaluation map.We calculated the MCR value of ecological source and living source,and divided the whole basin into five partitions according to the difference between ecological source and living source,and analyzed the patterns and characteristics of the ecological land suitability evaluation(ELSE)regions,respectively.The results showed that:1)The suitable ecological land includes prohibited development region and restricted development region,which accounts for 15.45%and 23.35%of the total land area of the Shiyang River Basin,respectively.These two regions mainly distributed high altitude region in the southern Qilian Mountain and low altitude region where had high density of rivers.2)The protection of ecological land requires not only conserving existing ecological land but also focusing on ecological buffer belts around ecological sources and improving ecological land service ability.3)Ecological networks should be constructed through artificial planting trees around the boundary of oasis and ecological restoration region.Buffer greenbelts should also be established between optimized development region and ecological restoration region. 展开更多
关键词 ecological land suitability evaluation minimum cumulative resistance(MCR)model arid inland region ecological management Shiyang River Basin
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Including predator presence in a refined model for assessing resistance of alfalfa cultivar to aphids 被引量:4
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作者 TU Xiong-bing FAN Yao-li +1 位作者 Mark McNeill ZHANG Ze-hua 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2018年第2期397-405,共9页
The aphid quantity ratio(AQR) is defined as the number of aphids on each cultivar divided by the number of aphids on all cultivars. AQR is based on the correlation between aphid populations and their host plants and... The aphid quantity ratio(AQR) is defined as the number of aphids on each cultivar divided by the number of aphids on all cultivars. AQR is based on the correlation between aphid populations and their host plants and is an important tool that has been utilized in evaluating Medicago sativa(alfalfa) cultivar resistance to aphids. However, assessment of alfalfa resistance to aphids can be confused by the presence of aphid predators, causing the assessment of plant resistance to aphids to be based on incorrect aphid population data. To refine the AQR and account for the effect of predators on aphid population assessments, we introduced a parameter ‘α', corresponding to the predator quantity ratio, and used αAQR as the ratio to quantify aphid populations. Populations of both aphids(4 species) and their predators(12 species) occurring in 28 M. sativa cultivars were sampled over two years at a research station near Cangzhou, Hebei Province, China. Results showed that the most suitable evaluation period was from May to June, as the aphid population was stable during this period. Compared with the AQR method, the predator population numbers based on the αAQR had a significant inverse relationship with aphid population numbers and the 28 cultivars were clustered into three classes: the resistant class, tolerant class, and susceptible class. In addition, 17 cultivars were reassigned when evaluated using αAQR. All numerical values calculated by αAQR were displayed as a Gaussian distribution, which showed that the 28 cultivars could be clustered into nine groups using a median value(±SE) of 1±0.1. Hence, ongoing alfalfa breeding trials will be assessed using the αAQR to establish a robust system that includes agronomic performance parameters in order to generalize the new method for further studies. 展开更多
关键词 aphid quantity ratio(AQR) model alfalfa cultivar resistance to aphids natural enemy
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Conductivity characteristics of landslide considering porosity,saturation,temperature and ion concentration
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作者 XIONG Bo-bo YANG Shi-jie +5 位作者 ZHAO Bing-qin LU Xiao-chun TIAN Bin LI Cheng WU Xuan-xuan TU Xiao-long 《Journal of Mountain Science》 SCIE CSCD 2023年第8期2133-2148,共16页
High-density resistivity imaging method is widely used in landslide monitoring.The resistivity of rock and soil is closely related to factors,such as porosity,moisture content,saturation and temperature.In this study,... High-density resistivity imaging method is widely used in landslide monitoring.The resistivity of rock and soil is closely related to factors,such as porosity,moisture content,saturation and temperature.In this study,the resistivity test was designed to investigate the influence of physical factors and pore solution components on the resistivity of landslide soil.Experimental and analytical results find that both moisture content and volumetric water content varies greatly under the same resistivity.At different temperatures,soil resistivity exhibits great changes.Under the same temperature,the ion concentration and species in pore solutions have great influence on soil resistivity.Based on the test results and grey correlation analysis,this study established a resistivity model by considering porosity,saturation,temperature and ion concentration.The study lays a foundation for the high-density resistivity method to measure the moisture content of landslides. 展开更多
关键词 Landslide monitoring High-density resistivity method Pore fluid composition resistivity model
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Dual-objective pattern optimization method for land suitability zoning in mountain counties
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作者 WANG Lei WU Lian +1 位作者 ZHANG Wei JING Wen-li 《Journal of Mountain Science》 SCIE CSCD 2023年第1期209-226,共18页
As the basic administrative unit of China,counties have grown rapidly in recent years in the context of rapid urbanization,especially for counties located in mountainous areas.The drastic changes in land in mountainou... As the basic administrative unit of China,counties have grown rapidly in recent years in the context of rapid urbanization,especially for counties located in mountainous areas.The drastic changes in land in mountainous areas can easily cause irreversible damage to the sensitive ecological environment.Through the dual-objective suitability zoning of ecological and construction balance,regional sustainable land use patterns can be realized.In this study,Hantai District in Southern Shaanxi province,China,was chosen as the research area aiming at creating a balance between ecological supply and the development of construction in spatial planning.A dual-objective process evaluation system for ecological protection and construction development was proposed with 15 resistance factors selected from three attributes:natural ecology,economic society,and policy.The minimum resistance surface discrimination methods for ecological land and construction development land were proposed based on vertical space superposition and horizontal minimum cumulative resistance models.Finally,the land in Hantai District was divided into four development grades from the optimal angle of dual goals,i.e.,the construction core zone being 134.56 km^(2),the suitable construction zone 115.77 km2,the ecological buffer zone 153.74 km^(2),and the ecological control zone 151.93 km^(2),using the method combining resistance difference and threshold division.In addition,the development direction of each town under jurisdiction was identified.This study compensates for the deficiency of traditional methods that evaluate land only from a single vertical or horizontal process. 展开更多
关键词 Dual-objective pattern Land suitability zoning Minimum cumulative resistance model Mountain county Hantai District
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Mechanical and electrical properties of coarse-grained soilaffected by cyclic freeze-thaw in high cold regions 被引量:11
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作者 QU Yong-long NI Wan-kui +3 位作者 NIU Fu-jun MU Yan-hu CHEN Guo-liang LUO Jing 《Journal of Central South University》 SCIE EI CAS CSCD 2020年第3期853-866,共14页
To evaluate the geotechnical properties of coarse-grained soil affected by cyclic freeze-thaw,the electrical resistivity and mechanical tests are conducted.The soil specimens are prepared under different water content... To evaluate the geotechnical properties of coarse-grained soil affected by cyclic freeze-thaw,the electrical resistivity and mechanical tests are conducted.The soil specimens are prepared under different water contents,dry densities and exposed to 0?20 freeze-thaw cycles.As a result,the stress?strain behavior of the specimen(w=14.0%andρd=1.90 g/cm^3)changes from strain-hardening into strain-softening due to the freeze-thaw effect.The electrical resistivity of test specimen increases with the freeze-thaw cycles change,but the mechanical parameters(the unconfined compressive strength qu and the deformation modulus E)and brittleness index decrease considerably at the same conditions.All of them tend to be stable after 7?9 cycles.Moreover,both the dry density and the water content have reciprocal effects on the freeze-thaw actions.The failure and pore characteristics of specimens affected by freeze-thaw cycles are discussed by using the image analysis method.Then,an exponential function equation is developed to assess the electrical resistivity of specimens affected by the cyclic freeze-thaw.Linear relations between the mechanical parameters and the electrical resistivity of specimens are established to evaluate the geotechnical properties of the soil exposed to freeze-thaw actions through the corresponding electrical resistivity. 展开更多
关键词 coarse-grained soil freeze-thaw cycle unconfined compressive strength electrical resistivity electrical resistivity model
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On the Origin of Crustal High Conductivity Zone in theWestern Tibet Plateau
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作者 GU Jiangfan DONG Hao +6 位作者 JIN Sheng WEI Wenbo YE Gaofeng ZHANG Letian JIN Jianen XIE Chengliang YIN Yaotian 《Acta Geologica Sinica(English Edition)》 SCIE CAS CSCD 2021年第S01期34-36,共3页
The subduction of the Indian continental lithosphere under the Asian continent caused the uplift of the Tibet Plateau,resulting in the formation of a thickened continental crust twice of the normal value and the crust... The subduction of the Indian continental lithosphere under the Asian continent caused the uplift of the Tibet Plateau,resulting in the formation of a thickened continental crust twice of the normal value and the crustal shortening of at least 1500 km.Therefore,many models have been proposed to explain the shortening and material transportation mechanism of the Tibetan Plateau. 展开更多
关键词 three-dimensional resistivity model high conductivity zone West Tibet plateau
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Evaluation of Land Reclamation and Implications of Ecological Restoration for Agro-pastoral Ecotone: Case Study of Horqin Left Back Banner in China 被引量:3
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作者 ZHOU Jian ZHANG Fengrong +2 位作者 XU Yan GAO Yang XIE Zhen 《Chinese Geographical Science》 SCIE CSCD 2017年第5期772-783,共12页
The agro-pastoral ecotone has been recognized as the main distribution area of reserved land resource for cultivation. Accordingly, clarifying this assumption, as well as concerting land reclamation and ecological res... The agro-pastoral ecotone has been recognized as the main distribution area of reserved land resource for cultivation. Accordingly, clarifying this assumption, as well as concerting land reclamation and ecological restoration, is important to ensure food security and environmental improvement in the agro-pastoral ecotone. We selected Horqin Left Back Banner(HLBB) as the subject of our case study. The landscape ecological security pattern of this area was determined using the minimum cumulative resistance model. Over-cultivation, quantity of reserved land resource for cultivation, and changes in landscape indexes before and after land use adjustment were then analyzed. Over-cultivation is a serious problem in the agro-pastoral ecotone. Reserved land resource for cultivation is less than that considered previously, and the area of reserved land resource for cultivation in HLBB only accounts for 11.50% of total uncultivated land. With regard to changes in landscape indexes, the adjusted land use pattern is effective for anti-desertification. The compensation standard for abandoned cultivated land should be improved and the comprehensive results of ‘Grain for Green' should be evaluated to further implement ecological restoration in the agro-pastoral ecotone. 展开更多
关键词 land reclamation ecological restoration minimum cumulative resistance model agro-pastoral ecotone China
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Thermal Analysis of Vehicular Twin-Tube Hydraulic Gas-Precharged Shock Absorbers 被引量:5
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作者 么鸣涛 顾亮 管继富 《Journal of Beijing Institute of Technology》 EI CAS 2010年第3期286-292,共7页
In this study of temperature rising in vehicular twin-tube hydraulic gas-precharged shock absorbers,thermodynamic analyses were conducted via simulations.Equations on heat conduction,heat convection as well as radiati... In this study of temperature rising in vehicular twin-tube hydraulic gas-precharged shock absorbers,thermodynamic analyses were conducted via simulations.Equations on heat conduction,heat convection as well as radiation were derived by applying certain laws governing heat transfer;an equivalent thermal resistance network model of a shock absorber undergoing heat transfer was established innovatively;moreover,the shock absorber’s thermodynamic model of control volume system was built by using the first law of thermodynamics;and finally,time required for shock absorber to reach thermal equilibrium and corresponding value of steady temperature were calculated by programming.In this way,a lower thermal equilibrium temperature will be achieved,hence help to improve reliability of shock absorbers in work by offering low ambient temperature,by reducing amplitudes and frequencies of external incentives exerted on them and by increasing flow rate of ambient air passing around them. 展开更多
关键词 shock absorber thermal resistance network model thermodynamic model thermal equilibrium
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Applicability of discrete element method with spherical and clumped particles for constitutive study of granular materials 被引量:3
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作者 Tongming Qu Min Wang Yuntian Feng 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2022年第1期240-251,共12页
Discrete element method(DEM)has been intensively used to study the constitutive behaviour of granular materials.However,to what extent a real granular material can be reproduced by virtual DEM simulations remains uncl... Discrete element method(DEM)has been intensively used to study the constitutive behaviour of granular materials.However,to what extent a real granular material can be reproduced by virtual DEM simulations remains unclear.This study attempts to answer this question by comparing DEM simulations with typical features of experimental granular materials.Three groups of models with spherical and clumped particles are investigated from four perspectives:(i)deviatoric stress and volumetric behaviour;(ii)critical state behaviour;(iii)stress-dilatancy relationship;and(iv)the evolution of principal stress ratio against axial strain.The results demonstrate that DEM with spherical or clumped particles is capable of qualitatively describing macroscopic deviatoric stress responses,volumetric behaviour,and critical state behaviour observed in experiments for granular materials.On the other hand,some qualitative deviations between experiments and the investigated DEM simulations are also observed,in terms of the stress-dilatancy behaviour and principal stress ratio against axial strain,which are proven to be critical for constitutive modelling.The results demonstrate that DEM with spherical or clumped particles may not necessarily fully capture experimental features of granular materials even from a qualitative perspective.It is thus encouraged to thoroughly validate DEM with experiments when developing constitutive models based on DEM observations. 展开更多
关键词 Discrete element method(DEM) Granular materials Constitutive behaviour Deviatoric hardening model Rolling resistance model Irregular particles
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Indentation size effect of germanium single crystal with different crystal orientations 被引量:6
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作者 Ning LIU Xiao-jing YANG +1 位作者 Zheng YU Lei ZHAO 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2020年第1期181-190,共10页
In order to study the indentation size effect(ISE)of germanium single crystals,nano-indentation experiments were carried out on the(100),(110)and(111)plane-orientated germanium single crystals.The true hardness of eac... In order to study the indentation size effect(ISE)of germanium single crystals,nano-indentation experiments were carried out on the(100),(110)and(111)plane-orientated germanium single crystals.The true hardness of each crystal plane of germanium single crystals was calculated based on the Meyer equation,proportional sample resistance(PSR)model and Nix-Gao model,and the indentation size effect(ISE)factor of each crystal plane was calculated.Results show that,the germanium single crystals experience elastic deformation,plastic deformation and brittle fracture during the loading process,and the three crystal planes all show obvious ISE phenomenon.All three models can effectively describe the ISE of germanium single crystals,and the calculated value of Nix-Gao model is the most accurate.Compared with the other two crystal planes,Ge(110)has the highest size effect factor m and the highest hardness,which indicates that Ge(110)has the worst plasticity. 展开更多
关键词 germanium single crystal indentation size effect Meyer equation proportional sample resistance(PSR)model Nix-Gao model
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Role of visfatin in obesity-induced insulin resistance 被引量:8
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作者 Mona Mohamed Ibrahim Abdalla 《World Journal of Clinical Cases》 SCIE 2022年第30期10840-10851,共12页
The growing worldwide burden of insulin resistance(IR) emphasizes the importance of early identification for improved management.Obesity,particularly visceral obesity,has been a key contributing factor in the developm... The growing worldwide burden of insulin resistance(IR) emphasizes the importance of early identification for improved management.Obesity,particularly visceral obesity,has been a key contributing factor in the development of IR.The obesity-associated chronic inflammatory state contributes to the development of obesity-related comorbidities,including IR.Adipocytokines,which are released by adipose tissue,have been investigated as possible indicators of IR.Visfatin was one of the adipocytokines that attracted attention due to its insulinmimetic activity.It is released from a variety of sources,including visceral fat and macrophages,and it influences glucose metabolism and increases inflammation.The relationship between visfatin and IR in obesity is debatable.As a result,the purpose of this review was to better understand the role of visfatin in glucose homeostasis and to review the literature on the association between visfatin levels and IR,cardiovascular diseases,and renal diseases in obesity. 展开更多
关键词 Homeostatic model assessment for insulin resistance Insulin resistance OBESITY VISFATIN pre-B cell colony enhancing factor Nicotinamide phosphoribosyl-transferase enzyme Diabetes ADIPOCYTOKINES
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Effects of intermittent fasting on health markers in those with type 2 diabetes:A pilot study 被引量:9
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作者 Terra G Arnason Matthew W Bowen Kerry D Mansell 《World Journal of Diabetes》 SCIE CAS 2017年第4期154-164,共11页
AIMTo determine the short-term biochemical effects and clinical tolerability of intermittent fasting (IF) in adults with type 2 diabetes mellitus (T2DM).METHODSWe describe a three-phase observational study (baseline 2... AIMTo determine the short-term biochemical effects and clinical tolerability of intermittent fasting (IF) in adults with type 2 diabetes mellitus (T2DM).METHODSWe describe a three-phase observational study (baseline 2 wk, intervention 2 wk, follow-up 2 wk) designed to determine the clinical, biochemical, and tolerability of IF in community-dwelling volunteer adults with T2DM. Biochemical, anthropometric, and physical activity measurements (using the Yale Physical Activity Survey) were taken at the end of each phase. Participants reported morning, afternoon and evening self-monitored blood glucose (SMBG) and fasting duration on a daily basis throughout all study stages, in addition to completing a remote food photography diary three times within each study phase. Fasting blood samples were collected on the final days of each study phase.RESULTSAt baseline, the ten participants had a confirmed diagnosis of T2DM and were all taking metformin, and on average were obese [mean body mass index (BMI) 36.90 kg/m<sup>2</sup>]. We report here that a short-term period of IF in a small group of individuals with T2DM led to significant group decreases in weight (-1.395 kg, P = 0.009), BMI (-0.517, P = 0.013), and at-target morning glucose (SMBG). Although not a study requirement, all participants preferentially chose eating hours starting in the midafternoon. There was a significant increase (P < 0.001) in daily hours fasted in the IF phase (+5.22 h), although few attained the 18-20 h fasting goal (mean 16.82 ± 1.18). The increased fasting duration improved at-goal (< 7.0 mmol/L) morning SMBG to 34.1%, from a baseline of 13.8%. Ordinal Logistic Regression models revealed a positive relationship between the increase in hours fasted and fasting glucose reaching target values (χ<sup>2</sup> likelihood ratio = 8.36, P = 0.004) but not for afternoon or evening SMBG (all P > 0.1). Postprandial SMBGs were also improved during the IF phase, with 60.5% readings below 9.05 mmol/L, compared to 52.6% at baseline, and with less glucose variation. Neither insulin resistance (HOMA-IR), nor inflammatory markers (C-reactive protein) normalized during the IF phase. IF led to an overall spontaneous decrease in caloric intake as measured by food photography (Remote Food Photography Method). The data demonstrated discernable trends during IF for lower energy, carbohydrate, and fat intake when compared to baseline. Physical activity, collected by a standardized measurement tool (Yale Physical Activity Survey), increased during the intervention phase and subsequently decreased in the follow-up phase. IF was well tolerated in the majority of individuals with 6/10 participants stating they would continue with the IF regimen after the completion of the study, in a full or modified capacity (i.e., every other day or reduced fasting hours).CONCLUSIONThe results from this pilot study indicate that short-term daily IF may be a safe, tolerable, dietary intervention in T2DM patients that may improve key outcomes including body weight, fasting glucose and postprandial variability. These findings should be viewed as exploratory, and a larger, longer study is necessary to corroborate these findings. 展开更多
关键词 Intermittent fasting Type 2 diabetes Remote food photography Self-monitored blood glucose Homeostasis model of assessment for insulin resistence index
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Hepatitis C virus induced insulin resistance impairs response to anti viral therapy 被引量:8
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作者 Abdel-Rahman El-Zayadi Mahmoud Anis 《World Journal of Gastroenterology》 SCIE CAS CSCD 2012年第3期212-224,共13页
Hepatitis C virus (HCV) infection is an important risk factor for insulin resistance (IR). The latter is the pathogenic foundation underlying metabolic syndrome, steatosis and cirrhosis, and possibly hepatocellular ca... Hepatitis C virus (HCV) infection is an important risk factor for insulin resistance (IR). The latter is the pathogenic foundation underlying metabolic syndrome, steatosis and cirrhosis, and possibly hepatocellular carcinoma (HCC). The interplay between genetic and environmental risk factors ultimately leads to the development of IR. Obesity is considered a major risk factor, with dysregulation of levels of secreted adipokines from distended adipose tissue playing a major role in IR. HCV-induced IR may be due to the HCV core protein inducing proteasomal degradation of insulin receptor substrates 1 and 2, blocking intracellular insulin signaling. The latter is mediated by increased levels of both tumour necrosis factor-α (TNF-α) and suppressor of cytokine signaling 3 (SOC-3). IR, through different mechanisms, plays a role in the development of steatosis and its progression to steatohepatitis, cirrhosis and even HCC. In addition, IR has a role in impairing TNF signaling cascade, which in turn blocks STAT-1 translocation and interferon stimulated genes production avoiding the antiviral effect of interferon. 展开更多
关键词 Hepatitis C virus-chronic hepatitis C Insulin resistance Sustained virological response Homeostasis model assessment
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Salivary resistin level and its association with insulin resistance in obese individuals 被引量:2
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作者 Mona Mohamed Ibrahim Abdalla 《World Journal of Diabetes》 SCIE 2021年第9期1507-1517,共11页
The escalating global burden of type 2 diabetes mellitus necessitates the implementation of strategies that are both more reliable and faster in order to improve the early identification of insulin resistance(IR)in hi... The escalating global burden of type 2 diabetes mellitus necessitates the implementation of strategies that are both more reliable and faster in order to improve the early identification of insulin resistance(IR)in high-risk groups,including overweight and obese individuals.The use of salivary biomarkers offers a promising alternative to serum collection because it is safer,more comfortable,and less painful to obtain saliva samples.As obesity is the foremost contributory factor in IR development,the adipocytokines such as leptin,adiponectin,resistin,and visfatin secreted from the adipose tissue have been studied as potential reliable biomarkers for IR.Measurement of salivary adipokines as predictors for IR has attracted widespread attention because of the strong correlation between their blood and salivary concentrations.One of the adipokines that is closely related to IR is resistin.However,there are conflicting findings on resistin’s potential role as an etiological link between obesity and IR and the reliability of measuring salivary resistin as a biomarker for IR.Hence this study reviewed the available evidence on the potential use of salivary resistin as a biomarker for IR in order to attempt to gain a better understanding of the role of resistin in the development of IR in obese individuals. 展开更多
关键词 Homeostatic model assessment of insulin resistance Insulin resistance OBESITY Salivary resistin Diabetes ADIPOCYTOKINES
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