Resolute支架在糖尿病患者复杂冠脉病变的应用

1病例资料 患者,男,54岁,汉族,河南省人,已婚。于2011年9月7日18:00入院,当日采集病史,患者本人陈述病史,可靠。主诉:阵发性心前区不适3月余。现病史:患者于2011年6月开始出现心前区不适症状,自觉与工作劳累有关,症状发作时无胸闷、胸痛、心悸、乏力等不适,一般持续时间不超过5秒钟症状可自行缓解。患者平时长距离快步行走、爬楼时无明显症状,一般活动可。后就诊于当地医院行冠状动脉CT提示:前降支狭窄约50％。

Resolute Forest Products公司位于美国田纳西州Calhoun工厂的新卫生用纸生产线投产

Resolute Forest Products公司近日宣布，成功启动其位于美国田纳西州Calhoun工厂的新卫生纸机，并已正式生产出第一个生活用纸母卷。

加拿大Resolute林产品公司转产生活用纸

总部位于蒙特利尔的Resolute林产品公司（Resolute Forest Products）近日决定将调整其新闻纸生产业务。Resolute林产品公司是一家全球领先的林产品公司。其主要业务包括新闻纸、特种纸、商品浆与木制品等多种产品，是世界最大的新闻纸生产商。

Attempt to Resolute Chiral Clusters by Optically Active Hydrazide

A new kind of hydrazone (I) diastereoisomers was prepared with enantiomeric hydazide (II) and chiral cluster (III), which was characterized by HMBC. Unfortunately, the mixture could not be separated into pure diastereoisomer. This could be a direction to separate the racemic chiral clusters.

Role of N-formyl peptide receptor 2 in germinal matrix hemorrhage:an intrinsic review of a hematoma resolving pathway

Germinal matrix hemorrhage is one of the leading causes of morbidity,mortality,and acquired infantile hydrocephalus in preterm infants in the United States,with little progress made in its clinical management.Blood clots have been shown to elicit secondary brain injury after germinal matrix hemorrhage,by disrupting normal cerebrospinal fluid circulation and absorption after germinal matrix hemorrhage causing post-hemorrhagic hydrocephalus development.Current evidence suggests that rapid hematoma resolution is necessary to improve neurological outcomes after hemorrhagic stroke.Various articles have demonstrated the beneficial effects of stimulating the polarization of microglia cells into the M2 phenotype,as it has been suggested that they play an essential role in the rapid phagocytosis of the blood clot after hemorrhagic models of stroke.N-formyl peptide receptor 2(FPR2),a G-protein-coupled receptor,has been shown to be neuroprotective after stroke.FPR2 activation has been associated with the upregulation of phagocytic macrophage clearance,yet its mechanism has not been fully explored.Recent literature suggests that FPR2 may play a role in the stimulation of scavenger receptor CD36.Scavenger receptor CD36 plays a vital role in microglia phagocytic blood clot clearance after germinal matrix hemorrhage.FPR2 has been shown to phosphorylate extracellular-signal-regulated kinase 1/2(ERK1/2),which then promotes the transcription of the dual-specificity protein phosphatase 1(DUSP1)gene.In this review,we present an intrinsic outline of the main components involved in FPR2 stimulation and hematoma resolution after germinal matrix hemorrhage.

Measurement of the high energyγ-rays from heavy ion reactions usingČerenkov detector

The energetic bremsstrahlung photons up to 100 MeV produced in heavy ion collisions can be used as a sensitive probe for short-range correlation in atomic nuclei. The energy of the γ-rays can be measured by collecting the Čerenkov light in the medium induced by the fast electrons generated in the Compton scattering or electromagnetic shower of the incident γray. Two types of detectors based on pure water and lead glass as sensitive materials were designed for this purpose. The γresponse and optical photon propagation in the detectors were simulated based on electromagnetic and optical processes in Geant4. The inherent energy resolutions of 0.022(4) + 0.51(2)∕E^(1/2)_(γ) for water and 0.0026(3) + 0.446(3)∕E^(1/2)_(γ) for lead glass were obtained. The geometry sizes of the lead glass and water were optimized to 30 cm × 30 cm × 30 cm and 60 cm × 60 cm ×120 cm, respectively, to detect high-energy γ-rays at 160 MeV. The Hough transform method was applied to reconstruct the direction of the incident γ-rays, providing the ability to experimentally distinguish the high-energy γ-rays produced in the reactions on the target from random background cosmic-ray muons.

Flexible,high-density,laminated ECoG electrode array for high spatiotemporal resolution foci diagnostic localization of refractory epilepsy

High spatiotemporal resolution brain electrical signals are critical for basic neuroscience research and high-precision focus diagnostic localization,as the spatial scale of some pathologic signals is at the submillimeter or micrometer level.This entails connecting hundreds or thousands of electrode wires on a limited surface.This study reported a class of flexible,ultrathin,highdensity electrocorticogram(ECoG)electrode arrays.The challenge of a large number of wiring arrangements was overcome by a laminated structure design and processing technology improvement.The flexible,ultrathin,high-density ECoG electrode array was conformably attached to the cortex for reliable,high spatial resolution electrophysiologic recordings.The minimum spacing between electrodes was 15μm,comparable to the diameter of a single neuron.Eight hundred electrodes were prepared with an electrode density of 4444 mm^(-2).In focal epilepsy surgery,the flexible,high-density,laminated ECoG electrode array with 36 electrodes was applied to collect epileptic spike waves inrabbits,improving the positioning accuracy of epilepsy lesions from the centimeter to the submillimeter level.The flexible,high-density,laminated ECoG electrode array has potential clinical applications in intractable epilepsy and other neurologic diseases requiring high-precision electroencephalogram acquisition.

High-resolution neutronics model for ^(238)Pu production in high-flux reactors

We proposed and compared three methods(filter burnup,single energy burnup,and burnup extremum analysis)to build a high-resolution neutronics model for 238Pu production in high-flux reactors.The filter burnup and single energy burnup methods have no theoretical approximation and can achieve a spectrum resolution of up to~1 eV,thereby constructing the importance curve and yield curve of the full energy range.The burnup extreme analysis method combines the importance and yield curves to consider the influence of irradiation time on production efficiency,thereby constructing extreme curves.The three curves,which quantify the transmutation rate of the nuclei in each energy region,are of physical significance because they have similar distributions.A high-resolution neutronics model for ^(238)Pu production was established based on these three curves,and its universality and feasibility were proven.The neutronics model can guide the neutron spectrum optimization and improve the yield of ^(238)Pu by up to 18.81%.The neutronics model revealed the law of nuclei transmutation in all energy regions with high spectrum resolution,thus providing theoretical support for high-flux reactor design and irradiation production of ^(238)Pu.

Image super‐resolution via dynamic network

Convolutional neural networks depend on deep network architectures to extract accurate information for image super‐resolution.However,obtained information of these con-volutional neural networks cannot completely express predicted high‐quality images for complex scenes.A dynamic network for image super‐resolution(DSRNet)is presented,which contains a residual enhancement block,wide enhancement block,feature refine-ment block and construction block.The residual enhancement block is composed of a residual enhanced architecture to facilitate hierarchical features for image super‐resolution.To enhance robustness of obtained super‐resolution model for complex scenes,a wide enhancement block achieves a dynamic architecture to learn more robust information to enhance applicability of an obtained super‐resolution model for varying scenes.To prevent interference of components in a wide enhancement block,a refine-ment block utilises a stacked architecture to accurately learn obtained features.Also,a residual learning operation is embedded in the refinement block to prevent long‐term dependency problem.Finally,a construction block is responsible for reconstructing high‐quality images.Designed heterogeneous architecture can not only facilitate richer structural information,but also be lightweight,which is suitable for mobile digital devices.Experimental results show that our method is more competitive in terms of performance,recovering time of image super‐resolution and complexity.The code of DSRNet can be obtained at https://github.com/hellloxiaotian/DSRNet.

Performance of AC-LGAD strip sensors designed for the DarkSHINE experiment

The DarkSHINE experiment proposes a novel approach to single-electron-on-fixed-target exploration that focuses on the search for dark photons through their invisible decay into dark matter particles.Central to this initiative is an advanced tracking detector designed to achieve exceptional sensitivity in the detection of light dark matter candidates.This study evaluates the performance of several prototype AC-coupled low-gain avalanche diode(AC-LGAD)strip sensors specifically developed for the DarkSHINE tracking detector.The electrical properties of the sensors from two batches of wafers with different n^(+)doses are thoroughly evaluated.Spatial and temporal resolutions are measured using an infrared laser source.The spatial resolutions range from 6.5 to 8.2μm and from 8.8 to 12.3μm for the sensors from two distinct dose batches,each with a 100μm pitch size.Furthermore,the sensors demonstrate time resolutions of 8.3 and 11.4 ps,underscoring the potential of AC-LGAD technology in enhancing the performance of the DarkSHINE tracking detector.

基于聚焦变换解卷积的宽带稳健波束形成

In the field of array signal processing,uniform linear arrays(ULAs)are widely used to detect/separate a weak target and estimate its direction of arrival from interference and noise.Conventional beamforming(CBF)is robust but restricted by a wide mainlobe and high sidelobe level.Covariance-matrix-inversed beamforming techniques,such as the minimum variance distortionless response and multiple signal classification,are sensitive to signal mismatch and data snapshots and exhibit high-resolution performance because of the narrow mainlobe and low sidelobe level.Therefore,compared with the wideband CBF,this study proposes a robust focused-and-deconvolved conventional beamforming(RFD-CBF),utilizing the Richardson–Lucy(R-L)iterative algorithm to deconvolve the focused conventional beam power of a half-wavelength spaced ULA.Then,the focused-and-deconvolved beam power achieves a narrower mainlobe and lower sidelobe level while retaining the robustness of wideband CBF.Moreover,compared with the wideband CBF,RFD-CBF can obtain a higher output signal-to-noise ratio(SNR).Finally,the performance of RFD-CBF is evaluated through numerical simulation and verified by sea trial data processing.

DTAIS:Distributed trusted active identity resolution systems for the Industrial Internet

In recent years,the Industrial Internet and Industry 4.0 came into being.With the development of modern industrial intelligent manufacturing technology,digital twins,Web3 and many other digital entity applications are also proposed.These applications apply architectures such as distributed learning,resource sharing,and arithmetic trading,which make high demands on identity authentication,asset authentication,resource addressing,and service location.Therefore,an efficient,secure,and trustworthy Industrial Internet identity resolution system is needed.However,most of the traditional identity resolution systems follow DNS architecture or tree structure,which has the risk of a single point of failure and DDoS attack.And they cannot guarantee the security and privacy of digital identity,personal assets,and device information.So we consider a decentralized approach for identity management,identity authentication,and asset verification.In this paper,we propose a distributed trusted active identity resolution system based on the inter-planetary file system(IPFS)and non-fungible token(NFT),which can provide distributed identity resolution services.And we have designed the system architecture,identity service process,load balancing strategy and smart contract service.In addition,we use Jmeter to verify the performance of the system,and the results show that the system has good high concurrent performance and robustness.

Advancing ophthalmic delivery of flurbiprofen via synergistic chiral resolution and ion-pairing strategies

Flurbiprofen(FB),a nonsteroidal anti-inflammatory drug,is widely employed in treating ocular inflammation owing to its remarkable anti-inflammatory effects.However,the racemic nature of its commercially available formulation(Ocufen^(R))limits the full potential of its therapeutic activity,as the(S)-enantiomer is responsible for the desired antiinflammatory effects.Additionally,the limited corneal permeability of FB significantly restricts its bioavailability.In this study,we successfully separated the chiral isomers of FB to obtain the highly active(S)-FB.Subsequently,utilizing ion-pairing technology,we coupled(S)-FB with various counter-ions,such as sodium,diethylamine,trimethamine(TMA),and l-arginine,to enhance its ocular bioavailability.A comprehensive evaluation encompassed balanced solubility,octanol-water partition coefficient,corneal permeability,ocular pharmacokinetics,tissue distribution,and in vivo ocular anti-inflammatory activity of each chiral isomer salt.Among the various formulations,S-FBTMA exhibited superior water solubility(about 1–12 mg/ml),lipid solubility(1<lgP_(ow)<3)and corneal permeability.In comparison to Ocufen^(R),S-FBTMA demonstrated significantly higher in vivo antiinflammatory activity and lower ocular irritability(such as conjunctival congestion and tingling).The findings from this research highlight the potential of chiral separation and ion-pair enhanced permeation techniques in providing pharmaceutical enterprises focused on drug development with a valuable avenue for improving therapeutic outcomes.

Vibration-assisted vat photopolymerization for pixelated-aliasing-free surface fabrication

Mask image projection-based vat photopolymerization(MIP-VPP)offers advantages like low cost,high resolution,and a wide material range,making it popular in industry and education.Recently,MIP-VPP employing liquid crystal displays(LCDs)has gained traction,increasingly replacing digital micromirror devices,particularly among hobbyists and in educational settings,and is now beginning to be used in industrial environments.However,LCD-based MIP-VPPsuffers from pronounced pixelated aliasing arising from LCD’s discrete image pixels and itsdirect-contact configuration in MIP-VPP machines,leading to rough surfaces on the 3D-printed parts.Here,we propose a vibration-assisted MIP-VPP method that utilizes a microscalevibration to uniformize the light intensity distribution of the LCD-based mask image on VPP’s building platform.By maintaining the same fabrication speed,our technique generates asmoother,non-pixelated mask image,reducing the roughness on flat surfaces and boundary segments of 3D-printed parts.Through light intensity modeling and simulation,we derived an optimal vibration pattern for LCD mask images,subsequently validated by experiments.We assessed the surface texture,boundary integrity,and dimensional accuracy of componentsproduced using the vibration-assisted approach.The notably smoother surfaces and improved boundary roughness enhance the printing quality of MIP-VPP,enabling its promisingapplications in sectors like the production of 3D-printed optical devices and others.

Design and construction of charged-particle telescope array for study of exotic nuclear clustering structure

The exploration of exotic shapes and properties of atomic nuclei,e.g.,αcluster and toroidal shape,is a fascinating field in nuclear physics.To study the decay of these nuclei,a novel detector aimed at detecting multipleα-particle events was designed and constructed.The detector comprises two layers of double-sided silicon strip detectors(DSSD)and a cesium iodide scintillator array coupled with silicon photomultipliers array as light sensors,which has the advantages of their small size,fast response,and large dynamic range.DSSDs coupled with cesium iodide crystal arrays are used to distinguish multipleαhits.The detector array has a compact and integrated design that can be adapted to different experimental conditions.The detector array was simulated using Geant4,and the excitation energy spectra of someα-clustering nuclei were reconstructed to demonstrate the performance.The simulation results show that the detector array has excellent angular and energy resolutions,enabling effective reconstruction of the nuclear excited state by multipleαparticle events.This detector offers a new and powerful tool for nuclear physics experiments and has the potential to discover interesting physical phenomena related to exotic nuclear structures and their decay mechanisms.

Three-dimensional crystal defect imaging by STEM depth sectioning

One of the major innovations awaiting in electron microscopy is full three-dimensional imaging at atomic resolution.Despite the success of aberration correction to deep sub-angstrom lateral resolution,spatial resolution in depth is still far from atomic resolution.In scanning transmission electron microscopy(STEM),this poor depth resolution is due to the limitation of the illumination angle.To overcome this physical limitation,it is essential to implement a next-generation aberration corrector in STEM that can significantly improve the depth resolution.This review discusses the capability of depth sectioning for three-dimensional imaging combined with large-angle illumination STEM.Furthermore,the statistical analysis approach remarkably improves the depth resolution,making it possible to achieve three-dimensional atomic resolution imaging at oxide surfaces.We will also discuss the future prospects of three-dimensional imaging at atomic resolution by STEM depth sectioning.

Pro-resolving lipid mediator reduces amyloid-β42–induced gene expression in human monocyte–derived microglia

Specialized pro-resolving lipid mediators including maresin 1 mediate resolution but the levels of these are reduced in Alzheimer's disease brain, suggesting that they constitute a novel target for the treatment of Alzheimer's disease to prevent/stop inflammation and combat disease pathology. Therefore, it is important to clarify whether they counteract the expression of genes and proteins induced by amyloid-β. With this objective, we analyzed the relevance of human monocyte–derived microglia for in vitro modeling of neuroinflammation and its resolution in the context of Alzheimer's disease and investigated the pro-resolving bioactivity of maresin 1 on amyloid-β42–induced Alzheimer's disease–like inflammation. Analysis of RNA-sequencing data and secreted proteins in supernatants from the monocyte-derived microglia showed that the monocyte-derived microglia resembled Alzheimer's disease–like neuroinflammation in human brain microglia after incubation with amyloid-β42. Maresin 1 restored homeostasis by down-regulating inflammatory pathway related gene expression induced by amyloid-β42 in monocyte-derived microglia, protection of maresin 1 against the effects of amyloid-β42 is mediated by a re-balancing of inflammatory transcriptional networks in which modulation of gene transcription in the nuclear factor-kappa B pathway plays a major part. We pinpointed molecular targets that are associated with both neuroinflammation in Alzheimer's disease and therapeutic targets by maresin 1. In conclusion, monocyte-derived microglia represent a relevant in vitro microglial model for studies on Alzheimer's disease-like inflammation and drug response for individual patients. Maresin 1 ameliorates amyloid-β42–induced changes in several genes of importance in Alzheimer's disease, highlighting its potential as a therapeutic target for Alzheimer's disease.

Rydberg-Atom Terahertz Heterodyne Receiver with Ultrahigh Spectral Resolution

Terahertz heterodyne receivers with high sensitivity and spectral resolution are crucial for various applications.Here,we present a room-temperature atomic terahertz heterodyne receiver that achieves ultrahigh sensitivity and frequency resolution.At a signal frequency of 338.7 GHz,we obtain a sensitivity of 2.88±0.09V·cm^(−1)·Hz^(−1/2) for electric field measurements.The calibrated linear dynamical range spans approximately 89 dB,ranging from−110 dBV/cm to−21 dBV/cm.We demodulate a 400 symbol stream encoded in 4-state phase-shift keying,demonstrating excellent phase detection capability.By scanning the frequency of the local oscillator,we realize a terahertz spectrometer with Hz level frequency resolution.This resolution is more than two orders of magnitude higher than that of existing terahertz spectrometers.The demonstrated terahertz heterodyne receiver holds promising potential for working across the entire terahertz spectrum,significantly advancing its practical applications.

Fast compressed sensing spectral measurement with adaptive gradient multiscale resolution

We propose a fast,adaptive multiscale resolution spectral measurement method based on compressed sensing.The method can apply variable measurement resolution over the entire spectral range to reduce the measurement time by over 75%compared to a global high-resolution measurement.Mimicking the characteristics of the human retina system,the resolution distribution follows the principle of gradually decreasing.The system allows the spectral peaks of interest to be captured dynamically or to be specified a priori by a user.The system was tested by measuring single and dual spectral peaks,and the results of spectral peaks are consistent with those of global high-resolution measurements.