Objective:To evaluate the applicable value of respiratory impedance for the stage 0 of chronic obstructive pulmonary disease （COPD）. Methods:Respiratory impedance was measured by impulse oscillometry （IOS） in 41 c...Objective:To evaluate the applicable value of respiratory impedance for the stage 0 of chronic obstructive pulmonary disease （COPD）. Methods:Respiratory impedance was measured by impulse oscillometry （IOS） in 41 cases at stage 0 of COPD （NHLBI/WHO, 2001 Standard） and their conventional pulmonary function values were compared with 42 healthy subjects. Both groups had no significant deviation in age, stature and avoirdupois, etc. Master-Screen pulmonary function test system （Jaeger Co, Germany） were used to determine IOS parameters including viscous resistance of 5Hz, 20 Hz and 35Hz （R5, R 20, R 35）, reactance of 5Hz, 35 Hz （X5, X 35 ）, resonant frequency （Fres） ,total respiratory impedance （Zrs） and routine pulmonary function values including forced expiratory volume in one second to predicted value （FEV1%）, forced expiratory volume in one second to forced vital capacity ratio（ FEV1/FVC%）, maximal mid-expiratory flow （MMEF%）,V 25% and V 50%. Results:Both groups had no significant deviation in FEV1%, FEV1/FVC% and X 35 （P>0.05）. It was increased significantly in viscous resistance of 5Hz, 20 Hz and 35Hz （R5, R 20, R 35） in COPD group than that in healthy group （P<0.01）. So were Fres and Zrs （P<0.01）. MMEF%,V 25%,V 50% and reactance of 5Hz （X5） in COPD group were marked lower than that in healthy group （P<0.01）. The sensitivity of MMEF%, V 25%,V 50% was higher than others, but its specificity was lower. In parameters of IOS, Fres was the most sensitive index for diagnosis of the small airway function and its specificity was higher than that of MMEF%, V 25%,V 50%. Conclusion:In the risk case at the stage 0 of COPD, MMEF%, V 25% and V 50% could be decreased, but Fres, R5,R 5-20 could be increased in spite of FEV1% and FEV1/FVC% in normal range.展开更多
Objective: To observe the relationship of deep slow respiratory pattern and respiratory impedance(RI) in patients with chronic obstructive pulmonary disease (COPD). Methods: RI under normal respiration and during deep...Objective: To observe the relationship of deep slow respiratory pattern and respiratory impedance(RI) in patients with chronic obstructive pulmonary disease (COPD). Methods: RI under normal respiration and during deep slow respira tion was measured one after the other with impulse oscillometry for 8 patients with COPD and for 9 healthy volunteers as control. Results: When r espiration was changed from normal pattern to the deep slow pattern, the tida l volume increased and respiratory frequency significantly decreased in both gro ups , the total respiratory impedance (Z respir) showed a decreasing trend in COPD group, but with no obvious change in the control group. No chang e in the resonant frequency (fres) was found in both groups, and the respiratory viscous resistance obviously decreased in the COPD group(R5: P =0.0168 ; R20: P =0.0498; R5—R20: P =0.0388),though in the control group it was unchanged. Conclusion: IOS detection could reflect the response he terogeneity of different compartments of respiratory system during tidal breathi ng. During deep slow respiration, the viscous resistance in both central airw ay and peripheral airway was decreased in patients with COPD. RI measurement by impulse oscillometry may be a convenient pathophysiological method for studying the application of breathing exercise in patients with COPD.展开更多
目的探讨血乳酸、血乳酸清除率(LCR)联合无创血流动力学监测预测慢性阻塞性肺疾病急性加重期(AECOPD)合并呼吸衰竭(RF)患者预后的临床价值。方法选择2022年1—12月收治的AECOPD合并RF 100例,入院后行常规治疗。统计28 d预后情况,分为预...目的探讨血乳酸、血乳酸清除率(LCR)联合无创血流动力学监测预测慢性阻塞性肺疾病急性加重期(AECOPD)合并呼吸衰竭(RF)患者预后的临床价值。方法选择2022年1—12月收治的AECOPD合并RF 100例,入院后行常规治疗。统计28 d预后情况,分为预后不良组(死亡)、预后良好组(存活)。比较2组临床资料、血流动力学指标[心脏指数(CI)、心排血量(CO)、血管阻力指数(SVRI)、每搏量(SV)]、血乳酸、LCR,分析预后不良影响因素,并分析血流动力学指标、血乳酸、LCR预测AECOPD合并RF患者预后的价值,进一步通过曲线下面积(AUC)、净重新分类指数(NRI)、综合判别改善指数(IDI)评价含与不含血流动力学指标、血乳酸、LCR预测方案的预测效果。结果100例AECOPD合并RF患者28 d病死率为29.00%(29/100)。预后不良组年龄、急性加重次数≥2次/年占比、治疗24 h SVRI和血乳酸、LCR<10%占比高于预后良好组,机械通气时间、住院时间长于预后良好组,治疗24 h CI、CO、SV低于预后良好组(P<0.01)。年龄、急性加重次数、机械通气时间、治疗24 h SVRI和血乳酸均为AECOPD合并RF患者预后不良的影响因素,治疗24 h CI、CO、SV及LCR为保护因素(P<0.01)。治疗24 h CI、CO、SVRI、SV、血乳酸及LCR预测预后不良的AUC为0.778、0.767、0.779、0.814、0.804、0.909。含血流动力学指标、血乳酸、LCR预测方案的AUC大于常规预测方案的AUC(P<0.05)。进一步通过NRI、IDI分析显示,与常规预测方案比较,含血流动力学指标、血乳酸、LCR预测方案的预测效果有明显改善(P<0.05)。结论血乳酸、LCR联合无创血流动力学监测在预测AECOPD合并RF患者预后方面具有良好效能。展开更多
文摘Objective:To evaluate the applicable value of respiratory impedance for the stage 0 of chronic obstructive pulmonary disease （COPD）. Methods:Respiratory impedance was measured by impulse oscillometry （IOS） in 41 cases at stage 0 of COPD （NHLBI/WHO, 2001 Standard） and their conventional pulmonary function values were compared with 42 healthy subjects. Both groups had no significant deviation in age, stature and avoirdupois, etc. Master-Screen pulmonary function test system （Jaeger Co, Germany） were used to determine IOS parameters including viscous resistance of 5Hz, 20 Hz and 35Hz （R5, R 20, R 35）, reactance of 5Hz, 35 Hz （X5, X 35 ）, resonant frequency （Fres） ,total respiratory impedance （Zrs） and routine pulmonary function values including forced expiratory volume in one second to predicted value （FEV1%）, forced expiratory volume in one second to forced vital capacity ratio（ FEV1/FVC%）, maximal mid-expiratory flow （MMEF%）,V 25% and V 50%. Results:Both groups had no significant deviation in FEV1%, FEV1/FVC% and X 35 （P>0.05）. It was increased significantly in viscous resistance of 5Hz, 20 Hz and 35Hz （R5, R 20, R 35） in COPD group than that in healthy group （P<0.01）. So were Fres and Zrs （P<0.01）. MMEF%,V 25%,V 50% and reactance of 5Hz （X5） in COPD group were marked lower than that in healthy group （P<0.01）. The sensitivity of MMEF%, V 25%,V 50% was higher than others, but its specificity was lower. In parameters of IOS, Fres was the most sensitive index for diagnosis of the small airway function and its specificity was higher than that of MMEF%, V 25%,V 50%. Conclusion:In the risk case at the stage 0 of COPD, MMEF%, V 25% and V 50% could be decreased, but Fres, R5,R 5-20 could be increased in spite of FEV1% and FEV1/FVC% in normal range.
文摘Objective: To observe the relationship of deep slow respiratory pattern and respiratory impedance(RI) in patients with chronic obstructive pulmonary disease (COPD). Methods: RI under normal respiration and during deep slow respira tion was measured one after the other with impulse oscillometry for 8 patients with COPD and for 9 healthy volunteers as control. Results: When r espiration was changed from normal pattern to the deep slow pattern, the tida l volume increased and respiratory frequency significantly decreased in both gro ups , the total respiratory impedance (Z respir) showed a decreasing trend in COPD group, but with no obvious change in the control group. No chang e in the resonant frequency (fres) was found in both groups, and the respiratory viscous resistance obviously decreased in the COPD group(R5: P =0.0168 ; R20: P =0.0498; R5—R20: P =0.0388),though in the control group it was unchanged. Conclusion: IOS detection could reflect the response he terogeneity of different compartments of respiratory system during tidal breathi ng. During deep slow respiration, the viscous resistance in both central airw ay and peripheral airway was decreased in patients with COPD. RI measurement by impulse oscillometry may be a convenient pathophysiological method for studying the application of breathing exercise in patients with COPD.
文摘目的探讨血乳酸、血乳酸清除率(LCR)联合无创血流动力学监测预测慢性阻塞性肺疾病急性加重期(AECOPD)合并呼吸衰竭(RF)患者预后的临床价值。方法选择2022年1—12月收治的AECOPD合并RF 100例,入院后行常规治疗。统计28 d预后情况,分为预后不良组(死亡)、预后良好组(存活)。比较2组临床资料、血流动力学指标[心脏指数(CI)、心排血量(CO)、血管阻力指数(SVRI)、每搏量(SV)]、血乳酸、LCR,分析预后不良影响因素,并分析血流动力学指标、血乳酸、LCR预测AECOPD合并RF患者预后的价值,进一步通过曲线下面积(AUC)、净重新分类指数(NRI)、综合判别改善指数(IDI)评价含与不含血流动力学指标、血乳酸、LCR预测方案的预测效果。结果100例AECOPD合并RF患者28 d病死率为29.00%(29/100)。预后不良组年龄、急性加重次数≥2次/年占比、治疗24 h SVRI和血乳酸、LCR<10%占比高于预后良好组,机械通气时间、住院时间长于预后良好组,治疗24 h CI、CO、SV低于预后良好组(P<0.01)。年龄、急性加重次数、机械通气时间、治疗24 h SVRI和血乳酸均为AECOPD合并RF患者预后不良的影响因素,治疗24 h CI、CO、SV及LCR为保护因素(P<0.01)。治疗24 h CI、CO、SVRI、SV、血乳酸及LCR预测预后不良的AUC为0.778、0.767、0.779、0.814、0.804、0.909。含血流动力学指标、血乳酸、LCR预测方案的AUC大于常规预测方案的AUC(P<0.05)。进一步通过NRI、IDI分析显示,与常规预测方案比较,含血流动力学指标、血乳酸、LCR预测方案的预测效果有明显改善(P<0.05)。结论血乳酸、LCR联合无创血流动力学监测在预测AECOPD合并RF患者预后方面具有良好效能。
