The effects of dismerinone (DMR), a derivative of milrinone, on high K+ depolarized slow response action potentials (APs) and intracellular cAMP levels were studied in guinea pig papillary muscles. DMR induced slow AP...The effects of dismerinone (DMR), a derivative of milrinone, on high K+ depolarized slow response action potentials (APs) and intracellular cAMP levels were studied in guinea pig papillary muscles. DMR induced slow APs in high K+ depolorized guinea pig papillary muscles and increased APA, Vmaxand APD50 of the slow APs in dose dependent way ; cAMP levels in same preparations were elevated by DMR. These effects of DMR are similar to isoprenaline (ISO). Bead adrenocepter blocker propranolol had no influence on DMR effect. Overall, the results from this study suggested that effects of DMR were not related to Beta adrenocepter, and might be related to its inhibiting phosphodiesterase Ⅲ(PDE Ⅲ) action.展开更多
The World Travel & Tourism Council (WTTC) today released case studies showing some of the world’s best examples of its ’Blueprint for new Tourism’ in action. The case studies feature successful development and ...The World Travel & Tourism Council (WTTC) today released case studies showing some of the world’s best examples of its ’Blueprint for new Tourism’ in action. The case studies feature successful development and delivery initiatives of leading organizations, which ensure benefits for customers, shareholders and hosting communities.展开更多
文摘The effects of dismerinone (DMR), a derivative of milrinone, on high K+ depolarized slow response action potentials (APs) and intracellular cAMP levels were studied in guinea pig papillary muscles. DMR induced slow APs in high K+ depolorized guinea pig papillary muscles and increased APA, Vmaxand APD50 of the slow APs in dose dependent way ; cAMP levels in same preparations were elevated by DMR. These effects of DMR are similar to isoprenaline (ISO). Bead adrenocepter blocker propranolol had no influence on DMR effect. Overall, the results from this study suggested that effects of DMR were not related to Beta adrenocepter, and might be related to its inhibiting phosphodiesterase Ⅲ(PDE Ⅲ) action.
文摘The World Travel & Tourism Council (WTTC) today released case studies showing some of the world’s best examples of its ’Blueprint for new Tourism’ in action. The case studies feature successful development and delivery initiatives of leading organizations, which ensure benefits for customers, shareholders and hosting communities.
