Two-stage stochastic programming with robust constraints for the logistics network post-disruption response strategy optimization

Logistics networks (LNs) are essential for the transportation and distribution of goods or services from suppliers to consumers. However, LNs with complex structures are more vulnerable to disruptions due to natural disasters and accidents. To address the LN post-disruption response strategy optimization problem, this study proposes a novel two-stage stochastic programming model with robust delivery time constraints. The proposed model jointly optimizes the new-line-opening and rerouting decisions in the face of uncertain transport demands and transportation times. To enhance the robustness of the response strategy obtained, the conditional value at risk (CVaR) criterion is utilized to reduce the operational risk, and robust constraints based on the scenario-based uncertainty sets are proposed to guarantee the delivery time requirement. An equivalent tractable mixed-integer linear programming reformulation is further derived by linearizing the CVaR objective function and dualizing the infinite number of robust constraints into finite ones. A case study based on the practical operations of the JD LN is conducted to validate the practical significance of the proposed model. A comparison with the rerouting strategy and two benchmark models demonstrates the superiority of the proposed model in terms of operational cost, delivery time, and loading rate.

Challenges in and lessons learned during the implementation of the 1-3-7 malaria surveillance and response strategy in China: a qualitative study

Background:China has made great progress in malaria control over the last century and now aims to eliminate malaria by 2020.In 2012,the country launched its 1-3-7 surveillance and response strategy for malaria elimination.The strategy involves to case reporting within 1 day,case investigation within 3 days,and focus investigation and public health actions within 7 days.The aim of this study was to evaluate the challenges in and lessons learned during the implementation of the 1-3-7 strategy in China so far.Methods:This qualitative study was conducted in two provinces in China:Gansu province(northwestern China)and Jiangsu province(southeastern China)in 2014.Key informant interviews(n=6)and in-depth interviews(n=36)about the implementation aspects of the 1-3-7 strategy were conducted with malaria experts,health staff,laboratory practitioners,and village doctors at the provincial,city,county,township,and village levels.Results:Broad themes related to the challenges in and lessons learned during the implementation of the 1-3-7 strategy were identified according to:case reporting within 1 day,case investigation within 3 days,focus investigation within 7 days,and the overall strategy.The major challenges outlined were related to respecting the timeline of surveillance procedures,the absence of or difficulties in following guidelines on conducting focus investigations,diagnostics,and the increasing number of returning migrant workers from malaria-endemic countries.Important lessons learned revolve around the importance of continuous capacity building,supervision and motivation,quality control,information technology support,applied research,governmental commitment,and intersectoral collaboration.Conclusions:Surveillance is a key intervention in malaria elimination programs.The Chinese 1-3-7 strategy has already proven to be successful but still needs to be improved.In particular,dealing appropriately with imported malaria cases through the screening of migrant workers from malaria-endemic countries is essential for achieving and sustaining malaria elimination in China.China has perfect preconditions for successful malaria elimination provided political commitment and financial investment are guaranteed.The 1-3-7 strategy may also be considered as a model for other countries.

Optimal guidance strategy for flexible load based on hybrid direct load control and time of use

The time-of-use(TOU)strategy can effectively improve the energy consumption mode of customers,reduce the peak-valley difference of load curve,and optimize the allocation of energy resources.This study presents an Optimal guidance mechanism of the flexible load based on strategies of direct load control and time-of-use.First,this study proposes a period partitioning model,which is based on a moving boundary technique with constraint factors,and the Dunn Validity Index(DVI)is used as the objective to solve the period partitioning.Second,a control strategy for the curtailable flexible load is investigated,and a TOU strategy is utilized for further modifying load curve.Third,a price demand response strategy for adjusting transferable load is proposed in this paper.Finally,through the case study analysis of typical daily flexible load curve,the efficiency and correctness of the proposed method and model are validated and proved.

On the minimum cost of an evolutionary strategy response to environment stress

Two revised drafts about a simple evolution trade off function studied by Mitchell(Mitchell, 2000) were put up first. Considering the complex of the environment, or the nonlinear interaction of the environment and species, we put up two new cost functions:c(u,z)=c 0+c 1u+k(z+az 2)u,u>0;c(u,z)=c 0+c 1u+kz du,u>0,d>0. In the first case, if the environment is adverse to species ( a >0), the region of low stress which is more suitable for the intolerant species is very small, and at the same environment stress z , the tolerant species will pay the more cost than it will paid in the normal environment. However the tolerant species will pay more cost but low strategies in the environment of a <0 than that it will paid in the environment of a =0 or a >0. In the second case, the results showed that the greater the stress of the environment is, or the more complex the environment is, the lower cost the intolerant species will pay in the region of z <1. In order to exist or to evolve from an environment of high stress, the organisms must possess a higher u , or a better means of mitigating of the stress of environment. Meanwhile in the region d >1, when d decrease, the intolerant species will pays more lower cost of exploiting a habitat in the low stress environment while the tolerant one will pays more lower cost in the high stress environment. This means that scale d describes the selection character of the species system in the evolution process, the smaller the d(d <1) is, the better the selection or the mitigation the system will possesses.

Intrusion response goals and corresponding strategies

The effects of strategy on the network security defense and the related research on intrusion response strategy are briefly presented, with the focus on the status and function of intrusion re- sponse strategy in the intrusion response decision-making. Some specific response strategies for specific response goals are presented as well. The relevant knowledge of the planning, and a classification of response tasks are proposed. The intrusion response planning methods and models based on hierarchical task network （HTN） are described in detail. On this basis, the model of combining the response measure decision-making with the response time decision-making is expounded. The proposed model can integrate response strategy into response decision-making mechanism. In addition, the results of the intrusion response experiments are provided to verify the ability of using different response strategies to achieve different response goals. At last, the application needs of response strategy in network security are analyzed, and the approaches of the response strategy applied in in- trusion response system are summarized.

Trajectory of COVID-19 response and management strategy in China:scientific rationale driven strategy adjustments

The pneumonia caused by novel coronavirus SARS-CoV-2 infection in early December 2019,which was later named coronavirus disease 2019(COVID-19)by the World Health Organization(WHO),rapidly spread across the world.China has made extraordinary efforts to this unprecedented pandemic,put its response and control at a very high level of infectious disease management(Category B but with measures for Category A),given top priority to the people and their lives,and balanced the pandemic control and socio-economic development.After more than three years’fighting against this disease,China downgraded the management of COVID-19 to Category B infectious disease on January 8,2023 and the WHO declared the end of public health emergency on May 5,2023.However,the ending of pandemic does not mean that the disease is no longer a health threat.Experiences against COVID-19 from China and the whole world should be learned to prepare well for the future public health emergencies.This article gives a systematic review of the trajectory of COVID-19 development in China,summarizes the critical policy arrangements and provides evidence for the adjustment during policy making process,so as to share experiences with international community and contribute to the global health for all humanity.

Combustion mechanism and control approaches of underground coal fires:a review

With the large-scale mining of coal resources,the huge economic losses and environmental problems caused by underground coal fires have become increasingly prominent,and the research on the status quo and response strategies of underground coal fires is of great significance to accelerate the green prevention and control of coal fires,energy conservation and emission reduction.In this paper,we summarized and sorted out the research status of underground coal fires,focused on the theoretical and technical issues such as underground coal fire combustion mechanism,multiphysics coupling effect of coal fire combustion,fire prevention and extinguishing technology for underground coal fires,and beneficial utilization technology,and described the latest research progress of the prevention and control for underground coal fire hazards.Finally,the key research problems in the field of underground coal fire hazards prevention and control were proposed in the direction of the basic theory,technology research,comprehensive management and utilization,with a view to providing ideas and solutions for the management of underground coal fires.

The Impact of Global Financial Crisis on China Chemical Fiber Industry and Response Strategies (Part Ⅱ)

Prospects of Global Financial Crisis and Economic Crisis The widely spreading global financial crisis has halted the fast growth of world economy in five consecutive years,and heavily stricken the financial and economic sectors worldwide.It’s second only to the "Great Depression" in the 1930’s.Governments

上海市艾滋病防治工作现状及对策建议

艾滋病是我国重点控制的传染病之一。我国政府高度重视艾滋病防治工作,制定发布了系列政策文件,全面加强艾滋病防治工作,以推进联合国2030年终结艾滋病流行可持续发展目标的实现。上海市按照国家相关要求,结合本市特点和工作实际,制定了上海市艾滋病防治工作目标,全面落实艾滋病防治责任与任务,持续推进各项防控措施,取得了明显成效。分析近年来上海市艾滋病防治工作进展及现状,并提出下一步工作对策及建议。

上海市全科医生供需整合预测模型构建及响应策略模拟

目的构建上海全科医生供需整合的预测模型,进行政策的情景模拟,为解决上海全科医生供需失衡问题提供建议与策略。方法基于供给和需求的预测结果,计算上海全科医生的供需缺口,对增加供给和合理引导需求后全科医生的供需情况进行情景分析。结果根据供需整合预测结果,扩大全科规范化培训招生规模后,当需求参数保持不变时,2030年上海全科医生供需差值将达到578人,每万常住人口的全科医生供需差值将达到0.2人;扩大全科规范化培训招生规模后,当需求参数基于既往趋势变化时,2030年上海全科医生供需差值将达到2929人,每万常住人口的全科医生供需差值为1.1人。上海全科医生供需面临的风险主要为供不应求,通过增加全科医生的培养数量与扩大区域外招聘规模,可以缓解部分供需缺口;高龄化、首诊在社区等人口与政策的变化会增加全科医生的需求,从而扩大供需缺口。结论基于供需整合视角进行全科医生数量预测能够为更加系统、前瞻性地解决供需失衡问题提供综合、有力的证据支持。供需整合的系统动力学模型可以为模拟响应策略提供技术支持,其预测结果可以为上海全科医生的规划提供决策参考。

Comparison of environmental responding strategies between Ulva prolifera and Sargassum horneri:an in-situ study during the co-occurrence of green tides and golden tides in the Yellow Sea,China in 2017

Large-scale green tides in the Yellow Sea occurred for 13 consecutive years since 2007.The unusual co-occurrence of green tides and golden tides occurred in the Yellow Sea in 2017.The causative species are Ulva prolifera and/or Sargassum horneri.Previous studies on physiological response characteristics of U.prolifera and S.horneri are done in the laboratory mainly,and there is no in-situ comparative study in this regard.In this study,the in-situ physiological response characteristics of both species were measured.The results indicated that cyclic electron flow and antioxidant system play more important roles in protecting U.prolifera,while non-photochemical quenching is more important for adapting to the environment in S.horneri.U.prolifera has a stronger ability to utilize nutrients to rapidly increase its biomass under a suitable condition compared to S.horneri.

Organization and evolution of climate responsive strategies,used in Turpan vernacular buildings in arid region of China

Under the global crisis of energy shortage and environmental pollution,the climate responsive strategies used in vernacular buildings have attracted much attention for their potential to reduce energy consumption and carbon emissions.However,the relationships between these traditional climatic strategies were not precisely perceived,which may cause the inapplicability of these strategies for contemporary rural houses.In this paper,taking the Turpan vernacular buildings in arid region of China,the climate responsive strategies of buildings in the most significant periods such as the Gaochang period(before 1318),the Khanate and Republican period(1318–1949),the Modern period(1949–2010),and the Contemporary period(2011–present)were summarized.In addition,two different types of climatic strategies organizations,namely multilayer spaces and integrated building envelopes,were identified based on the temperature difference measurement and comparative analysis.The assessment of thermal performance of the organizations was conducted by the methodology of software simulation.Furthermore,the applicability of the organizations in rural areas was discussed,and a new combined organization was proposed.Consequently,this study can contribute to provide the main approaches for climatically responsive rural houses.

Immunotherapy resistance of lung cancer

In recent years,immunotherapy has made remarkable breakthroughs and brought long-term survival benefits to lung cancer patients.However,a high percentage of patients do not respond to immunotherapy or their responses are transient,indicating the existence of immune resistance.Current studies show that the interactions between cancer cells and immune system are continuous and dynamic.A range of cancer cell-autonomous characteristics,tumor microenvironment factors,and host-related influences account for heterogenous responses.Furthermore,with the identification of new targets of immunotherapy and the development of immune-based combinations,we propose the response strategies to overcome resistance.