Neurodevelopmental disorders are a group of conditions classified together by the most recent edition of the Diagnostic and Statistical Manual of Mental Disorders which include intellectual disability,communication di...Neurodevelopmental disorders are a group of conditions classified together by the most recent edition of the Diagnostic and Statistical Manual of Mental Disorders which include intellectual disability,communication disorders,autism spectrum disorder,attention-deficit/hyperactivity disorder,specific learning disorder(SLD),and motor disorders.SLD is present in many students,who exhibit significant difficulties in the acquisition of reading,written expression,and mathematics,mostly due to problems with executive functions(EF).The present study is a review of the current situation of neurodevelopmental disorders and SLD focusing on the benefits of the response to intervention model(RtI),which allows the combination of evaluation and intervention processes.It also addresses the key role of EF.The importance of adapting RtI to new possibilities such as the use of virtual reality is discussed and a theoretical framework for carrying that out is provided.展开更多
Objective: To investigate the effect of group psychological intervention on oxidative stress, apoptosis and inflammatory response in patients with schizophrenia. Methods: A total of 80 patients with schizophrenia who ...Objective: To investigate the effect of group psychological intervention on oxidative stress, apoptosis and inflammatory response in patients with schizophrenia. Methods: A total of 80 patients with schizophrenia who received hospitalization in the hospital between September 2014 and October 2016 were collected and divided into control group (n=40) and observation group (n=40) according to the random number table method. Control group received routine clinical intervention, the observation group received group psychological intervention on the basis of conventional intervention, and the differences in serum contents of oxidative stress indicators, apoptosis molecules and inflammatory factors were compared between the two groups of patients before and after intervention. Results: Before intervention, the differences in serum levels of oxidative stress indexes, apoptosis molecules and inflammatory factors were not statistically significant between the two groups of patients. After intervention, serum SOD and bcl-2 levels of both groups of patients were higher than those before intervention while MDA, bax, Caspace-3, Fas, IL-1β, IL-6 and TNF-α levels were lower than those before intervention, and serum SOD and bcl-2 levels of observation group were higher than those of control group while MDA, bax, Caspace-3, Fas, IL-1β, IL-6 and TNF-α levels were lower than those of control group. Conclusion: Group psychological intervention can effectively inhibit the systemic oxidative stress and inflammatory response, and reduce the process of apoptosis in patients with schizophrenia.展开更多
Objective: To study the effect of early enteral nutrition intervention on nerve function, systemic oxidative stress and inflammatory response in patients with hypertensive cerebral hemorrhage. Methods: A total of 98 p...Objective: To study the effect of early enteral nutrition intervention on nerve function, systemic oxidative stress and inflammatory response in patients with hypertensive cerebral hemorrhage. Methods: A total of 98 patients with hypertensive cerebral hemorrhage who received hospitalization in the hospital between April 2015 and February 2017 were collected and divided into control group and observation group by random number table method, 49 cases in each group. Control group received routine enteral nutrition intervention and observation group received early enteral nutrition intervention. The differences in serum levels of nerve function-related indexes, oxidative stress indexes and inflammatory mediators were compared between the two groups of patients before and after intervention. Results: Before intervention, the differences in serum levels of nerve function-related indexes, oxidative stress indexes and inflammatory mediators were not statistically significant between the two groups of patients. After 1 week of intervention, serum S100B, NSE, GFAP, MBP, LPO, MDA, PCT, IL-1β, IL-6 and TNF-α levels of both groups of patients were lower than those before intervention while GSH-PX levels were higher than those before intervention, and serum S100B, NSE, GFAP, MBP, LPO, MDA, PCT, IL-1β, IL-6 and TNF-α levels of observation group were lower than those of control group while GSH-PX level was higher than that of control group. Conclusion:Early enteral nutrition intervention can effectively optimize the nerve function and suppress the systemic oxidative stress and inflammatory response in patients with hypertensive cerebral hemorrhage.展开更多
Background: Pelvic fracture combined with massive bleeding(PFCMB) is a complex issue in clinical practice. Currently, the use of angiography and embolization for the treatment of PFCMB obtains good results. The aim of...Background: Pelvic fracture combined with massive bleeding(PFCMB) is a complex issue in clinical practice. Currently, the use of angiography and embolization for the treatment of PFCMB obtains good results. The aim of this study is to observe the effects of early internal iliac artery embolization on the systemic inflammatory response syndrome(SIRS) in dogs with simulated-pelvic-fracture combined with massive bleeding.Methods: Twenty adult dogs were randomly divided into an embolization group(EG) and a control group(CG). For the two groups, heart rate, respiratory rate and body temperature and other physiological variables were measured, and IL-6, TNF-α and arterial blood gas levels were monitored. These variables were assayed every 30 min until death in the CG, while dogs in the EG underwent arterial angiography after 60 min of modeling. The internal iliac artery was embolized on the injured side.Results: The average time to SIRS in the CG was 3.56 h, occurring at a rate of 90%(9/10) within 24 h, with a mortality rate of 50%(5/10); the average time to SIRS for the EG was 5.33 h, occurring at a rate of 30%(3/10) within 24 h, with a mortality rate of 10%(1/10). When SIRS occurred in the EG, the mean plasma IL-6 level was 52.66±7.38pg/ml and the TNF-ps, tα level was 11.45±2.72ng/ml, showing a significant difference with those of the CG(P<0.05). In the two grouhe respiratory rate and leukocyte levels were higher at each monitored time after modeling than those before modeling; the mean arterial pressure, levels of hemoglobin and oxygen partial pressure were significantly lower at each time point after modeling than those before modeling except for the mean arterial pressure at 0h in EG; the platelet levels at 4 and 8h were higher than those before modeling; and the differences were statistically significant(P<0.05). In the EG, the mean arterial pressure, heart rate, respiratory rate and hemoglobin levels at 2, 4 and 8h were lower than those at 0h; the levels of leukocytes, platelets and carbon dioxide partial pressure at 4 and 8h after modeling were higher than those at 0h, and the differences were statistically significant(P<0.05, P<0.01); in the CG after modeling, the mean arterial pressure, levels of hemoglobin and carbon dioxide partial pressure at 2, 4 and 8h were lower than those at 0h; the levels of heart rate and leukocytes were higher than those before modeling; the respiratory rate and platelet levels at 4 and 8h were higher than those at 0h; and the differences were statistically significant(P<0.05). The levels of the mean arterial pressure and hemoglobin at 4 and 8h and the p H values at 8h after modeling in the EG were significantly higher than those in the CG, while the heart rate and respiratory rate at 4 and 8h were significantly lower than those in the CG. The p H values at 8h after modeling were significantly lower than those of the other monitored times in the CG(P<0.05, P<0.01). The two groups had elevated levels of alkaline phosphatase after injury induction.Conclusion: Through the use of an on-spot interventional treatment cabin, early internal iliac artery embolization can control bleeding associated with pelvic fractures, delay the occurrence of SIRS, and improve the success rate of the treatment of pelvic fracture combined with bleeding.展开更多
Rice is the main food for over 95 percent of the Sierra Leonean populace. It accounts for the largest portion of the agricultural GDP of the country. On the contrary, its cultivation has been shrinking over the past d...Rice is the main food for over 95 percent of the Sierra Leonean populace. It accounts for the largest portion of the agricultural GDP of the country. On the contrary, its cultivation has been shrinking over the past decades. Consequently, importation now becomes the main source of supplying the grain for local needs since its cultivation or production could no longer meet domestic request. The deterioration in the local cultivation of rice has had severe socio-economic implications such as higher consumer prices and balance of payment burden. Therefore, the main objective of this study is to evaluate the effect of price and other related nonprice policy intervention on rice cultivation in the country. The tools utilized for analyzing the problem comprise, a coefficient of protection analysis as well as a supply response analysis by means of a time series regression (for the period 1980-2011). Major limitations established negatively affecting rice output are price disincentives to cultivators, public expenditure and fertilizer consumption. From the above findings, rice cultivators should be accorded the necessary incentives to keep them more effective in the rice cultivation career. The food policy approach that had over the years depended on huge importation of rice should be reviewed in favor of domestic cultivation. Increasing local cultivation through a meaningful protection of cultivators can independently reduce the price of rice to the advantage of the final consumers. This study also recommends that public funds should be redirected away from rice import toward investments in its domestic cultivation.展开更多
Beach erosion has occurred globally in recent decades due to frequent and severe storms.Dongsha beach,located in Zhujiajian Island,Zhejiang Province,China,is a typical embayed sandy beach.This study focused on the mor...Beach erosion has occurred globally in recent decades due to frequent and severe storms.Dongsha beach,located in Zhujiajian Island,Zhejiang Province,China,is a typical embayed sandy beach.This study focused on the morphodynamic response of Dongsha beach to typhoon events,based on beach topographies and surficial sediment characteristics acquired before and after four typhoon events with varying intensities.The four typhoons had different effects on the topography and sediment characteristics of Dongsha beach.Typhoons Ampil and Danas caused the largest(-51.72 m3/m)and the smallest erosion(-8.01 m3/m),respectively.Remarkable alongshore patterns of beach profile volumetric changes were found after the four typhoon events,with more erosion in the southern and central parts of the beach and few changes in the northern part.Grain size coarsening and poor sorting were the main sediment patterns on the beach influenced by different typhoons.Typhoons that occurred in the same year after another typhoon enhanced the effect of the previous typhoon on sediment coarsening and sorting variability,but this cumulative effect was not found between typhoons that occurred during different years.A comparison of the collected data revealed that the topographic state of the beach before the typhoon,typhoon characteristics,and tidal conditions were possible reasons for the difference in the responses of Dongsha beach to typhoon events.More severe beach erosion was caused by typhoons with higher intensity levels and longer durations,and high tide levels during typhoons can determine the upper limit of the beach profile erosion site.Taken together,these results can be used to improve beach management for storm prevention.展开更多
In 1945,Porter et al.published an electon microscopy study of cultured chick fibroblasts in which they observed:'a granular background and details of a darker lacelike reticulum which in places appears to be made up...In 1945,Porter et al.published an electon microscopy study of cultured chick fibroblasts in which they observed:'a granular background and details of a darker lacelike reticulum which in places appears to be made up of chains of"vesicles"'(Porter et al.,1945).This constituted the first published observation of the endoplasmic reticulum(ER)and,while it was not evident at that time,this cytoplasmic system of interconnecting membrane-lined channels, comprising vesicles, tubules and cisternae, has numerous important functions.展开更多
Objective:To investigate the changes of immune response and side effects before and after nutritional intervention in cervical cancer patients with concurrent chemoradiotherapy. Methods: A total of 160 patients with p...Objective:To investigate the changes of immune response and side effects before and after nutritional intervention in cervical cancer patients with concurrent chemoradiotherapy. Methods: A total of 160 patients with primary cervical cancer who received concurrent chemoradiotherapy in this hospital between May 2016 and September 2017 were selected as the research subjects. Their nutritional intervention plans were reviewed and used to divide the patients into the control group (n=83) who accepted conventional nutritional support and the nutritional intervention group (n=77) who accepted targeted nutritional intervention. The differences in the contents of Th1/Th2 immunity indexes and humoral immunity indexes as well as the levels of bone marrow suppression-related indexes were compared between the two groups before and after intervention.Results: Before intervention, the differences in the contents of Th1/Th2 immunity indexes and humoral immunity indexes as well as the levels of bone marrow suppression-related indexes were not statistically significant between the two groups. After intervention, serum IL-2, IFN-γ, IL-4 and IL-6 contents of nutritional intervention group were lower than those of control group;serum IgA, IgM, IgG, C3 and C4 contents were higher than those of control group;peripheral blood WBC, RBC, Hb and PLT levels were higher than those of control group.Conclusion: Nutritional intervention can effectively optimize the immune status and reduce the bone marrow suppression reaction in cervical cancer patients with concurrent chemoradiotherapy.展开更多
Objective:To study the effect of nicorandil on postoperative myocardial injury, platelet function and inflammatory response in patients with slow reflow in PCI.Methods: Patients who underwent emergency PCI and had int...Objective:To study the effect of nicorandil on postoperative myocardial injury, platelet function and inflammatory response in patients with slow reflow in PCI.Methods: Patients who underwent emergency PCI and had intraoperative slow reflow in Zigong Fourth People's Hospital between March 2015 and August 2017 were selected and divided into nicorandil group and normal control group according to the application of nicorandil after no reflow or not in the history data. The levels of myocardial injury indexes in serum as well as the expression of platelet activation molecules and inflammatory signaling molecules in peripheral blood were measured before PCI as well as 1 day and 3 days after PCI.Results: Compared with the corresponding indexes of same group before PCI, serum H-FABP, HIF-1α, CK-MB and cTnⅠlevels as well as peripheral blood PAR1, PAR4, CCR2, p38MAPK, HSP27, Notch1, NF-κB, MEK1, ERK1/2 and CaMKⅡ mRNA expression of both groups of patients were significantly lower 1 day and 3 days after PCI, and serum H-FABP, HIF-1α, CK-MB and cTnⅠ levels as well as peripheral blood PAR1, PAR4, CCR2, p38MAPK, HSP27, Notch1, NF-κB, MEK1, ERK1/2 and CaMKII mRNA expression of nicorandil group 1 day and 3 days after PCI were significantly lower than those of normal control group.Conclusions:Nicorandil has negative regulating effect on postoperative myocardial injury, platelet activation and inflammatory response activation in patients with slow reflow in PCI.展开更多
Objective:To investigate the effects of adjuvant bupleurum injection therapy in perioperative period of PCI on myocardial damage, oxidative stress response and apoptosis.Methods:Patients with acute myocardial infarcti...Objective:To investigate the effects of adjuvant bupleurum injection therapy in perioperative period of PCI on myocardial damage, oxidative stress response and apoptosis.Methods:Patients with acute myocardial infarction who received PCI in Chengyue Community Health Center of Xisaishan District Huangshi City Hubei Province between June 2014 and February 2017 were selected as the research subjects and randomly divided into the bupleurum group who received adjuvant bupleurum injection therapy in perioperative period of PCI and the control group who received routine therapy in perioperative period of PCI. The myocardial damage indexes, oxidative stress indexes and apoptosis indexes in serum and peripheral blood were measured before treatment and 1 d and 3 d after treatment.Results: 1 d and 3 d after treatment, H-FABP, cTnT, CK-MB, CTGF, MDA, AOPP, sFas, sTWEAK, sTRAIL and Caspase-3 contents in serum as well as O2-, NOX and HO-1 contents in the peripheral blood of both groups of patients were significantly lower than those before treatment and H-FABP, cTnT, CK-MB, CTGF, MDA, AOPP, sFas, sTWEAK, sTRAIL and Caspase-3 contents in serum as well as O2-, NOX and HO-1 contents in the peripheral blood of bupleurum group were significantly lower than those of control group.Conclusion:Adjuvant bupleurum injection therapy in perioperative period of PCI can reduce the myocardial damage, oxidative stress response and apoptosis.展开更多
Objective:To study the effect of exercise rehabilitation combined with trimetazidine on endothelial function, inflammatory response and blood lipid metabolism in patients with coronary heart disease after percutaneous...Objective:To study the effect of exercise rehabilitation combined with trimetazidine on endothelial function, inflammatory response and blood lipid metabolism in patients with coronary heart disease after percutaneous coronary intervention (PCI).Methods: The patients with stable angina pectoris who received PCI in our hospital between July 2015 and November 2017 were chosen and randomly divided into the observation group who received postoperative exercise rehabilitation combined with trimetazidine and the control group who received conventional intervention combined with trimetazidine. The reactive hyperemia index (RHI) as well as serum contents of endothelial markers, inflammatory cytokines and blood lipid indexes were determined before intervention and after intervention for 3 months.Results:After intervention for 3 months, the RHI levels as well as serum NO, HDL-C and Omentin-1 contents of both groups significantly increased while serum ET-1, vWF, M-CSF, IL-6, IL-8, RANTES, LDL-C and Chemerin contents significantly decreased;the RHI level as well as serum NO, HDL-C and Omentin-1 contents of the observation group was significantly higher than those of the control group while serum ET-1, vWF, M-CSF, IL-6, IL-8, RANTES, LDL-C and Chemerin contents were significantly lower than those of the control group.Conclusion:Exercise rehabilitation combined with trimetazidine can improve the endothelial function, inhibit the inflammatory response and regulate the blood lipid metabolism in patients with coronary heart disease after PCI.展开更多
Objective:To study the predictive value of serum S1P and STIM1 levels after percutaneous coronary intervention (PCI) for in-stent restenosis and their correlation with angiogenesis and inflammatory response.Methods:13...Objective:To study the predictive value of serum S1P and STIM1 levels after percutaneous coronary intervention (PCI) for in-stent restenosis and their correlation with angiogenesis and inflammatory response.Methods:130 patients who received PCI in our hospital between June 2013 and December 2016 were selected and divided into restenosis group and non-restenosis group according to the coronary angiography results 6-24 months after PCI. The serum levels of S1P, STIM1, angiogenesis molecules and inflammation molecules were detected 24 hours after PCI.Results:Serum S1P, NO, VEGF, Angptl2 and Angptl4 levels of restenosis group were significantly lower than those of non-restenosis group while STIM1, IFN-γ, IL-18, VCAM-1, P-selectin and L-selectin levels were significantly higher than those of non-restenosis group;serum NO, VEGF, Angptl2 and Angptl4 levels of restenosis group with lower STIM1 were significantly higher those of restenosis group with normal STIM1;serum IFN-γ, IL-18, VCAM-1, P-selectin and L-selectin levels of restenosis group with lower S1P were significantly higher than those of restenosis group with normal S1P.Conclusion:The decreased serum S1P and increased STIM1 after PCI have prediction value for in-stent restenosis and are closely related to the angiogenesis disorder and inflammation activation.展开更多
This article explores the intricate relationship between attachment styles formed during early childhood and the subsequent responses to traumatic events, particularly the death of a parent. Drawing on the theoretical...This article explores the intricate relationship between attachment styles formed during early childhood and the subsequent responses to traumatic events, particularly the death of a parent. Drawing on the theoretical framework of attachment theory and incorporating contemporary research, the paper discusses how parental interactions shape the neural circuitry of infants and children, influencing their ability to form secure or insecure attachments. These attachment styles, in turn, play a critical role in determining the child’s coping mechanisms when faced with trauma. This paper focuses on trying to understand how attachment theory is connected to the reaction to trauma with a highlight on the four major styles of attachments which are secure, anxious, avoidant, and disorganized to mention but a few, and how they influence stress and adversity in children. Attachment theory holds that human beings’ ability to form affectional bonds in infancy determines their patterns of relatedness across the life cycle. The type of attachment that is secure usually supports healthy adaptation and good coping mechanisms regardless of the trauma in the childhood of the child. While secure attachment mostly facilitates favorable trauma-related outcomes, anxious or avoidant attachment can exacerbate or alter the responses. The caregiving system that is avoidant attachment has implications of autonomous self-functioning which has features of suppression of the emotional response and poor search for emotional support during stress. From the principles of developmental psychology and trauma theory, the paper also focuses on the major significance of the child’s early caregivers’ interactions that define the resilience and vulnerability factor. This knowledge is therefore critical in designing specific interventions based on the improvement of coping behaviors and emotional regulatory systems of children who have been exposed to trauma. Finally, we have the synthesis of new knowledge about the role of secure attachment relationships as its fundamental element in shaping adaptive traumatization and psychological development. The article also delves into the physiological processes involved in emotional regulation and the role of cortisol in disrupting attachment. Finally, the implications of these findings for therapeutic interventions and the challenges of addressing prolonged grief and traumatic responses in clinical settings are considered.展开更多
学习障碍的早期鉴别能够有效预防学习障碍的发生,美国《残障人教育法》(IDEA,2004)明确建议在学习障碍的鉴别中用干预应答模型(Response to Intervention,RTI)替代"智力—成就差异模型"。RTI模式在美国得到了广泛推广,但是鉴...学习障碍的早期鉴别能够有效预防学习障碍的发生,美国《残障人教育法》(IDEA,2004)明确建议在学习障碍的鉴别中用干预应答模型(Response to Intervention,RTI)替代"智力—成就差异模型"。RTI模式在美国得到了广泛推广,但是鉴别的指标、标准一直是影响鉴别信度和效度的关键问题。本文对比分析了近十年来RTI研究中的测量指标和筛选标准及其鉴别结果,发现学业成就是有无应答的最佳指标,但是具体的指标和标准还取决于研究对象的特征。RTI鉴别借助了动态测量的方法,在实施中需要通过课程测量和任课教师的执行,未来的测量将朝着标准化和智能化的方向发展。RTI模式对于我国制定学习障碍的标准化测量工具以及建立学习障碍鉴别与干预体系具有借鉴作用。展开更多
Enhanced recovery after surgery (ERAS), a series of evidence-based optimization measures during the perioperative period, to reduce patients’ physical and psychological traumatic stress responses, to reduce complicat...Enhanced recovery after surgery (ERAS), a series of evidence-based optimization measures during the perioperative period, to reduce patients’ physical and psychological traumatic stress responses, to reduce complications, to shorten the length of hospital stay, to reduce the risk of readmission and mortality, and ultimately to promote rapid patient resuscitation, is adopted. The negative emotional experience of patients may aggravate the surgical stress response, interfere with the endocrine system and nervous system, cause the imbalance of internal environment, and have a negative impact on the surgical effect. This paper uses the concept of ERAS in combination with psychological stress interventions, perioperative psychological nursing instruction, reduces the laparoscopic surgery in patients with psychological stress reaction on the immune function of cells, improves the body’s immune function, improves the body of bacteria such as vitamin attack resistance, reduces the risk of complications such as infection, and accelerates the process of patient rehabilitation. Here is the report.展开更多
During the last decade of the 20th century, there were nine humanitarian interventions: in Northern Iraq, Bosnia, Somalia, Rwanda, Haiti, Albania, Kosovo, East Timor, and Sierra Leone. Of the cases cited, the consent ...During the last decade of the 20th century, there were nine humanitarian interventions: in Northern Iraq, Bosnia, Somalia, Rwanda, Haiti, Albania, Kosovo, East Timor, and Sierra Leone. Of the cases cited, the consent of the home government was obtained in five cases and two others had explicit Security Council authorization. However, two cases were carried out without consent of the government or authorization by the UN Security Council: Northern Iraq and Kosovo1. NATO bombing of FR Yugoslavia in 1999 received a particular attention and condemnation. Without UN Security Council’s resolution for that “air campaign”, there was justification that the action was about prevention of humanitarian catastrophe. This paper will attempt at identifying legal position of humanitarian intervention in international law;whether or not, and in what circumstances, it is safe to claim that there exists the right to humanitarian intervention. At the beginning of the 21st century, there has been extensive consideration of the “responsibility to protect” as a composite concept comprising the responsibilities to prevent humanitarian catastrophe, to react immediately when they do occur and to rebuild afterwards.2 Such an approach may be seen as an effort to redefine the principle of humanitarian intervention in a way that seeks to minimize the motives of the intervening powers. The paper also deals with the relation and differences between humanitarian intervention and “responsibility to protect” concept.展开更多
基金Supported by Ministry of Sciences and Innovation I+D+i Project,No.PID2019-107201GB-100Principality of Asturias,No.FCGRUPIN-IDI/2018/000199.
文摘Neurodevelopmental disorders are a group of conditions classified together by the most recent edition of the Diagnostic and Statistical Manual of Mental Disorders which include intellectual disability,communication disorders,autism spectrum disorder,attention-deficit/hyperactivity disorder,specific learning disorder(SLD),and motor disorders.SLD is present in many students,who exhibit significant difficulties in the acquisition of reading,written expression,and mathematics,mostly due to problems with executive functions(EF).The present study is a review of the current situation of neurodevelopmental disorders and SLD focusing on the benefits of the response to intervention model(RtI),which allows the combination of evaluation and intervention processes.It also addresses the key role of EF.The importance of adapting RtI to new possibilities such as the use of virtual reality is discussed and a theoretical framework for carrying that out is provided.
文摘Objective: To investigate the effect of group psychological intervention on oxidative stress, apoptosis and inflammatory response in patients with schizophrenia. Methods: A total of 80 patients with schizophrenia who received hospitalization in the hospital between September 2014 and October 2016 were collected and divided into control group (n=40) and observation group (n=40) according to the random number table method. Control group received routine clinical intervention, the observation group received group psychological intervention on the basis of conventional intervention, and the differences in serum contents of oxidative stress indicators, apoptosis molecules and inflammatory factors were compared between the two groups of patients before and after intervention. Results: Before intervention, the differences in serum levels of oxidative stress indexes, apoptosis molecules and inflammatory factors were not statistically significant between the two groups of patients. After intervention, serum SOD and bcl-2 levels of both groups of patients were higher than those before intervention while MDA, bax, Caspace-3, Fas, IL-1β, IL-6 and TNF-α levels were lower than those before intervention, and serum SOD and bcl-2 levels of observation group were higher than those of control group while MDA, bax, Caspace-3, Fas, IL-1β, IL-6 and TNF-α levels were lower than those of control group. Conclusion: Group psychological intervention can effectively inhibit the systemic oxidative stress and inflammatory response, and reduce the process of apoptosis in patients with schizophrenia.
文摘Objective: To study the effect of early enteral nutrition intervention on nerve function, systemic oxidative stress and inflammatory response in patients with hypertensive cerebral hemorrhage. Methods: A total of 98 patients with hypertensive cerebral hemorrhage who received hospitalization in the hospital between April 2015 and February 2017 were collected and divided into control group and observation group by random number table method, 49 cases in each group. Control group received routine enteral nutrition intervention and observation group received early enteral nutrition intervention. The differences in serum levels of nerve function-related indexes, oxidative stress indexes and inflammatory mediators were compared between the two groups of patients before and after intervention. Results: Before intervention, the differences in serum levels of nerve function-related indexes, oxidative stress indexes and inflammatory mediators were not statistically significant between the two groups of patients. After 1 week of intervention, serum S100B, NSE, GFAP, MBP, LPO, MDA, PCT, IL-1β, IL-6 and TNF-α levels of both groups of patients were lower than those before intervention while GSH-PX levels were higher than those before intervention, and serum S100B, NSE, GFAP, MBP, LPO, MDA, PCT, IL-1β, IL-6 and TNF-α levels of observation group were lower than those of control group while GSH-PX level was higher than that of control group. Conclusion:Early enteral nutrition intervention can effectively optimize the nerve function and suppress the systemic oxidative stress and inflammatory response in patients with hypertensive cerebral hemorrhage.
基金supported by the Key Project of the"Twelfth FiveYear Plan"for Medical Science and Technology Research of People’s Liberation Army(BWS12J006)the Scientific Key Project of Liaoning Province(2011225006)
文摘Background: Pelvic fracture combined with massive bleeding(PFCMB) is a complex issue in clinical practice. Currently, the use of angiography and embolization for the treatment of PFCMB obtains good results. The aim of this study is to observe the effects of early internal iliac artery embolization on the systemic inflammatory response syndrome(SIRS) in dogs with simulated-pelvic-fracture combined with massive bleeding.Methods: Twenty adult dogs were randomly divided into an embolization group(EG) and a control group(CG). For the two groups, heart rate, respiratory rate and body temperature and other physiological variables were measured, and IL-6, TNF-α and arterial blood gas levels were monitored. These variables were assayed every 30 min until death in the CG, while dogs in the EG underwent arterial angiography after 60 min of modeling. The internal iliac artery was embolized on the injured side.Results: The average time to SIRS in the CG was 3.56 h, occurring at a rate of 90%(9/10) within 24 h, with a mortality rate of 50%(5/10); the average time to SIRS for the EG was 5.33 h, occurring at a rate of 30%(3/10) within 24 h, with a mortality rate of 10%(1/10). When SIRS occurred in the EG, the mean plasma IL-6 level was 52.66±7.38pg/ml and the TNF-ps, tα level was 11.45±2.72ng/ml, showing a significant difference with those of the CG(P<0.05). In the two grouhe respiratory rate and leukocyte levels were higher at each monitored time after modeling than those before modeling; the mean arterial pressure, levels of hemoglobin and oxygen partial pressure were significantly lower at each time point after modeling than those before modeling except for the mean arterial pressure at 0h in EG; the platelet levels at 4 and 8h were higher than those before modeling; and the differences were statistically significant(P<0.05). In the EG, the mean arterial pressure, heart rate, respiratory rate and hemoglobin levels at 2, 4 and 8h were lower than those at 0h; the levels of leukocytes, platelets and carbon dioxide partial pressure at 4 and 8h after modeling were higher than those at 0h, and the differences were statistically significant(P<0.05, P<0.01); in the CG after modeling, the mean arterial pressure, levels of hemoglobin and carbon dioxide partial pressure at 2, 4 and 8h were lower than those at 0h; the levels of heart rate and leukocytes were higher than those before modeling; the respiratory rate and platelet levels at 4 and 8h were higher than those at 0h; and the differences were statistically significant(P<0.05). The levels of the mean arterial pressure and hemoglobin at 4 and 8h and the p H values at 8h after modeling in the EG were significantly higher than those in the CG, while the heart rate and respiratory rate at 4 and 8h were significantly lower than those in the CG. The p H values at 8h after modeling were significantly lower than those of the other monitored times in the CG(P<0.05, P<0.01). The two groups had elevated levels of alkaline phosphatase after injury induction.Conclusion: Through the use of an on-spot interventional treatment cabin, early internal iliac artery embolization can control bleeding associated with pelvic fractures, delay the occurrence of SIRS, and improve the success rate of the treatment of pelvic fracture combined with bleeding.
文摘Rice is the main food for over 95 percent of the Sierra Leonean populace. It accounts for the largest portion of the agricultural GDP of the country. On the contrary, its cultivation has been shrinking over the past decades. Consequently, importation now becomes the main source of supplying the grain for local needs since its cultivation or production could no longer meet domestic request. The deterioration in the local cultivation of rice has had severe socio-economic implications such as higher consumer prices and balance of payment burden. Therefore, the main objective of this study is to evaluate the effect of price and other related nonprice policy intervention on rice cultivation in the country. The tools utilized for analyzing the problem comprise, a coefficient of protection analysis as well as a supply response analysis by means of a time series regression (for the period 1980-2011). Major limitations established negatively affecting rice output are price disincentives to cultivators, public expenditure and fertilizer consumption. From the above findings, rice cultivators should be accorded the necessary incentives to keep them more effective in the rice cultivation career. The food policy approach that had over the years depended on huge importation of rice should be reviewed in favor of domestic cultivation. Increasing local cultivation through a meaningful protection of cultivators can independently reduce the price of rice to the advantage of the final consumers. This study also recommends that public funds should be redirected away from rice import toward investments in its domestic cultivation.
基金The Zhejiang Provincial Natural Science Foundation of China under contract No.LHZ22D060001the Scientific Research Funds of the Second Institute of Oceanography,Ministry of Natural Resources under contract Nos JG2315 and XRJH2309the National Key R&D Program of China under contract No.2022YFC3106200.
文摘Beach erosion has occurred globally in recent decades due to frequent and severe storms.Dongsha beach,located in Zhujiajian Island,Zhejiang Province,China,is a typical embayed sandy beach.This study focused on the morphodynamic response of Dongsha beach to typhoon events,based on beach topographies and surficial sediment characteristics acquired before and after four typhoon events with varying intensities.The four typhoons had different effects on the topography and sediment characteristics of Dongsha beach.Typhoons Ampil and Danas caused the largest(-51.72 m3/m)and the smallest erosion(-8.01 m3/m),respectively.Remarkable alongshore patterns of beach profile volumetric changes were found after the four typhoon events,with more erosion in the southern and central parts of the beach and few changes in the northern part.Grain size coarsening and poor sorting were the main sediment patterns on the beach influenced by different typhoons.Typhoons that occurred in the same year after another typhoon enhanced the effect of the previous typhoon on sediment coarsening and sorting variability,but this cumulative effect was not found between typhoons that occurred during different years.A comparison of the collected data revealed that the topographic state of the beach before the typhoon,typhoon characteristics,and tidal conditions were possible reasons for the difference in the responses of Dongsha beach to typhoon events.More severe beach erosion was caused by typhoons with higher intensity levels and longer durations,and high tide levels during typhoons can determine the upper limit of the beach profile erosion site.Taken together,these results can be used to improve beach management for storm prevention.
文摘In 1945,Porter et al.published an electon microscopy study of cultured chick fibroblasts in which they observed:'a granular background and details of a darker lacelike reticulum which in places appears to be made up of chains of"vesicles"'(Porter et al.,1945).This constituted the first published observation of the endoplasmic reticulum(ER)and,while it was not evident at that time,this cytoplasmic system of interconnecting membrane-lined channels, comprising vesicles, tubules and cisternae, has numerous important functions.
文摘Objective:To investigate the changes of immune response and side effects before and after nutritional intervention in cervical cancer patients with concurrent chemoradiotherapy. Methods: A total of 160 patients with primary cervical cancer who received concurrent chemoradiotherapy in this hospital between May 2016 and September 2017 were selected as the research subjects. Their nutritional intervention plans were reviewed and used to divide the patients into the control group (n=83) who accepted conventional nutritional support and the nutritional intervention group (n=77) who accepted targeted nutritional intervention. The differences in the contents of Th1/Th2 immunity indexes and humoral immunity indexes as well as the levels of bone marrow suppression-related indexes were compared between the two groups before and after intervention.Results: Before intervention, the differences in the contents of Th1/Th2 immunity indexes and humoral immunity indexes as well as the levels of bone marrow suppression-related indexes were not statistically significant between the two groups. After intervention, serum IL-2, IFN-γ, IL-4 and IL-6 contents of nutritional intervention group were lower than those of control group;serum IgA, IgM, IgG, C3 and C4 contents were higher than those of control group;peripheral blood WBC, RBC, Hb and PLT levels were higher than those of control group.Conclusion: Nutritional intervention can effectively optimize the immune status and reduce the bone marrow suppression reaction in cervical cancer patients with concurrent chemoradiotherapy.
文摘Objective:To study the effect of nicorandil on postoperative myocardial injury, platelet function and inflammatory response in patients with slow reflow in PCI.Methods: Patients who underwent emergency PCI and had intraoperative slow reflow in Zigong Fourth People's Hospital between March 2015 and August 2017 were selected and divided into nicorandil group and normal control group according to the application of nicorandil after no reflow or not in the history data. The levels of myocardial injury indexes in serum as well as the expression of platelet activation molecules and inflammatory signaling molecules in peripheral blood were measured before PCI as well as 1 day and 3 days after PCI.Results: Compared with the corresponding indexes of same group before PCI, serum H-FABP, HIF-1α, CK-MB and cTnⅠlevels as well as peripheral blood PAR1, PAR4, CCR2, p38MAPK, HSP27, Notch1, NF-κB, MEK1, ERK1/2 and CaMKⅡ mRNA expression of both groups of patients were significantly lower 1 day and 3 days after PCI, and serum H-FABP, HIF-1α, CK-MB and cTnⅠ levels as well as peripheral blood PAR1, PAR4, CCR2, p38MAPK, HSP27, Notch1, NF-κB, MEK1, ERK1/2 and CaMKII mRNA expression of nicorandil group 1 day and 3 days after PCI were significantly lower than those of normal control group.Conclusions:Nicorandil has negative regulating effect on postoperative myocardial injury, platelet activation and inflammatory response activation in patients with slow reflow in PCI.
文摘Objective:To investigate the effects of adjuvant bupleurum injection therapy in perioperative period of PCI on myocardial damage, oxidative stress response and apoptosis.Methods:Patients with acute myocardial infarction who received PCI in Chengyue Community Health Center of Xisaishan District Huangshi City Hubei Province between June 2014 and February 2017 were selected as the research subjects and randomly divided into the bupleurum group who received adjuvant bupleurum injection therapy in perioperative period of PCI and the control group who received routine therapy in perioperative period of PCI. The myocardial damage indexes, oxidative stress indexes and apoptosis indexes in serum and peripheral blood were measured before treatment and 1 d and 3 d after treatment.Results: 1 d and 3 d after treatment, H-FABP, cTnT, CK-MB, CTGF, MDA, AOPP, sFas, sTWEAK, sTRAIL and Caspase-3 contents in serum as well as O2-, NOX and HO-1 contents in the peripheral blood of both groups of patients were significantly lower than those before treatment and H-FABP, cTnT, CK-MB, CTGF, MDA, AOPP, sFas, sTWEAK, sTRAIL and Caspase-3 contents in serum as well as O2-, NOX and HO-1 contents in the peripheral blood of bupleurum group were significantly lower than those of control group.Conclusion:Adjuvant bupleurum injection therapy in perioperative period of PCI can reduce the myocardial damage, oxidative stress response and apoptosis.
文摘Objective:To study the effect of exercise rehabilitation combined with trimetazidine on endothelial function, inflammatory response and blood lipid metabolism in patients with coronary heart disease after percutaneous coronary intervention (PCI).Methods: The patients with stable angina pectoris who received PCI in our hospital between July 2015 and November 2017 were chosen and randomly divided into the observation group who received postoperative exercise rehabilitation combined with trimetazidine and the control group who received conventional intervention combined with trimetazidine. The reactive hyperemia index (RHI) as well as serum contents of endothelial markers, inflammatory cytokines and blood lipid indexes were determined before intervention and after intervention for 3 months.Results:After intervention for 3 months, the RHI levels as well as serum NO, HDL-C and Omentin-1 contents of both groups significantly increased while serum ET-1, vWF, M-CSF, IL-6, IL-8, RANTES, LDL-C and Chemerin contents significantly decreased;the RHI level as well as serum NO, HDL-C and Omentin-1 contents of the observation group was significantly higher than those of the control group while serum ET-1, vWF, M-CSF, IL-6, IL-8, RANTES, LDL-C and Chemerin contents were significantly lower than those of the control group.Conclusion:Exercise rehabilitation combined with trimetazidine can improve the endothelial function, inhibit the inflammatory response and regulate the blood lipid metabolism in patients with coronary heart disease after PCI.
基金Natural Science Foundation of China No:81170138.
文摘Objective:To study the predictive value of serum S1P and STIM1 levels after percutaneous coronary intervention (PCI) for in-stent restenosis and their correlation with angiogenesis and inflammatory response.Methods:130 patients who received PCI in our hospital between June 2013 and December 2016 were selected and divided into restenosis group and non-restenosis group according to the coronary angiography results 6-24 months after PCI. The serum levels of S1P, STIM1, angiogenesis molecules and inflammation molecules were detected 24 hours after PCI.Results:Serum S1P, NO, VEGF, Angptl2 and Angptl4 levels of restenosis group were significantly lower than those of non-restenosis group while STIM1, IFN-γ, IL-18, VCAM-1, P-selectin and L-selectin levels were significantly higher than those of non-restenosis group;serum NO, VEGF, Angptl2 and Angptl4 levels of restenosis group with lower STIM1 were significantly higher those of restenosis group with normal STIM1;serum IFN-γ, IL-18, VCAM-1, P-selectin and L-selectin levels of restenosis group with lower S1P were significantly higher than those of restenosis group with normal S1P.Conclusion:The decreased serum S1P and increased STIM1 after PCI have prediction value for in-stent restenosis and are closely related to the angiogenesis disorder and inflammation activation.
文摘This article explores the intricate relationship between attachment styles formed during early childhood and the subsequent responses to traumatic events, particularly the death of a parent. Drawing on the theoretical framework of attachment theory and incorporating contemporary research, the paper discusses how parental interactions shape the neural circuitry of infants and children, influencing their ability to form secure or insecure attachments. These attachment styles, in turn, play a critical role in determining the child’s coping mechanisms when faced with trauma. This paper focuses on trying to understand how attachment theory is connected to the reaction to trauma with a highlight on the four major styles of attachments which are secure, anxious, avoidant, and disorganized to mention but a few, and how they influence stress and adversity in children. Attachment theory holds that human beings’ ability to form affectional bonds in infancy determines their patterns of relatedness across the life cycle. The type of attachment that is secure usually supports healthy adaptation and good coping mechanisms regardless of the trauma in the childhood of the child. While secure attachment mostly facilitates favorable trauma-related outcomes, anxious or avoidant attachment can exacerbate or alter the responses. The caregiving system that is avoidant attachment has implications of autonomous self-functioning which has features of suppression of the emotional response and poor search for emotional support during stress. From the principles of developmental psychology and trauma theory, the paper also focuses on the major significance of the child’s early caregivers’ interactions that define the resilience and vulnerability factor. This knowledge is therefore critical in designing specific interventions based on the improvement of coping behaviors and emotional regulatory systems of children who have been exposed to trauma. Finally, we have the synthesis of new knowledge about the role of secure attachment relationships as its fundamental element in shaping adaptive traumatization and psychological development. The article also delves into the physiological processes involved in emotional regulation and the role of cortisol in disrupting attachment. Finally, the implications of these findings for therapeutic interventions and the challenges of addressing prolonged grief and traumatic responses in clinical settings are considered.
文摘学习障碍的早期鉴别能够有效预防学习障碍的发生,美国《残障人教育法》(IDEA,2004)明确建议在学习障碍的鉴别中用干预应答模型(Response to Intervention,RTI)替代"智力—成就差异模型"。RTI模式在美国得到了广泛推广,但是鉴别的指标、标准一直是影响鉴别信度和效度的关键问题。本文对比分析了近十年来RTI研究中的测量指标和筛选标准及其鉴别结果,发现学业成就是有无应答的最佳指标,但是具体的指标和标准还取决于研究对象的特征。RTI鉴别借助了动态测量的方法,在实施中需要通过课程测量和任课教师的执行,未来的测量将朝着标准化和智能化的方向发展。RTI模式对于我国制定学习障碍的标准化测量工具以及建立学习障碍鉴别与干预体系具有借鉴作用。
文摘Enhanced recovery after surgery (ERAS), a series of evidence-based optimization measures during the perioperative period, to reduce patients’ physical and psychological traumatic stress responses, to reduce complications, to shorten the length of hospital stay, to reduce the risk of readmission and mortality, and ultimately to promote rapid patient resuscitation, is adopted. The negative emotional experience of patients may aggravate the surgical stress response, interfere with the endocrine system and nervous system, cause the imbalance of internal environment, and have a negative impact on the surgical effect. This paper uses the concept of ERAS in combination with psychological stress interventions, perioperative psychological nursing instruction, reduces the laparoscopic surgery in patients with psychological stress reaction on the immune function of cells, improves the body’s immune function, improves the body of bacteria such as vitamin attack resistance, reduces the risk of complications such as infection, and accelerates the process of patient rehabilitation. Here is the report.
文摘During the last decade of the 20th century, there were nine humanitarian interventions: in Northern Iraq, Bosnia, Somalia, Rwanda, Haiti, Albania, Kosovo, East Timor, and Sierra Leone. Of the cases cited, the consent of the home government was obtained in five cases and two others had explicit Security Council authorization. However, two cases were carried out without consent of the government or authorization by the UN Security Council: Northern Iraq and Kosovo1. NATO bombing of FR Yugoslavia in 1999 received a particular attention and condemnation. Without UN Security Council’s resolution for that “air campaign”, there was justification that the action was about prevention of humanitarian catastrophe. This paper will attempt at identifying legal position of humanitarian intervention in international law;whether or not, and in what circumstances, it is safe to claim that there exists the right to humanitarian intervention. At the beginning of the 21st century, there has been extensive consideration of the “responsibility to protect” as a composite concept comprising the responsibilities to prevent humanitarian catastrophe, to react immediately when they do occur and to rebuild afterwards.2 Such an approach may be seen as an effort to redefine the principle of humanitarian intervention in a way that seeks to minimize the motives of the intervening powers. The paper also deals with the relation and differences between humanitarian intervention and “responsibility to protect” concept.