Despite a plethora of studies on how corporate social responsibility(CSR)generates favorable consumer outcomes,the existing literature provides limited insights about how CSR may affect inter-consumer connection and b...Despite a plethora of studies on how corporate social responsibility(CSR)generates favorable consumer outcomes,the existing literature provides limited insights about how CSR may affect inter-consumer connection and brand community engagement.Enhancing consumer engagement in the brand community is one of the key marketing objectives for strengthening the brand-consumer relationship.This study aims to explore the role of corporate social responsibility in enhancing brand community engagement and examines the dual mediating role of brand identification and community identification.Quantitative research was conducted and an adapted questionnaire was used.Survey data were collected from 405 Chinese consumers,and structural equational modeling was used to test the hypothesis.Results demonstrated that CSR motivates consumers to engage with the brand community.Further,brand identification and community identification perform the role of partial mediators.展开更多
Hotel as a hospitality industry should manage its reputation as a valuable asset for the business continuity. The hotel＇s reputation is built up by the employee＇s perceptions of treatment and sense of belonging and ...Hotel as a hospitality industry should manage its reputation as a valuable asset for the business continuity. The hotel＇s reputation is built up by the employee＇s perceptions of treatment and sense of belonging and engagement of the hotel. The purpose of this study is to analyze employee＇s perceptions of corporate social responsibility （CSR） activities, employee engagement, and corporate reputation that have been undertaken by the hotel industry in Jakarta and how demographic factors influence these perceptions. The structure equation model （SEM） was implemented to find each variable influence. Samples were taken from hotel employees who work in five-star hotels in Jakarta with 221 respondents （response rate 78.9%）. The results indicate that CSR activities significantly influence employee engagement and corporate reputation, and at the same time, employee engagement significantly influences cor0orate reputation.展开更多
Organizational corporate social responsibility is a good practice by organizations. Organizations engagement in corporate social responsibility programs may benefit the organization and stakeholders. The focus of this...Organizational corporate social responsibility is a good practice by organizations. Organizations engagement in corporate social responsibility programs may benefit the organization and stakeholders. The focus of this paper is to explore the extent of employees＇ engagement in the organization＇s corporate responsibility programs by utilizing Unerman＇s （2007） stakeholders engagement framework. The main research question is how employees engage themselves in corporate social responsibility programs. This study employs a case study research design approach. The findings have shown that there is empowerment between employees and the management in the corporate social responsibility programs. Their involvement appears from their feedbacks and views in the surveys as well as discussion with regards to corporate responsibility programs. All in all, employees＇ engagement is seen as an important practice in the organization, particularly in planning, implementing, monitoring, and reporting the corporate responsibility program.展开更多
The dynamic response behaviors of upright breakwaters under broken wave impact are analysed based on the mass-damper-spring dynamic system model. The effects of the mass, damping, stiffness, natural period, and impuls...The dynamic response behaviors of upright breakwaters under broken wave impact are analysed based on the mass-damper-spring dynamic system model. The effects of the mass, damping, stiffness, natural period, and impulse duration (or oscillation period) on the translation, rotation, sliding force, overturning moment, and corresponding dynamic amplifying factors are studied. It is concluded that the ampli-ying factors only depend on the ratio of the system natural period to impulse duration (or oscillation period) under a certain damping ratio. Moreover, the equivalent static approach to breakwater design is also discussed.展开更多
The genomes of eukaryotic cells are under continuous assault by environmental agents and endogenous metabolic byproducts. Damage induced in DNA usually leads to a cascade of cellular events, the DNA damage response. F...The genomes of eukaryotic cells are under continuous assault by environmental agents and endogenous metabolic byproducts. Damage induced in DNA usually leads to a cascade of cellular events, the DNA damage response. Failure of the DNA damage response can lead to development of malignancy by reducing the efficiency and fidelity of DNA repair. The NBS1 protein is a component of the MRE11/RAD50/NBS 1 complex （MRN） that plays a critical role in the cellular response to DNA damage and the maintenance of chromosomal integrity. Mutations in the NBS1 gene are responsible for Nijmegen breakage syndrome （NBS）, a hereditary disorder that imparts an increased predisposition to development of malignancy. The phenotypic characteristics of cells isolated from NBS patients point to a deficiency in the repair of DNA double strand breaks. Here, we review the current knowledge of the role of NBS1 in the DNA damage response. Emphasis is placed on the role of NBS1 in the DNA double strand repair, modulation of the DNA damage sensing and signaling, cell cycle checkpoint control and maintenance oftelomere stability.展开更多
An analysis has been developed to predict the transient aeroelastic response of gimballed tiltrotors during shipboard engage/disengage operations. A multi blade gimballed rotor is modeled with slender elastic beams ...An analysis has been developed to predict the transient aeroelastic response of gimballed tiltrotors during shipboard engage/disengage operations. A multi blade gimballed rotor is modeled with slender elastic beams rigidly attached to a hub and undergoing flap bending, lag bending, elastic twist, and axial deflection. The gimbal restraint is simulated using a conditional rotational spring. Blade element theory is used to calculate quasi steady loads in linear and nonlinear regimes. The rotor equations of motion are formulated using Hamiltons principle and spatially discretized using the finite element method. The discretized rotor equations of motion are integrated in the modal space for a specified rotor speed run up profile. Studies for a 1/5 size aeroelastically scaled tiltrotor model are conducted to validate the analysis and investigate the transient response and loads of the gimballed rotor during engagement. Blade bending moment and hub moment predictions indicated that gimbal restraint impacts can induce high transient loads on the rotor blades and hub.展开更多
In order to improve the nutritional quality of biscuits, a multigrain premix (MGP) was developed by using whole barley, sorghum, chickpea, pea and defatted soya flour, each at 20% level. The developed MGP had 26.28% p...In order to improve the nutritional quality of biscuits, a multigrain premix (MGP) was developed by using whole barley, sorghum, chickpea, pea and defatted soya flour, each at 20% level. The developed MGP had 26.28% protein, 10.13% insoluble dietary fiber and 7.38% soluble dietary fiber. The experiment was designed to optimise the MGP and wheat flour concentration for the development of multigrain biscuits with high protein, dietary fibre and to maximize the acceptability by the application of central composite rotatable design (CCRD) of Response Surface Methodology (RSM). The levels of incorporation of MGP and wheat flour were taken as variables whereas protein, soluble, insoluble fibers, biscuit dough hardness, breaking strength and overall acceptability (OAA) as responses. The optimum level of MGP and wheat flour obtained using numerical optimization was found to be 40 g and 60 g respectively. The biscuits prepared using these had 16.61% protein, 2.57% soluble fibre, and 6.67% insoluble fibre which is significantly (p ≤ 0.05) higher than control biscuit.展开更多
Recent studies have suggested an involvement of processing pathways for the initiation of cellular responses induced by topoisomerase-targeting drugs. Here, we showed that cellular exposure to camptothecin （CPT） ind...Recent studies have suggested an involvement of processing pathways for the initiation of cellular responses induced by topoisomerase-targeting drugs. Here, we showed that cellular exposure to camptothecin （CPT） induced formation of topoisomerase I cleavable complex （TOPlcc）, degradation of TOP1 and activation of DNA damage responses （DDR）. Transcription and proteasome-dependent proteolysis, but not replication, were involved in CPTo indneed TOPl degradation, while none of above three processing activities affected TOPlcc formation. Replication- and transcription-initiated proeessing （RIP and TIP） of TOPlee were identified as two independent pathways, which contribute distinctly to various CPT-activated DDR. Specifically, in cycling cells, RIP-processed TOPlec triggered the CPT-induced RPA pbosphorylation. At higher CPT dosages, the TIP pathway is required for other DDR activation, including ATM, p53 and Chkl/2 phosphorylation. The TIP pathway was further demonstrated to be S-phase independent by using three nonreplicating cell models. Furthermore, the effect of proteasome inhibitors mimicked that of transcription inhibition on the CPT-induced activation of DDR, suggesting the involvement of proteasome in the TIP pathway. Interestingly, the TIP pathway was important for TOPlcc-activated, but not ionization radiationactivated ATM, p53 and Chk2 phosphorylation. We have also found that pharmacological interferences of TIP and RIP pathways distinctively modulated the CPT-induced cell killing with treatments at low and high dosages, respec- tively. Together, our results support that both RIP and TIP pathways of TOPlcc are required for the activation of CPT-induced DDR and cytotoxicity.展开更多
Due to a wide range of clinical response in patients un-dergoing neo-adjuvant chemoradiation for rectal cancer it is essential to understand molecular factors that lead to the broad response observed in patients recei...Due to a wide range of clinical response in patients un-dergoing neo-adjuvant chemoradiation for rectal cancer it is essential to understand molecular factors that lead to the broad response observed in patients receiving the same form of treatment.Despite extensive research in this field,the exact mechanisms still remain elusive.Data raging from DNA-repair to specific molecules lead-ing to cell survival as well as resistance to apoptosis have been investigated.Individually,or in combination,there is no single pathway that has become clinically applicable to date.In the following review,we describe the current status of various pathways that might lead to resistance to the therapeutic applications of ionizing radiation in rectal cancer.展开更多
Accumulating evidence indicates that ataxia-telangiectasia mutated kinase is critical for maintaining cellular homeostasis and that it has both nuclear and cytoplasmic functions.However,the functions of ataxia-telangi...Accumulating evidence indicates that ataxia-telangiectasia mutated kinase is critical for maintaining cellular homeostasis and that it has both nuclear and cytoplasmic functions.However,the functions of ataxia-telangiectasia mutated that when lost lead to cerebellar degeneration are still unknown.In this review,we first describe the role of ataxia-telangiectasia mutated in cerebellar pathology.In addition to its canonical nuclear functions in DNA damage response circuits,ataxia-telangiectasia mutated functions in various cytoplasmic and mitochondrial processes that are critically important for cellular homeostasis.We discuss these functions with a focus on the role of ataxia-telangiectasia mutated in maintaining the homeostatic redox state.Finally,we describe the unique functions of ataxia-telangiectasia mutated in various types of neuronal and glial cells including cerebellar granule neurons,astrocytes,and microglial cells.展开更多
文摘Despite a plethora of studies on how corporate social responsibility(CSR)generates favorable consumer outcomes,the existing literature provides limited insights about how CSR may affect inter-consumer connection and brand community engagement.Enhancing consumer engagement in the brand community is one of the key marketing objectives for strengthening the brand-consumer relationship.This study aims to explore the role of corporate social responsibility in enhancing brand community engagement and examines the dual mediating role of brand identification and community identification.Quantitative research was conducted and an adapted questionnaire was used.Survey data were collected from 405 Chinese consumers,and structural equational modeling was used to test the hypothesis.Results demonstrated that CSR motivates consumers to engage with the brand community.Further,brand identification and community identification perform the role of partial mediators.
文摘Hotel as a hospitality industry should manage its reputation as a valuable asset for the business continuity. The hotel＇s reputation is built up by the employee＇s perceptions of treatment and sense of belonging and engagement of the hotel. The purpose of this study is to analyze employee＇s perceptions of corporate social responsibility （CSR） activities, employee engagement, and corporate reputation that have been undertaken by the hotel industry in Jakarta and how demographic factors influence these perceptions. The structure equation model （SEM） was implemented to find each variable influence. Samples were taken from hotel employees who work in five-star hotels in Jakarta with 221 respondents （response rate 78.9%）. The results indicate that CSR activities significantly influence employee engagement and corporate reputation, and at the same time, employee engagement significantly influences cor0orate reputation.
文摘Organizational corporate social responsibility is a good practice by organizations. Organizations engagement in corporate social responsibility programs may benefit the organization and stakeholders. The focus of this paper is to explore the extent of employees＇ engagement in the organization＇s corporate responsibility programs by utilizing Unerman＇s （2007） stakeholders engagement framework. The main research question is how employees engage themselves in corporate social responsibility programs. This study employs a case study research design approach. The findings have shown that there is empowerment between employees and the management in the corporate social responsibility programs. Their involvement appears from their feedbacks and views in the surveys as well as discussion with regards to corporate responsibility programs. All in all, employees＇ engagement is seen as an important practice in the organization, particularly in planning, implementing, monitoring, and reporting the corporate responsibility program.
文摘The dynamic response behaviors of upright breakwaters under broken wave impact are analysed based on the mass-damper-spring dynamic system model. The effects of the mass, damping, stiffness, natural period, and impulse duration (or oscillation period) on the translation, rotation, sliding force, overturning moment, and corresponding dynamic amplifying factors are studied. It is concluded that the ampli-ying factors only depend on the ratio of the system natural period to impulse duration (or oscillation period) under a certain damping ratio. Moreover, the equivalent static approach to breakwater design is also discussed.
文摘The genomes of eukaryotic cells are under continuous assault by environmental agents and endogenous metabolic byproducts. Damage induced in DNA usually leads to a cascade of cellular events, the DNA damage response. Failure of the DNA damage response can lead to development of malignancy by reducing the efficiency and fidelity of DNA repair. The NBS1 protein is a component of the MRE11/RAD50/NBS 1 complex （MRN） that plays a critical role in the cellular response to DNA damage and the maintenance of chromosomal integrity. Mutations in the NBS1 gene are responsible for Nijmegen breakage syndrome （NBS）, a hereditary disorder that imparts an increased predisposition to development of malignancy. The phenotypic characteristics of cells isolated from NBS patients point to a deficiency in the repair of DNA double strand breaks. Here, we review the current knowledge of the role of NBS1 in the DNA damage response. Emphasis is placed on the role of NBS1 in the DNA double strand repair, modulation of the DNA damage sensing and signaling, cell cycle checkpoint control and maintenance oftelomere stability.
文摘An analysis has been developed to predict the transient aeroelastic response of gimballed tiltrotors during shipboard engage/disengage operations. A multi blade gimballed rotor is modeled with slender elastic beams rigidly attached to a hub and undergoing flap bending, lag bending, elastic twist, and axial deflection. The gimbal restraint is simulated using a conditional rotational spring. Blade element theory is used to calculate quasi steady loads in linear and nonlinear regimes. The rotor equations of motion are formulated using Hamiltons principle and spatially discretized using the finite element method. The discretized rotor equations of motion are integrated in the modal space for a specified rotor speed run up profile. Studies for a 1/5 size aeroelastically scaled tiltrotor model are conducted to validate the analysis and investigate the transient response and loads of the gimballed rotor during engagement. Blade bending moment and hub moment predictions indicated that gimbal restraint impacts can induce high transient loads on the rotor blades and hub.
文摘In order to improve the nutritional quality of biscuits, a multigrain premix (MGP) was developed by using whole barley, sorghum, chickpea, pea and defatted soya flour, each at 20% level. The developed MGP had 26.28% protein, 10.13% insoluble dietary fiber and 7.38% soluble dietary fiber. The experiment was designed to optimise the MGP and wheat flour concentration for the development of multigrain biscuits with high protein, dietary fibre and to maximize the acceptability by the application of central composite rotatable design (CCRD) of Response Surface Methodology (RSM). The levels of incorporation of MGP and wheat flour were taken as variables whereas protein, soluble, insoluble fibers, biscuit dough hardness, breaking strength and overall acceptability (OAA) as responses. The optimum level of MGP and wheat flour obtained using numerical optimization was found to be 40 g and 60 g respectively. The biscuits prepared using these had 16.61% protein, 2.57% soluble fibre, and 6.67% insoluble fibre which is significantly (p ≤ 0.05) higher than control biscuit.
文摘Recent studies have suggested an involvement of processing pathways for the initiation of cellular responses induced by topoisomerase-targeting drugs. Here, we showed that cellular exposure to camptothecin （CPT） induced formation of topoisomerase I cleavable complex （TOPlcc）, degradation of TOP1 and activation of DNA damage responses （DDR）. Transcription and proteasome-dependent proteolysis, but not replication, were involved in CPTo indneed TOPl degradation, while none of above three processing activities affected TOPlcc formation. Replication- and transcription-initiated proeessing （RIP and TIP） of TOPlee were identified as two independent pathways, which contribute distinctly to various CPT-activated DDR. Specifically, in cycling cells, RIP-processed TOPlec triggered the CPT-induced RPA pbosphorylation. At higher CPT dosages, the TIP pathway is required for other DDR activation, including ATM, p53 and Chkl/2 phosphorylation. The TIP pathway was further demonstrated to be S-phase independent by using three nonreplicating cell models. Furthermore, the effect of proteasome inhibitors mimicked that of transcription inhibition on the CPT-induced activation of DDR, suggesting the involvement of proteasome in the TIP pathway. Interestingly, the TIP pathway was important for TOPlcc-activated, but not ionization radiationactivated ATM, p53 and Chk2 phosphorylation. We have also found that pharmacological interferences of TIP and RIP pathways distinctively modulated the CPT-induced cell killing with treatments at low and high dosages, respec- tively. Together, our results support that both RIP and TIP pathways of TOPlcc are required for the activation of CPT-induced DDR and cytotoxicity.
文摘Due to a wide range of clinical response in patients un-dergoing neo-adjuvant chemoradiation for rectal cancer it is essential to understand molecular factors that lead to the broad response observed in patients receiving the same form of treatment.Despite extensive research in this field,the exact mechanisms still remain elusive.Data raging from DNA-repair to specific molecules lead-ing to cell survival as well as resistance to apoptosis have been investigated.Individually,or in combination,there is no single pathway that has become clinically applicable to date.In the following review,we describe the current status of various pathways that might lead to resistance to the therapeutic applications of ionizing radiation in rectal cancer.
文摘Accumulating evidence indicates that ataxia-telangiectasia mutated kinase is critical for maintaining cellular homeostasis and that it has both nuclear and cytoplasmic functions.However,the functions of ataxia-telangiectasia mutated that when lost lead to cerebellar degeneration are still unknown.In this review,we first describe the role of ataxia-telangiectasia mutated in cerebellar pathology.In addition to its canonical nuclear functions in DNA damage response circuits,ataxia-telangiectasia mutated functions in various cytoplasmic and mitochondrial processes that are critically important for cellular homeostasis.We discuss these functions with a focus on the role of ataxia-telangiectasia mutated in maintaining the homeostatic redox state.Finally,we describe the unique functions of ataxia-telangiectasia mutated in various types of neuronal and glial cells including cerebellar granule neurons,astrocytes,and microglial cells.
