Objective:To determine the preventive effects of curcumin on peroxidative damage under two bed rest conditions.Methods:20 healthy male(10 with curcumin and 10 without curcumin ) volunteers were selected.They were stud...Objective:To determine the preventive effects of curcumin on peroxidative damage under two bed rest conditions.Methods:20 healthy male(10 with curcumin and 10 without curcumin ) volunteers were selected.They were studied before,during,and just on bed rest conditions at -6°head-down-tilt(HDT) bed rest and bed rest position(BD) for 10 days.We measured the salivary and serum oxidative markers such as Malonaldehyde,8-hydroxydeoxyguanosine, vitamin C and E just before HDT & BD.during HDT & BD experiment,and in course time of recovery with curcumin and without curcumin groups.Results:The values of serum and salivary vitamin C & E showed statistically significant decrease in both bed rest conditions as compared to those of the conditions before and during the recovery stage.However,these levels were not significantly lowered in curcumin groups in contrast to the groups without curcumin (P】0.05).MDA and 8-OHdG levels showed significant increase in simulating microgravity and zero gravity conditions as compared to those before and in the recovery stage.However,these levels were lower in curcumin groups in contrast to the groups without curcumin(P【0.05).Serum and salivary correlation analysis revealed a strong and highly significant correlation for MDA. vitamin C & E and 8 dihydro-2 deoxyguanosine(8-OHdG) in the conditions before,during and in the recovery periods in both bed rest conditions.Since saliva collection is easy and noninvasive, measurements of salivary marker levels may prove to be useful in the space research. Conclusions:Curcumin prevents peroxidative damage in both bed rest conditions.Further study is required on antioxidation actions of curcumin in space microgravity conditions.展开更多
目的探究女性乳腺癌患者术前新辅助化疗后脑静息态功能和类淋巴功能变化及其之间的相关性。方法40名健康女性被试及80名女性乳腺癌患者被纳入本次研究,乳腺癌患者均进行术前新辅助化疗。应用MMSE、DSST和FACT-CogPCI评分评估被试认知功...目的探究女性乳腺癌患者术前新辅助化疗后脑静息态功能和类淋巴功能变化及其之间的相关性。方法40名健康女性被试及80名女性乳腺癌患者被纳入本次研究,乳腺癌患者均进行术前新辅助化疗。应用MMSE、DSST和FACT-CogPCI评分评估被试认知功能。应用rsfMRI获取反映大脑功能活动的ALFF指标。应用DTI-ALPS技术获取反映脑类淋巴功能的ALPS指数。分析乳腺癌患者化疗前后ALFF及ALPS变化,分析各指标与认知评分之间的相关性,并分析ALFF与ALPS之间的相关性情况。结果乳腺癌患者化疗后MMSE、DSST及FACT-CogPCI评分均减低(P<0.05)。化疗后,左侧颞极中部、左侧丘脑腹外侧核及右侧顶后中回团块ALFF值减低,双侧颞叶、枕叶及顶叶多个脑区的ALFF值与FACTCogPCI评分呈正相关(pFDR-C<0.001)。化疗后ALPS指数相比正常被试增高(1.42±0.29 vs 1.56±0.24,P=0.011),同时ALPS指数与FACT-CogPCI评分呈正相关(r=0.241,P=0.04)。与此同时化疗后左侧舌状回ALFF值与ALPS指数呈正相关(r=0.69,P<0.001)。结论研究结果提示,大脑功能活动和类淋巴引流均参与化疗后认知功能改变的过程,同时两者存在相关性。展开更多
文摘Objective:To determine the preventive effects of curcumin on peroxidative damage under two bed rest conditions.Methods:20 healthy male(10 with curcumin and 10 without curcumin ) volunteers were selected.They were studied before,during,and just on bed rest conditions at -6°head-down-tilt(HDT) bed rest and bed rest position(BD) for 10 days.We measured the salivary and serum oxidative markers such as Malonaldehyde,8-hydroxydeoxyguanosine, vitamin C and E just before HDT & BD.during HDT & BD experiment,and in course time of recovery with curcumin and without curcumin groups.Results:The values of serum and salivary vitamin C & E showed statistically significant decrease in both bed rest conditions as compared to those of the conditions before and during the recovery stage.However,these levels were not significantly lowered in curcumin groups in contrast to the groups without curcumin (P】0.05).MDA and 8-OHdG levels showed significant increase in simulating microgravity and zero gravity conditions as compared to those before and in the recovery stage.However,these levels were lower in curcumin groups in contrast to the groups without curcumin(P【0.05).Serum and salivary correlation analysis revealed a strong and highly significant correlation for MDA. vitamin C & E and 8 dihydro-2 deoxyguanosine(8-OHdG) in the conditions before,during and in the recovery periods in both bed rest conditions.Since saliva collection is easy and noninvasive, measurements of salivary marker levels may prove to be useful in the space research. Conclusions:Curcumin prevents peroxidative damage in both bed rest conditions.Further study is required on antioxidation actions of curcumin in space microgravity conditions.
文摘目的探究女性乳腺癌患者术前新辅助化疗后脑静息态功能和类淋巴功能变化及其之间的相关性。方法40名健康女性被试及80名女性乳腺癌患者被纳入本次研究,乳腺癌患者均进行术前新辅助化疗。应用MMSE、DSST和FACT-CogPCI评分评估被试认知功能。应用rsfMRI获取反映大脑功能活动的ALFF指标。应用DTI-ALPS技术获取反映脑类淋巴功能的ALPS指数。分析乳腺癌患者化疗前后ALFF及ALPS变化,分析各指标与认知评分之间的相关性,并分析ALFF与ALPS之间的相关性情况。结果乳腺癌患者化疗后MMSE、DSST及FACT-CogPCI评分均减低(P<0.05)。化疗后,左侧颞极中部、左侧丘脑腹外侧核及右侧顶后中回团块ALFF值减低,双侧颞叶、枕叶及顶叶多个脑区的ALFF值与FACTCogPCI评分呈正相关(pFDR-C<0.001)。化疗后ALPS指数相比正常被试增高(1.42±0.29 vs 1.56±0.24,P=0.011),同时ALPS指数与FACT-CogPCI评分呈正相关(r=0.241,P=0.04)。与此同时化疗后左侧舌状回ALFF值与ALPS指数呈正相关(r=0.69,P<0.001)。结论研究结果提示,大脑功能活动和类淋巴引流均参与化疗后认知功能改变的过程,同时两者存在相关性。
